Página 14 dos resultados de 9995 itens digitais encontrados em 0.049 segundos

‣ Mechanotransduction via airway epithelial cells : the effect of compressive stress

Kojić, Nikola, 1978-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 157 leaves
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A classic finding in asthma is a change in the structural organization of the airway epithelium. This complex process known as airway remodeling is not fully understood, and we believe that the forces accompanying airway constriction activate the epithelium and contribute to airway remodeling. To better understand this mechanotransduction mechanism we used an in vitro system of cultured normal human bronchial epithelial cells that could simulate compressive stresses experienced by the epithelium during bronchoconstriction. The application of a transcellular pressure gradient (10-50cmH20) for 10 minutes resulted in transient activation of the epidermal growth factor receptor (EGFR) - MAP kinase (ERK) signaling pathway. Furthermore, specialized real-time high-speed imaging revealed an exponential decrease in the volume of the compliant lateral intercellular space (LIS) separating neighboring cells. The measured LIS volume collapse curves were directly inputted into 2-D and 3-D numerical finite element models, whose output was EGFR-ligand concentration dynamics in the LIS.; (cont.) During the first three minutes under pressure, the calculated increase in ligand concentration (specifically HB-EGF, which is made by the cells and shed into the LIS...

‣ Quantifying uncertainty in computational neuroscience with Bayesian statistical inference

Cronin, Beau D
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 106 p.
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Two key fields of computational neuroscience involve, respectively, the analysis of experimental recordings to understand the functional properties of neurons, and modeling how neurons and networks process sensory information in order to represent the environment. In both of these endeavors, it is crucial to understand and quantify uncertainty - when describing how the brain itself draws conclusions about the physical world, and when the experimenter interprets neuronal data. Bayesian modeling and inference methods provide many advantages for doing so. Three projects are presented that illustrate the advantages of the Bayesian approach. In the first, Markov chain Monte Carlo (MCMC) sampling methods were used to answer a range of scientific questions that arise in the analysis of physiological data from tuning curve experiments; in addition, a software toolbox is described that makes these methods widely accessible. In the second project, the model developed in the first project was extended to describe the detailed dynamics of orientation tuning in neurons in cat primary visual cortex. Using more sophisticated sampling-based inference methods, this model was applied to answer specific scientific questions about the tuning properties of a recorded population. The final project uses a Bayesian model to provide a normative explanation of sensory adaptation phenomena. The model was able to explain a range of detailed physiological adaptation phenomena.; by Beau D. Cronin.; Thesis (Ph. D.)--Massachusetts Institute of Technology...

‣ Reservoir monitoring using induced seismicity at a petroleum field in Oman

Sarkar, Sudipta
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 260 p.
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This thesis presents methods of analysis and results from a petroleum reservoir monitoring application using induced seismicity data. The dissertation work is comprised of four major studies, each focusing on a different aspect of induced seismicity. First, methods and issues in location of induced seismicity are discussed, and strategies are proposed for determining accurate hypocenters of induced events. The importance of velocity model and how it impacts the depth determination of reservoir-induced events are demonstrated with real field data. A location method that is better-suited than other existing methods for this application is proposed. The accuracy and efficiency of this proposed location method is demonstrated with field data application.Secondly, event locations and interpretations are presented for about 1300 induced events recorded by a near-surface network over a seven year period at a petroleum field in Oman. The event hypocenters delineate two major northeast-southwest striking faults in the field, which are consistent with fault maps derived from reflection seismic interpretations. Spatiotemporal analysis of induced event locations reveals ongoing large scale fault reactivation in the field, and also suggests compaction of the gas reservoir as the major cause and water injection in the oil reservoir as the secondary cause for inducing seismicity in the field.Thirdly...

