Últimos itens adicionados do Acervo: Biblioteca Digital da Produção Intelectual e Científica da Unicamp

A Biblioteca Digital da Produção Intelectual e Científica da Unicamp tem por objetivo reunir e disseminar a produção intelectual, acadêmica e cultural da universidade e preservar sua memória institucional, além de contribuir para ampliar a visibilidade da instituição e dos seus pesquisadores em âmbito nacional e internacional.

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‣ Fructose-Induced Hypothalamic AMPK Activation Stimulates Hepatic PEPCK and Gluconeogenesis due to Increased Corticosterone Levels

Kinote, Andrezza; Faria, Juliana A.; Roman, Erika A.; Solon, Carina; Razolli, Daniela S.; Ignacio-Souza, Leticia M.; Sollon, Carolina S.; Nascimento, Lucas F.; de Araujo, Thiago M.; Barbosa, Ana Paula L.; Lellis-Santos, Camilo; Velloso, Licio A.; Bordin,
Fonte: Endocrine Soc; Chevy Chase Publicador: Endocrine Soc; Chevy Chase
Tipo: Artigo de Revista Científica
Português
Fructose consumption causes insulin resistance and favors hepatic gluconeogenesis through mechanisms that are not completely understood. Recent studies demonstrated that the activation of hypothalamic 5'-AMP-activated protein kinase (AMPK) controls dynamic fluctuations in hepatic glucose production. Thus, the present study was designed to investigate whether hypothalamic AMPK activation by fructose would mediate increased gluconeogenesis. Both ip and intracerebroventricular (icv) fructose treatment stimulated hypothalamic AMPK and acetyl-CoA carboxylase phosphorylation, in parallel with increased hepatic phosphoenolpyruvate carboxy kinase (PEPCK) and gluconeogenesis. An increase in AMPK phosphorylation by icv fructose was observed in the lateral hypothalamus as well as in the paraventricular nucleus and the arcuate nucleus. These effects were mimicked by icv 5-amino-imidazole-4-carboxamide-1-beta-D-ribofuranoside treatment. Hypothalamic AMPK inhibition with icv injection of compound C or with injection of a small interfering RNA targeted to AMPK alpha 2 in the mediobasal hypothalamus (MBH) suppressed the hepatic effects of ip fructose. We also found that fructose increased corticosterone levels through a mechanism that is dependent on hypothalamic AMPK activation. Concomitantly...

‣ A controlled clinical trial on the effects of exercise on neuropsychiatric disorders and instrumental activities in women with Alzheimer's disease

Nascimento, Carla M. C.; Teixeira, Camila V. L.; Gobbi, Lilian T. B.; Gobbi, Sebastiao; Stella, Florindo
Fonte: Associacao Brasileira Pesquisa Pos-Graduacao Fisioterapia-Abrapg-Ft; Sao Carlos Publicador: Associacao Brasileira Pesquisa Pos-Graduacao Fisioterapia-Abrapg-Ft; Sao Carlos
Tipo: Artigo de Revista Científica
Português
Objective: To analyze the influence of a six-month exercise program on neuropsychiatric disorders and on the performance of instrumental activities in elderly patients with Alzheimer's disease (AD). Methods: The study included 20 patients with AD in the mild to moderate stages of the Clinical Dementia Rating (CDR) divided into two groups: the experimental group, composed of 10 women who participated in the six-month exercise program, and the control group, composed of the 10 remaining AD patients who did not take part in an exercise program during the same period. All participants were evaluated using the Mini-Mental State Exam for global cognitive function, the Neuropsychiatric Inventory Questionnaire for neuropsychiatric disorders, and the Pfeffer Functional Activities Questionnaire for the degree of functional impairment. Results: The control group showed functional and neuropsychiatric deterioration in the comparisons between pre-and post-intervention times and between groups. Conclusion: The experimental group showed a propensity for less deterioration in neuropsychiatric disorders and performance of instrumental activities compared to the sedentary group.

