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‣ Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium

Chuang, Shu-Chun; Jenab, Mazda; Heck, Julia E.; Bosetti, Cristina; Talamini, Renato; Matsuo, Keitaro; Castellsague, Xavier; Franceschi, Silvia; Herrero, Rolando; Winn, Deborah M.; La Vecchia, Carlo; Morgenstern, Hal; Zhang, Zuo-Feng; Levi, Fabio; Dal Maso
Fonte: SPRINGER; DORDRECHT Publicador: SPRINGER; DORDRECHT
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
35.918784%
We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43-0.62, p (trend) < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49-0.90, p (trend) = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p (trend) = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p (trend) < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97).; International Agency for Research on Cancer; International Agency for Research on Cancer; US National Institutes of Health (NIH)...

‣ Cancer de mama, menopausa e qualidade de vida

Delio Marques Conde
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 23/03/2005 Português
Relevância na Pesquisa
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Objetivos - Comparar a prevalência de sintomas climatéricos, a proporção de mulheres com atividade sexual e a qualidade de vida (QV) em mulheres com e sem câncer de mama e identificar os fatores associados à QV em mulheres com câncer de mama. Sujeitos e Métodos: Realizou-se um estudo de corte transversal em mulheres com idade entre 45 e 65 anos, não usuárias de terapia hormonal ou tamoxifeno nos últimos seis meses. As participantes foram selecionadas nos Ambulatórios de Oncologia Mamária e de Menopausa do Centro de Atenção Integral à Saúde da Mulher da Universidade Estadual de Campinas. Foram incluídas 97 mulheres com câncer de mama e 85 sem câncer de mama. As características sociodemográficas, clínicas e a prevalência de sintomas climatéricos foram descritas em cada grupo. A QV foi avaliada através do questionário Medical Outcomes Study 36-item Short-Form Health Survey (SF-36). Para comparar as características sociodemográficas e clínicas entre os grupos foram utilizados os testes t de Student e exato de Fisher. Modelos de regressão logística múltipla e de regressão linear foram aplicados com controle de potenciais variáveis confundidoras. A seguir, o modelo generalizado linear permitiu identificar os possíveis fatores associados à QV de mulheres com câncer de mama. Resultados: A média de idade das mulheres com câncer de mama foi de 53...

‣ Fatores de risco e de proteção para câncer de mama: revisão sistemática e estudo caso-controle; Risk and protective factors for breast cancer:systematic review and case-control study

INUMARU, Lívia Emi
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Nutricao e Saude; Ciencias da Saude Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Nutricao e Saude; Ciencias da Saude
Tipo: Dissertação Formato: application/pdf
Português
Relevância na Pesquisa
35.913232%
Breast cancer is an important health concern, being the neoplasm that most affects women. The aims of this study were to elaborate a systematic review on risk and protective factors for breast cancer, and to investigate these factors in women who received health care in two public hospitals of Goiânia, Goiás. In the systematic review, we surveyed the following variables: breastfeeding, physical activity, body composition and alcoholic drink consumption. In the first half of 2010, we performed a review on cohort and case-control studies corresponding to the years 2007 to 2010, through PubMed, Lilacs and Scielo databases. The analytical study was a case-control of outpatient basis. Cases were interviewed at Araújo Jorge Hospital (public hospital of Goiânia specialized in cancer) and at the breast service of Clinical Hospital from Federal University of Goiás (HC/UFG), and controls were selected among users of the Gynecology and Obstetrics Clinic at the HC/UFG. Investigated variables included: socioeconomic data, family history of cancer, hormonal variables, breastfeeding, anthropometric measures, alcoholic drink consumption, physical activity and smoking habit. Data were analyzed through Statistical Software for Professional, version 8.0. According to the systematic review...

