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‣ Retrospective study of survival and treatment pattern in a cohort of patients with oral and oropharyngeal tongue cancers from 1987 to 2004

Lam, L.; Logan, R.; Luke, C.; Rees, G.
Fonte: Pergamon-Elsevier Science Ltd Publicador: Pergamon-Elsevier Science Ltd
Tipo: Artigo de Revista Científica
Publicado em //2007 Português
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This is a retrospective study of patients with oral and oropharyngeal tongue cancers who presented to the Royal Adelaide Hospital (RAH) from 1987 to 2004. The aims of this study were to determine sociodemographic and tumour characteristics, treatment patterns and five-year disease-specific survival of the disease. All cases of tongue cancers, including untreated and palliative cases, were identified through the Royal Adelaide Hospital Cancer Registry and were included in statistical analysis. A total of 212 cases of tongue cancer were identified. Patients less than 45 years of age accounted for 15% of cases and had a tendency to present with advanced stage disease. Squamous cell carcinoma was the most common histological type. Almost 30% of recorded cases were oropharyngeal or base of tongue cancers. Nearly half of the patients had advanced stage (III and IV) disease at presentation, which was significantly associated with rural area of residence, base of tongue sub-site and early diagnostic period. Treatment involved a multidisciplinary approach and majority of patients were treated with a curative intent. Palliative treatment was more likely to be given to patient with oropharyngeal tongue cancers or advance stage disease. There was no significant improvement of five-year disease-specific survival over the 18-year period. Poorer survival was significantly associated with age 45 years or older...

‣ Impact of childhood exposure to a natural disaster on adult mental health: 20-year longitudinal follow-up study

McFarlane, A.; Van Hooff, M.
Fonte: Royal College of Psychiatrists Publicador: Royal College of Psychiatrists
Tipo: Artigo de Revista Científica
Publicado em //2009 Português
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Background: Studies examining the impact of childhood disaster exposure on the development of adult psychopathology report increased rates of post-traumatic stress disorder (PTSD) and other psychopathology. Aims: To examine the rates of PTSD and other lifetime DSM–IV disorders in adults exposed to an Australian bushfire disaster as children in 1983 using a matched control sample recruited at the time of the original study. Method: A total of 1011 adults recruited from an original sample of 1531 were assessed 20 years following the fires using the Composite International Diagnostic Interview (CIDI–2.1). Results: Results showed only a small direct impact of the fires on adult psychiatric morbidity. A higher proportion of bushfire survivors met criteria for ’any DSM–IV disorder’ and ’any anxiety’. Conclusions: Findings suggest that the long-term impact of a prominent trauma in childhood should be assessed in the context of other lifetime trauma in order to provide a more accurate account of PTSD prevalence rates. Declaration of interest: None.; Alexander C. McFarlane and Miranda Van Hooff

‣ Changes in the prevalence of major depression in an Australian community sample between 1998 and 2008

Goldney, R.; Eckert, K.; Hawthorne, G.; Taylor, A.
Fonte: Blackwell Publishing Asia Publicador: Blackwell Publishing Asia
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
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Objective: To identify changes in the prevalence of major depression between 1998, 2004 and 2008 in South Australia. Methods: Face-to-face Health Omnibus surveys were conducted in 1998, 2004 and 2008 with approximately 3000 participants aged 15 years and over, who were random and representative samples of the South Australian population. Each survey used the same methodology. Outcome measures were: major depression as detected by the Mood module of the Primary Care Evaluation of Mental Disorders instrument; mental health literacy by recognition and exposure to classical symptoms of depression; and health status using the SF-36 Physical and Mental Component summaries. Results: There was a significant increase in the prevalence of major depression from 6.8% (95%CI: 5.9% – 7.7%) to 10.3% (95%CI: 9.2% – 11.4%; X² 24.59, p < 0.001) between 1998 and 2008. Significant increases were observed in males aged 15 – 29 and females aged 30 – 49 years. There was no significant increase in any other sub-group. The strongest predictor of major depression was health status. Participants with poor/fair mental health literacy were 37% less likely to be classified with major depression. Conclusions: The prevalence of major depression increased significantly in South Australia over the last decade and there was a reduction in mental health status and an increase in persons reporting poor health. Unexpectedly...