‣ Surface uplift, fluvial incision, and geodynamics of plateau evolution, from the western margin of the Central Andean plateau

Schildgen, Taylor F. (Taylor Frances)
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 154 leaves
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The Colca-Majes and Cotahuasi-Ocona rivers in southwest Peru that cut through the western margin of the Andean plateau en route to the Pacific Ocean incised canyons over 3 km deep in response to late Cenozoic surface uplift. This latest uplift represents a fundamental shift in the style and magnitude of surface deformation that had been ongoing since at least late Cretaceous time, but only relatively recently created what represents the only major barrier to atmospheric circulation in the Southern Hemisphere. Studying canyon incision history as a proxy for surface uplift offers a promising route to understanding how climate and tectonics have interacted throughout the evolution of the Central Andean plateau. In this thesis, a combination of bedrock low-temperature thermochronology (apatite and zircon (UTh)/He techniques), 40Ar/39Ar dating of valley-filling volcanic flows, and three-dimensional thermal modeling using a modified version of Pecube were applied to investigate the incision history of the rivers. Results suggested between 2.6 and 3.0 km of incision occurred in the deepest reaches of the canyons starting at ca. 10 to 11 Ma and ending between 2.3 and 3.5 Ma. The onset of surface uplift that is likely to have driven incision probably did not precede incision by more than one million years...

‣ Biomechanical regulation of arteriogenesis : defining critical endothelial-dependent events; Defining critical endothelial-dependent events

Mack, Peter J. (Peter Joseph), 1980-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 115 p.
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Coronary heart disease (CHD) is a major health concern for Americans and people worldwide. Arteriogenesis, an adaptive remodeling process in which pre-existing collateral arterioles remodel to form large diameter conductance arteries, has received recent attention for its therapeutic potential in treating CHD, but the mechanisms regulating the process remain incompletely understood. In particular, little is known about how collateral flow, and the resulting effect of shear stress acting along the collateral vessel wall, regulates coronary collateralization. This Thesis combines a series of experimental systems to define the responses evoked in endothelial cells exposed to hemodynamic waveforms characteristic of coronary collateral vessels and the subsequent paracrine effects on smooth muscle cells. Initially, a lumped parameter model of the human coronary collateral circulation was used to simulate normal (NCC) and adaptive remodeling (ACC) coronary collateral shear stress waveforms. These waveforms were then applied to cultured human endothelial cells (EC) and the resulting differences in EC gene expression were assessed by genome-wide transcriptional profiling, identifying genes distinctly regulated by collateral flow, including genes important for endothelial-smooth muscle interactions. In particular...

‣ Combined-channel instantaneous frequency analysis for audio source separation based on comodulation

Jacobson, Barry David
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 303 p.
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Normal human listeners have a remarkable ability to focus on a single sound or speaker of interest and to block out competing sound sources. Individuals with hearing impairments, on the other hand, often experience great difficulty in noisy environments. The goal of our research is to develop novel signal processing methods inspired by neural auditory processing that can improve current speech separation systems. These could potentially be of use as assistive devices for the hearing impaired, and in many other communications applications. Our focus is the monaural case where spatial information is not available. Much perceptual evidence indicates that detecting common amplitude and frequency variation in acoustic signals plays an important role in the separation process. The physical mechanisms of sound generation in many sources cause common onsets/offsets and correlated increases/decreases in both amplitude and frequency among the spectral components of an individual source, which can potentially serve as a distinct signature. However, harnessing these common modulation patterns is difficult because when spectral components of competing sources overlap within the bandwidth of a single auditory filter, the modulation envelope of the resultant waveform resembles that of neither source. To overcome this...