‣ Análise epidemiológica dos cânceres de pulmão e da laringe em 30 anos; Epidemiological analysis of lung and larynx cancer in 30 years

Martins, Edesio
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Ciências da Saúde (FM); Faculdade de Medicina - FM (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Ciências da Saúde (FM); Faculdade de Medicina - FM (RG)
Tipo: Tese de Doutorado Formato: application/pdf
Português
Relevância na Pesquisa
35.916245%
Introduction: Studies have shown a relationship between smoking and various cancers, especially in the respiratory tract, causing major impact on public health. Lung cancer is the leading cause of cancer death in the world, accounting for 20 %, while Laryngeal cancer represents 3 %. Objective: To analyze trends in incidence and mortality from lung and larynx cancer in Goiania in 20 years and to assess trends in mortality for these cancers, over the past 30 years for the Brazilian regions. Methods: All incident cases of lung cancer and larynx were obtained from the database registered in Goiania RCBP/ACCG and deaths were extracted from the Mortality Information System (SIM/MS) for both, Goiania as for other Brazilian regions. Incidence rates and standardized mortality rates were calculated using the world standard population and calculating the trend used the Poisson regression model using Joinpoint Regression Program, Version 4.0.4. Graphs and tables were made using the Excel 2013 software. Results: Two points were analyzed: the first showed that the trend of incidence for lung and larynx cancers in both sexes and age groups in Goiania, were in contrast to trend mortality for lung cancer in women over 50 increased by 2.5% per year...

‣ A comunicação de uma má notícia: o diagnóstico de câncer de mama na perspectiva de pacientes e familiares; The comunication of a bad news: cancer’s diagnosis in a patient and family’s perspective

Oliveira, Luísa Todeschini Pereira
Fonte: Universidade Federal de Uberlândia Publicador: Universidade Federal de Uberlândia
Tipo: Dissertação
Português
Relevância na Pesquisa
35.918784%
Diante do aumento mundial dos casos de câncer de mama e da importância do momento da informação desse aos pacientes e seus familiares, o presente estudo teve como principal objetivo analisar o conteúdo das descrições dos relatos de pacientes e familiares dessas, sobre suas experiências durante a recepção e transmissão do diagnóstico de câncer de mama. Os objetivos específicos foram: descrever como pacientes e familiares nomearam a doença ao receber e transmitir o diagnóstico, identificar para quais membros da família as pacientes tiveram maior dificuldade para transmitir o diagnóstico e investigar se pacientes e familiares compartilharam entre si sentimentos relacionados à doença. Participaram da pesquisa doze mulheres com câncer de mama, e seus familiares respectivamente, compondo assim, dois grupos. A coleta de dados ocorreu por entrevistas individuais, semi-estruturadas com dois roteiros sendo um para cada grupo. Foi utilizada a técnica de análise de conteúdo temática para analisar os dados. Do resultado das entrevistas das pacientes, emergiram cinco grupos temáticos e catorze temas: 1) O início da doença: O encontro de alterações na mama e Em busca do diagnóstico. 2) Recepção do diagnóstico de câncer de mama: Descrição do momento...

‣ Variações transcricionais dos genes AR, SRD5A2, KLK2, PCA3, KLK3 e PSMA e implicações no diagnóstico molecular do câncer de próstata

Neves, Adriana Freitas
Fonte: Universidade Federal de Uberlândia Publicador: Universidade Federal de Uberlândia
Tipo: Tese de Doutorado
Português
Relevância na Pesquisa
35.913232%
CAPÍTULO I - O câncer de próstata é uma doença comum no mundo e já assumiu em alguns países uma das principais causas de mortalidade da população masculina. Vários marcadores moleculares têm sido associados à gênese do câncer de próstata. A fim de demonstrar a expressão diferencial dos níveis transcricionais dos genes AR, SRD5A2, KLK2, PSMA e PCA3 em doenças prostáticas, o RNAm foi analisado em tecidos com adenocarcinoma prostático (CaP, N= 48) e hiperplasia prostática benigna (HPB, N= 25) por meio da técnica RT-PCR multiplex semi-quantitativa. Foram observadas diferenças significativas na expressão relativa desses genes entre os tecidos cancerosos e nãocancerosos. A taxa de densidade ótica entre os amplicons para cDNA provenientes do gene AR foi 1.6 vezes maior no adenocarcinoma prostático. Por outro lado, os níveis de RNAm do gene SRD5A2 foi associado com a HPB e foi 1.4 vezes maior do que no CaP. Para os genes KLK2, PSMA e PCA3, os níveis transcricionais foram respectivamente, 1.9, 1.9 e 5 vezes maior no câncer comparado a tecidos benignos. Dos testes diagnósticos realizados, o gene PCA3 individualmente foi o que apresentou as melhores sensibilidade e acurácia, sendo que a inclusão das medidas de PSA sérico melhorou a sensibilidade (de 76 para 92%)...

