Últimos itens adicionados do Acervo: Biblioteca Digital da Produção Intelectual e Científica da Unicamp

A Biblioteca Digital da Produção Intelectual e Científica da Unicamp tem por objetivo reunir e disseminar a produção intelectual, acadêmica e cultural da universidade e preservar sua memória institucional, além de contribuir para ampliar a visibilidade da instituição e dos seus pesquisadores em âmbito nacional e internacional.

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‣ Thalassemia major phenotypes secondary to the association of beta 5 ' UTR +20(C -> T) allele with beta 39(C -> T)

Fattori, Andre; Fertrin, Kleber Y.; de Albuquerque, Dulcineia M.; Bezerra, Marcos A. C.; dos Santos, Magnun N. N.; de Castro, Simone M.; Costa, Fernando F.
Fonte: Wiley-Blackwell; Hoboken Publicador: Wiley-Blackwell; Hoboken
Tipo: Artigo de Revista Científica
Português

‣ Oxidized low-density lipoproteins and their antibodies: Relationships with the reverse cholesterol transport and carotid atherosclerosis in adults without cardiovascular diseases

Ferreira, Paolla F. C.; Zago, Vanessa H. S.; D'Alexandri, Fabio L.; Panzoldo, Natalia B.; Gidlund, Magnus A.; Nakamura, Rui T.; Schreiber, Roberto; Parra, Eliane S.; Santiago, Fernanda D.; Nakandakare, Edna R.; Quintao, Eder C. R.; de Faria, Eliana C.
Fonte: Elsevier; Amsterdam Publicador: Elsevier; Amsterdam
Tipo: Artigo de Revista Científica
Português
Background: Metabolic predictors and the atherogenicity of oxidized LDL (oxLDL) and the specific antibodies against oxLDL (oxLDL Ab) are unclear and controversial. Methods: In 107 adults without atherosclerotic manifestations, we measured oxLDL and oxLDL Ab, and also the activities of CETP. PLTP, lipases and the carotid intima-media thickness (cIMT). Comparisons were performed for the studied parameters between the lowest and the highest tertile of oxLDL and oxLDL Ab, and the relationships between studied variables were evaluated. Results: Subjects with higher oxLDL Ab present reduced hepatic lipase activity and borderline increased cIMT. In the highest oxLDL tertile, besides the higher levels of total cholesterol, LDL-C and apoB100, we found reduced CETP activity and higher cIMT. A significant correlation between oxLDL Ab and cIMT, independent of oxLDL, and a borderline correlation between oxLDL and cIMT independent of oxLDL Ab were found. In the multivariate analysis, apoAl was a significant predictor of oxLDL Ab, in contrast to regulation of oxLDL by apoB100, PLTP and inverse of CETP. Conclusions: In adults without atherosclerotic disease, the metabolic regulation and carotid atherosclerosis of oxLDLAb and oxLDL groups, characterized a dual trait in oxLDL Ab...

‣ Auxiliary device for calibration of roller pumps: development and experimental results

Vieira, F. U., Jr.; Dantas de Medeiros, J., Jr.; Antunes, N.; Vieira, R. W.; Costa, E. T.
Fonte: Sage Publications Ltd; London Publicador: Sage Publications Ltd; London
Tipo: Artigo de Revista Científica
Português
Introduction: Roller pumps are commonly used in surgeries involving extracorporeal circulation and its regulation may influence the hemolysis rate. Objective: To describe an auxiliary device for adjusting roller pumps using the dynamic calibration method and show preliminary results of its application in surgical procedures. Method:The device was tested in the laboratory environment with three disposable pressure transducers normally used in surgeries. In the operation room, tests were carried out with two groups of patients. Free hemoglobin plasma rates were measured,5 minutes after perfusion started and immediately before the passage of the residual volume of the pump. For Group 1 (n = 22), occlusion measurements were carried out using the drop rate method and for Group 2 (n = 18), measurements were carried out using the auxiliary device and 300 mmHg calibration (mean pressure for the dynamic calibration method). Results:The auxiliary calibration device has shown calibration results statistically equal to those obtained with a reference device in the laboratory environment. We have found less variability of hemolysis rates in the operating room, using the auxiliary device and we did not observe any influence of unbalanced rollers in the hemolysis rates.; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3

