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A Biblioteca Digital da Produção Intelectual e Científica da Unicamp tem por objetivo reunir e disseminar a produção intelectual, acadêmica e cultural da universidade e preservar sua memória institucional, além de contribuir para ampliar a visibilidade da instituição e dos seus pesquisadores em âmbito nacional e internacional.

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‣ TWO NEW WEAK CONSTRAINT QUALIFICATIONS AND APPLICATIONS

Andreani, Roberto; Haeser, Gabriel; Laura Schuverdt, Maria; Silva, Paulo J. S.
Fonte: Siam Publications; Philadelphia Publicador: Siam Publications; Philadelphia
Tipo: Artigo de Revista Científica
Português
We present two new constraint qualifications (CQs) that are weaker than the recently introduced relaxed constant positive linear dependence (RCPLD) CQ. RCPLD is based on the assumption that many subsets of the gradients of the active constraints preserve positive linear dependence locally. A major open question was to identify the exact set of gradients whose properties had to be preserved locally and that would still work as a CQ. This is done in the first new CQ, which we call the constant rank of the subspace component (CRSC) CQ. This new CQ also preserves many of the good properties of RCPLD, such as local stability and the validity of an error bound. We also introduce an even weaker CQ, called the constant positive generator (CPG), which can replace RCPLD in the analysis of the global convergence of algorithms. We close this work by extending convergence results of algorithms belonging to all the main classes of nonlinear optimization methods: sequential quadratic programming, augmented Lagrangians, interior point algorithms, and inexact restoration.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ On universal Banach spaces of density continuum

Brech, Christina; Koszmider, Piotr
Fonte: Hebrew Univ Magnes Press; Jerusalem Publicador: Hebrew Univ Magnes Press; Jerusalem
Tipo: Artigo de Revista Científica
Português
We consider the question whether there exists a Banach space X of density continuum such that every Banach space of density at most continuum isomorphically embeds into X (called a universal Banach space of density c). It is well known that a""(a)/c (0) is such a space if we assume the continuum hypothesis. Some additional set-theoretic assumption is indeed needed, as we prove in the main result of this paper that it is consistent with the usual axioms of set-theory that there is no universal Banach space of density c. Thus, the problem of the existence of a universal Banach space of density c is undecidable using the usual axioms of set-theory. We also prove that it is consistent that there are universal Banach spaces of density c, but a""(a)/c (0) is not among them. This relies on the proof of the consistency of the nonexistence of an isomorphic embedding of C([0, c]) into a""(a)/c (0).; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

‣ Augmented Lagrangian method with nonmonotone penalty parameters for constrained optimization

Birgin, Ernesto G.; Martinez, J. M.
Fonte: Springer; New York Publicador: Springer; New York
Tipo: Artigo de Revista Científica
Português
At each outer iteration of standard Augmented Lagrangian methods one tries to solve a box-constrained optimization problem with some prescribed tolerance. In the continuous world, using exact arithmetic, this subproblem is always solvable. Therefore, the possibility of finishing the subproblem resolution without satisfying the theoretical stopping conditions is not contemplated in usual convergence theories. However, in practice, one might not be able to solve the subproblem up to the required precision. This may be due to different reasons. One of them is that the presence of an excessively large penalty parameter could impair the performance of the box-constraint optimization solver. In this paper a practical strategy for decreasing the penalty parameter in situations like the one mentioned above is proposed. More generally, the different decisions that may be taken when, in practice, one is not able to solve the Augmented Lagrangian subproblem will be discussed. As a result, an improved Augmented Lagrangian method is presented, which takes into account numerical difficulties in a satisfactory way, preserving suitable convergence theory. Numerical experiments are presented involving all the CUTEr collection test problems.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

‣ Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus

Cabral, Rodrigo S.; Sartori, Maura C.; Cordeiro, Ines; Queiroga, Carmen L.; Eberlin, Marcos N.; Lago, Joao H. G.; Moreno, Paulo R. H.; Young, Maria C. M.
Fonte: Soc Brasileira Farmacognosia; Joao Pessoa Publicador: Soc Brasileira Farmacognosia; Joao Pessoa
Tipo: Artigo de Revista Científica
Português
Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguara, is a native and endemic tree from Sao Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), gamma-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5).; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Anomalous centrality evolution of two-particle angular correlations from Au-Au collisions at root s(NN)=62 and 200 GeV

Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alakhverdyants, A. V.; Alekseev, I.; Alford, J.; Anderson, B. D.; Anson, C. D.; Arkhipkin, D.; Averichev, G. S.; Balewski, J.; Beavis, D. R.; Behera, N. K.; Bellwied, R.; Betancourt, M. J.; Betts, R. R.; Bhasi
Fonte: Amer Physical Soc; College Pk Publicador: Amer Physical Soc; College Pk
Tipo: Artigo de Revista Científica
Português
We present two-dimensional (2D) two-particle angular correlations measured with the STAR detector on relative pseudorapidity eta and azimuth phi for charged particles from Au-Au collisions at root s(NN) = 62 and 200 GeV with transverse momentum p(t) >= 0.15 GeV/c, vertical bar eta vertical bar <= 1, and 2 pi in azimuth. Observed correlations include a same-side (relative azimuth

‣ Inclusive charged hadron elliptic flow in Au+Au collisions at root s(NN)=7.7-39 GeV

Adamczyk, L.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alakhverdyants, A. V.; Alekseev, I.; Alford, J.; Anderson, B. D.; Anson, C. D.; Arkhipkin, D.; Aschenauer, E.; Averichev, G. S.; Balewski, J.; Banerjee, A.; Barnovska, Z.; Beavis, D. R.; Bellwied
Fonte: Amer Physical Soc; College Pk Publicador: Amer Physical Soc; College Pk
Tipo: Artigo de Revista Científica
Português
A systematic study is presented for centrality, transverse momentum (p(T)), and pseudorapidity (eta) dependence of the inclusive charged hadron elliptic flow (v(2)) at midrapidity (vertical bar eta vertical bar < 1.0) in Au + Au collisions at root s(NN) = 7.7, 11.5, 19.6, 27, and 39 GeV. The results obtained with different methods, including correlations with the event plane reconstructed in a region separated by a large pseudorapidity gap and four-particle cumulants (v(2){4}), are presented to investigate nonflow correlations and v(2) fluctuations. We observe that the difference between v(2){2} and v(2){4} is smaller at the lower collision energies. Values of v(2), scaled by the initial coordinate space eccentricity, v(2)/epsilon, as a function of p(T) are larger in more central collisions, suggesting stronger collective flow develops in more central collisions, similar to the results at higher collision energies. These results are compared to measurements at higher energies at the Relativistic Heavy Ion Collider (root s(NN) = 62.4 and 200 GeV) and at the Large Hadron Collider (Pb + Pb collisions at root s(NN) = 2.76 TeV). The v(2)(pT) values for fixed pT rise with increasing collision energy within the pT range studied (<2 GeV/c). A comparison to viscous hydrodynamic simulations is made to potentially help understand the energy dependence of v(2)(pT). We also compare the v(2) results to UrQMD and AMPT transport model calculations...

‣ Measurements of D-0 and D* production in p plus p collisions at root s=200 GeV

Adamczyk, L.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alakhverdyants, A. V.; Alekseev, I.; Alford, J.; Anderson, B. D.; Anson, C. D.; Arkhipkin, D.; Aschenauer, E.; Averichev, G. S.; Balewski, J.; Banerjee, A.; Barnovska, Z.; Beavis, D. R.; Bellwied
Fonte: Amer Physical Soc; College Pk Publicador: Amer Physical Soc; College Pk
Tipo: Artigo de Revista Científica
Português
We report measurements of charmed-hadron (D-0, D*) production cross sections at midrapidity in p + p collisions at a center-of-mass energy of 200 GeV by the STAR experiment. Charmed hadrons were reconstructed via the hadronic decays D-0 -> K- pi(+), D*(+) -> D-0 pi(+) -> K-pi(+)pi(+) and their charge conjugates, covering the p(T) range of 0.6-2.0 and 2.0-6.0 GeV/c for D-0 and D*(+), respectively. From this analysis, the charm-pair production cross section at midrapidity is d sigma/dy vertical bar(c (c) over bar)(y-0) = 170+/-45(stat)(-59)(+38()sys) mu b. The extracted charm-pair cross section is compared to perturbative QCD calculations. The transverse momentum differential cross section is found to be consistent with the upper bound of a fixed-order next-to-leading logarithm calculation.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Potential Contribution of Translational Factors to Triiodo-L-Thyronine-Induced Insulin Synthesis by Pancreatic Beta Cells