‣ Immuno-oncology of human prostate cancer : phenotypical characterization and study of the tumor-derived, androgen-regulated immunosuppressive microenvironment

Gannon, Philippe
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
Português
Relevância na Pesquisa
35.9234%
Le cancer de la prostate est le cancer le plus fréquemment diagnostiqué chez les hommes canadiens et la troisième cause de décès relié au cancer. Lorsque diagnostiqué à un stade précoce de la maladie, le cancer de la prostate est traité de manière curative par chirurgie et radiothérapie. Par contre, les thérapies actuelles ne peuvent éradiquer la maladie lorsqu’elle progresse à des stades avancés. Ces thérapies, comme la chimiothérapie et l’hormonothérapie, demeurent donc palliatives. Il est primordial d’optimiser de nouvelles thérapies visant l’élimination des cellules cancéreuses chez les patients atteints des stades avancés de la maladie. Une de ces nouvelles options thérapeutiques est l’immunothérapie. L’immunothérapie du cancer a fait des progrès considérables durant les dernières années. Cependant, les avancements encourageants obtenus lors d’essais précliniques ne se sont pas encore traduits en des résultats cliniques significatifs. En ce qui concerne le cancer de la prostate, les résultats négligeables suivants des interventions immunothérapeutiques peuvent être causés par le fait que la plupart des études sur le microenvironnement immunologique furent effectuées chez des modèles animaux. De plus la majorité des études sur l’immunologie tumorale humaine furent effectuées chez des patients atteints d’autres cancers...

‣ Étude cas témoin de la nutrition, du style de vie et du cancer du sein chez les femmes Canadiennes Françaises porteuses d’une mutation fondatrice sur un des gènes BRCA 1 ou BRCA 2

Houssaini, Najlaa
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
Português
Relevância na Pesquisa
35.918784%
Le cancer du sein est une maladie multifactorielle, plusieurs facteurs socio-économiques, alimentaires ainsi que le style de vie ayant été incriminés dans son développement. Une mutation germinale sur un des gènes BRCA1 ou BRCA2 serait responsable d’une augmentation du risque de développer un cancer du sein de 50 à 80% chez les femmes porteuses d’une mutation sur BRCA1 ou BRCA2 par comparaison aux non- porteuses. Plusieurs études rapportant l’existence d’une association entre la fréquence des cancers du sein sporadiques, les habitudes alimentaires et le style de vie des femmes atteintes, ceci, nous a amené à nous interroger sur le rôle que pourrait jouer ces mêmes facteurs chez les femmes porteuses d’une mutation sur BRCA1 ou BRCA2. Pour répondre à cette question, nous avons effectué une étude cas-témoin. Nos quarante-quatre cas sont porteuses d’une mutation germinale parmi 6 des 14 mutations fondatrices sur BRCA1 et BRCA2 les plus fréquentes dans la population Canadienne Française. Elles sont issues d’une cohorte de plus de 1000 femmes Canadiennes Françaises atteintes de cancers du sein recrutées depuis 1994 et testées pour ces 6 mutations. Les témoins sont recrutés parmi des femmes de la population Canadienne Française...

‣ Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update analyses

The ATAC (Arimidex, T.; Gill, P.
Fonte: American Cancer Society Publicador: American Cancer Society
Tipo: Artigo de Revista Científica
Publicado em //2003 Português
Relevância na Pesquisa
45.72968%
Copyright © 2003 American Cancer Society

‣ Predictors of re-participation in faecal occult blood test-based screening for colorectal cancer