Bigarella, Carolina L.; Vieira Ferro, Karla P.; Barcellos, Karin S. A.; Martins-de-Souza, Daniel; Traina, Fabiola; Novello, Jose C.; Olalla Saad, Sara T.; Archangelo, Leticia Froehlich
Fonte: Elsevier; Amsterdam Publicador: Elsevier; Amsterdam
Tipo: Artigo de Revista Científica
Português
ARHGAP21 is a 217 kDa RhoGAP protein shown to modulate cell migration through the control of Cdc42 and FAK activities. In the present work a 250 kDa-ARHGAP21 was identified by mass spectrometry. This modified form is differentially expressed among cell lines and human primary cells. Co-immunoprecipitations and in vitro SUMOylation confirmed ARHGAP21 specific modification by SUMO2/3 and mapped the SUMOylation site to ARHGAP21 lysine K1443. Immunofluorescence staining revealed that ARHGAP21 co-localizes with SUMO2/3 in the cytoplasm and membrane compartments. Interestingly, our results suggest that ARHGAP21 SUMOylation may be related to cell proliferation. Therefore, SUMOylation of ARHGAP21 may represent a way of guiding its function. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Elevated plasma levels and platelet-associated expression of the pro-thrombotic and pro-inflammatory protein, TNFSF14 (LIGHT), in sickle cell disease

Garrido, Vanessa T.; Proenca-Ferreira, Renata; Dominical, Venina M.; Traina, Fabiola; Bezerra, Marcos A. C.; de Mello, Mariana R. B.; Colella, Marina P.; Araujo, Aderson S.; Saad, Sara T. O.; Costa, Fernando F.; Conran, Nicola
Fonte: Wiley-Blackwell; Hoboken Publicador: Wiley-Blackwell; Hoboken
Tipo: Artigo de Revista Científica
Português
Chronic vascular inflammation and endothelial activation may initiate vaso-occlusion in sickle cell disease (SCD). TNFSF14 (CD258; LIGHT), a recently-identified pro-thrombotic and pro-inflammatory tumour necrosis factor (TNF)-superfamily cytokine, has a potent activating effect on endothelial cells. We evaluated whether TNFSF14 production is altered in SCD and whether platelets contribute to this production. TNFSF14 was measured in platelet-free plasma from healthy-control individuals (CON), steady-state sickle cell anaemia (SCA), SCA on hydroxycarbamide therapy (SCAHC) and haemoglobin SC (HbSC) patients. Mean plasma TNFSF14 was significantly increased in SCA, SCAHC and HbSC, compared to CON individuals. In SCA/SCAHC patients, plasma TNFSF14, showed no correlation with haematological variables, but was significantly correlated with serum lactate dehydrogenase and inflammatory markers (CD40LG , IL8 and ICAM1). Platelet-membrane TNFSF14 expression was significantly augmented on SCA platelets, and correlated with platelet activation; furthermore, measurement of platelet TNFSF14 release indicated that platelets may be a major source of circulating TNFSF14 in SCA. Interestingly, high plasma TNFSF14 was significantly associated with elevated tricuspid regurgitant velocity (=2.5 m/s) in a population of SCA/SCAHC patients. The pro-inflammatory and atherogenic cytokine...

‣ Thalidomide plus dexamethasone as a maintenance therapy after autologous hematopoietic stem cell transplantation improves progression-free survival in multiple myeloma

