Últimos itens adicionados do Acervo: Biblioteca Digital da Produção Intelectual e Científica da Unicamp

A Biblioteca Digital da Produção Intelectual e Científica da Unicamp tem por objetivo reunir e disseminar a produção intelectual, acadêmica e cultural da universidade e preservar sua memória institucional, além de contribuir para ampliar a visibilidade da instituição e dos seus pesquisadores em âmbito nacional e internacional.

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‣ Infiltration of a mixture of different immune cells may be related to molecular profile of differentiated thyroid cancer

Cunha, Lucas Leite; Morari, Elaine Cristina; Guihen, Ana Carolina Trindade; Razolli, Daniela; Gerhard, Rene; Nonogaki, Suely; Soares, Fernando Augusto; Vassallo, Jose; Ward, Laura Sterian
Fonte: Bioscientifica Ltd; Bristol Publicador: Bioscientifica Ltd; Bristol
Tipo: Artigo de Revista Científica
Português

‣ Evidence that polymorphisms in detoxification genes modulate the susceptibility for sporadic medullary thyroid carcinoma

Barbieri, R. B.; Bufalo, N. E.; Secolin, R.; Silva, A. C. N.; Assumpcao, L. V. M.; Maciel, R. M. B.; Cerutti, J. M.; Ward, L. S.
Fonte: Bioscientifica Ltd; Bristol Publicador: Bioscientifica Ltd; Bristol
Tipo: Artigo de Revista Científica
Português
Aim: Polymorphic low-penetrance genes have been consistently associated with the susceptibility to a series of human tumors, including differentiated thyroid cancer. Methods: To determine their role in medullary thyroid cancer (MTC), we used TaqMan SNP method to genotype 47 sporadic MTC (s-MTC) and a control group of 578 healthy individuals for CYP1A2* F, CYP1A1m1, GSTP1, NAT2 and 72TP53. A logistic regression analysis showed that NAT2C/C (OR=3.87; 95% CI=2.11-7.10; P=2.2 x 10(-5)) and TP53C/C genotypes (OR=3.87; 95% CI=1.78-6.10; P=2.8 x 10(-4)) inheritance increased the risk of s-MTC. A stepwise regression analysis indicated that TP53C/C genotype contributes with 8.07% of the s-MTC risk. Results: We were unable to identify any relationship between NAT2 and TP53 polymorphisms suggesting they are independent factors of risk to s-MTC. In addition, there was no association between the investigated genes and clinical or pathological features of aggressiveness of the tumors or the outcome of MTC patients. Conclusion: In conclusion, we demonstrated that detoxification genes and apoptotic and cell cycle control genes are involved in the susceptibility of s-MTC and may modulate the susceptibility to the disease.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

‣ Analysis of anti-Mullerian hormone (AMH) and its receptor (AMHR2) genes in patients with persistent Mullerian duct syndrome

Nishi, Mirian Yumie; Domenice, Sorahia; Maciel-Guerra, Andrea Trevas; Zaba Neto, Alberto; Cavalaro Pereira da Silva, Marcia Alessandra; Frade Costa, Elaine Maria; Guerra-Junior, Gil; de Mendonca, Berenice Bilharinho
Fonte: Sbem-Soc Brasil Endocrinologia & Metabologia; Rio de Janeiro Publicador: Sbem-Soc Brasil Endocrinologia & Metabologia; Rio de Janeiro
Tipo: Artigo de Revista Científica
Português
Objective: To screen for mutations in AMH and AMHR2 genes in patients with persistent Mullerian duct syndrome (PMDS). Patients and method: Genomic DNA of eight patients with PMDS was obtained from peripheral blood leukocytes. Directed sequencing of the coding regions and the exon-intron boundaries of AMH and AMHR2 were performed. Results: The AMH mutations p.Arg95*, p.Arg123Trp, c.556-2A>G, and p. Arg502Leu were identified in five patients; and p.Gly323Ser and p.Arg407* in AMHR2 of two individuals. In silico analyses of the novel c.556-2A>G, p.Arg502Leu and p.Arg407* mutations predicted that they were harmful and were possible causes of the disease. Conclusion: A likely molecular etiology was found in the eight evaluated patients with PMDS. Four mutations in AMH and two in AMHR2 were identified. Three of them are novel mutations, c.556-2A>G, and p. Arg502Leu in AMH; and p.Gly323Ser in AMHR2. Arq Bras Endocrinol Metab. 2012;56(8):473-8; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Foxp3 expression is associated with aggressiveness in differentiated thyroid carcinomas

