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‣ Imunologia das interações materno-fetais na asma: padrões de reatividade imunológica no colostro e no sangue de mães asmáticas e no sangue de cordão de seus respectivos recém-nascidos.; Immunology Interaction fetal-maternal in asthma: immunological reactive patterns in blood and colostrum from healthy and asthmatic mothers and in blood from their respective newborns.

Silva, Simone Corrêa da
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 08/04/2008 Português
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A Asma vem apresentando taxas de prevalência crescentes em todo o mundo. Os objetivos deste trabalho são avaliar a presença de elementos celulares e humorais indicativos em sangue e colostro de mães asmáticas e saudáveis e no sangue de cordão umbilical de seus recém-nascidos (RN). Observamos menor produção de IgG pelas mães asmáticas. Células dendríticas de mães asmáticas possuem maior expressão de CD80 e CD86. Mães asmáticas possuem mais células de memória central. Linfócitos T CD4+ de mães asmáticas produzem níveis maiores IFN-g. Células CD3+ e CD4+ de mães asmáticas produziram mais IL-13. Mães saudáveis produziram maiores quantidades de IL-10. Concluímos que mães asmáticas possuem menores níveis de IgG e IgM, o que parece aumentar dos níveis de IgE, mães asmáticas possuem mais células de memória central, linfócitos T CD4+ produzem maiores quantidades de citocinas como IL-13 e IFN-g, células dendríticas de mães asmáticas possuem maior expressão das moléculas co-estimulatórias, assim como seus RNs possuem maior expressão de CD80. Células de mães asmáticas produzem níveis menores de IL-10, o colostro de mães atópicas não possui diferenças entre os parâmetros aqui estudados. O aleitamento materno deve ser indicado para mães asmáticas e seus filhos.; Asthma has been presenting higher prevalence rates worldwide. The objective of this work is to evaluate the presence of cellular elements and humoral indicative in blood and colostrums of healthy and asthmatic mothers and in cord umbilical blood of their newborn (NB). Lower production of IgG from asthmatic mothers was observed. Dendritic cells of asthmatic mothers have higher CD80 and CD86 expression. Asthmatic mothers have more central memory cells. TCD4+ lymphocyte of asthmatic mothers produce higher levels of IFN-g. CD3+ and CD4+ cells of asthmatic mothers produce higher quantity of IL-13. Healthy mothers produce higher quantity of IL-10. We conclude that asthmatic mothers have lower levels of IgG and IgM...

‣ 4th Symposium of Immunology: Tumor Immunobiology

Kaneno, Ramon; Fecchio, Denise
Fonte: Universidade Estadual Paulista (UNESP) Publicador: Universidade Estadual Paulista (UNESP)
Tipo: Artigo de Revista Científica
Português
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This Abstract book includes all Abstracts of presentations at the 4th Symposion of Immunology: Tumor Immunology, which occurred in the São Paulo State University - UNESP, Bioscience Institute, Botucatu, SP, Brazil, from May 20-22nd, 2011.

‣ Multimedia Resources as a Complementary tool of Teaching and Learning. Case Study of a Game Designed to Teach Immunology Contents.

Teresa Correia; André Moreira; Isabel Martins
Fonte: Universidade do Porto Publicador: Universidade do Porto
Tipo: Artigo de Revista Científica
Português
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In 2003 the University of Porto recognized the potential of internet based learning systems and in that year started a project to implement the use of learning management systems (LMS) in classes based on a blended-learning model. The implementation of this project at universities large as the University of Porto (U.Porto) was a complex process that necessarily involved a large number of actors, so it was necessary for the University to define new ways to resolve their constraints. One of the strategies defined was through the Unit for New Technologies in Education (GATIUP) gives direct support to the teachers who wants to use e-learning platforms and also support the development of relevant educational multimedia contents to be used in the courses. In the last years the number of teachers at U.Porto interested in multimedia contents with educational purposes grew, and the number of requests that arrive at the unit increased. To demonstrate the importance of this type of resources we intend to shortly present here one of ours recent works: a game based on basic immunology learning contents. In this paper we intent to provide a brief description of what is one of the biggest concerns of todays University of Porto, the support of use and development of educational multimedia resources. We intend in a few words present a successful example of an Immunology course that uses multimedia contents specifically games conceptualized by students - to support learning.