‣ MLVA and phage typing as complementary tools in the epidemiological investigation of Salmonella enterica serovar typhimurium clusters

Ross, I.; Davos, D.; Mwanri, L.; Raupach, J.; Heuzenroeder, M.
Fonte: Springer Publicador: Springer
Tipo: Artigo de Revista Científica
Publicado em //2011 Português
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In South Australia serotyping and phage typing are employed for routine Salmonella surveillance. Molecular techniques such as Multiple-locus variable number tandem repeat analysis (MLVA) are increasingly utilized to aid outbreak investigations. During 2007 three Salmonella enterica serovar Typhimurium outbreaks involving phage types DT9, DT29, and DT44 were investigated. Human, food and environmental isolates were also typed by MLVA. In the DT9 outbreak cluster MLVA demonstrated distinct groupings that corresponded to epidemiological differences in time, place, and descriptive information on potential transmission mechanisms. In contrast, the human and food isolates of both the DT29 and DT44 clusters had identical MLVA profiles for all but one case. These data correlated with the epidemiology suggesting that these isolates were closely related and probably a single agent. These findings illustrate that phage typing and MLVA can provide different but complementary information for epidemiological investigations of Salmonella outbreaks.; Ian L. Ross, Dianne E. Davos, Lillian Mwanri, Jane Raupach and Michael W. Heuzenroeder

‣ A brief conceptual tutorial on multilevel analysis in social epidemiology: investigating contextual phenomena in different groups of people

Merlo, J.; Yang, M.; Chaix, B.; Lynch, J.; Rastam, L.
Fonte: British Med Journal Publ Group Publicador: British Med Journal Publ Group
Tipo: Artigo de Revista Científica
Publicado em //2005 Português
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Study objective: (1) To provide a didactic and conceptual (rather than mathematical) link between multilevel regression analysis (MLRA) and social epidemiological concepts. (2) To develop an epidemiological vision of MLRA focused on measures of health variation and clustering of individual health status within areas, which is useful to operationalise the notion of “contextual phenomenon”. The paper shows how to investigate (1) whether there is clustering within neighbourhoods, (2) to which extent neighbourhood level differences are explained by the individual composition of the neighbourhoods, (3) whether the contextual phenomenon differs in magnitude for different groups of people, and whether neighbourhood context modifies individual level associations, and (4) whether variations in health status are dependent on individual level characteristics. Design and participants: Simulated data are used on systolic blood pressure (SBP), age, body mass index (BMI), and antihypertensive medication (AHM) ascribed to 25 000 subjects in 39 neighbourhoods of an imaginary city. Rather than assessing neighbourhood variables, the paper concentrated on SBP variance between individuals and neighbourhoods as a function of individual BMI. Results: The variance partition coefficient (VPC) showed that clustering of SBP within neighbourhoods was greater for people with a higher BMI. The composition of the neighbourhoods with respect to age...

‣ A brief conceptual tutorial on multilevel analysis in social epidemiology: interpreting neighbourhood differences and the effect of neighbourhood characteristics on individual health

