Últimos itens adicionados do Acervo: Biblioteca Digital da Produção Intelectual e Científica da Unicamp

A Biblioteca Digital da Produção Intelectual e Científica da Unicamp tem por objetivo reunir e disseminar a produção intelectual, acadêmica e cultural da universidade e preservar sua memória institucional, além de contribuir para ampliar a visibilidade da instituição e dos seus pesquisadores em âmbito nacional e internacional.

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‣ Effect of a Physical Exercise Program During Pregnancy on Uteroplacental and Fetal Blood Flow and Fetal Growth A Randomized Controlled Trial

de Oliveria Melo, Adriana S.; Silva, Joao Luiz P.; Tavares, Jousilene S.; Barros, Vivianne O.; Leite, Debora F. B.; Amorim, Melania M. R.
Fonte: Lippincott Williams & Wilkins; Philadelphia Publicador: Lippincott Williams & Wilkins; Philadelphia
Tipo: Artigo de Revista Científica
Português
OBJECTIVE: To estimate the effect of supervised physical exercise on maternal physical fitness, fetoplacental blood flow, and fetal growth. METHODS: This was a randomized controlled trial comparing three groups of pregnant women. Groups were as follows: exercise initiated at 13 weeks (group A); exercise initiated at 20 weeks (group B); and a control group (no supervised exercise; group C). The women in groups A and B walked at moderate intensity three times weekly. Physical fitness level was evaluated at weeks 13, 20, and 28. Fetal growth and uteroplacental blood flow were evaluated monthly. Birth weight was registered. Analysis of variance for repeat measures was used for outcomes evaluated throughout pregnancy. Risk ratio was used as a measure of the relative risk of preeclampsia, fetal growth restriction, macrosomia, small-for-gestational-age new-borns, and large-for-gestational-age newborns. RESULTS: All the women analyzed completed more than 85% of the program. According to the evaluation conducted at week 28, physical fitness improved, with mean maximal oxygen consumptions (VO2max) of 27.3 +/- 4.3 (group A), 28 +/- 3.3 (group B), and 25.5 +/- 3.8 (group C; P=.03). Mean birth weights were 3,279 +/- 453 g (group A), 3,285 +/- 477 g (group B)...

‣ Use of contraceptive methods and contraceptive recommendations among health care providers actively involved in contraceptive counseling - results of an international survey in 10 countries

Gemzell-Danielsson, Kristina; Cho, SiHyun; Inki, Pirjo; Mansour, Diana; Reid, Robert; Bahamondes, Luis
Fonte: Elsevier; New York Publicador: Elsevier; New York
Tipo: Artigo de Revista Científica
Português
Background: This study was conducted to determine the personal choices of contraceptive methods among an international sample of contraception health care professionals (HCPs) and to determine if these choices are concordant with their recommendations to women. Study Design: In an anonymous online survey, 1001 HCPs actively involved in contraceptive counseling [obstetrician/gynecologists (OB/GYNs), general practitioners (GPs) and midwives (only in Sweden)] from 10 countries (Australia, Brazil, Canada, France, Germany, Korea, Mexico, Spain, Sweden and the United Kingdom) were asked about their personal use of contraceptive methods and their recommendations to women in two different clinical scenarios: for spacing between children (Group A) and after completion of the family (Group B). Results: The largest HCP group was OB/GYNs (67.1%), followed by GPs (31.4%) and midwives (1.5%). A total of 42.7% of respondents were male, and 57.3% were female. The majority of respondents were aged 36-45 years (38.9%) or 46-55 years (42.8%), 79.7% had children, and 53.9% were currently using contraception (by themselves or by their partners). Among 540 contraceptive users, the three most common methods were the levonorgestrel-releasing intrauterine system (LNG-IUS; 29.3%)...