‣ Modélisation de l’engagement et de la charge mentale de travail dans les Systèmes Tutoriels Intelligents

Chaouachi, Maher
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
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Les récents avancements en sciences cognitives, psychologie et neurosciences, ont démontré que les émotions et les processus cognitifs sont intimement reliés. Ce constat a donné lieu à une nouvelle génération de Systèmes Tutoriels Intelligents (STI) dont la logique d’adaptation repose sur une considération de la dimension émotionnelle et affective de l’apprenant. Ces systèmes, connus sous le nom de Systèmes Tutoriels Émotionnellement Intelligents (STEI), cherchent à se doter des facultés des tuteurs humains dans leurs capacités à détecter, comprendre et s’adapter intuitivement en fonction de l’état émotionnel des apprenants. Toutefois, en dépit du nombre important de travaux portant sur la modélisation émotionnelle, les différents résultats empiriques ont démontré que les STEI actuels n’arrivent pas à avoir un impact significatif sur les performances et les réactions émotionnelles des apprenants. Ces limites sont principalement dues à la complexité du concept émotionnel qui rend sa modélisation difficile et son interprétation ambiguë. Dans cette thèse, nous proposons d’augmenter les STEI des indicateurs d’états mentaux d’engagement et de charge mentale de travail. Ces états mentaux ont l’avantage d’englober à la fois une dimension affective et cognitive. Pour cela...

‣ Determining the Effectiveness of the Therapeutic Recreation Specialist - Certified Training at Baycrest Health Sciences

Hirshfeld, Karen
Fonte: Brock University Publicador: Brock University
Tipo: Electronic Thesis or Dissertation
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The purpose of this study was to determine the effectiveness of the “Champion” training of the Therapeutic Recreation Specialist – Certified (TRSC) at Baycrest Health Sciences (BHS). BHS recently implemented a new model for Therapeutic Recreation Services that employs the model of champion for implementation of both best and next practices within the organization. This mixed methods study used both case study and program evaluation in order to understand whether the training that comprised of five different topics allowed the six participants to develop the skills needed to be champions. The results supported that learning did occur during the training and that the experience was positive for the participants. The overall finding from this study is that while the training was useful, the participants did not feel confident about utilizing these skills without further training; hence, this training can only be considered an introduction to the concepts presented.

‣ Evaluation of the visual stress grading standard on French Spruce (Picea excelsa) and Douglas-fir (Pseudotsuga menziesii) sawn timber

ROBLOT, Guillaume; COUDEGNAT, Damien; BLERON, Laurent; COLLET, Robert
Fonte: EDP Sciences Publicador: EDP Sciences
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We wish to thank J.C. Sève and S. Vives from Monnet-Sève sawmills who provided us with the two batches of boards. Acknowledgments also go to people from LaBoMap, especially J.C. Butaud who helped us during the tests. Finally, we thank L. Brancheriau from CIRAD, who assisted us with the data exploitation.; In this paper an evaluation of the visual grading standard for softwood sawn timber was made. • In order to do so, visual grading according to EN 518 and theoretical grading according to EN 338 and EN 384 (measurements of MOE, MOR and density) were applied to lumber. Two batches of 111 and 102 French boards were graded, respectively, of Spruce (Picea excelsa) and Douglas-fir (Pseudotsuga menziesii). For the visual grading the most discriminant criterion was noted: knots, cracks, wane, etc. • Finally, the results of the two grading methods were compared, and it was shown that the visual stress grading gave quite low results for our two French species.

‣ Giving the head a hand : constructing a microworld to build relationships with ideas in balance control; Constructing a microworld to build relationships with ideas in balance control

Sipitakiat, Arnan, 1974-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 124 p.
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The major promise of computational technology for learning is in making discovery and acquisition of knowledge accessible to a wider range of people. The protean expressive and constructive nature of computational technology facilitates more powerful and effective learning methodologies. Enabling multiple forms of representation through computational approaches to thinking about various phenomena not only potentially opens new domains of knowledge, but also permits a re-structuration of domains by rethinking content and activity. This thesis provides an exemplar of this potential through children learning about Balance Control in Dynamic Systems (BCDS), which adds a particular value given that BCDS is considered too complex for young learners. A Balance Control Microworld was created to help learners think about how to program physical robots to perform balancing acts, such as balancing an inverted pendulum, based on the observations of their own body motions. A Spatial Computing Paradigm (SCP) was developed to allow learners to carry out various control operations using familiar 2D properties of on-screen objects. The physical robots have a dual-mode ability that allowed learners to record and observe motions while controlling the robots manually by hand as well as under program control. The study involved two groups of learners...