Goulart-Silva, Francemilson; Teixeira, Silvania da Silva; Luchessi, Augusto Ducati; Bichara dos Santos, Laila Romagueira; Rebelato, Eduardo; Carpinelli, Angelo Rafael; Nunes, Maria Tereza
Fonte: Mary Ann Liebert Inc; New Rochelle Publicador: Mary Ann Liebert Inc; New Rochelle
Tipo: Artigo de Revista Científica
Português
Background: Thyroid hormones (THs) are known to regulate protein synthesis by acting at the transcriptional level and inducing the expression of many genes. However, little is known about their role in protein expression at the post-transcriptional level, even though studies have shown enhancement of protein synthesis associated with mTOR/p70S6K activation after triiodo-l-thyronine (T3) administration. On the other hand, the effects of TH on translation initiation and polypeptidic chain elongation factors, being essential for activating protein synthesis, have been poorly explored. Therefore, considering that preliminary studies from our laboratory have demonstrated an increase in insulin content in INS-1E cells in response to T3 treatment, the aim of the present study was to investigate if proteins of translational nature might be involved in this effect. Methods: INS-1E cells were maintained in the presence or absence of T3 (10(-6) or 10(-8) M) for 12 hours. Thereafter, insulin concentration in the culture medium was determined by radioimmunoassay, and the cells were processed for Western blot detection of insulin, eukaryotic initiation factor 2 (eIF2), p-eIF2, eIF5A, EF1A, eIF4E binding protein (4E-BP), p-4E-BP, p70S6K, and p-p70S6K. Results: It was found that...

‣ PREPARATION OF PERCENTILE TABLES THROUGH ANTHROPOMETRIC, PERFORMANCE, BIOCHEMICAL, HEMATOLOGICAL, HORMONAL AND PSYCHOLOGICAL PARAMETERS IN PROFESSIONAL SOCCER PLAYERS

Ramos da Silva, Adelino Sanchez; Papoti, Marcelo; Pauli, Jose Rodrigo; Gobatto, Claudio Alexandre
Fonte: Soc Brasileira Med Esporte; Sao Paulo Publicador: Soc Brasileira Med Esporte; Sao Paulo
Tipo: Artigo de Revista Científica
Português
Introduction: The lack of reference values of anthropometric, performance, biochemical, hematological, hormonal and psychological parameters is an important limitation in the investigations with soccer players. Objective: To elaborate percentile tables to be used as comparison reference for further studies. Methods: 82 professional soccer players were evaluated approximately 30 days after the beginning of the main competition played by their teams. On the first day of evaluation, fast blood samples were collected for measurement of hematological parameters (i.e. erythrocytes, hemoglobin, hematocrit, mean corpuscular volume - MCV, mean corpuscular hemoglobin - MCH, mean corpuscular hemoglobin concentration - MCHC, leukocytes, eosinophils, lymphocytes, monocytes and platelets) and of concentrations of adrenaline, cortisol, creatine kinase, creatinine, norepinephrine, testosterone and urea. Subsequently, the soccer players had their anthropometric characteristics and psychological parameters assessed. In addition, the evaluation of the lactic anaerobic system efficiency was performed on a 400-m track. On the second day, both the alactic anaerobic and aerobic system efficiency was measured. Results: The percentile distribution (P-0, P-15...