‣ Lung-to-head ratio: a need to unify the technique

Jani, J. C.; Peralta, C. F. A.; Nicolaides, K. H.
Fonte: Wiley-Blackwell; Malden Publicador: Wiley-Blackwell; Malden
Tipo: Artigo de Revista Científica
Português

‣ Effectiveness of a Clinically Integrated e-Learning Course in Evidence-Based Medicine for Reproductive Health Training A Randomized Trial

Kulier, Regina; Guelmezoglu, Ahmet Metin; Zamora, Javier; Nieves Plana, M.; Carroli, Guillermo; Cecatti, Jose G.; Germar, Maria J.; Pisake, Lumbiganon; Mittal, Sunneeta; Pattinson, Robert; Wolomby-Molondo, Jean-Jose; Bergh, Anne-Marie; May, Win; Souza, Jo
Fonte: Amer Medical Assoc; Chicago Publicador: Amer Medical Assoc; Chicago
Tipo: Artigo de Revista Científica
Português
Context For evidence-based practice to embed culturally in the workplace, teaching of evidence-based medicine(EBM) should be clinically integrated. In low-middle-in come countries (LMICs) there is a scarcity of EBM-trained clinical tutors, lack of protected time for teaching EBM, and poor access to relevant databases in languages other than English. Objective To evaluate the effects of a clinically integrated e-learning EBM course incorporating the World Health Organization( WHO) Reproductive Health Library(RHL) on knowledge, skills, and educational environment compared with traditional EBM teaching. Design, Setting, and Participants International cluster randomized trial conducted between April 2009 and November 2010 among postgraduate trainees in obstetrics-gynecology in 7 LMICs (Argentina, Brazil, Democratic Republic of the Congo, India, Philippines, South Africa, Thailand). Each training unit was randomized to an experimental clinically integrated course consisting of e-modules using the RHL for learning activities and trainee assessments (31 clusters, 123 participants) or to a control self-directed EBM course incorporating the RHL (29 clusters, 81 participants). A facilitator with EBM teaching experience was available at all teaching units. Courses were administered for 8 weeks...

‣ Effect of exposure to ulipristal acetate on sperm function

Munuce, Maria Jose; Zumoffen, Carlos; Cicare, Juliana; Caille, Adriana; Ghersevich, Sergio; Bahamondes, Luis
Fonte: Informa Healthcare; London Publicador: Informa Healthcare; London
Tipo: Artigo de Revista Científica
Português
Objective A pill containing ulipristal acetate (UPA) is used for emergency contraception (EC). Considering that, following its intake, spermatozoa may be exposed to UPA in the female genital tract we intended to evaluate sperm functions after incubation with this compound. Methods Motile spermatozoa were selected by swim-up and were incubated under capacitating conditions with UPA (at concentrations of 1, 10, 100, 1,000, and 10,000 ng/ml) or control medium. The main outcome measures were sperm vitality, sperm protein tyrosine phosphorylation (TyrP), spontaneous acrosomal reaction (AR), and human follicular fluid (hFF)-induced AR. Results Sperm vitality and TyrP pattern were similar between spermatozoa exposed to UPA or control. In addition, spontaneous AR ranged from 14.0. +/- 1.5% to 18.0. +/- 1.9% after exposure to UPA or control medium without significant differences, and UPA did not prevent hFF-induced AR. Conclusions Incubation of sperm with UPA at concentrations around the expected plasma levels after ingestion of this EC pill (similar to 100-200 ng/ml) did not modify the signal transduction of TyrP involved in sperm capacitation. Moreover, UPA showed no agonist effect on progesterone receptors because it did not induce AR. Considering that progesterone in hFF is essential for AR induction...

‣ Is the Immunohistochemical Expression of Proliferation (Ki-67) and Apoptosis (Bcl-2) Markers and Cyclooxigenase-2 (COX-2) Related to Carcinogenesis in Postmenopausal Endometrial Polyps?

