Página 1 dos resultados de 9995 itens digitais encontrados em 2.530 segundos

‣ Interfacing metal-organic frameworks with structured supports

Domingos, Mariana Garcia
Fonte: Universidade do Porto Publicador: Universidade do Porto
Tipo: Dissertação Formato: VIII, 87 p., 30 cm; application/pdf
Português
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Tese de mestrado integrado. Engenharia Química. Faculdade de Engenharia. Universidade do Porto, Faculty of Applied Sciences. Delft University of Technology. 2009

‣ PHA production by a mixed culture under dissolved oxygen limitation

Campos, Filipe Venn Vieira de
Fonte: Universidade do Porto Publicador: Universidade do Porto
Tipo: Dissertação Formato: X, 52 f., 30 cm; application/pdf
Português
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Tese de mestrado integrado. Engenharia Química. Faculdade de Engenharia. Universidade do Porto, Faculty of Applied Sciences. Delft University of Technology. 2010

‣ A unified kinetics and thermodynamics model for electrochemically active biofilms

Cruz, Filipe António Nogueira da
Fonte: Universidade do Porto Publicador: Universidade do Porto
Tipo: Dissertação Formato: pag. var., 30 cm; application/pdf
Português
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Trabalho de investigação desenvolvido na Delft University of Technology. Faculty of Applied Sciences. Department of Biotechnology; Tese de Mestrado Integrado. Bioengenharia. Faculdade de Engenharia. Universidade do Porto. 2012

‣ The value of public health research and the division between basic vs. applied science

Almeida-Filho,Naomar; Goldbaum,Moisés
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2003 Português
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We question the movement towards exclusion of population and social health research from the field of science. The background under analysis is contemporary Brazil, where the scientific field that hosts this kind of research is known as Collective Health. First, the problem is formalized on logical grounds, evaluating the pertinence of considering unscientific the many objects and methods of public health research. Secondly, the cases of pulmonary tuberculosis and external causes are brought in as illustrations of the kind of scientific problem faced in health research today. The logical and epistemological basis of different forms of "scientific segregation" based on biomedical reductionism is analyzed, departing from three theses: (i) the ethics of the general application of science; (ii) the inappropriateness of monopolies for objectivity in the sciences; (iii) the specificity of scientific fields. In the current panorama of health research in Brazil, a residual hegemonic position that defends a narrow and specific definition of the object of knowledge was found. The denial of validity and specificity to objects, methods and research techniques that constitute social and population research in health is linked to elements of irrationality in reductionism approaches. Nevertheless...

‣ Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells

Davis, Brian M.; Encell, Lance P.; Zielske, Steven P.; Christians, Fred C.; Liu, Lili; Friebert, Sarah E.; Loeb, Lawrence A.; Gerson, Stanton L.
Fonte: The National Academy of Sciences Publicador: The National Academy of Sciences
Tipo: Artigo de Revista Científica
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Applied molecular evolution is a rapidly developing technology that can be used to create and identify novel enzymes that nature has not selected. An important application of this technology is the creation of highly drug-resistant enzymes for cancer gene therapy. Seventeen O6-alkylguanine-DNA alkyltransferase (AGT) mutants highly resistant to O6-benzylguanine (BG) were identified previously by screening 8 million variants, using genetic complementation in Escherichia coli. To examine the potential of these mutants for use in humans, the sublibrary of AGT clones was introduced to human hematopoietic cells and stringently selected for resistance to killing by the combination of BG and 1,3-bis(2-chloroethyl)-1-nitrosourea. This competitive analysis between the mutants in human cells revealed three AGT mutants that conferred remarkable resistance to the combination of BG and 1,3-bis(2-chloroethyl)-1-nitrosourea. Of these, one was recovered significantly more frequently than the others. Upon further analysis, this mutant displayed a level of BG resistance in human hematopoietic cells greater than that of any previously reported mutant.