Cunha, Lucas Leite; Morari, Elaine Cristina; Nonogaki, Suely; Soares, Fernando Augusto; Vassallo, Jose; Ward, Laura Sterian
Fonte: Hospital Clinicas, Univ Sao Paulo; Sao Paulo Publicador: Hospital Clinicas, Univ Sao Paulo; Sao Paulo
Tipo: Artigo de Revista Científica
Português
OBJECTIVES: Forkhead box P3 (FoxP3) expression has been observed in human cancer cells but has not yet been reported in thyroid cells. We investigated the prognostic significance of both FoxP3 expression and intratumoral FoxP3(+) lymphocyte infiltration in differentiated thyroid carcinoma cells. METHODS: We constructed a tissue microarray with 385 thyroid tissues, including 266 malignant tissues (from 253 papillary thyroid carcinomas and 13 follicular carcinomas), 114 benign lesions, and 5 normal thyroid tissues. RESULTS: We determined the expression of FoxP3 in both tumor cells and tumor-infiltrating lymphocytes using immunohistochemical techniques. Cellular expression of FoxP3 was evident in 71% of benign and 91.9% of malignant tissues. The nuclear and cytoplasmic expression patterns were quantified separately. A multivariate logistic regression analysis indicated that cytoplasmic FoxP3 expression is an independent risk factor for thyroid malignancy. Cytoplasmic FoxP3 staining was inversely correlated with patient age. Nuclear FoxP3 staining was more intense in younger patients and in tumors presenting with metastasis at diagnosis. FoxP3+ lymphocytes were more frequent in tumors smaller than 2 cm, those without extrathyroidal invasion...

‣ Gene Expression Profile in Genetic Models of Generalized Epilepsy: Clues into Underlying Mechanism

Matos, Alexandre; Pascoal, Vinicius; Nascimento, Deborah; Rocha, Cristiane; Vasconcellos, Jaira; Chamma, Maria; Maurer-Morelli, Claudia; Martins, Almir; Valle, Angela; Godard, Ana Lucia; Lopes-Cendes, Iscia
Fonte: Lippincott Williams & Wilkins; Philadelphia Publicador: Lippincott Williams & Wilkins; Philadelphia
Tipo: Artigo de Revista Científica
Português

‣ Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticus

do Nascimento, Andre Luiz; dos Santos, Neide Ferreira; Pelagio, Fernanda Campos; Teixeira, Simone Aparecida; De Moraes Ferrari, Elenice A.; Langone, Francesco
Fonte: Elsevier; Amsterdam Publicador: Elsevier; Amsterdam
Tipo: Artigo de Revista Científica
Português
Temporal lobe epilepsy (TLE) is the most common type of human epilepsy and has been related with extensive loss of hippocampal pyramidal and dentate hilar neurons and gliosis. Many characteristics of TLE are reproduced in the pilocarpine model of epilepsy in mice. This study analyzed the neuronal damage, assessed with Fluoro-Jade (FJB) and cresyl violet, and gliosis, investigated with glial fibrilary acidic protein (GFAP) immunohistochemistry, occurring in the hippocampal formation of mice at 3, 6, 12 and 24 h, 1 and 3 weeks after the pilocarpine-induced status-epilepticus (SE) onset. The maximum neuronal damage score and the FJB-positive neurons peak were found in the hilus of dentate gyrus 3 and 12h after SE onset (P<0.05), respectively. At 1 week after SE onset, the greatest neuronal damage score was detected in the CA1 pyramidal cell layer and the greatest numbers of FJB-positive neurons were found both in the CA1 and CA3 pyramidal cell layers (P<0.05). The molecular, CA3 and CA1 pyramidal cell layers expressed highest presence of GFAP immunoreaction at 1 and 3 weeks after SE onset (P<0.05). Our findings show that, depending on the affected area, neuronal death and gliosis can occur within few hours or weeks after SE onset. Our results corroborate previous studies and characterize short time points of temporal evolution of neuropathological changes after the onset of pilocarpine-induced SE in mice and evidences that additional studies of this temporal evolution may be useful to the comprehension of the cellular mechanisms underlying epileptogenesis. (C) 2012 Elsevier B.V. All rights reserved.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

‣ mRNA BRAF expression helps to identify papillary thyroid carcinomas in thyroid nodules independently of the presence of BRAFV600E mutation