‣ Transverse single-spin asymmetry and cross section for pi(0) and eta mesons at large Feynman x in p(up arrow) + p collisions at root s=200 GeV

Adamczyk, L.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alakhverdyants, A. V.; Alekseev, I.; Alford, J.; Anderson, B. D.; Anson, C. D.; Arkhipkin, D.; Aschenauer, E.; Averichev, G. S.; Balewski, J.; Bannerjee, A.; Barnovska, Z.; Beavis, D. R.; Bellwie
Fonte: Amer Physical Soc; College Pk Publicador: Amer Physical Soc; College Pk
Tipo: Artigo de Revista Científica
Português
Measurements of the differential cross section and the transverse single-spin asymmetry, A(N), vs x(F) for pi(0) and eta mesons are reported for 0.4 < x(F) < 0.75 at an average pseudorapidity of 3.68. A data sample of approximately 6.3 pb(-1) was analyzed, which was recorded during p(up arrow) + p collisions at root s = 200 GeV by the STAR experiment at RHIC. The average transverse beam polarization was 56%. The cross section for pi(0), including the previously unmeasured region of x(F) > 0.55, is consistent with a perturbative QCD prediction, and the eta/pi(0) cross-section ratio agrees with existing midrapidity measurements. For 0.55 < x(F) < 0.75, the average A(N) for eta is 0.210 +/- 0.056, and that for pi(0) is 0.081 +/- 0.016. The probability that these two asymmetries are equal is similar to 3%.

‣ High density lipoprotein levels are strongly associated with the recovery rate of insulin sensitivity during acute phase of myocardial infarction: a study by euglycemic hyperinsulinemic clamp

Carvalho, L. S. F.; Moura, F. A.; Martins, N. V.; Cintra, R. M. R.; Silva, J. C. Quinaglia E.; Coelho, O. R.; Sposito, A. C.
Fonte: Oxford Univ Press; Oxford Publicador: Oxford Univ Press; Oxford
Tipo: Artigo de Revista Científica
Português

‣ Cost-effectiveness of dabigatran etexilate versus warfarin for stroke prevention in patients with non-valvular atrial fibrillation under the public and private healthcare system in Brazil

Nasciben, V. D.; Giangrande, L.; Piegas, L.; Figueiredo, M.; Darrieux, F.; Martins, S.
Fonte: Oxford Univ Press; Oxford Publicador: Oxford Univ Press; Oxford
Tipo: Artigo de Revista Científica
Português

‣ Atherosclerotic disease in octogenarians: A challenge for science and clinical practice

Freitas, Wladimir M.; Carvalho, Luiz Sergio F.; Moura, Filipe A.; Sposito, Andrei C.
Fonte: Elsevier; Clare Publicador: Elsevier; Clare
Tipo: Artigo de Revista Científica
Português
Besides the time of exposure to the traditional risk factors, new players take the lead in the modulation of atherogenesis in the very elderly, promoting a step increase in the incidence of cardiovascular events. Accordingly, atherosclerotic plaques become more abundant and portray more unstable features, such as increased inflammatory activity and reduction of smooth muscle cells in the very elderly. This new scenario is composed of new potential modulators of atherogenesis such as cellular senescence, immunosenescence, frailty syndrome, sarcopenia and sirtuins, and changes among the traditional cardiovascular risk factors which gain new attributes and new magnitudes of interaction with atherosclerotic disease. Consistent with this concept, mortality from atherosclerotic disease has shown a decrease in individuals younger than 60 years, but no change in incidence in individuals over the age of 60 years. In this review, we present the most recent and relevant pieces of evidence to the peculiarities of traditional cardiovascular risk factors and new aging-related potential modulators of atherosclerotic disease in very elderly. (C) 2012 Elsevier Ireland Ltd. All rights reserved.; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ SUBCLINICAL CARDIOVASCULAR DISEASE IN HEALTHY OCTOGENARIANS: THE BRAZILIAN STUDY ON HEALTHY AGING

Freitas, Wladimir M.; Quaglia, Luiz; Santos, Simone; Blaha, Michael; Blumenthal, Roger; Agatston, Arthur; Santos, Raul; Nasir, Khurram; Sposito, Andrei
Fonte: Elsevier; New York Publicador: Elsevier; New York
Tipo: Artigo de Revista Científica
Português