Maiolino, Angelo; Hungria, Vania T. M.; Garnica, Marcia; Oliveira-Duarte, Gislaine; Oliveira, Luciana C. O.; Mercante, Daniel R.; Miranda, Eliana C.; Quero, Adriana A.; Peres, Ana L. M.; Barros, Jose C.; Tanaka, Paola; Magalhaes, Roberto P.; Rego, Eduardo
Fonte: Wiley-Blackwell; Hoboken Publicador: Wiley-Blackwell; Hoboken
Tipo: Artigo de Revista Científica
Português
Despite the good response of stem cell transplant (SCT) in the treatment of multiple myeloma (MM), most patients relapse or do not achieve complete remission, suggesting that additional treatment is needed. We assessed the impact of thalidomide in maintenance after SCT in untreated patients with MM. A hundred and eight patients (<70 years old) were randomized to receive maintenance with dexamethasone (arm A; n = 52) or dexamethasone with thalidomide (arm B; n = 56; 200 mg daily) for 12 months or until disease progression. After a median follow-up of 27 months, an intention to treat analysis showed a 2-year progression-free survival (PFS) of 30% in arm A (95% CI 2238) and 64% in arm B (95% CI 5771; P = 0.002), with median PFS of 19 months and 36 months, respectively. In patients who did not achieve at least a very good partial response, the PFS at 2 years was significantly higher when in use of thalidomide (19 vs. 59%; P = 0.002). Overall survival at 2 years was not significantly improved (70 vs. 85% in arm A and arm B, respectively; P = 0.27). The addition of thalidomide to dexamethasone as maintenance improved the PFS mainly in patients who did not respond to treatment after SCT. Am. J. Hematol. (c) 2012 Wiley Periodicals, Inc.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ The impact of medical education and networking on the outcome of leukemia treatment in developing countries. The experience of International Consortium on Acute Promyelocytic Leukemia (IC-APL)

Rego, Eduardo M.; Kim, Haesook T.; Ruiz-Argueelles, Guillermo J.; del Rosario Uriarte, Maria; Jacomo, Rafael H.; Gutierrez-Aguirre, Homero; Melo, Raul A. M.; Bittencourt, Rosane; Pasquini, Ricardo; Pagnano, Katia; Fagundes, Evandro M.; Chauffaille, Maria
Fonte: Maney Publishing; Leeds Publicador: Maney Publishing; Leeds
Tipo: Artigo de Revista Científica
Português
Objectives: Several clinical trials conducted in Europe and US reported favorable outcomes of patients with APL treated with the combination of all trans retinoic acid (ATRA) and anthracyclines. Nevertheless, the results observed in developing countries with the same regimen was poorer, mainly due to high early mortality mainly due bleeding. The International Consortium on Acute Promyelocytic Leukemia (IC-APL) is an initiative of the International Members Committee of the ASH and the project aims to reduce this gap through the establishment of international network, which was launched in Brazil, Mexico and Uruguay. Methods: The IC-APL treatment protocol is similar to the PETHEMA 2005, but changing idarubicin to daunorubicin. All patients with a suspected diagnosis of APL were immediately started on ATRA, while bone marrow samples were shipped to a national central lab where genetic verification of the diagnosis was performed. The immunofluorescence using an anti-PML antibody allowed a rapid confirmation of the diagnosis and, the importance of supportive measures was reinforced. Results: The interim analysis of 97 patients enrolled in the IC-APL protocol showed that complete remission (CR) rate was 83% and the 2-year overall survival and disease-free survival were 80% and 90%...

‣ Continuing education program in hemophilia: Touching base by getting all professionals together

Lima Shcaira, V. R.; Villaca, P. R.; Antunes, S. V.; Vinicius De Paula, E.; De Castro Ozelo, M.; Cerqueira Fernades De Oliveira, M. H.; Haubrichs De Freitas E Silva, T.; Bosso Jose Da Silva, J.; Cassis, F.; Perseke Wolff, A. L.; Aparecida Piccoloto Matta,
Fonte: Wiley-Blackwell; Hoboken Publicador: Wiley-Blackwell; Hoboken
Tipo: Artigo de Revista Científica
Português

‣ SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes

Visconte, Valeria; Rogers, Heesun J.; Singh, Jarnail; Barnard, John; Bupathi, Manoj; Traina, Fabiola; McMahon, James; Makishima, Hideki; Szpurka, Hadrian; Jankowska, Anna; Jerez, Andres; Sekeres, Mikkael A.; Saunthararajah, Yogen; Advani, Anjali S.; Copel
Fonte: Amer Soc Hematology; Washington Publicador: Amer Soc Hematology; Washington
Tipo: Artigo de Revista Científica
Português
Whole exome/genome sequencing has been fundamental in the identification of somatic mutations in the spliceosome machinery in myelodysplastic syndromes (MDSs) and other hematologic disorders. SF3B1, splicing factor 3b subunit 1 is mutated in 60%-80% of refractory anemia with ring sideroblasts (RARS) and RARS associated with thrombocytosis (RARS-T), 2 distinct subtypes of MDS and MDS/myeloproliferative neoplasms (MDSs/MPNs). An idiosyncratic feature of RARS/RARS-T is the presence of abnormal sideroblasts characterized by iron over-load in the mitochondria, called RS. Based on the high frequency of mutations of SF3B1 in RARS/RARS-T, we investigated the consequences of SF3B1 alterations. Ultrastructurally, SF3B1 mutants showed altered iron distribution characterized by coarse iron deposits compared with wild-type RARS patients by transmission electron microscopy. SF3B1 knockdown experiments in K562 cells resulted in down-regulation of U2-type intron-splicing by RT-PCR. RNA-sequencing analysis of SF3B1 mutants showed differentially used genes relevant inMDSpathogenesis, such as ASXL1, CBL, EZH, and RUNX families. A SF3B pharmacologic inhibitor, meayamycin, induced the formation of RS in healthy BM cells. Further, BM aspirates of Sf3b1 heterozygous knockout mice showed RS by Prussian blue. In conclusion...