‣ Polyvinyl alcohol associated with carbon nanotube scaffolds for osteogenic differentiation of rat bone mesenchymal stem cells

Rodrigues, Ana A.; Batista, Nilza A.; Bavaresco, Vanessa P.; Baranauskas, Vitor; Ceragioli, Helder J.; Peterlevitz, Alfredo C.; Santos, Arnaldo R., Jr.; Belangero, William D.
Fonte: Pergamon-Elsevier Science Ltd; Oxford Publicador: Pergamon-Elsevier Science Ltd; Oxford
Tipo: Artigo de Revista Científica
Português
Polyvinyl alcohol (PVAl) hydrogel, alone and reinforced with two types of carbon nanopartides, was studied in cultured cells to assess its potential use in treating osteochondral defects. The carbon nanoparticles were produced by hot-filament chemical vapour deposition. The carbon material was characterised with a Renishaw Invia Raman microscope system and the morphological particles were characterised with field emission scanning electron microscopy and high-resolution transmission electron microscopy. Cytotoxicity was evaluated by measuring the Vero fibroblast-type cells' metabolic activity and studying their morphology. The osteogenic differentiation of mesenchymal stem cells obtained from rat bone marrow was evaluated by alkaline phosphatase (ALP) and alizarin red S (ARS) staining. Cell viability and morphology were assessed with thiazolyl blue tetrazolium bromide and scanning electron microscopy, respectively. The materials did not interfere with the viability, metabolic activity, morphology and spreading of either of the cell types analysed. Nodules of mineralised organic matrix were identified with ARS and ALP, confirming osteogenic differentiation. These results indicated higher concentration of ALP and mineralised matrix for PVAl with carbon nanoparticles. The results of this study indicate the potential use of carbon nanoparticles with PVAl hydrogels as orthopaedic biomaterials to treat osteochondral defects...

‣ Koebner's phenomenon in systemic lupus erythematosus

Longhi, Barbara S.; Centeville, Maraisa; Marini, Roberto; Appenzeller, Simone
Fonte: Springer; Heidelberg Publicador: Springer; Heidelberg
Tipo: Artigo de Revista Científica
Português
Koebner phenomenon is defined as a nonspecific skin stimulus eliciting a disease skin reaction. The nature of the skin trauma varies greatly and includes areas of thermal injury, excoriations, surgical incisions, and scars. We report a patient with recent onset of systemic lupus erythematosus who developed Herpes zoster on immunosuppressant medication. Two weeks after resolution of the vesicles, the patient presented with new ulcerative reddish lesions over the herpes zoster scare and worsening of her malar rash without evidence of worsening of any other organ. Koebner phenomenon was suspected. We review the literature on Koebner phenomenon in SLE.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts

Visconte, V.; Makishima, H.; Jankowska, A.; Szpurka, H.; Traina, F.; Jerez, A.; O'Keefe, C.; Rogers, H. J.; Sekeres, M. A.; Maciejewski, J. P.; Tiu, R. V.
Fonte: Nature Publishing Group; London Publicador: Nature Publishing Group; London
Tipo: Artigo de Revista Científica
Português

‣ Purification, characterization and structural determination of chitinases produced by Moniliophthora perniciosa