Cole, S.; Gregory, T.; Whibley, A.; Ward, P.; Turnbull, D.; Wilson, C.; Flight, I.; Esterman, A.; Young, G.
Fonte: Asian Pacific Organization for Cancer Prevention Publicador: Asian Pacific Organization for Cancer Prevention
Tipo: Artigo de Revista Científica
Publicado em //2012 Português
Relevância na Pesquisa
45.72968%
Background: There is little information on longitudinal patterns of participation in faecal occult blood test (FOBT) based colorectal cancer (CRC) screening or on demographic or behavioural factors associated with participation in re-screening. The lack of an agreed system for describing participatory behaviour over multiple rounds also hampers our ability to report, understand and make use of observed associations. Our aims were to develop a system for describing patterns of participatory behaviour in FOBT-based CRC screening programs and to identify factors associated with particular behavioural patterns. Methods: A descriptive framework was developed and applied to a data extract of screening invitation outcomes over two rounds of the NBCSP. The proportion of invitees in each behaviour category was determined and associations between behaviour patterns and demographic and program factors were identified using multivariate analyses. Results: We considered Re-Participants, Dropouts, Late Entrants and Never Participants to be the most appropriate labels for the four possible observed participatory categories after two invitation rounds. The screening participation rate of the South Australian cohort of the NBCSP remained stable over two rounds at 51%...

‣ Androgen signalling in the prostate cancer microenvironment.

Leach, Damien Alexander
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2014 Português
Relevância na Pesquisa
35.9153%
Prostate cancer remains the second leading cause of cancer related death in Australian males, with approximately 28000 Australian men being diagnosed in 2007 and more than 3000 deaths as a result of this disease. The probability of patient survival from prostate cancer is greatly diminished when the disease has spread outside of the confines of the prostate. Disease spread, or the potential for spread, also determines the therapy received by the patient, be it surgical removal, chemotherapy, radiotherapy, or hormonal therapy, or any of these in combination. The advent of serum PSA testing has allowed for both earlier and increased detection of prostate cancer over the past 20 years. Despite this, the mortality rate for prostate cancer has remained relatively constant. Moreover, it is thought that increased detection may lead to over diagnosis and over treatment of indolent disease in up to 50% of cases, burdening patients who would not actually die from prostate cancer. Central to this issue is that there is no accurate means of predicting, at the time of diagnosis, the likelihood of prostate cancer becoming aggressive and metastasising, and thus identifying the patient population that would benefit most from more aggressive treatment. The prostate is a glandular structure composed of secretory epithelial cells embedded in a stroma containing smooth muscle cells...

‣ Relacionamento entre câncer colorretal e indicadores socioeconômicos no município de São Paulo: uso de modelos de regressão espacial; Relationship between colorectal cancer and socioeconomic indicators in São Paulo: use of spatial regression models.

Medeiros, Márcio José de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 22/05/2015 Português
Relevância na Pesquisa
35.920957%
Introdução: O câncer de localização colorretal é o terceiro tipo de câncer mais comumente diagnosticado no mundo. As taxas de incidências do câncer colorretal não são homogêneas, apresentando diferenças entre os países. Não há estudos brasileiros que investiguem a variação geográfica da incidência de câncer colorretal conjuntamente com indicadores socioeconômicos. Esta avaliação pode revelar diferenças locais importantes na ocorrência da doença. Objetivos: Descrever as taxas de incidência e de mortalidade do câncer colorretal no Município de São Paulo, segundo sexo e faixa etária, no período de 1997 a 2009 e realizar análise da distribuição espacial segundo distrito dos casos de câncer colorretal diagnosticados em residentes no Município de São Paulo entre 1997 e 2009. Material e Métodos: Foram analisados os novos casos de câncer colorretal diagnosticados em residentes no Município de São Paulo de 1997 a 2009. Estes dados foram fornecidos pelo Registro de Câncer de Base Populacional de São Paulo (RCBP-SP). A análise dos dados foi realizada em duas etapas: na primeira, com cárater exploratório/descritivo, os dados analíticos foram utilizados para descrever a incidência e mortalidade por câncer colorretal no período pesquisado. Na segunda etapa...