‣ Natural immunoglobulins (contribution to a debate on biomedical education)

Vaz,Nelson M
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2000 Português
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Immunology has contributed to biomedical education in many important ways since the creation of scientific medicine in the last quarter of the 19th century. Today, immunology is a major area of biomedical research. Nevertheless, there are many basic problems unresolved in immunological activities and phenomena. Solving these problems is probably necessary to devise predictable and safe ways to produce new vaccines, treat allergy and autoimmune diseases and perform safe transplants. This challenge involves not only technical developments but also changes in attitude, of which the most fundamental is to abandon the traditional stimulus-response perspective in favor of more "systemic" views. Describing immunological activities as the operation of a complex multiconnected network, raises biological and epistemological issues not usually dealt with in biomedical education. Here we point to one example of systemic approaches. A new form of immunoblot (Panama blot), by which the reaction of natural immunoglobulins with complex protein mixtures may be analyzed by a special software and multivariate statistics, has been recently used to characterize human autoimmune diseases. Our preliminary data show that Panama blots can also be used to characterize global (systemic) immunogical changes in chronic human parasitic diseases...

‣ Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil

Castello-Branco,Luiz RR; Ortigão-de-Sampaio,Maria Beatriz
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2000 Português
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Mucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.

‣ FIMM, a database of functional molecular immunology: update 2002

Schönbach, Christian; Koh, Judice L. Y.; Flower, Darren R.; Wong, Limsoon; Brusic, Vladimir
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Publicado em 01/01/2002 Português
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FIMM database (http://sdmc.krdl.org.sg:8080/fimm) contains data relevant to functional molecular immunology, focusing on cellular immunology. It contains fully referenced data on protein antigens, major histocompatibility complex (MHC) molecules, MHC-associated peptides and relevant disease associations. FIMM has a set of search tools for extraction of information and results are presented as lists or as reports.

‣ FIMM, a database of functional molecular immunology

Schönbach, Christian; Koh, Judice L.Y.; Sheng, Xin; Wong, Limsoon; Brusic, Vladimir
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Publicado em 01/01/2000 Português
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FIMM database (http://sdmc.krdl.org.sg:8080/fimm ) contains data relevant to functional molecular immunology, focusing on cellular immunology. It contains fully referenced data on protein antigens, major histocompatibility complex (MHC) molecules, MHC-associated peptides and relevant disease associations. FIMM has a set of search tools for extraction of information and results are presented as lists or as reports.

‣ Center for disease control diagnostic immunology proficiency testing program results for 1976.

Taylor, R N; Fulford, K M; Przybyszewski, A; Pope, V
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /09/1977 Português
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Over 900 laboratories participated in the Diagnostic Immunology portion of the 1976 Proficiency Testing Program, which was provided by the Center of Disease Control under the authority of the Clinical Laboratories Improvement Act of 1967. One hundred specimens prepared by the Center for Disease Control for analysis were distributed on a quarterly schedule or in special surveys. Feedback from participating laboratories included over 37,500 qualitative and 33,000 quantitative responses, which were analyzed to determine individual laboratory proficiency levels. In addition, information supplied by participants in each survey helped to delineate trends in testing protocols. The specimens chosen for analysis called for a broad range of tests commonly performed in diagnostic immunology laboratories, including those for rubella antibodies, hepatitis B surface antigen, bacterial antibodies, rheumatoid factor, immunoglobulins and other serum-specific proteins, and carcinoembryonic antigen. A summary of the data analysis is provided so that the laboratories can improve their overall performance levels.

‣ Allergy and Immunology: New-Generation Antihistamines

Welch, Michael J.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /04/1991 Português
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The Scientific Board of the California Medical Association presents the following inventory of items of progress in allergy and immunology. Each item, in the judgment of a panel of knowledgeable physicians, has recently become reasonably firmly established, both as to scientific fact and important clinical significance. The items are presented in simple epitome, and an authoritative reference, both to the item itself and to the subject as a whole, is generally given for those who may be unfamiliar with a particular item. The purpose is to assist busy practitioners, students, researchers, or scholars to stay abreast of these items of progress in allergy and immunology that have recently achieved a substantial degree of authoritative acceptance, whether in their own field of special interest or another.

‣ Allergy and Immunology: Platelet-Activating Factor

Valone, Frank H.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /03/1989 Português
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The Scientific Board of the California Medical Association presents the following inventory of items of progress in allergy and immunology. Each item, in the judgment of a panel of knowledgeable physicians, has recently become reasonably firmly established, both as to scientific fact and important clinical significance. The items are presented in simple epitome and an authoritative reference, both to the item itself and to the subject as a whole, is generally given for those who may be unfamiliar with a particular item. The purpose is to assist busy practitioners, students, research workers, or scholars to stay abreast of these items of progress in allergy and immunology that have recently achieved a substantial degree of authoritative acceptance, whether in their own field of special interest or another.