Galante, Rafaela S.; Taranto, Alex G.; Koblitz, Maria G. B.; Goes-Neto, Aristoteles; Pirovani, Carlos P.; Cascardo, Julio C. M.; Cruz, Sandra H.; Pereira, Goncalo A. G.; de Assisi, Sandra A.
Fonte: Acad Brasileira De Ciencias; Rio de Janeiro Publicador: Acad Brasileira De Ciencias; Rio de Janeiro
Tipo: Artigo de Revista Científica
Português
The enzyme chitinase from Moniliophthora perniciosa the causative agent of the witches' broom disease in Theobroma cacao, was partially purified with ammonium sulfate and filtration by Sephacryl S-200 using sodium phosphate as an extraction buffer. Response surface methodology (RSM) was used to determine the optimum pH and temperature conditions. Four different isoenzymes were obtained: ChitMp I, ChitMp II, ChitMp III and ChitMp IV. ChitMp I had an optimum temperature at 44-73 degrees C and an optimum pH at 7.0-8.4. ChitMp II had an optimum temperature at 45-73 degrees C and an optimum pH at 7.0-8.4. ChitMp III had an optimum temperature at 54-67 degrees C and an optimum pH at 7.3-8.8. ChitMp IV had an optimum temperature at 60 degrees C and an optimum pH at 7.0. For the computational biology, the primary sequence was determined in silico from the database of the Genome/Proteome Project of M. perniciosa, yielding a sequence with 564 bp and I 88 amino acids that was used for the three-dimensional design in a comparative modeling methodology. The generated models were submitted to validation using Procheck 3.0 and ANOLEA. The model proposed for the chitinase was subjected to a dynamic analysis over a 1 ns interval, resulting in a model with 91.7% of the residues occupying favorable places on the Ramachandran plot and an RMS of 2.68.; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Araçá: biodiversidade, impactos e ameaças

AMARAL, Antonia Cecília Zacagnini; MIGOTTO, Alvaro Esteves; TURRA, Alexander; SCHAEFFER-NOVELLI, Yara
Fonte: Instituto Virtual da Biodiversidade | BIOTA - FAPESP Publicador: Instituto Virtual da Biodiversidade | BIOTA - FAPESP
Tipo: Artigo de Revista Científica
Português
Inserida em uma das mais belas e turísticas regiões litorâneas do país - o Litoral Norte do Estado de São Paulo -, a Baía do Araçá (São Sebastião, SP), além de conter remanescentes de manguezal e de abrigar alta diversidade biológica, é também um verdadeiro laboratório a céu aberto e um importante reduto de catadores de moluscos e pescadores artesanais. Com o objetivo de compilar preliminarmente a biodiversidade da baía, este estudo reúne a extensa bibliografia dedicada à região e apresenta a lista das espécies da fauna e da flora formalmente reportadas para o local. O texto sumaria ainda o histórico das alterações antrópicas sofridas nas últimas décadas e destaca certos representantes da fauna (espécies novas, ameaçadas de extinção, bioindicadoras e como recursos naturais), como exemplos da peculiaridade e riqueza biológica dessa pequena baía. Pretende-se, assim, fornecer subsídios para tomadas de decisão e planos de manejo, e despertar a atenção para a preservação desse frágil patrimônio ambiental, uma área que pode ser revitalizada e integrada ao ambiente urbanizado.; Araçá Bay (São Sebastião, State of São Paulo), within one of Brazil's most beautiful coastlines, has small relict mangrove stands and a very diverse marine ecosystem. As such...

‣ Muscle reinnervation in one or two stages? Experimental study in rats with end-to-side nerve graft

Bersaneti, Joseli Assem; Viterbo, Fausto; Jorge, Jacks; Denadai, Rafael
Fonte: Acta Cirurgica Brasileira; Sao Paulo Publicador: Acta Cirurgica Brasileira; Sao Paulo
Tipo: Artigo de Revista Científica
Português
Purpose: To compare muscle reinnervation in one and two surgical stages using end-to-side neurorrhaphy (ESN) without donor nerve injury. Methods: The experiment was performed on four groups of 20 rats. Group 1 (G1), one stage, received the graft which was sutured to the tibial nerve, with ESN, and its free stump was sutured end-to-end to the distal stump of the sectioned peroneal nerve (PN), all in the same operation. In Group 2 (G2), two stages, the nerve graft was sutured to the tibial nerve, with ESN. Two months later the PN was sectioned and its distal stump connected to the distal stump of the graft as in G1. Normal control group (Gn) received the graft only sutured to the tibial nerve, with ESN. Denervated control group (Gd), as well received the graft and had the PN sectioned and its two stumps buried in adjacent musculature, with the aim of denervating the cranial tibial muscle (CTM), the target of this study. The parameters used to evaluate CTM reinnervation were muscle mass, muscle fiber's minimum diameter and area. Results : The mean CTM mass, the average of the muscular fibers areas and the average of the muscular fiber minimum diameters was higher (all p<0.0001) in G2 than in G1. Comparing the four groups, these parameters had their maximum expression in Gn and the minimum in Gd...

