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‣ Educação mediada por tecnologia em fonoaudiologia: uma comparação entre três métodos de aprendizagem sobre o sistema miofuncional orofacial; Technology-mediated learning in speech-language and hearing sciences: a comparison between three learning methods about the orofacial miofuncional system

Melo, Silmara Rondon
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 17/06/2015 Português
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O objetivo deste estudo foi comparar três métodos de aprendizagem sobre Anatomia e Fisiologia do Sistema Miofuncional Orofacial (SMFO) em relação ao desempenho prático e à motivação para a aprendizagem de estudantes de Fonoaudiologia. Participaram 36 estudantes do segundo ano de graduação, em disciplina obrigatória, após assinatura de termo de consentimento livre e esclarecido. Cada estudante foi alocado randomicamente em um dentre três grupos: Grupo I (GI) - 12 participantes do Método Interativo 1 (MI1); Grupo II (GII) - 12 participantes do Método Interativo 2 (MI2); Grupo III (GIII) - 12 participantes do Método Tradicional (MT). Os métodos de aprendizagem foram aplicados durante horário de estudo complementar semanal (uma hora de duração), após aula expositiva da disciplina, contendo os mesmos tópicos de estudo relacionados à aula. Concluída a aplicação dos três métodos de aprendizagem, foi aplicada avaliação de desempenho prático sendo requerido dos estudantes que realizassem procedimentos referentes à avaliação fonoaudiológica segundo critérios do protocolo de Avaliação Miofuncional Orofacial com Escores - Expandido. Em outro dia, foi aplicado o questionário Instructional Materials Motivation Survey (IMMS) para avaliação da motivação para a aprendizagem. O questionário avalia quatro aspectos da motivação: atenção...

‣ Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors

Hartley, Oliver; Gaertner, Hubert; Wilken, Jill; Thompson, Darren; Fish, Richard; Ramos, Alejandra; Pastore, Cristina; Dufour, Brigitte; Cerini, Fabrice; Melotti, Astrid; Heveker, Nikolaus; Picard, Laurent; Alizon, Marc; Mosier, Donald; Kent, Stephen; Off
Fonte: National Academy of Sciences Publicador: National Academy of Sciences
Tipo: Artigo de Revista Científica
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We have used total chemical synthesis to perform high-resolution dissection of the pharmacophore of a potent anti-HIV protein, the aminooxypentane oxime of [glyoxylyl1]RANTES(2-68), known as AOP–RANTES, of which we designed and made 37 analogs. All involved incorporation of one or more rationally chosen nonnatural noncoded structures, for which we found a clear comparative advantage over coded ones. We investigated structure–activity relationships in the pharmacophore by screening the analogs for their ability to block the HIV entry process and produced a derivative, PSC-RANTES {N-nonanoyl, des-Ser1[l-thioproline2, l-cyclohexylglycine3]-RANTES(2–68)}, which is 50 times more potent than AOP–RANTES. This promising group of compounds might be optimized yet further as potential prophylactic and therapeutic anti-HIV agents. The remarkable potency of our RANTES analogs probably involves the unusual mechanism of intracellular sequestration of CC-chemokine receptor 5 (CCR5), and it has been suggested that this arises from enhanced affinity for the receptor. We found that inhibitory potency and capacity to induce CCR5 down-modulation do appear to be correlated, but that unexpectedly, inhibitory potency and affinity for CCR5 do not. We believe this study represents the proof of principle for the use of a medicinal chemistry approach...

‣ Kernel energy method applied to vesicular stomatitis virus nucleoprotein

Huang, Lulu; Massa, Lou; Karle, Jerome
Fonte: National Academy of Sciences Publicador: National Academy of Sciences
Tipo: Artigo de Revista Científica
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The kernel energy method (KEM) is applied to the vesicular stomatitis virus (VSV) nucleoprotein (PDB ID code 2QVJ). The calculations employ atomic coordinates from the crystal structure at 2.8-Å resolution, except for the hydrogen atoms, whose positions were modeled by using the computer program HYPERCHEM. The calculated KEM ab initio limited basis Hartree-Fock energy for the full 33,175 atom molecule (including hydrogen atoms) is obtained. In the KEM, a full biological molecule is represented by smaller “kernels” of atoms, greatly simplifying the calculations. Collections of kernels are well suited for parallel computation. VSV consists of five similar chains, and we obtain the energy of each chain. Interchain hydrogen bonds contribute to the interaction energy between the chains. These hydrogen bond energies are calculated in Hartree-Fock (HF) and Møller-Plesset perturbation theory to second order (MP2) approximations by using 6–31G** basis orbitals. The correlation energy, included in MP2, is a significant factor in the interchain hydrogen bond energies.