‣ The Molecular Immunology of Mucositis: Implications for Evidence-Based Research in Alternative and Complementary Palliative Treatments

Chiappelli, Francesco
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Publicado em /12/2005 Português
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The terms ‘mucositis’ and ‘stomatitis’ are often used interchangeably. Mucositis, however, pertains to pharyngeal-esophago-gastrointestinal inflammation that manifests as red, burn-like sores or ulcerations throughout the mouth. Stomatitis is an inflammation of the oral tissues proper, which can present with or without sores, and is made worse by poor dental hygiene. Mucositis is observed in a variety of immunosuppressed patients, but is most often consequential to cancer therapy. It appears as early as the third day of intervention, and is usually established by Day 7 of treatment. Mucositis increases mortality and morbidity and contributes to rising health care costs. The precise immune components involved in the etiology of mucositis are unclear, but evidence-based research (EBR) data has shown that applications of granulocyte–macrophage-colony stimulating factor prevent the onset or the exacerbation of oropharyngeal mucositis. The molecular implications of this observation are discussed from the perspective of future developments of complementary and alternative treatments for this condition. It must be emphasized that this article is meant to be neither a review on mucositis and the various treatments for it, nor a discussion paper on its underlying molecular immunology. It is a statement of the implications of EBR for CAM-based interventions for mucositis. It explores and discusses the specific domain of molecular immunology in the context of mucositis and its direct implications for EBR research in CAM-based treatments for mucositis.

‣ Allergy and Immunology: Food-Induced Anaphylaxis

Celestin, Jocelyn; Heiner, Douglas C.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /06/1993 Português
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The Council on Scientific Affairs of the California Medical Association presents the following inventory of items of progress in allergy and immunology. Each item, in the judgment of a panel of knowledgeable physicians, has recently become reasonably firmly established, both as to scientific fact and important clinical significance. The items are presented in simple epitome, and an authoritative reference, both to the item itself and to the subject as a whole, is generally given for those who may be unfamiliar with a particular item. The purpose is to assist busy practitioners, students, researchers, and scholars to stay abreast of these items of progress in allergy and immunology that have recently achieved a substantial degree of authoritative acceptance, whether in their own field of special interest or another.

‣ A Semester-long Student-directed Research Project Involving Enzyme Immunoassay: Appropriate for Immunology, Endocrinology, or Neuroscience Courses

Ramos Goyette, Sharon; DeLuca, Jane
Fonte: American Society for Cell Biology Publicador: American Society for Cell Biology
Tipo: Artigo de Revista Científica
Publicado em //2007 Português
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The following project aimed at promoting integrated and long-lasting learning is described for an Immunology course, but it may be adapted to other disciplines. Students were asked to develop and carry out a research project to examine the relationship between immune function and stress. The experiments were required to include the assessment of salivary cortisol and salivary IgA (sIgA) with enzyme immunoassays. All other aspects of the experiments were developed by student groups with appropriate guidance from the instructor. Data are presented for one group project that assessed the effect of music on cortisol and sIgA. Overall levels of sIgA and cortisol were consistent with reported values. Students found a significant decrease in cortisol over time. Additionally, there was a trend that supported the overall student hypothesis regarding the effect of stress and immune function. Compared with the same Immunology course that included an instructor-designed experiment using enzyme immunoassays for cortisol and sIgA, several assessments (e.g., final grades and comments on student evaluations) show that overall learning seemed to be much better in the course with the student-directed research project.

‣ BAC to immunology – bacterial artificial chromosome-mediated transgenesis for targeting of immune cells

Sparwasser, Tim; Eberl, Gérard
Fonte: Blackwell Science Inc Publicador: Blackwell Science Inc
Tipo: Artigo de Revista Científica
Publicado em /07/2007 Português
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Thirty years after the first transgenic mouse was produced, a plethora of genetic tools has been developed to study immune cells in vivo. A powerful development is the bacterial artificial chromosome (BAC) transgenic approach, combining advantages of both conventional transgenic and knock-in gene-targeting strategies. In immunology the potential of BAC transgenic technology has yet to be fully harvested and, combined with a variety of elegant genetic tools, it will allow the analysis of complex immunological processes in vivo. In this short review, we discuss the applications of BACs in immunology, such as identification of regulatory regions, expression and cell-fate mapping, cell ablation, conditional mutations and the generation of humanized mice.

‣ Trends in research on the immunology of trypanosomiasis

Lumsden, W. H. R.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em //1967 Português
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It was thought timely, in view of the increasingly close association between immunology and parasitology, to attempt a synthesis of research on trypanosomiasis immunology—research which may be expected both to lead to the solution of practical problems in this disease and to provide models for the study of basic immunological problems.

‣ At the Crossroads: Mucosal Immunology of the Larynx

Thibeault, Susan; Rees, Louisa; Pazmany, Laszlo; Birchall, Martin A.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
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The larynx sits at the crossroads between gastrointestinal and respiratory tracts. Besides its intrinsic importance in breathing, swallowing and voice production, the larynx is also exposed to unique immunological challenges. Given the propensity of chronic inflammatory conditions such as chronic laryngitis, which affects up to 20% of Western populations, it is perhaps surprising that our understanding of the immunology of this organ remains relatively limited. However, recent work on the immunological architecture of the laryngeal mucosa, and its changes that result from external challenges and inflammatory conditions, provided valuable insight into the fascinating immunology of this organ. The lessons learnt from these investigations may go beyond devising improved therapy for chronic laryngeal inflammation. Establishing whether and how the laryngeal mucosa may be involved in the modulation of wider mucosal responses may provide novel routes to the treatment of other inflammatory diseases of the respiratory and alimentary tracts such as asthma and inflammatory bowel disease.