‣ Molecular alterations associated with liver metastases development in colorectal cancer patients

Bruin, S.; He, Y.; Mikolajewska-Hanclich, I.; Liefers, G.; Klijn, C.; Vincent, A.; Verwaal, V.; de Groot, K.; Morreau, H.; van Velthuysen, M.L.; Tollenaar, R.; van't Veer, L.
Fonte: Cancer Research UK Publicador: Cancer Research UK
Tipo: Artigo de Revista Científica
Publicado em //2011 Português
Relevância na Pesquisa
45.72968%
Background: Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predict liver metastases. Methods: Formalin-fixed paraffin-embedded material from primary colorectal tumours of three different groups were investigated: patients with CRC without metastases (M0, n=39), patients who were treated with hyperthermal intraperitoneal chemotherapy for CRC metastases confined to the peritoneum (PM, n=46) and those who had isolated hepatic perfusion for CRC metastases confined to the liver (LM, n=48). Results: All samples were analysed for DNA copy number changes, PIK3CA, KRAS, BRAF mutations, CIMP and microsatellite instability. The primary CRCs of the LM group had significantly higher frequency of amplified chromosome 20q (P=0.003), significantly fewer mutations in the PI(3)K signalling pathway (P=0.003) and fewer CIMP high tumours (P=0.05). There was a strong inverse correlation between 20q and the PI(3)K pathway mutations. Conclusion: The development of CRC liver metastases is associated with amplification of chromosome 20q and not driven by mutations in the PI(3)K signalling pathway.; S C Bruin...

‣ Influence of mammographic screening on breast cancer incidence trends in South Australia

Beckmann, K.R.; Roder, D.M.; Hiller, J.E.; Farshid, G.; Lynch, J.W.
Fonte: National Cancer Center, Korea Publicador: National Cancer Center, Korea
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
Relevância na Pesquisa
45.72968%
PURPOSE: To examine breast cancer (BC) incidence trends in relation to mammographic screening and risk factor prevalence in South Australia (SA). MATERIALS AND METHODS: Trends in annual BC incidence rates were calculated using direct standardisation and compared with projected incidence derived from Poisson regression analysis of pre-screening rates. Annual percentage change and change time points were estimated using Joinpoint software. Biennial mammography screening participation rates were calculated using data from BreastScreen SA. Trends in overweight/obesity, alcohol use and hormone replacement therapy (HRT) use were examined using 1991-2009 Health Omnibus Survey data. Trends in total fertility were examined using data from the Australian Bureau of Statistics. RESULTS: BC incidence increased around the time BreastScreen commenced and then stabilised in the mid-1990s. However rates have remained higher than projected, even though the proportion and age distribution of first time screening attendees stabilised around 1998. A decrease in BC incidence was observed among women aged 50-59yrs from the late-1990's but not among older women. Obesity and alcohol use have increased steadily in all age groups, while HRT use declined sharply from the late-1990s. CONCLUSIONS: BC incidence has remained higher than projected since mammography screening began. The sustained elevation is likely to be due to lead time effects...

‣ Evaluating DNA damage response (DDR) activation in human prostate cancer

Delouya, Guila
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
Português
Relevância na Pesquisa
35.916245%
Introduction: Au Canada, le cancer de la prostate est le cancer le plus fréquemment diagnostiqué chez les hommes et le plus mortel après les cancers du poumon et du côlon. Il y a place à optimiser le traitement du cancer de la prostate de manière à mettre en œuvre une médecine personnalisée qui s’adapte aux caractéristiques de la maladie de chaque patient de façon individuelle. Dans ce mémoire, nous avons évalué la réponse aux dommages de l’ADN (RDA) comme biomarqueur potentiel du cancer de la prostate. Les lésions potentiellement oncogènes de l'ADN déclenche une cascade de signalisation favorisant la réparation de l'ADN et l’activation des points de contrôle du cycle cellulaire pour préserver l’intégrité du génome. La RDA est un mécanisme central de suppression tumorale chez l’homme. La RDA joue un rôle important dans l’arrêt de la prolifération des cellules dont les génomes sont compromis, et donc, prévient la progression du cancer en agissant comme une barrière. Cette réponse cellulaire détermine également comment les cellules normales et cancéreuses réagissent aux agents utilisés pour endommager l'ADN lors du traitement du cancer comme la radiothérapie ou la chimiothérapie, en plus la présence d...