‣ Heterogeneity explains features of “anomalous” thermodynamics and statistics

Gheorghiu, Stefan; Coppens, Marc-Olivier
Fonte: National Academy of Sciences Publicador: National Academy of Sciences
Tipo: Artigo de Revista Científica
Português
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Phenomena characterized by power-law probability distributions abound in nature and the applied sciences. We show that many of these power laws are well described by the Student, or t, distribution, and we discuss the origin of this universality based on three examples (Brownian motion, Knudsen diffusion in rough pores, and bubbly multiphase flow). These case studies are representative for a large class of systems with heterogeneous features, examples of which can be found from Earth sciences to astrophysics, and even in the social sciences. We show that common forms of polydispersity, such as polydispersity arising naturally as a result of aggregation–fragmentation phenomena, typically lie at the basis of the observed scaling. We conclude that complicated arguments based on long-range correlations or nonergodicity are often incorrect or misleading in explaining many naturally observed power laws and, in particular, those described by the Student distribution.

‣ Long-term cortical plasticity evoked by electric stimulation and acetylcholine applied to the auditory cortex

Ma, Xiaofeng; Suga, Nobuo
Fonte: National Academy of Sciences Publicador: National Academy of Sciences
Tipo: Artigo de Revista Científica
Português
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Auditory fear conditioning with tone bursts followed by electric leg stimulation activates neurons not only in the auditory and somatosensory systems but also in many other regions of the brain and elicits shifts in the best frequencies (BFs) of collicular and cortical neurons, i.e., reorganization of the frequency (co-chleotopic) maps in the inferior colliculus and auditory cortex (AC). What are the neural elements minimally necessary for evoking long-term cortical BF shifts? We found that: (i) both electric stimulation and acetylcholine applied to the AC evoke the long-term cortical BF shift as does the conditioning; (ii) both electric stimulation of the AC and acetylcholine applied to the inferior colliculus increase the short-term collicular BF shift evoked by the cortical electric stimulation but do not change it into long-term; and (iii) as this short-term collicular BF shift is blocked by atropine, the development of the long-term cortical BF shift becomes slow and small. Therefore, the most essential neural elements for evoking the long-term cortical BF shift are the AC, corticofugal feedback and the cholinergic nucleus. Our current data support the Gao–Suga model, which hypothesizes that the small short-term cortical BF shifts are evoked by tonal stimuli without the association of conditioned and unconditioned stimuli in the multisensory thalamic nuclei and that these BF shifts are augmented and changed into the large long-term BF shifts by cholinergic neurons.

‣ Continuous polyelectrolyte adsorption under an applied electric potential

Ngankam, A. Pascal; Van Tassel, Paul R.
Fonte: National Academy of Sciences Publicador: National Academy of Sciences
Tipo: Artigo de Revista Científica
Português
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Interactions between charged macromolecules (e.g., proteins, nucleic acids, polyelectrolytes) and charged surfaces govern many natural and industrial processes. We investigate here the influence of an applied electric potential on the adsorption of charged polymers, and report the following significant result: the adsorption of certain amine side chain-containing polycations may become continuous, i.e., asymptotically linear (or nearly linear) in time over hours, upon the application of a modest anodic potential. Employing optical waveguide lightmode spectroscopy (OWLS) and an indium tin oxide (ITO) substrate, we show that asymptotic kinetics, and the adsorbed mass at the onset of the asymptotic regime, depend sensitively on polymer chemistry (in particular, side chain volume and charge location), increase with applied potential and ionic strength (conditions favoring a thicker initial layer), and are independent of bulk polymer concentration (suggesting postadsorption events to be rate limiting). X-ray photoelectron spectra reveal a suppressed polymer charge within layers formed via continuous adsorption, but no evidence of electrochemical reactions. We propose a mechanism based on polymer–polymer binding within the adsorbed layer...

‣ Membrane shape as a reporter for applied forces

Lee, Heun Jin; Peterson, Eric L.; Phillips, Rob; Klug, William S.; Wiggins, Paul A.
Fonte: National Academy of Sciences Publicador: National Academy of Sciences
Tipo: Artigo de Revista Científica
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Recent advances have enabled 3-dimensional reconstructions of biological structures in vivo, ranging in size and complexity from single proteins to multicellular structures. In particular, tomography and confocal microscopy have been exploited to capture detailed 3-dimensional conformations of membranes in cellular processes ranging from viral budding and organelle maintenance to phagocytosis. Despite the wealth of membrane structures available, there is as yet no generic, quantitative method for their interpretation. We propose that by modeling these observed biomembrane shapes as fluid lipid bilayers in mechanical equilibrium, the externally applied forces as well as the pressure, tension, and spontaneous curvature can be computed directly from the shape alone. To illustrate the potential power of this technique, we apply an axial force with optical tweezers to vesicles and explicitly demonstrate that the applied force is equal to the force computed from the membrane conformation.