Merlo, J.; Chaix, B.; Yang, M.; Lynch, J.; Rastam, L.
Fonte: British Med Journal Publ Group Publicador: British Med Journal Publ Group
Tipo: Artigo de Revista Científica
Publicado em //2005 Português
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Study objective: Using a conceptual rather than a mathematical approach, this article proposed a link between multilevel regression analysis (MLRA) and social epidemiological concepts. It has been previously explained that the concept of clustering of individual health status within neighbourhoods is useful for operationalising contextual phenomena in social epidemiology. It has been shown that MLRA permits investigating neighbourhood disparities in health without considering any particular neighbourhood characteristic but only information on the neighbourhood to which each person belongs. This article illustrates how to analyse cross level (neighbourhood–individual) interactions, how to investigate associations between neighbourhood characteristics and individual health, and how to use the concept of clustering when interpreting those associations and geographical differences in health. Design and participants: A MLRA was performed using hypothetical data pertaining to systolic blood pressure (SBP) from 25 000 subjects living in the 39 neighbourhoods of an imaginary city. Associations between individual characteristics (age, body mass index (BMI), use of antihypertensive drug, income) or neighbourhood characteristic (neighbourhood income) and SBP were analysed. Results: About 8% of the individual differences in SBP were located at the neighbourhood level. SBP disparities and clustering of individual SBP within neighbourhoods increased along individual BMI. Neighbourhood low income was associated with increased SBP over and above the effect of individual characteristics...

‣ A brief conceptual tutorial of multilevel analysis in social epidemiology: linking the statistical concept of clustering to the idea of contextual phenomenon

Merlo, J.; Chaix, B.; Yang, M.; Lynch, J.; Rastam, L.
Fonte: British Med Journal Publ Group Publicador: British Med Journal Publ Group
Tipo: Artigo de Revista Científica
Publicado em //2005 Português
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Study objective: This didactical essay is directed to readers disposed to approach multilevel regression analysis (MLRA) in a more conceptual than mathematical way. However, it specifically develops an epidemiological vision on multilevel analysis with particular emphasis on measures of health variation (for example, intraclass correlation). Such measures have been underused in the literature as compared with more traditional measures of association (for example, regression coefficients) in the investigation of contextual determinants of health. A link is provided, which will be comprehensible to epidemiologists, between MLRA and social epidemiological concepts, particularly between the statistical idea of clustering and the concept of contextual phenomenon. Design and participants: The study uses an example based on hypothetical data on systolic blood pressure (SBP) from 25 000 people living in 39 neighbourhoods. As the focus is on the empty MLRA model, the study does not use any independent variable but focuses mainly on SBP variance between people and between neighbourhoods. Results: The intraclass correlation (ICC = 0.08) informed of an appreciable clustering of individual SBP within the neighbourhoods, showing that 8% of the total individual differences in SBP occurred at the neighbourhood level and might be attributable to contextual neighbourhood factors or to the different composition of neighbourhoods. Conclusions: The statistical idea of clustering emerges as appropriate for quantifying "contextual phenomena" that is of central relevance in social epidemiology. Both concepts convey that people from the same neighbourhood are more similar to each other than to people from different neighbourhoods with respect to the health outcome variable.; Juan Merlo...

‣ Commentary: Using innovative inequality measures in epidemiology

Harper, S.; Lynch, J.
Fonte: Oxford Univ Press Publicador: Oxford Univ Press
Tipo: Artigo de Revista Científica
Publicado em //2007 Português
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Sam Harper and John Lynch

‣ Measuring the oral health of populations

Mejia, G.
Fonte: Blackwell Munksgaard Publicador: Blackwell Munksgaard
Tipo: Artigo de Revista Científica
Publicado em //2012 Português
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OBJECTIVES This article provides a conceptual base for population oral health measurement and argues that problems associated with particular indices are subject to the basic issues of knowing what to measure and the level of measurement required to address the object of study and provide clear information about the health of the population as a whole. METHODS Alternative approaches to caries measurement are presented using data from South Australian children attending the school dental services during 2007. RESULTS While threshold selection of case definitions depicted different profiles of the same population, the inclusion of non-cavitated lesions did not alter the general disease profile of the population. CONCLUSIONS The types of measures used depend on the purpose, nature of the data, and conceptualization of the phenomenon, and should continually refer to the population level. In population oral health, controversies surrounding outcome measures, such as caries indices, are moving away from addressing core issues to narrowing mechanistic views. Fundamental deliberations should include the valuation of health states, clearly defining health and disease and distinguishing between disease, determinants and the impacts of disease.; Gloria C. Mejia

‣ Patterns of vaginal bleeding during the first 20 weeks of pregnancy and risk of pre-eclampsia in nulliparous women: results from the SCOPE study