Costa Araujo, Priscila Pereira; Marcello, Marjory Alana; Tincani, Alfio Jose; Trindade Guilhen, Ana Carolina; Morari, Elaine Cristina; Ward, Laura Sterian
Fonte: Elsevier; Jena Publicador: Elsevier; Jena
Tipo: Artigo de Revista Científica
Português
Literature has consistently shown associations of BRAFV600E mutation with papillary thyroid cancer clinical features. However, the clinical utility of BRAF expression has not been clinically explored so far. We studied 67 thyroid nodules (32 benign nodules and 35 PTC cases). BRAF mRNA expression levels measured by a quantitative real-time PCR and a PCR-RFLP were used to identify BRAFV600E mutation. BRAF mRNA expression was significantly higher in malignant (198.2 +/- 373.9 AU) than in benign (4.1 +/- 6.9 AU) nodules (p < 0.0001). BRAF expression identified malignancy with a sensitivity of 80.6%, specificity of 77.1%, positive predictive value of 75.8%, and negative predictive value of 81.8%. A cut-point of 4.712, identified by the ROC curve, was able to sort out malignant nodules with an accuracy of 78.8%. Although we did not find any correlation between the presence of BRAF V600E mutation and clinical or tumor features such as age (p = 0.309), gender (p = 0.5453), ethnicity (p = 0.9820), tumor size (p = 1.000), multifocality (p = 0.2530) or mRNA levels (p = 0.7510), the study power for BRAF expression and diagnosis (99%; FPRP = 0.85) indicated that data is noteworthy despite the relative small number of patients investigated. We concluded that BRAF mRNA expression may help to identify PTC among thyroid nodules independently of the presence of BRAFV600E mutation. (C) 2012 Elsevier GmbH. All rights reserved.

‣ Genotypic and phenotypic analysis of 396 individuals with mutations in Sonic Hedgehog

Solomon, Benjamin D.; Bear, Kelly A.; Wyllie, Adrian; Keaton, Amelia A.; Dubourg, Christele; David, Veronique; Mercier, Sandra; Odent, Sylvie; Hehr, Ute; Paulussen, Aimee; Clegg, Nancy J.; Delgado, Mauricio R.; Bale, Sherri J.; Lacbawan, Felicitas; Arding
Fonte: B M J Publishing Group; London Publicador: B M J Publishing Group; London
Tipo: Artigo de Revista Científica
Português
Background Holoprosencephaly (HPE), the most common malformation of the human forebrain, may result from mutations in over 12 genes. Sonic Hedgehog (SHH) was the first such gene discovered; mutations in SHH remain the most common cause of nonchromosomal HPE. The severity spectrum is wide, ranging from incompatibility with extrauterine life to isolated midline facial differences. Objective To characterise genetic and clinical findings in individuals with SHH mutations. Methods Through the National Institutes of Health and collaborating centres, DNA from approximately 2000 individuals with HPE spectrum disorders were analysed for SHH variations. Clinical details were examined and combined with published cases. Results This study describes 396 individuals, representing 157 unrelated kindreds, with SHH mutations; 141 (36%) have not been previously reported. SHH mutations more commonly resulted in non-HPE (64%) than frank HPE (36%), and non-HPE was significantly more common in patients with SHH than in those with mutations in the other common HPE related genes (p<0.0001 compared to ZIC2 or SIX3). Individuals with truncating mutations were significantly more likely to have frank HPE than those with non-truncating mutations (49% vs 35%, respectively; p=0.012). While mutations were significantly more common in the N-terminus than in the C-terminus (including accounting for the relative size of the coding regions...

‣ Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticus (vol 1470, pg 98, 2012)

do Nascimento, Andre Luiz; dos Santos, Neide Ferreira; Pelagio, Fernanda Campos; Teixeira, Simone Aparecida; de Moraes Ferrari, Elenice A.; Langone, Francesco
Fonte: Elsevier; Amsterdam Publicador: Elsevier; Amsterdam
Tipo: Artigo de Revista Científica
Português