‣ Correlation of soil microbial community responses to contamination with crude oil with and without chromium and copper

dos Santos, Eder da C.; Silva, Isis S.; Simoes, Tiago H. N.; Simioni, Karen C. M.; Oliveira, Valeria M.; Grossman, Matthew J.; Durrant, Lucia R.
Fonte: Elsevier; Oxford Publicador: Elsevier; Oxford
Tipo: Artigo de Revista Científica
Português
Soil microcosms contaminated with crude oil with or without chromium and copper were monitored over a period of 90 days for microbial respiration, biomass, and for dehydrogenase, lipase, acid phosphatase, and arylsulfatase activities. In addition, the community structure was followed by enumerating the total heterotrophic and oil-degrading viable bacteria and by performing a denaturing gradient gel electrophoresis (DGGE) of the PCR amplified 16S rDNA. A significant difference was observed for biochemical activities and microbial community structures between the microcosms comprised of uncontaminated soil, soil contaminated with crude oil and soil contaminated with crude oil and heavy metals. The easily measured soil enzyme activities correlated well with microbial population levels, community structures and rates of respiration (CO2 production). The estimation of microbial responses to soil contamination provides a more thorough understanding of the microbial community function in contaminated soil, in situations where technical and financial resources are limited and may be useful in addressing bioremediation treatability and effectiveness. (C) 2012 Published by Elsevier Ltd.; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Caffeic acid phenethyl ester reduces the activation of the nuclear factor kappa B pathway by high-fat diet-induced obesity in mice

Neves Bezerra, Rosangela Maria; Veiga, Lucimara Fernanda; Caetano, Aline Camila; Rosalen, Pedro Luiz; Corezola Amaral, Maria Esmeria; Palanch, Adrianne Christine; de Alencar, Severino Matias
Fonte: W B Saunders Co-Elsevier Inc; Philadelphia Publicador: W B Saunders Co-Elsevier Inc; Philadelphia
Tipo: Artigo de Revista Científica
Português
Objective. The aim of this study was to investigate the effect of CAPE on the insulin signaling and inflammatory pathway in the liver of mice with high fat diet induced obesity. Material/Methods. Swiss mice were fed with standard chow or high-fat diet for 12-week. After the eighth week, animals in the HFD group with serum glucose levels higher than 200 mg/dL were divided into two groups, HFD and HFD receiving 30 mg/kg of CAPE for 4 weeks. After 12 weeks, the blood samples could be collected and liver tissue extracted for hormonal and biochemical measurements, and insulin signaling and inflammatory pathway analyzes. Results. The high-fat diet group exhibited more weight gain, glucose intolerance, and hepatic steatosis compared with standard diet group. The CAPE treatment showed improvement in glucose sensitivity characterized by an area under glucose curve similar to the control group in an oral glucose tolerance test Furthermore, CAPE treatment promoted amelioration in hepatic steatosis compared with the high-fat diet group. The increase in glucose sensitivity was associated with the improvement in insulin-stimulated phosphorylation of the insulin receptor substrate-2, followed by an increase in Akt phosphorylation. In addition, it was observed that CAPE reduced the induction of the inflammatory pathway...