Smits, L.; North, R.; Kenny, L.; Myers, J.; Dekker, G.; McCowan, L.
Fonte: Munksgaard Int Publ Ltd Publicador: Munksgaard Int Publ Ltd
Tipo: Artigo de Revista Científica
Publicado em //2012 Português
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Objective. To describe patterns of vaginal bleeding in the first 20 weeks of pregnancy and evaluate the association between patterns of bleeding and risk of subsequent pre-eclampsia in nulliparous women. Design. Cohort study. Setting. Participating centres of the Screening for Pregnancy Endpoints (SCOPE) study in Auckland (New Zealand), Adelaide (Australia), Manchester and London (UK) and Cork (Ireland). Population. Healthy nulliparous women (n= 3431). Methods. Logistic regression was used to assess the association between bleeding characteristics and pre-eclampsia while controlling for known determinants of pre-eclampsia. Main outcome measures. Preeclampsia, defined as gestational hypertension with proteinuria or any multi-system complication of preeclampsia. Four bleeding variables were evaluated: any bleeding during the first 20 weeks; maximal bleeding intensity; duration of bleeding; and number of bleeding episodes. Results. Of the 3431 women enrolled, 780 (23%) experienced vaginal bleeding during the first 20 weeks of pregnancy. Risk of pre-eclampsia was not associated with the presence or absence of bleeding (adjusted odds ratio (ORa) 0.96, 95% confidence interval (95% CI) 0.67–1.38). Analyses confined to women with vaginal bleeding showed that any bleeding episode of five or more consecutive days...

‣ Weighting of the data and analytical approaches may account for differences in overcoming the inadequate representativeness of the respondents to the third wave of a cohort study

Taylor, A.; DalGrande, E.; Grant, J.; Appleton, S.; Gill, T.; Shi, Z.; Adams, R.
Fonte: Pergamon-Elsevier Science Ltd Publicador: Pergamon-Elsevier Science Ltd
Tipo: Artigo de Revista Científica
Publicado em //2013 Português
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OBJECTIVES: Attrition in cohort studies can cause the data to be nonreflective of the original population. Although of little concern if intragroup comparisons are being made or cause and effect assessed, the assessment of bias was undertaken in this study so that intergroup or descriptive analyses could be undertaken. STUDY DESIGN AND SETTING: The North West Adelaide Health Study is a chronic disease and risk factor cohort study undertaken in Adelaide, South Australia. In the original wave (1999), clinical and self-report data were collected from 4,056 adults. In the third wave (2008-2010), 2,710 adults were still actively involved. Comparisons were made against two other data sources: Australian Bureau of Statistics Estimated Residential Population and a regular conducted chronic disease and risk factor surveillance system. RESULTS: Comparisons of demographics (age, sex, area, education, work status, and income) proved to be statistically significantly different. In addition, smoking status, body mass index, and general health status were statistically significant from the comparison group. No statistically significant differences were found for alcohol risk. CONCLUSION: Although the third wave of this cohort study is not representative of the broader population on the variables assessed...

‣ Interlaboratory variability of caspofungin MICs for Candida spp. using CLSI and EUCAST methods: Should the clinical laboratory be testing this agent?