‣ Caractérisation de DKK1 comme antigène tumoral et manipulation des lymphocytes T CD8 : utilisation de la voie de Wnt en immunothérapie du cancer

Forget, Marie-Andrée
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
Português
Relevância na Pesquisa
35.913232%
L’immunothérapie tumorale à médiation cellulaire est un traitement qui utilise le système immunitaire des patients afin d’induire une réponse des lymphocytes T CD8+ (T CD8+) contre la tumeur. Cette réponse est produite suite à la reconnaissance des antigènes par les T CD8+. Ces cibles sont appelées antigènes tumoraux (TAA) et définies comme des protéines exprimées par les cellules cancéreuses mais absentes des tissus normaux. Par une approche bio-informatique, notre laboratoire a identifié Dickkopf-1 (DKK1), une protéine inhibitrice de la voie de Wnt, comme un TAA potentiel. Une immunothérapie à médiation cellulaire efficace requiert l’identification de TAA candidats pertinents. Le traitement de patients par immunothérapie pourrait également être améliorées par l’augmentation de la puissance d’action anti-tumorale ainsi que la persistante des T CD8+ spécifiques aux TAA. Ce projet de doctorat se divise en deux parties : 1- La caractérisation de l’expression de DKK1 dans les cancers communs et la détermination de son immunogénicité afin de valider sa candidature comme TAA. 2- La reprogrammation des T CD8+, de patients atteints d’un cancer commun, vers un phénotype moins différentié afin d’augmenter leur potentiel anti-tumoral et leur persistance. Dans le premier objectif...

‣ Câncer de esôfago no centro-oeste do Brasil: incidência, mortalidade e tendências; Esophageal cancer in central-western Brazil: incidence, mortality and trens

SILVA, Diego Rodrigues Mendonça e
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
Português
Relevância na Pesquisa
35.914297%
Introduction: Esophageal cancer is a malignancy of high mortality worldwide. Studies on Population-based of this neoplasm in Brazil are scarce. In the central-western of Brazil there are population-based cancer registries to monitor the impact of cancer. However there are no studies describing the profile of this tumor in the central-western of Brasil. Another reason for this study is the large-scale of internal migration happened in the 70's from Porto Alegre to the central-western. Such migration may have influenced the incidence and mortality rates of esophageal cancer in the region. Objective: To evaluate the performance of the Population-Based Cancer Registry of Goiânia (PBCR of Goiânia) in the collecting of basic variables and recommended variable (clinical staging) of incident cases of esophageal cancer. To describe the epidemiological profile of the incidence, mortality and trends esophageal cancer in central-western Brazil. Methods: From the PBCR of Goiânia it was analyzed the completeness of variables related to the patient, tumor and clinical staging of esophageal cancer cases for incidence analysis the period were: Cuiabá (2000-2005), Brasília (1999-2002) and Goiânia (1995-2008). Mortality data were obtained from DATASUS (2010) for the period 1980-2008 for all capitals of central western region. For statistical analysis we used version 15.0 of SPSS for Windows ®...

‣ Qualidade de vida relacionada à saúde e fadiga de pessoas com câncer de pulmão em cuidados paliativos; Quality of life related to realth and fatigue of people with lung cancer in palliative care

Cardoso, Renata Carvalho
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 06/07/2015 Português
Relevância na Pesquisa
35.913232%
O câncer de pulmão é uma doença maligna que acomete principalmente a população de adultos e idosos na faixa etária dos 40 aos 80 anos. Sua principal causa continua sendo o tabagismo, e sua sobrevida varia com o estadiamento da doença no momento do diagnóstico e sua alta taxa de mortalidade está associada ao diagnóstico tardio da doença, o que limita as opções de tratamento curativo. A Qualidade de Vida Relacionada à Saúde (QVRS) de sujeitos com câncer de pulmão é influenciada por múltiplos fatores, incluindo sintomas, capacidade funcional, estratégias de enfrentamento e rede social de suporte, dentre outros. Entretanto, ainda falta esclarecer o impacto da fadiga na QVRS de pessoas com câncer de pulmão avançado. O objetivo deste estudo é avaliar a QVRS e a fadiga de sujeitos com diagnóstico de câncer de pulmão em cuidados paliativos e identificar a relação entre a presença de fadiga e percepção da QVRS desta população. Trata-se de um estudo transversal e com abordagem quantitativa, correlacional, com uma casuística composta por 120 sujeitos, sendo 60 com câncer de pulmão em cuidados paliativos (grupo de estudo) e 60 sem diagnóstico oncológico (grupo controle). Durante a coleta de dados foram aplicadas as escalas: Karnofsky Performance Scale (KPS)...