‣ Dynamic risk adjustment of prediction models using statistical process control methods

Chuo, John, 1969-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 70 p.; 3543768 bytes; 3550703 bytes; application/pdf; application/pdf
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Introduction. Models that represent mathematical relationships between clinical outcomes and their predictors are useful to the decision making process in patient care. Many models, such as the score of neonatal physiology (SNAP II) that predicts in-hospital mortality, have been well validated on several large populations. However, the performance profile of such models in the midst of changing predictor-outcome relationships or newly appearing outcome predictors have not been well studied. We address this problem using statistical process control (SPC) techniques in a novel way. Although widely used in the manufacturing industry to maintain high quality in critical processes, SPC's value to healthcare has begun only recently to gain attention from decision makers. It has been used to construct risk-adjusted charts to track outcomes in the intensive care unit and the surgical arena, and to monitor hospital acquired infections. However, there are no reports of using SPC techniques to scrutinize the performance quality of a clinical model over time. The series of experiments in this manuscript show that the deterioration of a model's performance can be a useful indicator of unexpected changes in the environment that it represents; therefore...

‣ Managing revisions of rules and guidelines used in clinical information systems : exploring a hierarchical knowledge representation model

Scott-Wright, Alicia, 1949-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 51 leaves; 2620739 bytes; 2624752 bytes; application/pdf; application/pdf
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One important purpose for creating clinical practice guidelines is to improve quality of care by reducing variations in practice. In the current healthcare environment, guidelines are being advocated as a means to disseminate research findings, standardize care, improve quality of care, and increase the cost-effectiveness of health care services. Unfortunately, compliance with text-based clinical practice guidelines is unsatisfactory. On the other hand, adherence to guideline recommendations is increased when providers receive patient-specific recommendations during the patient-provider consultation. Guideline-based point of care decision support systems have been shown to increase provider consultation. Guideline-based point of care decision support systems have been shown to increase provider adherence to guideline recommendations. Computer-interpretable formats for clinical practice guidelines are a prerequisite for decision support systems. The development process of a text-based clinical practice guideline is long and arduous and in most cases this process is repeated when text-based guidelines are revised to include new medical knowledge. Clearly, once text-based guideline knowledge is translated into a computer-interpretable format...

‣ Hybrid percussion : extending physical instruments using sampled acoustics; Extending physical instruments using sampled acoustics

Aimi, Roberto Mario, 1973-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 138 p.
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This thesis presents a system architecture for creating hybrid digital-acoustic percussion instruments by combining extensions of existing signal processing techniques with specially-designed semi-acoustic physical controllers. This work aims to provide greater realism to digital percussion, gaining much of the richness and understandability of acoustic instruments while preserving the flexibility of digital systems. For this thesis, I have collaborated with percussionists to develop a range of instruments, to refine and extend the algorithmic and physical designs, and to determine successful models of interaction. Conventional percussion controllers measure and discretize the intensity of strikes into discrete trigger messages, but they also ignore the timbre of the hits and fail to track more ambiguous input. In this work, the continuous acoustic output of a struck physical object is processed to add the resonance of a sampled instrument. This is achieved by employing existing low-latency convolution algorithms which have been extended to give the player control over features such as damping, spectral flattening, nonlinear effects, and pitch.; (cont.) One of the advantages of this approach is that light taps, scrapes, rubs, or stirring with brushes all take on a hybrid timbre of the real and sampled sound that is surprisingly realistic and controllable. Since part of its behavior is inherently acoustic...