‣ Clinical and MRI investigation of temporomandibular joint in major depressed patients

Lopes, S. L. P. C.; Costa, A. L. F.; Cruz, A. D.; Li, L. M.; de Almeidas, S. M.
Fonte: British Inst Radiology; London Publicador: British Inst Radiology; London
Tipo: Artigo de Revista Científica
Português
Objective: The aim of the present study was to describe the clinical and MRI findings of the temporomandibular joint (TMJ) in patients with major depressive disorders (MDDs) of the non-psychotic type. Methods: 40 patients (80 TMJs) who were diagnosed as having MDDs were selected for this study. The clinical examination of the TMJs was conducted according to the research diagnostic criteria and temporomandibular disorders (TMDs). The MRIs were obtained bilaterally in each patient with axial, parasagittal and paracoronal sections within a real-time dynamic sequence. Two trained oral radiologists assessed all images. For statistical analyses, Fisher's exact test and chi(2) test were applied (alpha = 0.05). Results: Migraine was reported in 52.5% of subjects. Considering disc position, statistically significant differences between opening patterns with and without alteration (p = 0.00) and between present and absent joint noises (p = 0.00) were found. Regarding muscular pain, patients with and without abnormalities in disc function and patients with and without abnormalities in disc position were not statistically significant (p = 0.42 and p = 0.40, respectively). Significant differences between mandibular pathway with and without abnormalities (p=0.00) and between present and absent joint noises (p=0.00) were observed. Conclusion: Based on the preliminary results observed by clinical and MRI examination of the TMJ...

‣ Salivary IgA antibody responses to Streptococcus mitis and Streptococcus mutans in preterm and fullterm newborn children

Nogueira, Ruchele Dias; Talarico Sesso, Maria Lucia; Loureiro Borges, Mariana Castro; Mattos-Graner, Renata O.; Smith, Daniel James; Leme Ferriani, Virginia Paes
Fonte: Pergamon-Elsevier Science Ltd; Oxford Publicador: Pergamon-Elsevier Science Ltd; Oxford
Tipo: Artigo de Revista Científica
Português
Objectives: The intensities and specificities of salivary IgA antibody responses to antigens of Streptococcus mutans, the main pathogen of dental caries, may influence colonization by these organisms during the first 1.5 year of life. Thus, the ontogeny of salivary IgA responses to oral colonizers continues to warrant investigation, especially with regard to the influence of birth conditions, e.g. prematurity, on the ability of children to efficiently respond to oral microorganisms. In this study, we characterised the salivary antibody responses to two bacterial species which are prototypes of pioneer and pathogenic microorganisms of the oral cavity (Streptococcus mitis and Streptococcus mutans, respectively) in fullterm (FT) and preterm (PT) newborn children. Methods: Salivas from 123 infants (70 FT and 53 PT) were collected during the first 10 h after birth and levels of IgA and IgM antibodies and the presence of S. mutans and S. mitis were analysed respectively by ELISA and by chequerboard DNA-DNA hybridization. Two subgroups of 24 FT and 24 PT children were compared with respect to patterns of antibody specificities against S. mutans and S. mitis antigens, using Western blot assays. Cross-adsorption of 10 infant's saliva was tested to S. mitis...