Espinel-Ingroff, A.; Arendrup, M.; Pfaller, M.; Bonfietti, L.; Bustamante, B.; Canton, E.; Chryssanthou, E.; Cuenca-Estrella, M.; Dannaoui, E.; Fothergill, A.; Fuller, J.; Gaustad, P.; Gonzalez, G.; Guarro, J.; Lass-Florl, C.; Lockhart, S.; Meis, J.; Moor
Fonte: Amer Soc Microbiology Publicador: Amer Soc Microbiology
Tipo: Artigo de Revista Científica
Publicado em //2013 Português
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Although Clinical and Laboratory Standards Institute (CLSI) clinical breakpoints (CBPs) are available for interpreting echinocandin MICs for Candida spp., epidemiologic cutoff values (ECVs) based on collective MIC data from multiple laboratories have not been defined. While collating CLSI caspofungin MICs for 145 to 11,550 Candida isolates from 17 laboratories (Brazil, Canada, Europe, Mexico, Peru, and the United States), we observed an extraordinary amount of modal variability (wide ranges) among laboratories as well as truncated and bimodal MIC distributions. The species-specific modes across different laboratories ranged from 0.016 to 0.5 μg/ml for C. albicans and C. tropicalis, 0.031 to 0.5 μg/ml for C. glabrata, and 0.063 to 1 μg/ml for C. krusei. Variability was also similar among MIC distributions for C. dubliniensis and C. lusitaniae. The exceptions were C. parapsilosis and C. guilliermondii MIC distributions, where most modes were within one 2-fold dilution of each other. These findings were consistent with available data from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) (403 to 2,556 MICs) for C. albicans, C. glabrata, C. krusei, and C. tropicalis. Although many factors (caspofungin powder source...

‣ Incidence and prevalence of idiopathic inflammatory myopathies in South Australia: a 30-year epidemiologic study of histology-proven cases

Tan, J.; Roberts-Thomson, P.; Blumbergs, P.; Hakendorf, P.; Cox, S.; Limaye, V.
Fonte: Wiley-Blackwell Publishing Asia Publicador: Wiley-Blackwell Publishing Asia
Tipo: Artigo de Revista Científica
Publicado em //2013 Português
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Aim:  To describe the epidemiology of biopsy-proven idiopathic inflammatory myopathies (IIM) in South Australia (SA). Methods:  Cases of IIM were ascertained by review of all muscle biopsy reports from the Neuropathology Laboratory, Hanson Institute (wherein all adult muscle biopsies in SA are reported) from 1980 to 2009. Clinical correlation of these patients by review of medical records was undertaken. SA population denominator numbers were obtained from the Australian Bureau of Statistics. Results:  Three hundred and fifty-two biopsy-proven cases of IIM were identified between 1980 and 2009. The overall annual incidence of IIM appeared to be rising with a mean incidence of eight cases per million population (95% CI: 7.2–8.9). This corresponded with an increasing annual incidence of inclusion body myositis (IBM) (prevalence of 50.5 cases per million population in 2009, 95% CI: 40.2–62.7). A female preponderance was noted in both dermatomyositis (DM) (F : M = 2.75 : 1.00) and polymyositis (PM) (F : M = 1.55 : 1.00) but gender distribution was almost equal in IBM (F : M = 1.1 : 1.0). Mean age at diagnosis for IBM (67.5 years) was higher than for DM (55.1 years) and PM (59.0 years). A higher proportion of DM patients reported living in urban dwellings and DM patients tended to be predominantly professionals. Conclusions:  In SA there is an increasing incidence of IBM and the prevalence is one of the highest reported to date. This may reflect an increase in the number of biopsies performed...

‣ Revisión clínico-epidemiológica del carcinoma de nasofaringe en Cantabria; Clinical and epidemiologic review of nasopharyngeal carcinoma in Cantabria

Río González, Gloria María del
Fonte: Universidade de Cantabria Publicador: Universidade de Cantabria
Tipo: Trabalho de Conclusão de Curso
Português
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Objetivo: Analizar las características clínico-epidemiológicas de los carcinomas de nasofaringe en Cantabria y compararlas con estudios previos realizados. Material y métodos: Se realizó un análisis retrospectivo de los casos tratados en el Hospital Universitario Marqués de Valdecilla, entre los años 2004 y 2015, a partir de un protocolo que examinaba datos, tales como edad de diagnóstico, profesión, hábitos tóxicos, forma de aparición, diagnóstico, tratamiento y evolución. Resultados: Cuarenta y cinco pacientes con edades comprendidas entre los 35 y los 85 años fueron diagnosticados de carcinoma de nasofaringe en el citado periodo, siendo la incidencia de 0,71/100.000/año. Treinta y ocho eran varones (84,5%) y siete eran mujeres (15,6%), siendo la edad más frecuente de aparición la década de los 50 (28,9%). Los síntomas más frecuentes de inicio fueron los óticos (40%), seguido de las adenopatías cervicales (26,6%). Un paciente consultó por un síndrome paraneoplásico con anticuerpos anti- Yo. En cuanto al tipo histológico predomina el carcinoma indiferenciado (68,9%). Los pacientes fueron diagnosticados en un alto porcentaje en estadío avanzado. Conclusiones El carcinoma de nasofaringe es un tumor infrecuente en Cantabria. Su forma de presentación...