Antunes, Armando, Jr.; Andrade, Liliana A. L. A.; Pinto, Glauce A.; Leao, Rogerio; Pinto-Neto, Aarao M.; Costa-Paiva, Lucia
Fonte: Sci Printers & Publ Inc; St Louis Publicador: Sci Printers & Publ Inc; St Louis
Tipo: Artigo de Revista Científica
Português
OBJECTIVE: To evaluate the pattern of Ki-67, Bcl-2 and COX-2 expression in the glandular epithelium and stroma of malignant and benign endometrial polyps in post-menopause. STUDY DESIGN: A total of 390 postmenopausal women underwent surgical hysteroscopy; women with endometrial polyps were included. Polypoid lesions were histologically classified as benign, premalignant or malignant lesions. Ki-67, Bcl-2 and COX-2 expression were evaluated by immunohistochemistry according to percentage of stained cells, staining intensity, and final score. RESULTS: The prevalence of malignancy in endometrial polyps was 7.1% and was associated with postmenopausal bleeding. The final score showed that only mean COX-2 expression was higher in malignant polyps both in the glandular epithelium (6.1 +/- 2.5) (p < 0.001) and stroma (2.4 +/- 3.0) (p < 0.01). There was a higher Bcl-2 expression, especially in the glandular epithelium, with no differences between benign polyps and premalignant/malignant polyps. Ki-67 expression was low in both benign polyps and premalignant/malignant polyps. CONCLUSION: Polyps in postmenopause have a high COX-2 expression that is higher in malignant polyps than in benign polyps. There was no difference in Ki-67 and Bcl-2 expression between malignant polyps and premalignant/malignant polyps. (Anal Quant Cytopathol Histopathol 2012;34:264-272); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

‣ Strategies for the prevention of unsafe abortion

Faundes, Anibal
Fonte: Elsevier; Clare Publicador: Elsevier; Clare
Tipo: Artigo de Revista Científica
Português
Unsafe abortion is one of the main causes of maternal mortality and severe morbidity in countries with restrictive abortion laws. In 2007, the International Federation of Gynecology and Obstetrics (FIGO) created a Working Group on the Prevention of Unsafe Abortion and its Consequences (WGPUA). This led to a FIGO initiative with that aim which has the active participation of 43 FIGO member societies. The WGPUA has recommended that the plans of action of the countries participating in the initiative consider several levels of prevention shown to have the potential to successfully reduce unsafe abortions: (1) primary prevention of unintended pregnancy and induced abortion; (2) secondary prevention to ensure the safety of an abortion procedure that could not be avoided; (3) tertiary prevention of further complications of an unsafe abortion procedure that has taken place already, through high-quality postabortion care; and (4) quaternary prevention of repeated abortion procedures through postabortion family planning counseling and contraceptive services. This paper reviews these levels of prevention and the evidence that they can be effective. (c) 2012 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

‣ The prognostic value of a normal oral glucose tolerance test in pregnant women who tested positive at screening: a validation study

Rehder, Patricia M.; Pereira, Belmiro G.; Luiz Pinto e Silva, Joao
Fonte: Biomed Central Ltd; London Publicador: Biomed Central Ltd; London
Tipo: Artigo de Revista Científica
Português
Background: Controversies surround a diagnosis of gestational diabetes mellitus (GDM). The objective of this study was to evaluate the oral glucose tolerance test (OGTT) for the prediction of adverse gestational and perinatal outcomes in pregnant women with a positive screening test for diabetes mellitus and a negative diagnosis, i.e. a normal 3-hour OGTT. Methods: This validation study evaluated 409 pregnant women who tested positive for diabetes mellitus at screening. Perinatal and maternal outcomes were considered. Sensitivity and specificity were calculated for each of the values of the OGTT as a diagnostic test, with the gold standard being perinatal outcome. Results: The most frequent risk factors were obesity, arterial hypertension and advanced maternal age. The most common neonatal outcomes were large-for-gestational-age infants, Cesarean delivery and preterm birth. A fasting blood glucose level of 87 mg/dL was the most powerful predictor of adverse perinatal outcome. Conclusions: At the cut-off level adopted by the American Diabetes Association, gestational OGTT was able to successfully identify in which pregnant women outcome would be unfavorable.