‣ Cholesteryl ester transfer protein role during acute phase of myocardial infarction

Carvalho, L. S. F.; Virginio, V. W. M.; Alexandre, F.; Panzoldo, N. B.; Silva, J. C. Quinaglia E.; De Faria, E. C.; Sposito, A. C.
Fonte: Oxford Univ Press; Oxford Publicador: Oxford Univ Press; Oxford
Tipo: Artigo de Revista Científica
Português

‣ High density lipoprotein reduces oxidative stress during acute phase of myocardial infarction

Carvalho, L. S. F.; Panzoldo, N. B.; De Faria, E. C.; Sposito, A. C.
Fonte: Oxford Univ Press; Oxford Publicador: Oxford Univ Press; Oxford
Tipo: Artigo de Revista Científica
Português

‣ Reappraisal of immunohistochemical profiling of special histological types of breast carcinomas: a study of 121 cases of eight different subtypes

Alvarenga, Cesar Augusto; Paravidino, Paula Itagyba; Alvarenga, Marcelo; Gomes, Madalena; Dufloth, Rozany; Zeferino, Luiz Carlos; Vassallo, Jose; Schmitt, Fernando C.
Fonte: Bmj Publishing Group; London Publicador: Bmj Publishing Group; London
Tipo: Artigo de Revista Científica
Português
Histological special types (HST) account for about 25% of breast cancers, and correspond to at least 17 pathological entities. However, their molecular characteristics remain to be determined. The purpose of the present study is to apply the recently used immunohistochemical profiling of HST breast carcinomas (BC), as a surrogate for the molecular subtyping, what could be relevant for therapeutic purposes. One hundred and twenty-one cases were included. Immunohistochemical study was performed on paraffin sections, including markers for oestrogen, progesterone and androgen receptors, keratin 5, HER2/neu, epithelial growth factor receptor, p63 protein, P-cadherin, and Ki-67. Tubular (16 cases), mucinous (27) and papillary (9) types were all categorised as luminal-like A and B. The medullary (21) and metaplastic (10) types corresponded largely to the basal-like tumours (85.7% and 90%, respectively). Cases of the micropapillary type (8) were luminal A (3/8), luminal B (4/8) and HER2 overexpressing (1/8), whereas the apocrine carcinomas (24) presented a heterogeneous profile. The proliferation rate (Ki-67) varied among the types, being the medullary carcinoma subtype with higher proliferation. Comparing the current data with those based on molecular studies...

‣ Cytopathic effects of human papillomavirus infection and the severity of cervical intraepithelial neoplasia : A frequency study

Alves de Sousa, Nadja Lindany; Figueiredo Alves, Rosane Ribeiro; Martins, Marcelo Rodrigues; da Silva Barros, Narriman Kennia; Ribeiro, Andrea Alves; Zeferino, Luiz Carlos; Dufloth, Rozany Mucha; Rabelo-Santos, Silvia Helena
Fonte: Wiley-Blackwell; Hoboken Publicador: Wiley-Blackwell; Hoboken
Tipo: Artigo de Revista Científica
Português
Cytopathic effects related to the human papillomavirus (HPV) infection are more frequently found in cervical intraepithelial neoplasia (CIN) 1; however, there are indications that at least half the histological diagnoses of CIN2 and CIN3 include koilocytosis areas. The objective of this study was to evaluate the frequency of the cytological criteria suggestive of HPV infection in the cervical smears of women with a histological diagnosis of CIN. One hundred and sixty-two women with abnormal cervical smears and a diagnosis of CIN confirmed by histopathology were selected, including 46 cases of CIN 1, 42 of CIN 2 and 74 cases of CIN 3. Koilocytosis was found in 63% of the smears from women with a histopathological diagnosis of CIN 1. This sign was observed in 26.2% and 25.7% of smears of women with a diagnosis of CIN 2 and CIN 3, respectively. Cytomegaly also was frequent in cervical smears of women with histopathological diagnosis of CIN 1 (71.8%). On the other hand, spindle cells and atypical metaplasia were more frequent in women with CIN 2 and CIN 3. Atypical parakeratosis showed similar frequency in all grades of CIN diagnosis. Koilocytois and cytomegaly were inversely correlated with the diagnosis of CIN2 or CIN 3, with OR values respectively of 0.30 (95%CI 0.130.68) and 0.26 (95%CI 0.110.58). The others signs analyzed did not show any significant association. Koilocitosis and cytomegaly can provides good reassurance that a patient with atypical cervical smear have CIN 1. Diagn. Cytopathol. 2012. (C) 2011 Wiley Periodicals...