‣ CLINICAL ASSESSMENT AND MAGNETIC RESONANCE IMAGING OF THE SHOULDER OF PATIENTS WITH SPINAL CORD INJURY

Alves, Alex Pereira; Terrabuio Junior, Alberto Antonio; Pimenta, Ciro Jabur; Subira Medina, Giovanna Ignacio; Rimkus, Carolina de Medeiros; Cliquet Junior, Alberto
Fonte: Atha Comunicacao & Editora; Sao Paulo Publicador: Atha Comunicacao & Editora; Sao Paulo
Tipo: Artigo de Revista Científica
Português
Objective: To study the shoulder of this group of patients using magnetic resonance imaging to detect clinical and subclinical disorders and establish a rehabilitation program. Methods: Nine patients with spinal cord injury followed in the Laboratory of Biomechanics and Rehabilitation of the Locomotive System at HC/ UNICAMP were divided into two groups according to the presence of paraplegia and tetraplegia and were clinically assessed for correlation with the imaging exams. Results: Normal results were found in 41% of the shoulders. Most common injuries were tendinopathy of the supraspinatus and acromioclavicular joint degeneration. Eighty percent of injured shoulders had combined lesions. Conclusion: A great variety of causes of shoulder pain was identified in paraplegic and tetraplegic subjects. Routine clinical assessment and imaging studies of the shoulder may contribute to the evolution of rehabilitation and reduction of pain and musculoskeletal disorders.

‣ Work ability among nursing personnel in public hospitals and health centers in Campinas - Brazil

Monteiro, Ines; Pi Chillida, Manuela de Santana; Moreno, Luciana Contrera
Fonte: IOS Press; Amsterdam Publicador: IOS Press; Amsterdam
Tipo: Artigo de Revista Científica
Português
Nursing personnel is essential in hospital, health centers and enterprises and is the large work force in health system. A cross-sectional study was conducted in a large city in two public hospitals and five health centre with the objective of to evaluate the work ability and health aspects of nursing staff. The sample was composed by 570 workers. The Work Ability Index - WAI and a questionnaire with socio-demographic, health and life style data was applied. The majority of workers was women (83%), married (50.4%), and was working in night shift work (65.6%); 61.4% was auxiliary nursing, 22.3% was registered nurses (RN). The average age was 38.9 years (SD 7.8) and the Body Mass Index mean was 25.8 (SD 5.3). Only 17.2% referred to practice at least 150 minutes of physical exercise five times per week or more. 26.8% had a second job. The work ability mean was 39.3 (SD 5.3) points. Age had a negative correlation with WAI (p=0.0052). Public hospital and health centre workers had poor work ability score when compared with workers from another branches. Public policies related to workplace health promotion need to be implemented in public hospital and health centre to improve the work ability.

‣ CHARACTERIZATION AND USE OF SWINE DEEP BEDDING ASHES IN CEMENTITIOUS COMPOSITES

de Oliveira, Debora C. G.; Rodrigues, Michelle S.; dos Santos, Sergio F.; Savastano Junior, Holmer
Fonte: Soc Brasil Engenharia Agricola; Jaboticabal Publicador: Soc Brasil Engenharia Agricola; Jaboticabal
Tipo: Artigo de Revista Científica
Português
The deep bedding is a swine alternative production, especially in the finishing phase, whose byproduct can be recycled, reducing the environmental impact. The objectives of this study were to characterize the ash coming from the controlled burning of the swine deep bedding (SDBA) based on rice husk, and to evaluate their performance in composites as a partial substitute for Portland cement (PC). To measure the differences between SDBA and rice husk ash (RHA) as a reference, we have characterized: particle size distribution, real specific density, x-ray diffraction, electrical conductivity, scanning electron microscopy, chemical analysis and loss on ignition. Samples were prepared for two experimental series: control, and another one with the partial replacement of 30% of SDBA in relation to the mass of the Portland cement. According to the results obtained for physical and mechanical characterization, the composites with SDBA can be used as a constructive element in the rural construction.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression

Letra, Ariadne; Silva, Renato M.; Rylands, Ryan J.; Silveira, Elcia M.; de Souza, Ana P.; Wendell, Steven K.; Garlet, Gustavo P.; Vieira, Alexandre R.
Fonte: Wiley-Blackwell; Hoboken Publicador: Wiley-Blackwell; Hoboken
Tipo: Artigo de Revista Científica
Português
Aim Matrix metalloproteinases (MMPs) play a key role in the tissue destruction characteristic of chronic periodontitis. The purpose of this study was to investigate the association of MMP and TIMP polymorphisms with chronic periodontitis in two populations. Material and Methods A total of 34 polymorphisms spanning 12 MMP and 2 TIMP genes were genotyped in 401 individuals from Brazil (99 cases with chronic periodontitis and 302 controls), and 274 individuals from the US (70 cases and 204 controls). Individuals were considered cases if presenting at least three teeth exhibiting sites of clinical attachment loss =5 mm in two different quadrants. Controls were characterized by absence of clinical attachment loss and no sites with probing depth >3 mm. MMP3 and TIMP1 mRNA expression was evaluated in healthy and diseased periodontal tissues. Results TIMP1 showed association with chronic periodontitis in the Brazilian population (for rs5906435, p = 0.0004), whereas MMP3 showed association in the US population (for rs679620, p = 0.0003; and rs650108, p = 0.002) and in the Brazilian population (for rs639752, p = 0.005). MMP3 and TIMP1 mRNA expression was significantly higher in diseased tissues when compared to control tissues. Conclusions Our results further support a role for variations in MMP3 in chronic periodontitis and report a novel association with TIMP1. These genes may be considered additional candidate genes for chronic periodontitis.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

‣ Knowledge, habits, preferences, and protective behavior in relation to loud sound exposures among Brazilian children

Baraldi Knobel, Keila Alessandra; Marconi Pinheiro Lima, Maria Cecilia
Fonte: Informa Healthcare; London Publicador: Informa Healthcare; London
Tipo: Artigo de Revista Científica
Português
Objective: Identification of the beliefs and attitudes towards noise exposure and the risk of noise-induced hearing loss in Brazilian children. Design: Prospective cross-sectional study through interviews with children and their parents. Study sample: 753 children were selected and invited to participate. The final sample was 475 children and 404 parents. Results: In general, children disliked noisy places (67%). Although 87.4% of the children and 93.9% of the parents considered loud sounds damaging to the ears, children were poorly informed about hearing protection and did not have hearing protection devices. Children were mostly exposed to parties and concerts with loud music (51.9%), carnaval (Mardi Gras) parties (38.2%), firecrackers (36.8%), and loud music at home or in the car (33.1%), or from listening to loud music with earphones (17.3%). Compared to children from private schools, children from public schools had a greater preference for loud sounds and were less informed about hearing protection. Conclusions: Knowledge of hearing risk from loud sounds was not enough to prompt preventive behaviors, and adults exposed children to loud sounds.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

‣ PLAYING THE MUSIC: DIFFERENT BRAIN RESPONSES FOR TECHNIQUE OR EXPRESSIVENESS

Higuchi, Marcia K.; Sanchez, Tiago A.; Sturzbecher, Marcio J.; Betti, Kelley C.; Fornari, Jose E.; Araujo, Draulio B.; Del-Ben, Cristina M.; Graeff, Frederico G.; Leite, Joao P.
Fonte: Wiley-Blackwell; Hoboken Publicador: Wiley-Blackwell; Hoboken
Tipo: Artigo de Revista Científica
Português

‣ Nanogravimetric study of lead underpotential deposition on selenium thin films as a semiconductor alloy formation procedure

Cabral, M. F.; Calegaro, M. L.; Machado, S. A. S.
Fonte: Royal Society Of Chemistry; Cambridge Publicador: Royal Society Of Chemistry; Cambridge
Tipo: Artigo de Revista Científica
Português
An electrochemical quartz crystal microbalance Au electrode modified with a Se thin film was used to investigate the electrochemical behavior of lead ad-atoms using underpotential deposition (UPD) conditions. A specific quasi-reversible process was observed during the reduction of Pb2+ on Se thin films in perchloric acid media. The charge density of Pb ad-atoms on Se thin film (46.86 mu C cm(-2)) suggests a recovery of 0.1 monolayers, which is in good agreement with EQCM data. The Se thin film can be successfully alloyed with Pb atoms that are deposited by chronoamperometry using time intervals large enough to allow for diffusion toward the inner Se phase. Linear sweep voltammetry combined with EQCM in perchloric acid was used to characterize the amount of Pb absorbed in the Se thin film. These findings offer a new strategy for alloy formation in semiconductor films using UPD as an effective tool to quantify the exact amount of the incorporated metal.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Matayba obovata, a new species of Matayba sect. Matayba (Sapindaceae) from Brazil

Gayoso Coelho, Rubens L.; Souza, Vinicius Castro; Ferrucci, Maria S.
Fonte: Springer; New York Publicador: Springer; New York
Tipo: Artigo de Revista Científica
Português
The new species, Matayba obovata (Sapindaceae), from southern and southeastern Brazil is described, illustrated, and contrasted to its putatively closest relatives. Palynological characters are also described. The new species belongs to sect. Matayba. A key to identify M. obovata and related species in the Atlantic Forest is included.; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Impairment on sperm quality and fertility of adult rats after antiandrogen exposure during prepuberty

