Página 1 dos resultados de 20101 itens digitais encontrados em 0.011 segundos

## ‣ Universal Set-top Box: A Simple Design to Provide Accessible Services

COSTA, Laisa C. P.; HIRA, Celio; Biase, Marcelo Grigoletto de; Alonso, Rafael Herrero; Zuffo, Marcelo Knorich
Fonte: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC Publicador: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Tipo: Artigo de Revista Científica
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This paper presents the design of a low cost accessible digital television set-top box. This set-top box was designed and tested to the International ISDB-T system and considered the adoption of solutions that would provide accessible services in digital television in the simplest digital television receiver. The accessible set-top box was evaluated regarding the processing and memory requirements impacts to provide the features for accessible services. The work presents also the access services bandwidth consumption analysis(1).

## ‣ An accessible video player for older people: issues from a user test

Villena, Johana Maria Rosas; Ramos, Bruno Costa; Fortes, Renata Pontin de Mattos; Goularte, Rudinei
Fonte: Elsevier; Amsterdam Publicador: Elsevier; Amsterdam
Tipo: Artigo de Revista Científica
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There is a huge availability of videos that have been produced in a very fast and wide way, along with the popularity of Internet. This scenario should be carefully considered by the video authors since many users have different needs. It is important to keep in mind the accessibility requirements so that any user can overcome the barriers to access content regardless of their limitations imposed by either impairment or some temporary restriction. The current video players present barriers for many people, especially to the elderly, and one of the main barriers is the restriction to reproduce videos accessible on the Web. This paper describes a research, and the design and evaluation of an accessible video player (called Facilitas), in which a user test with older people is conducted. As a result, we discuss the issues reported by older people and the controls that were developed to assist them.; CAPES (PEC-PG); 5th International Conference on Software Development and Technologies for Enhancing Accessibility and Fighting Info-exclusion (DSAI 2013). Vigo, Spain. 13-15 november 2013.

## ‣ mRNA accessible site tagging (MAST): a novel high throughput method for selecting effective antisense oligonucleotides

Zhang, Hong-Yan; Mao, Jianping; Zhou, Daixing; Xu, Yunhe; Thonberg, Håkan; Liang, Zicai; Wahlestedt, Claes
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
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A solution-based method, mRNA accessible site tagging (MAST), has been developed to map the accessible sites of any given mRNA in high throughput fashion. mRNA molecules were immobilized and hybridized to randomized oligonucleotide libraries. Oligonucleotides specifically hybridized to the mRNA were sequenced and found to be able to precisely define the accessible sites of the mRNA. A number of ways were used to validate the accessible sites defined by the MAST process. Mapping of rabbit β-globin mRNA demonstrates the efficacy and advantage of MAST over other technologies in identifying accessible sites. Antisense oligonucleotides designed according to the accessible site map of human RhoA and Renilla luciferase mRNA result in knockdown effects that are in good correlation with the degrees of accessibility. The MAST methodology can be applied to mRNA of any length using a universal protocol.

## ‣ Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains).

Novotný, J; Handschumacher, M; Haber, E; Bruccoleri, R E; Carlson, W B; Fanning, D W; Smith, J A; Rose, G D
Tipo: Artigo de Revista Científica
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We evaluated surface areas on proteins that would be accessible to contacts with large (1-nm radius) spherical probes. Such spheres are comparable in size to antibody domains that contain antigen-combining sites. We found that all the reported antigenic sites correspond to segments particularly accessible to a large sphere. The antigenic sites were also evident as the most prominently exposed regions (hills and ridges) in contour maps of the solvent-accessible (small-probe) surface. In myoglobin and cytochrome c, virtually all of the van der Waals surface is accessible to the large probe and therefore potentially antigenic; in myohemerythrin, distinct large-probe-inaccessible, and nonantigenic, surface regions are apparent. The correlation between large-sphere-accessibility and antigenicity in myoglobin, lysozyme, and cytochrome c appears to be better than that reported to exist between antigenicity and segmental flexibility; that is, surface regions that are rigid often constitute antigenic epitopes, whereas some of the flexible parts of the molecules do not appear antigenic. We propose that the primary reason why certain polypeptide-chain segments are antigenic is their exceptional surface exposure, making them readily available for contacts with antigen-combining sites. Exposure of these segments frequently results in high mobility and...