‣ Sleep quality in women with endometriosis

Nunes, Fabiana Roberta; Ferreira, Jessica Mayra; Bahamondes, Luis Gillermo
Fonte: Mary Ann Liebert Inc; New Rochelle Publicador: Mary Ann Liebert Inc; New Rochelle
Tipo: Artigo de Revista Científica
Português

‣ Expression of cyclooxygenase-2 (COX-2) and p53 in neighboring invasive and in situ components of breast tumors

Serra, Katia Piton; Sarian, Luis Otavio; Rodrigues-Peres, Raquel Mary; Vassallo, Jose; Soares, Fernando Augusto; Pinto, Glauce Aparecida; da Cunha, Isabela Werneck; Shinzato, Julia Yoriko; Derchain, Sophie F. M.
Fonte: Elsevier; Jena Publicador: Elsevier; Jena
Tipo: Artigo de Revista Científica
Português
The aim of the study was to assess the relationship between the expression of COX-2 and p53, hormone receptors and HER-2 in the in situ (DCIS) and invasive components of ductal carcinomas (IDC) of the same breast. The expression of COX-2, p53, and hormone receptors was assessed in 87 cases of IDC with contiguous areas of DCIS. Results showed that there was no difference in COX-2 expression comparing the in situ and invasive components of the tumors. In the in situ component, there was a statistically borderline increase in p53 expression in tumors that also expressed COX-2. ER-positive specimens were more common in the group of tumors that expressed COX-2 in the invasive component. From this study we conclude that the expression of COX-2 was similar in the in situ and invasive components of the breast carcinomas. COX-2 positivity was marginally related with the expression of p53 in the in situ components, and with the ER expression in the invasive components. (C) 2011 Elsevier GmbH. All rights reserved.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Sequential Organ Failure Assessment Score for Evaluating Organ Failure and Outcome of Severe Maternal Morbidity in Obstetric Intensive Care

Oliveira-Neto, Antonio; Parpinelli, Mary A.; Cecatti, Jose G.; Souza, Joao P.; Sousa, Maria H.
Fonte: Hindawi Publishing Corporation; New York Publicador: Hindawi Publishing Corporation; New York
Tipo: Artigo de Revista Científica
Português
Objective. To evaluate the performance of Sequential Organ Failure Assessment (SOFA) score in cases of severe maternal morbidity (SMM). Design. Retrospective study of diagnostic validation. Setting. An obstetric intensive care unit (ICU) in Brazil. Population. 673 women with SMM. Main Outcome Measures. mortality and SOFA score. Methods. Organ failure was evaluated according to maximum score for each one of its six components. The total maximum SOFA score was calculated using the poorest result of each component, reflecting the maximum degree of alteration in systemic organ function. Results. highest total maximum SOFA score was associated with mortality, 12.06 +/- 5.47 for women who died and 1.87 +/- 2.56 for survivors. There was also a significant correlation between the number of failing organs and maternal mortality, ranging from 0.2% (no failure) to 85.7% (>= 3 organs). Analysis of the area under the receiver operating characteristic (ROC) curve (AUC) confirmed the excellent performance of total maximum SOFA score for cases of SMM (AUC = 0.958). Conclusions. Total maximum SOFA score proved to be an effective tool for evaluating severity and estimating prognosis in cases of SMM. Maximum SOFA score may be used to conceptually define and stratify the degree of severity in cases of SMM.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

‣ The WHO Maternal Near-Miss Approach and the Maternal Severity Index Model (MSI): Tools for Assessing the Management of Severe Maternal Morbidity

Souza, Joao Paulo; Cecatti, Jose Guilherme; Haddad, Samira M.; Parpinelli, Mary Angela; Costa, Maria Laura; Katz, Leila; Say, Lale
Fonte: Public Library Science; San Francisco Publicador: Public Library Science; San Francisco
Tipo: Artigo de Revista Científica
Português
Objectives: To validate the WHO maternal near-miss criteria and develop a benchmark tool for severe maternal morbidity assessments. Methods: In a multicenter cross-sectional study implemented in 27 referral maternity hospitals in Brazil, a one-year prospective surveillance on severe maternal morbidity and data collection was carried out. Diagnostic accuracy tests were used to assess the validity of the WHO maternal near-miss criteria. Binary logistic regression was used to model the death probability among women with severe maternal complications and benchmark the management of severe maternal morbidity. Results: Of the 82,388 women having deliveries in the participating health facilities, 9,555 women presented pregnancy-related complications, including 140 maternal deaths and 770 maternal near misses. The WHO maternal near-miss criteria were found to be accurate and highly associated with maternal deaths (Positive likelihood ratio 106.8 (95% CI 99.56-114.6)). The maternal severity index (MSI) model was developed and found to able to describe the relationship between life-threatening conditions and mortality (Area under the ROC curve: 0.951 (95% CI 0.909-0.993)). Conclusion: The identification of maternal near-miss cases using the WHO list of pregnancy-related life-threatening conditions was validated. The MSI model can be used as a tool for benchmarking the performance of health services managing women with severe maternal complications and provide case-mix adjustment.; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Greater Need for FVIII Replacement in Patients of Type Non-O Blood Groups with Moderate Hemophilia A