‣ Correlation between maxillofacial radiographic features and systemic severity as sickle cell disease severity predictor

Neves, Frederico Sampaio; Passos, Cristina Pinho; Oliveira-Santos, Christiano; Teixeira Cangussu, Maria Cristina; Flores Campos, Paulo Sergio; Meyer Nascimento, Roberto Jose; Crusoe-Rebello, Ieda; Guimaraes Campos, Maria Isabela
Fonte: Springer; Heidelberg Publicador: Springer; Heidelberg
Tipo: Artigo de Revista Científica
Português
This study was conducted to investigate the relationship among radiographic features observed on panoramic radiographs of sickle cell disease patients and analyze their relationship with history of systemic severity of the disease. Panoramic radiographs of 71 subjects with sickle cell disease were evaluated for the presence of the following radiographic bony alterations: radiopaque areas, increased spacing of bony trabeculae, horizontal arrangement of bony trabeculae and corticalization of mandibular canal. History of clinical systemic severity was assessed through direct questioning about the frequency of vaso-occlusive crisis, history of stroke, clinical jaundice, femur head necrosis, and leg ulceration. Chi-square or Fisher's exact test were applied in order to analyze possible associations between radiographic features and history of complications, with < 0.05 significance level. Increased spacing of bony trabeculae was statistically associated with absence of corticalization of mandibular canal ( < 0.01) and horizontal arrangement of bony trabeculae ( = 0.04). Statistically significant associations were demonstrated between history of clinical jaundice and presence of increased spacing of bony trabeculae ( = 0.02) and between history of stroke and presence of horizontal arrangement of bony trabeculae ( = 0.04). Based on the results of the current study...

‣ Underground leaves of Philcoxia trap and digest nematodes

Pereira, Caio G.; Almenara, Daniela P.; Winter, Carlos E.; Fritsch, Peter W.; Lambers, Hans; Oliveira, Rafael S.
Fonte: Natl Acad Sciences; Washington Publicador: Natl Acad Sciences; Washington
Tipo: Artigo de Revista Científica
Português
The recently described genus Philcoxia comprises three species restricted to well lit and low-nutrient soils in the Brazilian Cerrado. The morphological and habitat similarities of Philcoxia to those of some carnivorous plants, along with recent observations of nematodes over its subterranean leaves, prompted the suggestion that the genus is carnivorous. Here we report compelling evidence of carnivory in Philcoxia of the Plantaginaceae, a family in which no carnivorous members are otherwise known. We also document both a unique capturing strategy for carnivorous plants and a case of a plant that traps and digests nematodes with underground adhesive leaves. Our findings illustrate how much can still be discovered about the origin, distribution, and frequency of the carnivorous syndrome in angiosperms and, more generally, about the diversity of nutrient-acquisition mechanisms that have evolved in plants growing in severely nutrient-impoverished environments such as the Brazilian Cerrado, one of the world's 34 biodiversity hotspots.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

‣ Main conclusions of the joint FAPESP Programs BIOTA-BIOEN-Climate Change Workshop: Science and Policy for a Greener Economy in the context of RIO+20

Joly, Carlos Alfredo; de Souza Berlinck, Roberto Gomes; Bolzani, Vanderlan da Silva; Baptista Haddad, Celio Fernando; de Oliveira, Mariana Cabral; Van Sluys, Marie-Anne; Souza, Glaucia Mendes; Verdade, Luciano Martins; Victoria, Reynaldo Luiz
Fonte: Revista Biota Neotropica; Campinas Publicador: Revista Biota Neotropica; Campinas
Tipo: Artigo de Revista Científica
Português
This Point of View summarizes the conclusion of a joint workshop organized by FAPESP's Environmental Research Programs - BIOTA (The Virtual Institute of Biodiversity) - BIOEN (Bioenergy Research) - Climate Change, to discuss the scientific contribution to the RIO+20 UN Conference. Brazilian scientists gathered at FAPESP's headquarters in Sao Paulo City in the first week of March 2012 raised the following concerns: a) that there are very few opportunities for the scientific community to interact with Conferences like the RIO+20; b) the deficiencies of the ZeroDraft, document produced by UN's Division for Sustainable Development for the RIO+20; c) the fact that the focus of all three research programs - biodiversity, bioenergy and climate change - are not on the agenda of discussions of RIO +20; d) that little emphasis is given to the oceans in the Conference Agenda; e) regarding market mechanisms associated with the transition to a greener economy, the need to emphasize the reduction of perverse subsidies and promotion of economic incentives to activities or processes to mitigate emissions and/or carbon sequestration; f) that in Brazil we need to stimulate and consolidate research focused on Ecosystem Services Assessments and Evaluation. The workshop participants recognized the need to strengthen knowledge about international conventions...