‣ Injuries caused by aquatic animals in Brazil: an analysis of the data present in the information system for notifiable diseases

Reckziegel,Guilherme Carneiro; Dourado,Flávio Santos; Garrone Neto,Domingos; Haddad Junior,Vidal
Fonte: Sociedade Brasileira de Medicina Tropical - SBMT Publicador: Sociedade Brasileira de Medicina Tropical - SBMT
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2015 Português
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AbstractINTRODUCTION:We present a review of injuries in humans caused by aquatic animals in Brazil using the Information System for Notifiable Diseases [ Sistema de Informação de Agravos de Notificação (SINAN)] database.METHODS:A descriptive and retrospective epidemiological study was conducted from 2007 to 2013.RESULTS:A total of 4,118 accidents were recorded. Of these accidents, 88.7% (3,651) were caused by venomous species, and 11.3% (467) were caused by poisonous, traumatic or unidentified aquatic animals. Most of the events were injuries by stingrays (69%) and jellyfish (13.1%). The North region was responsible for the majority of reports (66.2%), with a significant emphasis on accidents caused by freshwater stingrays (92.2% or 2,317 cases). In the South region, the region with the second highest number of records (15.7%), jellyfish caused the majority of accidents (83.7% or 452 cases). The Northeastern region, with 12.5% of the records, was notable because almost all accidents were caused by toadfish (95.6% or 174 cases).CONCLUSIONS:Although a comparison of different databases has not been performed, the data presented in this study, compared to local and regional surveys, raises the hypothesis of underreporting of accidents. As the SINAN is the official system for the notification of accidents by venomous animals in Brazil...

‣ Determinants of non adherence to tuberculosis treatment in Argentina: barriers related to access to treatment

Herrero,María Belén; Ramos,Silvina; Arrossi,Silvina
Fonte: Associação Brasileira de Saúde Coletiva Publicador: Associação Brasileira de Saúde Coletiva
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2015 Português
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OBJECTIVE: To identify the association between non-adherence to tuberculosis treatment and access to treatment. METHODS: A cross-sectional study was carried out in the Metropolitan Area of Buenos Aires, Argentina. One hundred twenty three patients notified in 2007 (38 non adherent and 85 adherents) were interviewed regarding the health care process and socio-demographic characteristics. Factors associated to non-adherence were assessed through logistic regression analysis. RESULTS: An increased risk of non-adherence with to treatment was found in male patients (OR = 2.8; 95%CI 1.2 - 6.7), patients who had medical check-ups at hospitals (OR = 3.4; 95%CI 1.1 - 10.0) and those who had difficulties with transportation costs (OR = 2.5; 95%CI 1.1 - 5.9). CONCLUSION: Risk of non-adherence increases as a result of economic barriers in accessing health care facilities. Decentralization of treatment to primary health care centers and social protection measures for patients should be considered as priorities for disease control strategies in order to lessen the impact of those barriers on adherence to treatment.

‣ Hormone replacement therapy and breast cancer: What are the facts?

MacLennan, A.; Smith, M.
Fonte: Australasian Medical Publishing Co. Publicador: Australasian Medical Publishing Co.
Tipo: Artigo de Revista Científica
Publicado em //1995 Português
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Selective quotation in the popular press of studies showing a potential association between hormone replacement therapy (HRT) and breast cancer has fuelled women's concern. However, the increase in detected breast cancer among long term HRT users that was seen in some studies is compatible with surveillance bias and confounding caused by increased risk factors among HRT users (e.g., higher socioeconomic class, alcohol intake and body mass index). Until adequate data are available from randomised controlled trials, the evidence-based conclusion is that HRT has no effect on breast cancer rates. HRT may reduce mortality and morbidity from other diseases and the overall risk-benefit ratio should be considered for each woman.