## ‣ Transcription of the nonrepeated fraction of "accessible" DNA in rat liver chromatin.

Arnold, E A; Young, K E
Tipo: Artigo de Revista Científica
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The relationship between structure and function in eukaryotic chromatin has been studied in rat liver cells. To elucidate the functional significance of "accessible" DNA, the transcription of this DNA (prepared by titration of liver chromatin with poly-D-lysine) has been examined by RNA-DNA hybridization. The maximum extent to which nuclear RNA will hybridize to the nonrepeated fraction of "accessible" DNA has been measured and compared to the extent that whole chromatin DNA will hybridize. The results show that "accessible" DNA has the same number of sequences complementary to nuclear RNA as does total DNA. In addition DNA-DNA reassociation experiments indicate that there is only a small difference between the total unique sequence populations of "accessible" and total DNA. These results indicate that nonrepeated "accessible" DNA is not preferentially transcribed in the cell as is predicted by some models of chromatin structure.

## ‣ Analysis of accessible surface of residues in proteins

Lins, Laurence; Thomas, Annick; Brasseur, Robert
Fonte: Cold Spring Harbor Laboratory Press Publicador: Cold Spring Harbor Laboratory Press
Tipo: Artigo de Revista Científica
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We analyzed the total, hydrophobic, and hydrophilic accessible surfaces (ASAs) of residues from a nonredundant bank of 587 3D structure proteins. In an extended fold, residues are classified into three families with respect to their hydrophobicity balance. As expected, residues lose part of their solvent-accessible surface with folding but the three groups remain. The decrease of accessibility is more pronounced for hydrophobic than hydrophilic residues. Amazingly, Lysine is the residue with the largest hydrophobic accessible surface in folded structures. Our analysis points out a clear difference between the mean (other studies) and median (this study) ASA values of hydrophobic residues, which should be taken into consideration for future investigations on a protein-accessible surface, in order to improve predictions requiring ASA values. The different secondary structures correspond to different accessibility of residues. Random coils, turns, and β-structures (outside β-sheets) are the most accessible folds, with an average of 30% accessibility. The helical residues are about 20% accessible, and the difference between the hydrophobic and the hydrophilic residues illustrates the amphipathy of many helices. Residues from β-sheets are the most inaccessible to solvent (10% accessible). Hence...

## ‣ Rapid Determination of RNA Accessible Sites by Surface Plasmon Resonance Detection of Hybridization to DNA arrays

Mandir, Joshua B.; Lockett, Matthew R.; Phillips, Margaret F.; Allawi, Hatim T.; Lyamichev, Victor I.; Smith, Lloyd M.
Tipo: Artigo de Revista Científica
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RNA accessible sites are the regions in an RNA molecule, which are available for hybridization with complementary DNA or RNA molecules. The identification of these accessible sites is a critical first step in identifying antisense-mediated gene suppression sites, as well as in a variety of other RNA-based analysis methods. Here, we present a rapid, hybridization-based, label-free method of identifying RNA accessible sites with surface plasmon resonance imaging (SPRi) on in situ synthesized oligonucleotide arrays prepared on carbon-on-metal substrates. The accessible sites of three pre-miRNAs, miRNA precursors of ~75 nt in length, were determined by hybridizing the RNA molecules to RNA-specific tiling arrays. An array comprised of all possible 6mer oligonucleotide sequences was also utilized in this work, offering a universal platform capable of studying RNA molecules in a high throughput manner.

## ‣ Complementarity of quantum discord and classically accessible information

Zwolak, Michael; Zurek, Wojciech H.
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
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The sum of the Holevo quantity (that bounds the capacity of quantum channels to transmit classical information about an observable) and the quantum discord (a measure of the quantumness of correlations of that observable) yields an observable-independent total given by the quantum mutual information. This split naturally delineates information about quantum systems accessible to observers – information that is redundantly transmitted by the environment – while showing that it is maximized for the quasi-classical pointer observable. Other observables are accessible only via correlations with the pointer observable. We also prove an anti-symmetry property relating accessible information and discord. It shows that information becomes objective – accessible to many observers – only as quantum information is relegated to correlations with the global environment, and, therefore, locally inaccessible. The resulting complementarity explains why, in a quantum Universe, we perceive objective classical reality while flagrantly quantum superpositions are out of reach.