‣ Floristic and phytosociology in permanent plots of the Atlantic Rainforest along an altitudinal gradient in southeastern Brazil

Joly, Carlos Alfredo; Assis, Marco Antonio; Bernacci, Luis Carlos; Tamashiro, Jorge Yoshio; Rodrigues de Campos, Mariana Cruz; Mantelli Aboin Comes, Jose Ataliba; Lacerda, Maryland Sanchez; Maes dos Santos, Flavio Antonio; Pedroni, Fernando; Pereira, Lari
Fonte: Revista Biota Neotropica; Campinas Publicador: Revista Biota Neotropica; Campinas
Tipo: Artigo de Revista Científica
Português
This paper summarizes floristic and phytossociology data of 11, out of 14 plots of 1 ha, allocated along an altitudinal gradient in the Serra do Mar, Silo Paulo, Brazil. The study was conducted at Serra do Mar State Park and the plots start at the sea level (10 m - plot of Restinga Forest that occurs at Praia da Fazenda, Picinguaba, municipality of Ubatuba) up to 1100 m above sea level (the Montane Ombrophilous Dense occurs alongside the Itamambuca Trail, municipality of Silo Luis do Paraitinga). The Restinga Forest occurs in Pleistocenic Coastal Plain where the soil is classified as a sandy Quartzipsamment (Quartzenic Neosol), while along the slopes of the Serra do Mar, the Ombrophylus Dense Forest grows on the top of a pre-Cambrian crystalline basement with granitic rocks, where the soil is a sandy-loam Dystrophic Inceptisol (Cambisol/Latosol). In all 14 plots soils are acidic (pH 3 - 4), chemically poor, with high dilution of nutrients and high saturation of aluminum. In the Restinga and at the foot of the slope the climate is Tropical/Subtropical Humid (Af/Cfa), with no dry season, an average annual rainfall over 2,200 mm and an average annual temperature of 22 degrees C. Towards the top of the Serra do Mar there is a gradual cooling along the slope...

‣ Antioxidant, anti-acetylcholinesterase and cytotoxic activities of ethanol extracts of peel, pulp and seeds of exotic Brazilian fruits Antioxidant, anti-acetylcholinesterase and cytotoxic activities in fruits

Bazilio Omena, Cristhiane Maria; Valentim, Iara Barros; Guedes, Glaucevane da S.; Rabelo, Luiza A.; Mano, Camila Marinho; Henriques Bechara, Etelvino Jose; Sawaya, Alexandra C. H. F.; Salles Trevisan, Maria Teresa; da Costa, Joao Gomes; Silva Ferreira, Ro
Fonte: Elsevier; Amsterdam Publicador: Elsevier; Amsterdam
Tipo: Artigo de Revista Científica
Português
Ethanol extracts of powdered genipap (Genipa americana L), umbu (Spondia tuberosa A.) and siriguela (Spondia purpurea L) prepared from separate pulp, seeds and peel were investigated for their (i) antioxidant capacity, which was evaluated by various known methods; (ii) acetylcholinesterase (AChE) inhibitory activity; and (iii) cytotoxic effect on corneal epithelial cells of sheep. The highest values of total phenolic content were obtained with peel and seed extracts. Siriguela and umbu (seeds and peel) extracts displayed the highest antioxidant activities. Lipid peroxidation assays using mimetic biomembranes and mouse liver homogenates indicated that genipap pulp is a promising antioxidant. The investigation of phenols and organic acid contents revealed the presence of quercetin, citric and quinic acids, chlorogenic acid derivatives, among others, in several extracts, with the highest amount found in siriguela seeds. Genipap pulp and siriguela seed ethanol extracts presented an AChE inhibition zone similar to that of the positive control, carbachol. AChE inhibition assay with chlorogenic acid, one of the main constituents of siriguela seeds, revealed that this acid showed activity similar to that of the control physostigmine. These data suggest that these extracts are potentially important antioxidant supplements for the everyday human diet...