‣ Optimal experimental design applied to DC resistivity problems

Coles, Darrell Ardon, 1971-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 323 p.
Português
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The systematic design of experiments to optimally query physical systems through manipulation of the data acquisition strategy is termed optimal experimental design (OED). This dissertation introduces the state-of-the-art in OED theory and presents a new design methodology, which is demonstrated by application to DC resistivity problems. The primary goal is to minimize inversion model errors and uncertainties, where the inversion is approached via nonlinear least squares with L1 smoothness constraints. An equally important goal is to find ways to expedite experimental design to make it practical for a wider variety of surveying situations than is currently possible.A fast, sequential ED strategy is introduced that designs surveys accumulatively by an efficient method that maximizes the determinant of the Jacobian matrix. An analysis of electrode geometries for multielectrode data acquisition systems reveals that experiment-space can be usefully decimated by using special subsets of observations, reducing design CPU times. Several techniques for decimating model-space are also considered that reduce design times.A law of diminishing returns is observed; compact, information-dense designed surveys produce smaller model errors than comparably sized random and standard surveys...

‣ Sponsored Programs Annual Report / Graduate School of Engineering and Applied Sciences, Fiscal Year 2005.

Fonte: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office Publicador: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office
Tipo: Relatório
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The Graduate School of Engineering and Applied Sciences (GSEAS) at the Naval Postgraduate School in Monterey, California provides graduate education leading to the master of science, engineer, doctor of philosophy, and doctor of engineering degrees. This FY2005 annual report provides brief program information ; Sponsored Program expenditures by type of activity, by sponsor and by department. These departments are: Applied Mathematics (MA), Electrical and Computer Engineering (ECE) ; Mechanical and Astronautical Engineering (MAE) ; Meteorology (MR) ; Oceanography (OC) ; Physics (PH) ; Systems Engineering (SE) ; and the Space Systems Academic Group (SP).

‣ Sponsored Programs Annual Report / Graduate School of Engineering and Applied Sciences, Fiscal Year 2006.

Fonte: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office Publicador: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office
Tipo: Relatório
Português
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56.692246%
The Graduate School of Engineering and Applied Sciences (GSEAS) at the Naval Postgraduate School in Monterey, California provides graduate education leading to the master of science, engineer, doctor of philosophy, and doctor of engineering degrees. This FY2006 report provides brief program information ; Sponsored Program expenditures by type of activity, by sponsor and by department. These departments are: Applied Mathematics (MA), Electrical and Computer Engineering (ECE) ; Electrical and Computer Engineering ; Mechanical and Astronautical Engineering (MAE) ; Meteorology (MR) ; Oceanography (OC) ; Physics (PH) ; Systems Engineering (SE) ; and the Space Systems Academic Group.

‣ Sponsored Programs Annual Report / Graduate School of Operational and Information Sciences, Fiscal Year 2006.

Fonte: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office Publicador: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office
Tipo: Relatório
Português
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46.50083%
The Graduate School of Operational and Information Sciences (GSOIS) includes graduate resident programs consisting of sixteen technical curricula and awards masters of science and Ph.D. degrees across four academic departments. This annual report provides a brief overview of the Program ; The Sponsored Program Profile covering FY 2000-2004 ; and Sponsored Program expenditures by activity, by sponsor and by NPS organization. The following organizations covered are the School of International Studies (SIGS) ; the Graduate School of Engineering and Applied Sciences (GSEAS) ; The Graduate School of Business and Public Policy (GSBPP) and the Graduate School of Operational and Informational Sciences (GSOIS).

‣ Sponsored Programs Annual Report / Graduate School of Engineering and Applied Sciences, Fiscal Year 2007.