‣ A new overtraining protocol for mice based on downhill running sessions

Pereira, Bruno C.; Filho, Luis A. L.; Alves, Guilherme F.; Pauli, Jose R.; Ropelle, Eduardo R.; Souza, Claudio T.; Cintra, Dennys E.; Saad, Mario J. A.; Silva, Adelino S. R.
Fonte: Wiley-Blackwell; Hoboken Publicador: Wiley-Blackwell; Hoboken
Tipo: Artigo de Revista Científica
Português
The purpose of the present study was to verify whether a downhill running protocol was able to induce non-functional overreaching in > 75% of mice. Mice were divided into control (C), trained (TR) and overtrained (OTR) groups. Bodyweight and food intake were recorded weekly. The incremental load test (ILT) and the exhaustive test (ET) were used to measure performance before and after aerobic training and overtraining protocols. Although the bodyweight of the OTR group was lower than that of the C group at the end of Week 7, the food intake of the OTR group was higher than that of the C and TR groups at the end of Week 8. Evaluation of results from the ILT and ET revealed significant intra- and inter-group differences: whereas the parameters measured by both tests increased significantly in the TR group, they were significantly decreased in the OTR group. In conclusion, this new overtraining protocol based on downhill running sessions induced non-functional overreaching in 100% of mice.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

‣ Current recommendations for levothyroxine treatment of differentiated thyroid cancer patients are not properly implemented in clinical practice

Martins de Almeida, J. F.; Goncalves Tsumura, W.; Vaisman, M.; Montalli Assumpcao, L. V.; Ward, L. S.
Fonte: Editrice Kurtis S R L; Milan Publicador: Editrice Kurtis S R L; Milan
Tipo: Artigo de Revista Científica
Português
Background: Levothyroxine (L-T-4) treatment aims to minimize the risk of differentiated thyroid cancer (DTC) recurrence and should be tailored to patient risk stratification and potential morbidity from adverse effects. Aim: To evaluate the effectiveness of current recommendations on L-T-4 treatment of DTC patients in clinical practice. Material and methods: We submitted to in-person interviews and revised the charts of 139 low-risk (LR) and 57 not-low-risk (NLR) DTC patients. A second evaluation made 24-60 months after surgery reclassified 131 patients who maintained (thyroglobulin) Tg <= 2 ng/dl with no evidence of relapse/recurrence as LR, whereas the remaining 65 cases were considered NLR. Results: Only 27% LR patients were appropriately controlled; 18% were kept suppressed; 49% maintained serum TSH levels between 0.11-0.4 mu/l; 21% had TSH=2.5-4.5 mu/l; and 12% TSH>4.5 mu/l. Among the NLR patients, 24 (37%) of the patients presented serum TSH levels above goal, including 13 (20%) patients with TSH>4.5 mu/l. There were 4 NLR elders whose TSH levels were kept between 0.41 and 4.5 for medical reasons; likewise, 28 NLR patients maintained with low but not undetectable serum TSH levels had cardiovascular and/or bone risk factors, but all the remaining 24 NLR patients were not adequately controlled because of poor treatment compliance. On the other hand...

‣ Infiltration of a mixture of immune cells may be related to good prognosis in patients with differentiated thyroid carcinoma

Cunha, Lucas L.; Morari, Elaine C.; Guihen, Ana C. T.; Razolli, Daniela; Gerhard, Rene; Nonogaki, Suely; Soares, Fernando A.; Vassallo, Jose; Ward, Laura S.
Fonte: Wiley-Blackwell; Hoboken Publicador: Wiley-Blackwell; Hoboken
Tipo: Artigo de Revista Científica
Português
Objective Immune responses against differentiated thyroid carcinomas (DTC) have long been recognized. We aimed to investigate the role of immune cell infiltration in the progression of DTC. Design We studied 398 patients 253 with papillary and 13 with follicular thyroid cancers, as well as 132 with nonmalignant tissues. Patients and measurements Immune cell infiltration was identified using CD3, CD4, CD8, CD20, CD68 and FoxP3 immunohistochemical markers. In addition, we assessed colocalization of CD4 and IL-17 to identify Th17 lymphocytic infiltration and colocalization of CD33 and CD11b to identify infiltration of myeloid-derived suppressor cells (MDSC). Results Immune cells infiltrated malignant tissues more often than benign lesions. The presence of chronic lymphocytic thyroiditis (CLT) concurrent to DTC, CD68+, CD4+, CD8+, CD20+, FoxP3+ and Th17 lymphocytes but not MDSCs was associated with clinical and pathological features of lower tumour aggressiveness and a more favourable patient outcome. A log-rank test confirmed an association between concurrent CLT, tumour-associated macrophage infiltration, and CD8+ lymphocytes and an increased in disease-free survival, suggesting that evidence of these immune reactions is associated with a favourable prognosis. Conclusion Our data suggest that the tumour or peri-tumoural microenvironment may act to modify the observed pattern of immune response. Immune cell infiltration and the presence of concurrent CLT helped characterize specific tumour histotypes associated with favourable prognostic features.