‣ Formation of oxysulfide LnO(2)S(2) and oxysulfate LnO(2)SO(4) phases in the thermal decomposition process of lanthanide sulfonates (Ln = La, Sm)

Machado, Luiz Carlos; D'Orlando de Azeredo, Marcos Tadeu; Soares Correa, Hamilton Perez; Matos, Jivaldo do Rosario; Mazali, Italo Odone
Fonte: Springer; Dordrecht Publicador: Springer; Dordrecht
Tipo: Artigo de Revista Científica
Português
This study investigates two lanthanide compounds (La(3+) and Sm(3+)) obtained in water/ethyl alcohol solutions employing the anionic surfactant diphenyl-4-amine sulfonate (DAS) as ligand. Both sulfonates were characterized through IR, TG/DTG (O(2) and N(2)). The thermal treatment of both compounds at 1273 K under air leaves residues containing variable percentages of lanthanide oxysulfide/oxysulfate phases shown by synchrotron high-resolution XRD pattern including the Rietveld analysis. The phase distributions found in the residues evidence the differences in the relative stability of the precursors.; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

‣ Magnetic fabric of Araguainha complex impact structure (Central Brazil): Implications for deformation mechanisms and central uplift formation

Yokoyama, E.; Trindade, R. I. F.; Lana, C.; Souza Filho, C. R.; Baratoux, D.; Marangoni, Y. R.; Tohver, E.
Fonte: Elsevier; Amsterdam Publicador: Elsevier; Amsterdam
Tipo: Artigo de Revista Científica
Português
The weakening mechanisms involved in the collapse of complex impact craters are controversial. The Araguainha impact crater, in Brazil, exposes a complex structure of 40 km in diameter, and is an excellent object to address this issue. Its core is dominated by granite. In addition to microstructural observations, magnetic studies reveal its internal fabric acquired during the collapse phase. All granite samples exhibit impact-related planar deformation features (PDFs) and planar fractures (PFs), which were overprinted by cataclasis. Cataclastic deformation has evolved from incipient brittle fracturing to the development of discrete shear bands in the center of the structure. Fracture planes are systematically decorated by tiny grains (<10 mu m) of magnetite and hematite, and the orientation of magnetic lineation and magnetic foliation obtained by the anisotropies of magnetic susceptibility (AMS) and anhysteretic remanence (AAR) are perfectly coaxial in all studied sites. Therefore, we could track the orientation of deformation features which are decorated by iron oxides using the AMS and AAR. The magnetic fabrics show a regular pattern at the borders of the central peak, with orientations consistent with the fabric of sediments at the crater's inner collar and complex in the center of the structure. Both the cataclastic flow revealed from microstructural observations and the structural pattern of the magnetic anisotropy match the predictions from numerical models of complex impact structures. The widespread occurrence of cataclasis in the central peak...

