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‣ The Contribution of Missense Mutations in Core and Rim Residues of Protein–Protein Interfaces to Human Disease

David, Alessia; Sternberg, Michael J.E.
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
Publicado em 28/08/2015 Português
Relevância na Pesquisa
473.12305%
Missense mutations at protein–protein interaction sites, called interfaces, are important contributors to human disease. Interfaces are non-uniform surface areas characterized by two main regions, “core” and “rim”, which differ in terms of evolutionary conservation and physicochemical properties. Moreover, within interfaces, only a small subset of residues (“hot spots”) is crucial for the binding free energy of the protein–protein complex.