‣ A Systems Immunology Approach to the Host-Tumor Interaction: Large-Scale Patterns of Natural Autoantibodies Distinguish Healthy and Tumor-Bearing Mice

Merbl, Yifat; Itzchak, Royi; Vider-Shalit, Tal; Louzoun, Yoram; Quintana, Francisco J.; Vadai, Ezra; Eisenbach, Lea; Cohen, Irun R.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 25/06/2009 Português
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Traditionally, immunology has considered a meaningful antibody response to be marked by large amounts of high-affinity antibodies reactive with the specific inciting antigen; the detection of small amounts of low-affinity antibodies binding to seemingly unrelated antigens has been considered to be beneath the threshold of immunological meaning. A systems-biology approach to immunology, however, suggests that large-scale patterns in the antibody repertoire might also reflect the functional state of the immune system. To investigate such global patterns of antibodies, we have used an antigen-microarray device combined with informatic analysis. Here we asked whether antibody-repertoire patterns might reflect the state of an implanted tumor. We studied the serum antibodies of inbred C57BL/6 mice before and after implantation of syngeneic 3LL tumor cells of either metastatic or non-metastatic clones. We analyzed patterns of IgG and IgM autoantibodies binding to over 300 self-antigens arrayed on slides using support vector machines and genetic algorithm techniques. We now report that antibody patterns, but not single antibodies, were informative: 1) mice, even before tumor implantation, manifest both individual and common patterns of low-titer natural autoantibodies; 2) the patterns of these autoantibodies respond to the growth of the tumor cells...

‣ A Prescription for Human Immunology

Davis, Mark M.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 19/12/2008 Português
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Inbred mice have been an extremely successful tool for basic immunology, but much less so as models of disease. Thus, to maximize the use of immunologic approaches to improve human health, we need more strategically directed efforts in human immunology. This would also open up new opportunities for basic research.

‣ Theoretical Modeling Techniques and Their Impact on Tumor Immunology

Woelke, Anna Lena; Murgueitio, Manuela S.; Preissner, Robert
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
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Currently, cancer is one of the leading causes of death in industrial nations. While conventional cancer treatment usually results in the patient suffering from severe side effects, immunotherapy is a promising alternative. Nevertheless, some questions remain unanswered with regard to using immunotherapy to treat cancer hindering it from being widely established. To help rectify this deficit in knowledge, experimental data, accumulated from a huge number of different studies, can be integrated into theoretical models of the tumor-immune system interaction. Many complex mechanisms in immunology and oncology cannot be measured in experiments, but can be analyzed by mathematical simulations. Using theoretical modeling techniques, general principles of tumor-immune system interactions can be explored and clinical treatment schedules optimized to lower both tumor burden and side effects. In this paper, we aim to explain the main mathematical and computational modeling techniques used in tumor immunology to experimental researchers and clinicians. In addition, we review relevant published work and provide an overview of its impact to the field.

‣ The European Academy of Tumor Immunology: Bridging fields, continents and generations

Kroemer, Guido; Fridman, Wolf Hervé; Sautès-Fridman, Catherine; Zitvogel, Laurence
Fonte: Landes Bioscience Publicador: Landes Bioscience
Tipo: Artigo de Revista Científica
Publicado em 01/03/2012 Português
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The European Academy of Tumor Immunology (EATI, official website: http://eati.landesbioscience.com/index.html) has been founded in 2011 with the idea of creating a novel organization that responds to the need of structuring the European research space in this expanding, clinically ever more important area of research. Rapidly, this initiative, which regroups (part of) the elite of tumor immunologists, has been joined by 110 scientists, who accepted to join EATI as founding members. Obviously, EATI will not enter in competition with existing prestigious organizations, be they supranational (such as the Cancer Research Institute, CRI; the European Society for Cancer Immunology and Immunotherapy, ESCII; and the Society for the Immunotherapy of Cancer, SITC), or national [such as the Cancer Immunology Working Group, CIMM, of the American Association for Cancer Reserch; the (German) Association for Cancer Immunotherapy, CIMT; the (US) Cancer Immunotherapy Consortium, CIC; the (US) Cancer Vaccine Consortium, CVC; and the Italian Network for Cancer Biotherapy, NIBIT]. The choice of cooperation (rather than competition) with these organizations is clearly documented by the fact that many prominent members of CIMM, CIC, CIMT, CRI, CVC, ESCII...