Perobelli, Juliana Elaine; Alves, Thais Regina; de Toledo, Fabiola Choqueta; Fernandez, Carla Dal Bianco; Anselmo-Franci, Janete A.; Klinefelter, Gary R.; Kempinas, Wilma De Grava
Fonte: Pergamon-Elsevier Science Ltd; Oxford Publicador: Pergamon-Elsevier Science Ltd; Oxford
Tipo: Artigo de Revista Científica
Português
This study evaluated the effects of antiandrogen exposure during the prepubertal period on reproductive development and reproductive competence in adults. Male rats were divided into two groups: flutamide, receiving 25 mg/kg/day of flutamide by oral gavage and control, receiving vehicle daily. Dosing continued from PND 21 to 44, and animals were killed on PND 50 or PND 75-80. The epididymis, prostate, vas deferens and seminal vesicle weights were lower in Flutamide group on PND 50, while on PND 80 only seminal vesicle weight was reduced. Fertility assessed by IUI revealed a decrease in the fertility potential in the flutamide-treated adults. Flutamide accelerated sperm transit time through the epididymis, impairing sperm motility and storage. A quantitative analysis of the cauda sperm membrane proteome revealed a few significant changes in protein expression. Thus, exposure to flutamide during the prepubertal period compromises the function of the epididymis along with epididymal sperm quality at adulthood. (C) 2011 Elsevier Inc. All rights reserved.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ SPERM QUALITY IN ADULT MALE RATS EXPOSED TO CADMIUM IN UTERO AND LACTATION

Banzato, Thais Petrochelli; Godinho, Antonio Francisco; Mathias da Silva Zacarin, Elaine Cristina; Perobelli, Juliana Elaine; Fernandez, Carla Dal Bianco; Alves Favareto, Ana Paula; Kempinas, Wilma De Grava
Fonte: Taylor & Francis; Philadelphia Publicador: Taylor & Francis; Philadelphia
Tipo: Artigo de Revista Científica
Português
Recent studies indicate that several anomalies of the male reproductive system may be produced by acute or chronic exposure to chemical substances released into the environment, attributed to increased industrial development. Among these substances are trace metals such as cadmium (Cd). The aim of this study was to assess reproductive parameters in adult male rats whose mothers were exposed to Cd during pregnancy and lactation. For this, pregnant rats were divided into two experimental groups: treated rats, which received ad libitum cadmium acetate (CdAc) solution in distilled water (10 mg Cd/L), and control rats, which received sodium acetate (NaAc) solution in distilled water (equimolar to the CdAc). The results showed that the exposure to Cd in utero and through lactation adversely affected sperm quality of adult rats, as evidenced by compromised sperm morphology and motility and increased rate of cell death in testis.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Height-diameter relationships of tropical Atlantic moist forest trees in southeastern Brazil

da Silva Scaranello, Marcos Augusto; Alves, Luciana Ferreira; Vieira, Simone Aparecida; de Camargo, Plinio Barbosa; Joly, Carlos Alfredo; Martinelli, Luiz Antonio
Fonte: Univ Sao Paolo; Cerquera Cesar Publicador: Univ Sao Paolo; Cerquera Cesar
Tipo: Artigo de Revista Científica
Português
Site-specific height-diameter models may be used to improve biomass estimates for forest inventories where only diameter at breast height (DBH) measurements are available. In this study, we fit height-diameter models for vegetation types of a tropical Atlantic forest using field measurements of height across plots along an altitudinal gradient. To fit height-diameter models, we sampled trees by DBH class and measured tree height within 13 one-hectare permanent plots established at four altitude classes. To select the best model we tested the performance of 11 height-diameter models using the Akaike Information Criterion (AIC). The Weibull and Chapman-Richards height-diameter models performed better than other models, and regional site-specific models performed better than the general model. In addition, there is a slight variation of height-diameter relationships across the altitudinal gradient and an extensive difference in the stature between the Atlantic and Amazon forests. The results showed the effect of altitude on tree height estimates and emphasize the need for altitude-specific models that produce more accurate results than a general model that encompasses all altitudes. To improve biomass estimation, the development of regional height-diameter models that estimate tree height using a subset of randomly sampled trees presents an approach to supplement surveys where only diameter has been measured.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)