Lima, Magaly B. P. L. V.; Siqueira, Lucia Helena; Saraiva, Ana Suely; Montalvao, Silmara Aparecida; Gomes Siegl Machado, Tania de Fatima; Trento, Thais; Oliveira-Filho, Aldemir Branco; Ozelo, Margareth C.; Rodrigues Lemos, Jose Alexandre
Fonte: Amer Soc Hematology; Washington Publicador: Amer Soc Hematology; Washington
Tipo: Artigo de Revista Científica
Português

‣ Aberrant Expression of the MLL5, BAALC, ID1, and WT1 Genes Is Associated with Higher Induction Mortality and Poorer Overall Survival in Acute Promyelocytic Leukemia Patients Treated with ATRA and Anthracycline-Based Chemotherapy: An International Consortium On Acute Promyelocytic Leukemia Study

Lucena-Araujo, Antonio R.; Jacomo, Rafael Henriques; Kim, Haesook T.; Melo, Raul A.; Bittencourt, Rosane; Pasquini, Ricardo; Pagnano, Katia B.; Fagundes, Evandro; Chauffaille, Maria de Lourdes L. F.; Chiattone, Carlos S.; Kwaan, Hau C.; Gallagher, Robert
Fonte: Amer Soc Hematology; Washington Publicador: Amer Soc Hematology; Washington
Tipo: Artigo de Revista Científica
Português

‣ Early Assessment of Molecular Response in Chronic Myeloid Leukemia Patients On Dasatinib After Imatinib Failure Identify Patients with Poor Cytogenetic and Molecular Responses

Pagnano, Katia B.; Ribeiro, Beatriz F.; Miranda, Eliana C. M.; Delamain, Marcia T.; De Souza, Carmino Antonio; Duarte, Gislaine O.; Vergilio, Bruna; Albuquerque, Dulcineia Martins; dos Santos, Andrey; Tavares, Anderson; Lorand-Metze, Irene
Fonte: Amer Soc Hematology; Washington Publicador: Amer Soc Hematology; Washington
Tipo: Artigo de Revista Científica
Português

‣ Hematopoietic Cell Kinase (HCK) Is Highly Expressed in Myelodysplastic Syndrome (MDS) and Regulates Proliferation, Cell Cycle Progression and Hematopoietic Differentiation

Roversi, Fernanda Marconi; Machado-Neto, Joao; Palodetto, Bruna; Corrocher, Flavia Adolfo; Baratti, Mariana Ozello; Campos, Paula de Melo; Traina, Fabiola; Olalla Saad, Sara T.
Fonte: Amer Soc Hematology; Washington Publicador: Amer Soc Hematology; Washington
Tipo: Artigo de Revista Científica
Português

‣ Molecular Mutations in U2AF1 Are Most Commonly Found in Del20q Myelodysplastic Syndromes but Do Not Lead to Poor Prognosis in This Karyotypic Subtype

Tabarroki, Ali; Zhang, Li; Visconte, Valeria; Bupathi, Manoj; Rogers, Heesun J.; Makishima, Hideki; Traina, Fabiola; Hamilton, Betty K.; Hasrouni, Edy; Clemente, Michael J.; Campos, Paula de Melo; Duong, Hien K.; Advani, Anjali; Sekeres, Mikkael A.; Copel
Fonte: Amer Soc Hematology; Washington Publicador: Amer Soc Hematology; Washington
Tipo: Artigo de Revista Científica
Português