‣ OVEREXPRESSION OF IGF1R BUT NOT IGF2 IS ASSOCIATED WITH UNFAVORABLE EVENT AND METASTASIS IN ADRENOCORTICAL CARCINOMAS

Peixoto Lira, Regia Caroline; Fedatto, Paola Fernanda; Martinelli, Carlos Eduardo, Jr.; Rauber Antonini, Sonir Roberto; Castro, Margaret; Tucci, Silvio, Jr.; Neder, Luciano; Ramalho, Leandra; Seidinger, Ana Luiza; Cardinalli, Izilda; Mastellaro, Maria Jos
Fonte: Wiley-Blackwell; San Francisco Publicador: Wiley-Blackwell; San Francisco
Tipo: Artigo de Revista Científica
Português

‣ Solid-phase microextraction combined with comprehensive two-dimensional gas chromatography for fatty acid profiling of cell wall phospholipids

Bogusz, Stanislau, Jr.; Hantao, Leandro Wang; Gonzaga Neves Braga, Soraia Cristina; Rodrigues de Matos Franca, Valtenice de Cassia; da Costa, Marcelo Fernandes; Hamer, Russell David; Ventura, Dora Fix; Augusto, Fabio
Fonte: Wiley-Blackwell; Weinheim Publicador: Wiley-Blackwell; Weinheim
Tipo: Artigo de Revista Científica
Português
The combination of solid-phase microextraction (SPME) with comprehensive two-dimensional gas chromatography is evaluated here for fatty acid (FA) profiling of the glycerophospholipid fraction from human buccal mucosal cells. A base-catalyzed derivatization reaction selective for polar lipids such as glycerophospholipid was adopted. SPME is compared to a miniaturized liquidliquid extraction procedure for the isolation of FA methyl esters produced in the derivatization step. The limits of detection and limits of quantitation were calculated for each sample preparation method. Because of its lower values of limits of detection and quantitation, SPME was adopted. The extracted analytes were separated, detected, and quantified by comprehensive two-dimensional gas chromatography with flame ionization detection (FID). The combination of SPME and comprehensive two-dimensional gas chromatography with FID, using a selective derivatization reaction in the preliminary steps, proved to be a simple and fast procedure for FA profiling, and was successfully applied to the analysis of adult human buccal mucosal cells.

‣ Neutral pion and eta meson production in proton-proton collisions at root s=0.9 TeV and root s=7 TeV

Abelev, B.; Abrahantes Quintana, A.; Adamova, D.; Adare, A. M.; Aggarwal, M. M.; Aglieri Rinella, G.; Agocs, A. G.; Agostinelli, A.; Salazar, S. Aguilar; Ahammed, Z.; Ahmad, N.; Masoodi, A. Ahmad; Ahn, S. U.; Akindinov, A.; Aleksandrov, D.; Alessandro, B.
Fonte: Elsevier; Amsterdam Publicador: Elsevier; Amsterdam
Tipo: Artigo de Revista Científica
Português
The first measurements of the invariant differential cross sections of inclusive pi(0) and eta meson production at mid-rapidity in proton-proton collisions root s = 0.9 TeV and root s = 7 TeV are reported. The pi(0) measurement covers the ranges 0.4 < p(T) < 7 GeV/c and 0.3 < p(T) < 25 GeV/c for these two energies, respectively. The production of eta mesons was measured at root s = 7 TeV in the range 0.4 < p(T) < 15 GeV/c. Next-to-Leading Order perturbative QCD calculations, which are consistent with the pi(0) spectrum at root s = 0.9 TeV, overestimate those of pi(0) and eta mesons at root s = 7 TeV, but agree with the measured eta/pi(0) ratio at root s = 7 TeV. (C) 2012 CERN. Published by Elsevier B.V. All rights reserved.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Production of Muons from Heavy Flavor Decays at Forward Rapidity in pp and Pb-Pb Collisions at root s(NN)=2.76 TeV