‣ Approach to discover T- and B-cell antigens of intracellular pathogens applied to the design of Chlamydia trachomatis vaccines

Finco, Oretta; Frigimelica, Elisabetta; Buricchi, Francesca; Petracca, Roberto; Galli, Giuliano; Faenzi, Elisa; Meoni, Eva; Bonci, Alessandra; Agnusdei, Mauro; Nardelli, Filomena; Bartolini, Erika; Scarselli, Maria; Caproni, Elena; Laera, Donatello; Zedda
Fonte: National Academy of Sciences Publicador: National Academy of Sciences
Tipo: Artigo de Revista Científica
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Natural immunity against obligate and/or facultative intracellular pathogens is usually mediated by both humoral and cellular immunity. The identification of those antigens stimulating both arms of the immune system is instrumental for vaccine discovery. Although high-throughput technologies have been applied for the discovery of antibody-inducing antigens, few examples of their application for T-cell antigens have been reported. We describe how the compilation of the immunome, here defined as the pool of immunogenic antigens inducing T- and B-cell responses in vivo, can lead to vaccine candidates against Chlamydia trachomatis. We selected 120 C. trachomatis proteins and assessed their immunogenicity using two parallel high-throughput approaches. Protein arrays were generated and screened with sera from C. trachomatis-infected patients to identify antibody-inducing antigens. Splenocytes from C. trachomatis-infected mice were stimulated with 79 proteins, and the frequency of antigen-specific CD4+/IFN-γ+ T cells was analyzed by flow cytometry. We identified 21 antibody-inducing antigens, 16 CD4+/IFN-γ+–inducing antigens, and five antigens eliciting both types of responses. Assessment of their protective activity in a mouse model of Chlamydia muridarum lung infection led to the identification of seven antigens conferring partial protection when administered with LTK63/CpG adjuvant. Protection was largely the result of cellular immunity as assessed by CD4+ T-cell depletion. The seven antigens provided robust additive protection when combined in four-antigen combinations. This study paves the way for the development of an effective anti-Chlamydia vaccine and provides a general approach for the discovery of vaccines against other intracellular pathogens.

‣ Critical quasiparticle theory applied to heavy fermion metals near an antiferromagnetic quantum phase transition

Abrahams, Elihu; Wölfle, Peter
Fonte: National Academy of Sciences Publicador: National Academy of Sciences
Tipo: Artigo de Revista Científica
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We use the recently developed critical quasiparticle theory to derive the scaling behavior associated with a quantum critical point in a correlated metal. This is applied to the magnetic-field induced quantum critical point observed in YbRh2Si2, for which we also derive the critical behavior of the specific heat, resistivity, thermopower, magnetization and susceptibility, the Grüneisen coefficient, and the thermal expansion coefficient. The theory accounts very well for the available experimental results.

‣ A catalogue of [100], [110], and [111] symmetric tilt boundaries in face-centered cubic hard sphere crystals.

Frost, H.J.; Ashby, M.F.; Spaepen, Frans A.
Fonte: Harvard Division of Applied Sciences Publicador: Harvard Division of Applied Sciences
Tipo: Research Paper or Report
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Engineering and Applied Sciences

‣ Cellular responses to mechanical stresses applied via magnetic manipulators

Huang, Hayden.
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 166 p.; 17152852 bytes; 17152609 bytes; application/pdf; application/pdf
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A mechanotransduction model aims to explain how a cell senses mechanical forces and translates them into molecular events, such as changes in intracellular ion concentrations, gene expression, post-translational protein modification, or cytoskeletal redistribution. Many studies of mechanotransduction explore the responses of cell populations to large and, occasionally, poorly characterized deformation. More recent techniques provide the means for characterizing the physical properties of the cell, with the potential for uniting the molecular responses with the material properties and deformation characteristics of the cell. These recent techniques have an additional advantage - they can be used to probe cells at the single cell level. Single cell studies have the potential to elucidate more precisely the specific mechanisms by which a cell senses and transmits signals, because the information gathered from each cell is not averaged over thousands or millions of cells. Over the past decade, several approaches to studying mechanical properties at the single cell level were developed. Atomic force microscopy, optical and magnetic tweezers, micropipette aspiration and other techniques have been used to explore and develop physical models of the cell. By using these techniques...

‣ Unusual catalytic properties of horseradish peroxidase

Dordick, Jonathan Seth
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 231 leaves; 15024513 bytes; 15024266 bytes; application/pdf; application/pdf
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by Jonathan Seth Dordick.; Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1986.; MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCE; Bibliography: leaves 217-231.

‣ Factors affecting the thrombin inhibiting activity of heparin when immobilised to hydrogels by covalent bonding

Tay, Sew Wah
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 182 leaves; 9297609 bytes; 9297363 bytes; application/pdf; application/pdf
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by Sew-Wah Tay.; Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1986.; MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCE.; Bibliography: leaves 157-166.