‣ Identification, improved modeling and integration of signals to predict constitutive and altering splicing

Yeo, Gene W. (Gene Wei-Ming), 1977-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 259 p.; 13699870 bytes; 13734221 bytes; application/pdf; application/pdf
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(cont.) manipulation of intronic elements that enables fish genes to be spliced properly in mammalian cells; (iii) A computational analysis using EST data, genome sequence data, and microarray expression data of tissue- specific alternative splicing is conducted, which distinguishes human brain, testis and liver as having unusually high levels of AS, highlights differences in the types of AS occurring commonly in different tissues, and identifies candidate cis-regulatory elements and trans-factors likely to play important roles in tissue-specific AS in human cells; (iv) The identification of a set of discriminatory sequence features and their integration into a statistical machine-learning algorithm, ACEScan, which distinguishes exons subject to evolutionarily conserved alternative splicing from constitutively spliced or lineage-specifically-spliced exons is described; (v) The genome-wide search for and experimental validation of exon-skipping events using the combination of two silencing cis-elements, UAGG and GGGG.; The regulation of pre-messenger RNA splicing by the spliceosomal machinery via interactions between cis-regulatory elements and splicing trans-factors to generate a specific mRNA i.e. constitutive splicing, or sometimes many distinct mRNA isoforms i.e. alternative splicing...

‣ Effect of time horizon on incremental cost-effectiveness ratios

Sondhi, Manu
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 76 leaves; 3854827 bytes; 3857937 bytes; application/pdf; application/pdf
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Background: Estimation of cost-effectiveness of a therapy as compared with another, in healthcare, is often based on a single perspective and a single time horizon. In this thesis, I explored methods of extrapolating the survival effect of different interventions and the effect of time horizon on incremental cost-effectiveness ratios when comparing two strategies. Methods: Two strategies for a patient are compared: new or usual treatment. A hypothetical model based on US life tables (for a 64-year old) assumed that the new and usual treatment strategies resulted in patient survivals identical to a person who is 5 and 10 years older, respectively, than the patient's chronologic age. The hazard rates over time were calculated and transformed to linear equations for least-squares linear regression to fit exponential, linear exponential, Weibull and Gompertz distributions. The survival model yielding the maximal likelihood estimate was extrapolated over different time horizons: 5, 10 and 15-year in addition to lifetime. In addition, I extracted survival data from a published trial evaluating thrombolysis in patients with myocardial infarction and applied this methodology over different time horizons.; (cont.) Finally, I developed a matrix of incremental cost-effectiveness ratios over different time horizons...

‣ Learning the meaning of music

Whitman, Brian A. (Brian Alexander)
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 104 p.
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Expression as complex and personal as music is not adequately represented by the signal alone. We define and model meaning in music as the mapping between the acoustic signal and its contextual interpretation - the 'community metadata' based on popularity, description and personal reaction, collected from reviews, usage, and discussion. In this thesis we present a framework for capturing community metadata from free text sources, audio representations general enough to work across domains of music, and a machine learning framework for learning the relationship between the music signals and the contextual reaction iteratively at a large scale. Our work is evaluated and applied as semantic basis functions - meaning classifiers that are used to maximize semantic content in a perceptual signal. This process improves upon statistical methods of rank reduction as it aims to model a community's reaction to perception instead of relationships found in the signal alone. We show increased accuracy of common music retrieval tasks with audio projected through semantic basis functions. We also evaluate our models in a 'query-by-description' task for music, where we predict description and community interpretation of audio. These unbiased learning approaches show superior accuracy in music and multimedia intelligence tasks such as similarity...

‣ Functional analysis of middle temporal visual area and its associated behavior

Zhao, Ruilin, 1972-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 120 leaves; 9124776 bytes; 9124529 bytes; application/pdf; application/pdf
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Our lab's long-term goal is to elucidate the circuitry of the visual cortex, to develop quantitative computational models of neuronal function in the visual cortex, and to establish how these models may relate to visual perception and visually guided behavior. Central to this goal is the analysis of functional architecture, which is crucial to an understanding of how the brain works. In my thesis research, I applied behavioral and microstimulation techniques to demonstrate the causal connections between neural activity and behavior. Understanding these relationships is one of the fundamental issues needed to be addressed in Neurobiology. Specifically, I focused on the functional analysis of the middle temporal visual area (MT) and the behavior associated with it. MT is an extrastriate area that is primarily involved in visual motion processing. A very important function within MT is a segregation of center-surround interactions which plays a critical role in processing visual motion cues. There are two types of motion center-surround interactions in MT neurons: surrounds may reinforce (at wide-field sites) or suppress (at local-motion sites) the centers' directional responses. They are important in representing the initial stages of a functional segregation between wide-field and local-contrast motion processing. To further study the computational model used by the brain to readout sensory information...