‣ Haplotypes of susceptibility to chronic periodontitis in the Interleukin 8 gene do not influence protein level in the gingival crevicular fluid

Corbi, Samia C. T.; Anovazzi, Giovana; Finoti, Livia S.; Kim, Yeon J.; Capela, Marisa V.; Secolin, Rodrigo; Marcaccini, Andrea M.; Gerlach, Raquel F.; Orrico, Silvana R. P.; Cirelli, Joni A.; Scarel-Caminaga, Raquel M.
Fonte: Pergamon-Elsevier Science Ltd; Oxford Publicador: Pergamon-Elsevier Science Ltd; Oxford
Tipo: Artigo de Revista Científica
Português
Objective: Previously, we identified that the ATC/TTC haplotype formed by polymorphisms in the Interleukin-(IL)8 gene conferred susceptibility to chronic periodontitis (CP). The aim of the study was to investigate whether the IL8 haplotype ATC/TTC was associated with the volume of gingival crevicular fluid (GCF), the concentration of interleukin IL-8 in the GCF, as well as periodontal conditions in patients with CP in comparison to controls without CP. Methods: Seventy-nine individuals (CP: n = 41, controls: n = 38) were grouped according to the presence (susceptible for CP) or absence (not susceptible for CP) of the IL8 ATC/TTC haplotype. After periodontal clinical evaluation, they were subdivided by the presence or absence of CP. GCF was collected from each patient and the IL-8 levels were determined by ELISA. The GCF volume of each subject was measured by means of a calibrated electronic device. Comparisons of means between carriers and non-carriers of the ATC/TTC haplotype were evaluated using the Mann-Whitney test. Linear regression and stepwise linear regression analysis were used to analyse the association of the GCF volume with potential covariates and their contribution for the phenotype. Results: We did not find significant differences of both periodontal conditions and IL-8 concentration in the GCF of patients with the presence or absence of the IL8 ATC/TTC haplotype. However...

‣ DIFFERENTIAL MICRORNAS EXPRESSIONS ARE ASSOCIATED WITH RELAPSE AND TP53 P.R377H MUTATION IN PEDIATRICS ADRENOCORTICAL TUMORS

Fedatto, Paola Fernanda; de Oliveira, Jaqueline Carvalho; Peixoto Lira, Regia Caroline; Tucci, Silvio, Jr.; Martinelli, Carlos Eduardo, Jr.; Antonini, Sonir Rauber; de Castro, Margaret; Yunes, Jose Andres; Mastellaro, Maria Jose; Brandalise, Silvia Regina
Fonte: Wiley-Blackwell; San Francisco Publicador: Wiley-Blackwell; San Francisco
Tipo: Artigo de Revista Científica
Português

‣ Insertional translocation of 15q25-q26 into 11p13 and duplication at 8p23.1 characterized by high resolution arrays in a boy with congenital malformations and aniridia

Simioni, Milena; Vieira, Tarsis Paiva; Sgardioli, Ilaria Cristina; Freitas, Erika Lopes; Rosenberg, Carla; Maurer-Morelli, Claudia Vianna; Lopes-Cendes, Iscia; Fett-Conte, Agnes Cristina; Gil-da-Silva-Lopes, Vera Lucia
Fonte: Wiley-Blackwell; Hoboken Publicador: Wiley-Blackwell; Hoboken
Tipo: Artigo de Revista Científica
Português
We report on a boy presenting submucous cleft palate, hydronephrosis, ventriculoseptal defect, aniridia, and developmental delay. Additional material on 11p13 was cytogenetically visible and array analyses identified a duplicated segment on 15q25-26 chromosome region; further, array analyses revealed a small deletion (49?kb) at 11p13 region involving the ELP4 gene and a duplication at 8p23.1. Results were confirmed with both molecular and molecular cytogenetics techniques. Possibilities for etiological basis of clinical phenotype are discussed. (c) 2012 Wiley Periodicals, Inc.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)