‣ Electro acoustic stimulation of the auditory system: UNICAMP's surgical approach

de Carvalho, Guilherme Machado; Peral Valente, Joao Paulo; Mathias Duarte, Alexandre Scalli; Muranaka, Eder Barbosa; Guimaraes, Alexandre Caixeta; Soki, Marcelo Naoki; Bianchini, Walter Adriano; Castilho, Arthur Menino; Paschoal, Jorge Rizzato
Fonte: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial; Sao Paulo Publicador: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial; Sao Paulo
Tipo: Artigo de Revista Científica
Português
A new era has arrived in auditory rehabilitation with the introduction of new technologies such as electroacoustic stimulation (EAS). EAS is indicated for patients with residual hearing at low frequencies and severe or profound hearing loss at high frequencies. These patients have no indication for conventional cochlear implant and have difficulties in adapting to individual sound amplification devices. Preservation of hearing is vital in this process; the surgical technique must be based on this concept. Objectives: To present the cochlear implant surgical technique with MED-EL Mand FlexEAS to preserve hearing in patients with hearing loss at high frequencies and to maintain low frequency hearing. We are the first institution to carry out this treatment in Brazil. Methods: A case report of the surgical technique carried out in four patients; the procedure was carried out by the cochlear implant group of a specialized clinical hospital. Results: The procedures were successful and uneventful. Conclusion: We described the technique used at our institution for implants using EAS; the surgical technique is complex and includes steps for preservation of hearing.

‣ FACTORS ASSOCIATED WITH URINARY INCONTINENCE IN ELDERLY INDIVIDUALS WHO MEET FRAILTY CRITERIA

da Silva, Vanessa Abreu; D'Elboux, Maria Jose
Fonte: Univ Federal Santa Catarina; Florianopolis Publicador: Univ Federal Santa Catarina; Florianopolis
Tipo: Artigo de Revista Científica
Português
This study presents an analysis of factors associated with Urinary Incontinence among elderly individuals who meet frailty criteria (pre-frail and frail). It is a cross-sectional and quantitative study. One hundred elderly patients from a geriatric outpatient clinic at a university hospital in Campinas, SP, Brazil were interviewed. A total of 65.0% of the participants reported Urinary Incontinence, 40 (61.4%) of which reported loss of small quantities of urine several times a day. The multivariate regression analysis showed a statistically significant relationship among gender (OR=3.67), urinary tract infection (OR=6.16), and scores on the Functional Independence Measure (mobility), (OR=0.85). The results show that urinary tract infection, loss of mobility, and gender are factors associated with Urinary Incontinence in elderly patients who meet frailty criteria. These factors are susceptible to interventions designed to prevent and even reduce episodes of Urinary Incontinence.

‣ Serum levels and mesenteric fat tissue expression of adiponectin and leptin in patients with Crohn's disease

Rodrigues, V. S.; Milanski, M.; Fagundes, J. J.; Torsoni, A. S.; Ayrizono, M. L. S.; Nunez, C. E. C.; Dias, C. B.; Meirelles, L. R.; Dalal, S.; Coy, C. S. R.; Velloso, L. A.; Leal, R. F.
Fonte: Wiley-Blackwell; Hoboken Publicador: Wiley-Blackwell; Hoboken
Tipo: Artigo de Revista Científica
Português
Crohn's disease (CD) is characterized by inflammation and an aetiology that is still unknown. Hypertrophy of mesenteric fat is a reflection of disease activity, as this fat covers the entire length of the affected area. Adipocytes synthesize leptin and adiponectin, adipocytokines responsible for pro- and anti-inflammatory effects. Therefore, we evaluated serum levels of adiponectin and leptin, as well as mesenteral expression of adiponectin in active CD and those in remission. Sixteen patients with ileocaecal CD followed at the Outpatient Clinic, Coloproctology Unit of University of Campinas Clinical Hospital, participated in the study. Analysis of serum adiponectin and leptin by enzyme-linked immunosorbent assay was performed in patients with active CD (ACD group), remission CD (RCD group) and in six healthy controls. Ten patients with active ileocaecal CD (FCD group) and eight patients with non-inflammatory disease selected for surgery were also studied. The specimens were snap-frozen and the expression of adiponectin was determined by immunoblot of protein extracts. Serum C-reactive protein levels were higher in the ACD group when compared to the others and no difference of body mass index was observed between the groups. Serum adiponectin was lower in the ACD group when compared to control...