‣ Estimation of human exposure to the carcinogenic aromatic amine 4-aminobiphenyl via hemoglobin dosimetry

Bryant, Matthew S. (Matthew Scott)
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 207 leaves in various foliations; 12754792 bytes; 12754549 bytes; application/pdf; application/pdf
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by Matthew S. Bryant.; Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1987.; Bibliography: leaves 125-134.

‣ Controlled biosynthesis of yeast glucans

Jamas, Spiros
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 171 leaves; 9345132 bytes; 9344889 bytes; application/pdf; application/pdf
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by Spiros Jamas.; Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1986.; Title as it appeared in M.I.T. Graduate List June 1987: Control of the structure-function properties of yeast glucans.; Bibliography: leaves 166-171.

‣ Thermodynamics and kinetics of ice nucleation inside biological cells during freezing : as applied to mouse oocytes

Toner, Mehmet
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 2 v. (393 leaves); 19062142 bytes; 19061901 bytes; application/pdf; application/pdf
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by Mehmet Toner.; Thesis (Ph. D.)--Harvard University--Massachusetts Institute of Technology Division of Health Sciences and Technology, Program in Medical Engineering and Medical Physics, 1989.; Includes bibliographical references (leaves 372-393).

‣ Induced seismicity analysis for reservoir characterization at a petroleum field in Oman

Sze, Edmond Kin-Man
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 294 p.
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This thesis presents the analysis and interpretation of passive seismic data collected in a 20-month monitoring period. The investigation is divided into four studies, each focusing on a different aspect of the seismic data to infer the reservoir properties. First, I applied three different methods (the iterative linearized, nonlinear grid-search, and double-difference methods) to relocate 405 microearthquakes that occurred between October 1999 and June 2001 in a producing field in Oman. A numerical technique is applied to "collapse" the relocated hypocenters and to find the simplest structural interpretation consistent with the data. Comparing the methods, the applicability of waveform correlation methods such as the double-difference in this case is limited by the relatively large number of events with dissimilar waveforms. Unlike the iterative linearized method, the nonlinear grid-search method gives the best results with the smallest average rms error of the absolute locations because it avoids the local minimum problem.; (cont.) The relocated hypocenters clearly delineate nearly vertical, northeast-southwest striking faults near the crest of the field, which is consistent with the graben fault system mapped by surface geologic surveys and reflection seismic interpretations. I also performed statistical tests to estimate location errors...

‣ Physiological mechanisms of hippocampal memory processing : experiments and applied adaptive filtering

Nguyen, David P., 1977-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 156 p.
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The hippocampus is necessary for the formation and storage of episodic memory, however, the computations within and between hippocampal subregions (CA1, CA3, and dentate gyrus) that mediate these memory processing functions are not completely understood. We investigate by recording in the hippocampal subregions as rats execute an augmented linear track task. From these recordings, we construct ensemble rate representations using a point process adaptive filter to characterize single-unit activity from each subregion. We compared the dynamics of these rate representations by computing average max rate and average rate modulation during different experimental epochs and on different segments of the track. We found that the representations in CA3 were modulated most when compared to CAl and DG during the first 5 minutes of experience. With more experience, we found the average rate modulation decreased gradually across all areas and converged to values that were not statistically different. These results suggest a specialized role for CA3 during initial context acquisition, and suggest that rate modulation becomes coherent across HPC subregions after familiarization. Information transfer between the hippocampus and neocortex is important for the consolidation of spatial and episodic memory. This process of information transfer is referred to as memory consolidation and may be mediated by a phenomena called "replay." We know that the process of replay is associated with a rise in multi-unit activity and the presence of ripples (100-250 Hz oscillations lasting from 75ms to 100ms) in CAl. Because ripples result from the same circuits as replay activity...

‣ The Imperative of Skills Development for the Structural Transformation of Sub-Saharan Africa

Bashir, Sajitha
Fonte: World Bank, Washington, DC Publicador: World Bank, Washington, DC
Tipo: Trabalho em Andamento
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This paper proposes three ways in which China and the World Bank could collaborate in the area of skills development in Africa, building on the experience of both and recent efforts at collaboration. First, under the PASET initiative, China and the World Bank could undertake joint analytical work to assess the skills needs for different sectors in individual countries, continue the benchmarking of African universities piloted with Shanghai Jiao Tong University, share the development experience of China through targeted learning visits, and share experiences in skills development through regional forums. Second, China could support the regional initiatives of the PASET such as the establishment of the Regional Scholarship Fund for postgraduate studies in applied sciences, engineering and technology; the proposed regional TVET centres of excellence; and co-financing of the regional Africa Centres of Excellence project, currently financed by the World Bank. This would supplement China’s on-going investments...