‣ Comparison of active and passive forces of the pelvic floor muscles in women with and without stress urinary incontinence

Chamochumbi, Carla C. M.; Nunes, Fabiana R.; Guirro, Rinaldo R. J.; Guirro, Elaine C. O.
Fonte: Associacao Brasileira Pesquisa Pos-Graduacao Fisioterapia-Abrapg-Ft; Sao Carlos Publicador: Associacao Brasileira Pesquisa Pos-Graduacao Fisioterapia-Abrapg-Ft; Sao Carlos
Tipo: Artigo de Revista Científica
Português
Background: The reduction of the pelvic floor muscles (PFM) strength is a major cause of stress urinary incontinence (SUI). Objective: To compare active and passive forces, and vaginal cavity aperture in continent and stress urinary incontinent women. Method: The study included a total of thirty-two women, sixteen continent women (group 1 - G1) and sixteen women with SUI (group 2 - G2). To evaluate PFM passive and active forces in anteroposterior (sagittal plane) and left-right directions (frontal plane) a stainless steel specular dynamometer was used. Results: The anteroposterior active strength for the continent women (mean +/- standard deviation) (0.3 +/- 0.2 N) was greater compared to the values found in the evaluation of incontinent women (0.1 +/- 0.1 N). The left-right active strength (G1=0.43 +/- 0.1 N; G2=0.40 +/- 0.1 N), the passive force (G1=1.1 +/- 0.2 N; G2=1.1 +/- 0.3 N) and the vaginal cavity aperture (G1=21 +/- 3 mm; G2=24 +/- 4 mm) did not differ between groups 1 and 2. Conclusion: The function evaluation of PFM showed that women with SUI had a lower anteroposterior active strength compared to continent women.

‣ Low Bone Mineral Density in Middle-Aged Breast Cancer Survivors: Prevalence and Associated Factors

Conde, Delio Marques; Costa-Paiva, Lucia; Martinez, Edson Zangiacomi; Pinto-Neto, Aarao Mendes
Fonte: Karger; Basel Publicador: Karger; Basel
Tipo: Artigo de Revista Científica
Português
Background: The aim of this study was to investigate the prevalence of low bone mineral density (BMD) and associated factors in middle-aged breast cancer survivors (BCS). Patients and Methods: A cross-sectional study was conducted with 70 BCS of 45-65 years of age undergoing complete oncology treatment. Logistic regression models were used to identify factors associated with low BMD (osteopenia and osteoporosis taken together as a single group). Results: The mean age of participants was 53.2 +/- 5.9 years. BMD was low at the femoral neck in 28.6% of patients and at the lumbar spine in 45.7%. Body mass index <= 30 kg/m(2) (adjusted odds ratio (OR) 3.43; 95% confidence interval (CI) 1.0-11.3) and postmenopausal status (OR adjusted 20.42; 95% CI 2.0-201.2) were associated with low BMD at the lumbar spine. Femoral neck measurements, age > 50 years (OR 3.41; 95% CI 1.0-11.6), and time since diagnosis > 50 months (OR adjusted 3.34; 95% CI 1.0-11.3) increased the likelihood of low BMD. Conclusion: These findings show that low BMD is common in middle-aged BCS. Factors were identified that may affect BMD in BCS and should be considered when implementing strategies to minimize bone loss in middle-aged women with breast cancer.