‣ Dynamical mechanisms of neural firing irregularity and modulation sensitivity with applications to cochlear implants

O'Gorman, David E
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 107 leaves
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The degree of irregularity apparent in the discharge patterns of electrically stimulated auditory-nerve fibers depends upon the stimulation rate. Whereas fibers fire regularly at low stimulation rates, the same fibers fire irregularly at high rates. The irregularity observed at high stimulation rates has been attributed to noise caused by the random open and closing of voltage-gated ion channels. This explanation however is incomplete: an additional mechanism must be operating to account for the different effects of noise at the two stimulation rates. We have identified such an additional rate-dependent mechanism. Specifically, we show in the Fitzhugh-Nagumo (FN) model that the stability to perturbations such as noise depends upon the stimulation rate. At sufficiently high rates a dynamical instability arises that accounts for the main statistical features of the irregular discharge pattern, even in the absence of ongoing physiological noise. In addition, we show that this instability accounts for both the statistical independence exhibited by different fibers in the stimulated population and their sensitivity to amplitude modulations applied to an ongoing stimulus.; (cont.) In cochlear implants, amplitude modulations are used to encode acoustic information such as speech. Psychophysically...

‣ Height change detection in Antarcita using satellite altimetry data and Kriging / Kalman filtering techniques

Nguyen, An Thanh-Thuy
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 214 p.
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Studies of the response of ice sheets to climate change require data sets with high accuracy and uniform ice-sheet coverage. The most common technique used in analyzing satellite altimetry data to study height change in the ice sheets is the dH/dt technique based on the cross-over geometry. In this thesis two alternative techniques to cross-overs are studied and applied to all ERS radar and ICESat laser altimetry data to study height change in Antarctica. The first technique, block kriging, uses all available data to build a statistical model of the elevation field. Results of height rate of changes dh/dt ill Antarctica for the years 1995-2001 produced using block kriging and cross-over analysis are compared. In the Amery Ice Shelf and in the West Antarctic coastal area and near latitude -81°N, the difference in dh/dt between the two methods are statistically significant. A second technique combines kriging and Kalman filtering to allow for time evolutions of the height change rate and other parameters used in the description of the surface elevation field. An application of the technique to laser altimetry data from the current NASA's ICESat mission shows the potential of the technique in detecting height change.; (cont.) In addition...

‣ Computing point-of-view : modeling and simulating judgments of taste

Liu, Xinyu Hugo, 1979-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 163 p.
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People have rich points-of-view that afford them the ability to judge the aesthetics of people, things, and everyday happenstance; yet viewpoint has an ineffable quality that is hard to articulate in words, let alone capture in computer models. Inspired by cultural theories of taste and identity, this thesis explores end-to-end computational modeling of people's tastes-from model acquisition, to generalization, to application- under various realms. Five aesthetical realms are considered-cultural taste, attitudes, ways of perceiving, taste for food, and sense-of-humor. A person's model is acquired by reading her personal texts, such as a weblog diary, a social network profile, or emails. To generalize a person model, methods such as spreading activation, analogy, and imprimer supplementation are applied to semantic resources and search spaces mined from cultural corpora. Once a generalized model is achieved, a person's tastes are brought to life through perspective-based applications, which afford the exploration of someone else's perspective through interactivity and play. The thesis describes model acquisition systems implemented for each of the five aesthetical realms.; (cont.) The techniques of 'reading for affective themes' (RATE)...