‣ A partnering business model for technology transfer: The case of the Muenster University of Applied Sciences

Dottore, A.; Baaken, T.; Corkindale, D.
Fonte: Inderscience Enterprises Ltd. Publicador: Inderscience Enterprises Ltd.
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
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Theory and practice of technology transfer and entrepreneurial behaviour of academics are novel. We draw upon the literature of business models, transaction costs, professional and organisational culture and of agency theory to formulate a framework for a technology transfer business model. We present the range of options used by universities and we examine the spin out option, as context and contrast to the MUAS approach. The case of the MUAS is presented. It illustrates the conceptual framework developed and has thus far been successful in its specific environment. Replication might require adaptation, but this particular approach can offer useful lessons. Tentative hypotheses for research on business model adaptation are derived from the study.; Antonio G. Dottore, Thomas Baaken, David Corkindale

‣ Philosophy of science: a practical tool for applied geologists in the minerals industry

Vann, J.; Stewart, M.
Fonte: Inst Mining Metallurgy Publicador: Inst Mining Metallurgy
Tipo: Artigo de Revista Científica
Publicado em //2011 Português
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For applied geologists working in the minerals industry the tasks of problem formulation, observation and data collection, interpretation and modelling invoke various philosophical considerations whether the practitioner is aware of them or not. A primary goal of applied geologists is to build models that accurately predict reality to an acceptable degree. In this paper, we describe the key philosophical frameworks proposed for conducting scientific investigations and relate them to the field of applied geology. We consider the very important differences in the types of problem confronted in experimental sciences (such as physics and chemistry) compared to the historical sciences, such as geology, where the processes studied are unique and only evidential traces of past events are available. The prediction quality of models is likely to be materially improved if the geologist is firmly and consciously practiced in the scientific method. In addition, if the predictions are framed and presented in terms of the underlying science, the quality of decisions made based on those predictions will likewise be improved. The implications for creating additional value to a project or operation can be very significant when geological models are constructed and used by a practitioner with an understanding of the philosophical basis of the activities constituting a scientific investigation. The method of multiple working hypotheses is particularly important when working in historical sciences. We argue that working within the framework of multiple working hypotheses can provide a valuable insurance against the adoption of...

‣ Space Systems Academic Group Brochure / 2009

Panholzer, Rudolf
Fonte: Monterey, California; Naval Postgraduate School Publicador: Monterey, California; Naval Postgraduate School
Tipo: Brochure
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The Space Systems Academic Group (SSAG) along with eight academic departments is an integral part of the Graduate School of Engineering and Applied Sciences. As an interdisciplinary association of professors it provides direction and guidance for two in-residence curricula: Space Systems Engineering and Space Systems Operations and for the Space Systems Distance Learning program.

‣ Sponsored Program Annual Report / Graduate School of Engineering & Applied Sciences Overview. Fiscal Year 2002

Fonte: Naval Postgraduate School (U.S.) Publicador: Naval Postgraduate School (U.S.)
Tipo: Relatório
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The Naval Postgraduate School has a strong Sponsored Program that has grown steadily to provide the faculty and staff support that is required to sustain a strong and viable graduate school. In fiscal year 2002, the Naval Postgraduate School had available over $80M in sponsored program funding. This amount included multi-year projects from FY01 and those continuing into FY03. The total expenditures in FY02 exceeded $57M. An overview of the NPS Program is provided below, as well as data for the organizational units involved in sponsored program activities.

‣ Self-report measures of executive functioning are a determinant of academic performance in first-year students at a university of applied sciences

Baars, Maria A. E.; Nije Bijvank, Marije; Tonnaer, Geertje H.; Jolles, Jelle
Fonte: Frontiers Media S.A. Publicador: Frontiers Media S.A.
Tipo: Artigo de Revista Científica
Publicado em 05/08/2015 Português
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Recent studies in late adolescents (age 17+) show that brain development may proceed till around the 25th year of age. This implies that study performance in higher education could be dependent upon the stage of brain maturation and neuropsychological development. Individual differences in development of neuropsychological skills may thus have a substantial influence on the outcome of the educational process. This hypothesis was evaluated in a large survey of 1760 first-year students at a University of Applied Sciences, of which 1332 are included in the current analyses. This was because of their fit within the age range we pre-set (17–20 years' old at start of studies). Student characteristics and three behavioral ratings of executive functioning (EF) were evaluated with regard to their influence on academic performance. Self-report measures were used: self-reported attention, planning, and self-control and self-monitoring. Results showed that students with better self-reported EF at the start of the first year of their studies obtained more study credits at the end of that year than students with a lower EF self-rating. The correlation between self-control and self-monitoring on the one hand, and study progress on the other, appeared to differ for male and female students and to be influenced by the level of prior education. The results of this large-scale study could have practical relevance. The profound individual differences between students may at least partly be a consequence of their stage of development as an adolescent. Students who show lower levels of attention control...