‣ Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource

Mann, G.; Thorne, H.; Balleine, R.; Butow, P.; Clarke, C.; Edkins, E.; Evans, G.; Fereday, S.; Haan, E.; Gattas, M.; Giles, G.; Goldblatt, J.; Hopper, J.; Kirk, J.; Leary, J.; Lindeman, G.; Niedermayr, E.; Phillips, K.A.; Picken, S.; Pupo, G.; et al.
Fonte: Biomed Central Ltd Publicador: Biomed Central Ltd
Tipo: Artigo de Revista Científica
Publicado em //2006 Português
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INTRODUCTION: The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) is a multidisciplinary, collaborative framework for the investigation of familial breast cancer. Based in Australia, the primary aim of kConFab is to facilitate high-quality research by amassing a large and comprehensive resource of epidemiological and clinical data with biospecimens from individuals at high risk of breast and/or ovarian cancer, and from their close relatives. METHODS: Epidemiological, family history and lifestyle data, as well as biospecimens, are collected from multiple-case breast cancer families ascertained through family cancer clinics in Australia and New Zealand. We used the Tyrer-Cuzick algorithms to assess the prospective risk of breast cancer in women in the kConFab cohort who were unaffected with breast cancer at the time of enrolment in the study. RESULTS: Of kConFab's first 822 families, 518 families had multiple cases of female breast cancer alone, 239 had cases of female breast and ovarian cancer, 37 had cases of female and male breast cancer, and 14 had both ovarian cancer as well as male and female breast cancer. Data are currently held for 11,422 people and germline DNAs for 7,389. Among the 812 families with at least one germline sample collected...

‣ Cohort Profile: The Health In Men Study (HIMS)

Norman, P.; Flicker, L.; Almeida, O.; Hankey, G.; Hyde, Z.; Jamrozik, K.
Fonte: Oxford Univ Press Publicador: Oxford Univ Press
Tipo: Artigo de Revista Científica
Publicado em //2009 Português
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Paul E Norman, Leon Flicker, Osvaldo P Almeida, Graeme J Hankey, Zoë Hyde and Konrad Jamrozik; First published online: March 3, 2008

‣ Statistiques appliquées en chirurgie cardiaque adulte : analyses de survie et applications du “propensity score”

Stevens, Louis-Mathieu
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
Português
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L'objectif principal de ce travail est d’étudier en profondeur certaines techniques biostatistiques avancées en recherche évaluative en chirurgie cardiaque adulte. Les études ont été conçues pour intégrer les concepts d'analyse de survie, analyse de régression avec “propensity score”, et analyse de coûts. Le premier manuscrit évalue la survie après la réparation chirurgicale de la dissection aigüe de l’aorte ascendante. Les analyses statistiques utilisées comprennent : analyses de survie avec régression paramétrique des phases de risque et d'autres méthodes paramétriques (exponentielle, Weibull), semi-paramétriques (Cox) ou non-paramétriques (Kaplan-Meier) ; survie comparée à une cohorte appariée pour l’âge, le sexe et la race utilisant des tables de statistiques de survie gouvernementales ; modèles de régression avec “bootstrapping” et “multinomial logit model”. L'étude a démontrée que la survie s'est améliorée sur 25 ans en lien avec des changements dans les techniques chirurgicales et d’imagerie diagnostique. Le second manuscrit est axé sur les résultats des pontages coronariens isolés chez des patients ayant des antécédents d'intervention coronarienne percutanée. Les analyses statistiques utilisées comprennent : modèles de régression avec “propensity score” ; algorithme complexe d'appariement (1:3) ; analyses statistiques appropriées pour les groupes appariés (différences standardisées...