Abelev, B.; Adam, J.; Adamova, D.; Adare, A. M.; Aggarwal, M. M.; Rinella, G. Aglieri; Agocs, A. G.; Agostinelli, A.; Aguilar Salazar, S.; Ahammed, Z.; Masoodi, A. Ahmad; Ahmad, N.; Ahn, S. A.; Ahn, S. U.; Akindinov, A.; Aleksandrov, D.; Alessandro, B.; A
Fonte: Amer Physical Soc; College Pk Publicador: Amer Physical Soc; College Pk
Tipo: Artigo de Revista Científica
Português
The ALICE Collaboration has measured the inclusive production of muons from heavy-flavor decays at forward rapidity, 2.5 < y < 4, in pp and Pb-Pb collisions at root s(NN) = 2.76 TeV. The p(t)-differential inclusive cross section of muons from heavy-flavor decays in pp collisions is compared to perturbative QCD calculations. The nuclear modification factor is studied as a function of p(t) and collision centrality. A weak suppression is measured in peripheral collisions. In the most central collisions, a suppression of a factor of about 3-4 is observed in 6 < p(t) < 10 GeV/c. The suppression shows no significant p(t) dependence.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Production of K*(892)(0) and phi(1020) in pp collisions at root s=7 TeV

Abelev, B.; Adam, J.; Adamova, D.; Adare, A. M.; Aggarwal, M. M.; Rinella, G. Aglieri; Agocs, A. G.; Agostinelli, A.; Aguilar Salazar, S.; Ahammed, Z.; Masoodi, A. Ahmad; Ahmad, N.; Ahn, S. U.; Akindinov, A.; Aleksandrov, D.; Alessandro, B.; Alfaro Molina
Fonte: Springer; New York Publicador: Springer; New York
Tipo: Artigo de Revista Científica
Português
The production of K*(892)(0) and phi(1020) in pp collisions at root s = 7 TeV was measured by the ALICE experiment at the LHC. The yields and the transverse momentum spectra d(2)N/dydp(T) at midrapidity vertical bar y vertical bar < 0.5 in the range 0 < p(T) < 6 GeV/c for K*(892)(0) and 0.4 < p(T) < 6 GeV/c for phi(1020) are reported and compared to model predictions. Using the yield of pions, kaons, and Omega baryons measured previously by ALICE at root s = 7 TeV, the ratios K*/K-, phi/K*, phi/ K-, phi/pi(-), and (Omega + <(Omega)over bar>)/phi are presented. The values of the K*/K-, phi/K* and phi/K- ratios are similar to those found at lower centre-of-mass energies. In contrast, the phi/pi(-) ratio, which has been observed to increase with energy, seems to saturate above 200 GeV. The (Omega + (Omega) over bar)/phi ratio in the p(T) range 1-5 GeV/ c is found to be in good agreement with the prediction of the HIJING/B (B) over bar v2.0model with a strong colour field.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Direct Determination of Sugar Cane Quality Parameters by X-ray Spectrometry and Multivariate Analysis

Melquiades, F. L.; Bortoleto, G. G.; Marchiori, L. F. S.; Bueno, M. I. M. S.
Fonte: Amer Chemical Soc; Washington Publicador: Amer Chemical Soc; Washington
Tipo: Artigo de Revista Científica
Português
Current methods for quality control of sugar cane are performed in extracted juice using several methodologies, often requiring appreciable time and chemicals (eventually toxic), making the methods not green and expensive. The present study proposes the use of X-ray spectrometry together with chemometric methods as an innovative and alternative technique for determining sugar cane quality parameters, specifically sucrose concentration, POL, and fiber content. Measurements in stem, leaf, and juice were performed, and those applied directly in stem provided the best results. Prediction models for sugar cane stem determinations with a single 60 s irradiation using portable X-ray fluorescence equipment allows estimating the % sucrose, % fiber, and POL simultaneously. Average relative deviations in the prediction step of around 8% are acceptable if considering that field measurements were done. These results may indicate the best period to cut a particular crop as well as for evaluating the quality of sugar cane for the sugar and alcohol industries.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)