Fonte: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office Publicador: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office
Tipo: Relatório
Português
Relevância na Pesquisa
56.692246%
The Graduate School of Engineering and Applied Sciences (GSEAS) at the Naval Postgraduate School in Monterey, California provides graduate education leading to the master of science, engineer, doctor of philosophy, and doctor of engineering degrees. This FY2007 report provides brief program information ; Sponsored Program expenditures by type of activity, by sponsor and by department. These departments are: Applied Mathematics (MA), Electrical and Computer Engineering (ECE) ; Electrical and Computer Engineering ; Mechanical and Astronautical Engineering (MAE) ; Meteorology (MR) ; Oceanography (OC) ; Physics (PH) ; Systems Engineering (SE) ; and the Space Systems Academic Group (SP).

‣ Sponsored Programs Annual Report / Graduate School of Engineering and Applied Sciences, Fiscal Year 2008.

Fonte: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office Publicador: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office
Tipo: Relatório
Português
Relevância na Pesquisa
56.588276%
This FY2008 annual report on Sponsored Programs at The Graduate School of Engineering and Applied Sciences (GSEAS) Naval Postgraduate School in Monterey, California provides a program overview ; sponsored program expenditures by activity, sponsor and department.

‣ Sponsored Programs Annual Report / Graduate School of Engineering and Applied Sciences, Fiscal Year 2010.

Fonte: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office Publicador: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office
Tipo: Relatório
Português
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56.588276%
This FY2010 annual report on Sponsored Programs at The Graduate School of Engineering and Applied Sciences (GSEAS) Naval Postgraduate School in Monterey, California provides a program overview ; sponsored program expenditures by activity, sponsor and department.

‣ Dr. Philip Durkee, Dean, School of Engineering and Applied Sciences, Biography

Fonte: Naval Postgraduate School, Monterey, CA. Publicador: Naval Postgraduate School, Monterey, CA.
Tipo: Biography
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Biography and Awards of Dr. Philip Durkee, Dean, School of Engineering and Applied Sciences, Naval Postgraduate School, Monterey, CA.; Dr. Philip Durkee, Professor of Meteorology, was appointed the Dean of the Graduate School of Engineering and Applied Sciences (GSEAS) on January 1, 2012. Prof. Durkee earned his B.S. in Physics with distinction in 1978 from the University of Minnesota, and his M.S. (1980) and Ph.D. (1984) at Colorado State University. He joined the NPS Meteorology Department upon graduating from CSU, and served as Meteorology Department Chairman from 2004-2011.

‣ Graduate School of Engineering & Applied Sciences: Message from the Dean

Fonte: Monterey, California. Naval Postgraduate School Publicador: Monterey, California. Naval Postgraduate School
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Greetings from the Graduate School of Engineering and Applied Sciences at NPS! We are initiating this periodic GSEAS newsletter for the purpose of sharing information to a large audience that includes GSEAS and NPS, as well as a broad external group that ranges from future students to senior leaders in the defense community. The intent is to raise levels of awareness of the quality, breadth and relevance of our education and research programs by offering short, easy to read articles, calendars of events and descriptions of who we are and what we do. We hope that with each edition, readers will learn something new about our great school. GSEAS exists to serve the needs of the Navy and national security needs. We welcome feedback and are always at your service.

‣ Graduate School of Engineering & Applied Sciences, web page capture

Naval Postgraduate School (U.S.)
Fonte: Monterey, California: Naval Postgraduate School Publicador: Monterey, California: Naval Postgraduate School
Tipo: web page capture
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Web page capture from the NPS website of the Graduate School of Engineering & Applied Sciences homepage.; The Graduate School of Engineering & Applied Sciences includes Resident Programs consisting of 14 Curricula and approximately 350 Students.

‣ Sponsored Programs Annual Report / Graduate School of Engineering and Applied Sciences, Fiscal Year 2009.

Fonte: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office Publicador: Monterey, California. Naval Postgraduate School, Research and Sponsored Programs Office
Tipo: Relatório
Português
Relevância na Pesquisa
56.692246%
The Graduate School of Engineering and Applied Sciences (GSEAS) at the Naval Postgraduate School in Monterey, California provides graduate education leading to the master of science, engineer, doctor of philosophy, and doctor of engineering degrees. This FY 2009 Annual Report provides an overview of the Program ; Expenditures by activity, by sponsor and by organization ; Information about how NPS's research and education institutes apply interdisciplinary research to military challenges, offering or facilitating degree programs, executive and continuing education, student contact with senior naval leadership, and student and faculty research from basic to applied ; and additional research facts about the Sponsored Programs in FY 2009.