‣ Primeros síntomas, signos y actitudes del paciente con cáncer colorrectal. Demora del paciente, demora diagnóstica e intervalos entre los primeros síntomas y diagnóstico

González Santamaría, María Paloma
Fonte: Universidade da Corunha Publicador: Universidade da Corunha
Tipo: Tese de Doutorado
Português
Relevância na Pesquisa
35.913232%
[Resumen]Objetivo: Determinar las características clínicas de pacientes con cáncer colorrectal, la relación de pruebas diagnósticas tras los primeros síntomas y los diferentes intervalos de tiempo desde el inicio hasta el tratamiento. Material Y Métodos: Estudio observacional de seguimiento prospectivo. Se incluyen casos incidentes diagnosticados en el Área Sanitaria de A Coruña (período:2006- 2013;n=1891;Seguridad=95%,Precisión=±2,26%). Análisis descriptivo y multivariante para ,identificar variables asociadas a los diferentes intervalos de demora diagnóstica y terapéutica. Autorizado por el CEIC Galicia (código 2004/159 y 2009/110). Resultados: La mediana de edad es de 71 años y el 60,3% son varones. El 63,1% están localizados en el colon y el 36,9% en el recto. La localización más frecuente es el colon sigma id e (50,3%). El tipo histológico más frecuente es el adenocarcinoma (92,2%). Los primeros síntomas más frecuentes son diferentes según la localización del tumor. En el cáncer de colon, los más frecuentes son el dolor abdominal (48,8%), la rectorragia (43,9%) y la astenia (41,6%). En el cáncer de recto, la rectorragia (81,5%), astenia (31,9%), pérdida de peso (31,3%) y diarrea de nueva aparición (27...

‣ Novel associations between common breast cancer susceptibility variants and risk-predicting mammographic density measures

Stone, Jennifer; Thompson, Deborah J; dos Santos Silva, Isabel; Scott, Christopher; Tamimi, Rulla M.; Lindstrom, Sara; Kraft, Peter; Hazra, Aditi; Li, Jingmei; Eriksson, Louise; Czene, Kamila; Hall, Per; Jensen, Matt; Cunningham, Julie; Olson, Janet E.; P
Fonte: American Association for Cancer Research Publicador: American Association for Cancer Research
Tipo: Article; accepted version
Português
Relevância na Pesquisa
35.920957%
This is the author accepted manuscript. The final version is available via American Association for Cancer Research at http://cancerres.aacrjournals.org/content/early/2015/04/10/0008-5472.CAN-14-2012.abstract.; Mammographic density measures adjusted for age and body mass index (BMI) are heritable predictors of breast cancer risk but few mammographic density-associated genetic variants have been identified. Using data for 10,727 women from two international consortia, we estimated associations between 77 common breast cancer susceptibility variants and absolute dense area, percent dense area and absolute non-dense area adjusted for study, age and BMI using mixed linear modeling. We found strong support for established associations between rs10995190 (in the region of ZNF365), rs2046210 (ESR1) and rs3817198 (LSP1) and adjusted absolute and percent dense areas (all p <10-5). Of 41 recently discovered breast cancer susceptibility variants, associations were found between rs1432679 (EBF1), rs17817449 (MIR1972-2: FTO), rs12710696 (2p24.1), and rs3757318 (ESR1) and adjusted absolute and percent dense areas, respectively. There were associations between rs6001930 (MKL1) and both adjusted absolute dense and non-dense areas, and between rs17356907 (NTN4) and adjusted absolute non-dense area. Trends in all but two associations were consistent with those for breast cancer risk. Results suggested that 18% of breast cancer susceptibility variants were associated with at least one mammographic density measure. Genetic variants at multiple loci were associated with both breast cancer risk and the mammographic density measures. Further understanding of the underlying mechanisms at these loci could help identify etiological pathways implicated in how mammographic density predicts breast cancer risk.; ABCFS: The Australian Breast Cancer Family Registry (ABCFR; 1992-1995) was supported by the Australian NHMRC...