## ‣ Bus Rapid Transit Accessibility Guidelines

Rickert, Tom
Fonte: World Bank, Washington, DC Publicador: World Bank, Washington, DC
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In recent years helpful guides have appeared in both English and Spanish to assist planners and officials to construct accessible buildings and pedestrian infrastructure which are usable by seniors, persons with disabilities, and all others who especially benefit from universal design. Less has been written about access to public transport systems. Very little guidance is available concerning specific issues which confront those planning Bus Rapid Transit (BRT) systems, mass transit systems which incorporate a spectrum of design and operational features on integrated trunk and feeder routes and which were initiated in Latin America and are now spreading throughout the region and beyond. The guidelines focus on the BRT environment and assume that interested parties can take advantage of existing guidelines to clarify general issues of access to public space, buildings, and pedestrian infrastructure. The guidelines generally follow the travel path of a passenger using a full-featured Bus Rapid Transit system. The accessible travel chain begins with sidewalks and pedestrian crossings and continues into a typical mid-island station served by buses with left-side doors (in countries where traffic drives on the right side). Buses pull up to an enclosed station with a ramped platform the height of the bus floor. The guidelines then focus on station features...

## ‣ A novel and consistent method (TriPOD) to characterize an arbitrary porous solid for its accessible volume, accessible geometrical surface area and accessible pore size

Herrera, L.F.; Fan, C.; Do, D.D.; Nicholson, D.
Fonte: Springer US Publicador: Springer US
Tipo: Artigo de Revista Científica
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We present an improved Monte Carlo integration method to calculate the accessible pore size distribution of a porous solid having known configuration of solid atoms. The pore size distribution obtained with the present method is consistent with the accessible volume and the accessible geometric surface area presented in previous publications (Do and Do, in J. Colloid Interface Sci. 316(2):317–330, 2007; Do et al. in Adsorpt. J., 2010). The accessible volume, accessible geometrical surface area and the pore size distribution method construct an unambiguous and robust single framework to characterize porous solids. This framework is based on the derivation of the space accessible to the center of mass of a probe molecule. The accessible pore size presented is an absolute quantity in the sense that a zero value is possible. We present the entire framework of this characterization method and compare the improved method with the one presented previously for a set of porous solids such as graphitic slit pores, defective slit pores, bundle of carbon nanotubes, zeolite and some metal organic frameworks.; L. F. Herrera, Chunyan Fan, D. D. Do, D. Nicholson

## ‣ Turismo accesible, Turismo para todos: La situación en Cataluña y España; Accessible tourism, tourism for all: the current situation in Catalonia and Spain

Molina Hoyo, Mónica; Cánoves Valiente, Gemma
Fonte: Murcia: Escuela de Turismo Publicador: Murcia: Escuela de Turismo
Tipo: Artigo de Revista Científica Formato: application/pdf
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El artículo muestra la situación de la accesibilidad en los espacios turísticos, presenta como el tema del turismo accesible y el turismo para todos es un hecho reciente en España y Cataluña. El estudio expone la escasa atención que se ha prestado al tema desde el ámbito de los estudios de turismo y como existen una serie de colectivos que quieren incorporarse con pleno derecho al ocio y al disfrute de las actividades turísticas. Cataluña presenta recientes iniciativas que adaptan sus infraestructuras a los colectivos con discapacidad y/o necesidades especiales. El artículo repasa los casos más relevantes y muestra como en Francia ya existe una marca nacional, que reconoce la oferta turística adaptada y como el turismo accesible puede ser un producto en alza en los próximos años.; ABSTRACT The article shows the status of accessibility in tourist areas, presented as the theme of accessible tourism and tourism for all as a recent phenomenon in Spain and Catalonia. The study states that little attention has been paid to the subject from the field of tourism studies and since there are a number of groups that want to enter with full right to enjoy leisure and tourism activities. Catalonia presents recent initiatives to adapt their infrastructure to the groups with disabilities and / or special needs. The article reviews the most relevant cases and shows how in France there is already a national brand...

## ‣ Examining the use of evidence-based and social media supported tools in freely accessible physical activity intervention websites

Vandelanotte, C.; Kirwan, M.; Rebar, A.; Alley, S.; Short, C.; Fallon, L.; Buzza, G.; Schoeppe, S.; Maher, C.; Duncan, M.J.
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
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BACKGROUND: It has been shown that physical activity is more likely to increase if web-based interventions apply evidence-based components (e.g. self-monitoring) and incorporate interactive social media applications (e.g. social networking), but it is unclear to what extent these are being utilized in the publicly available web-based physical activity interventions. The purpose of this study was to evaluate whether freely accessible websites delivering physical activity interventions use evidence-based behavior change techniques and provide social media applications. METHODS: In 2013, a systematic search strategy examined 750 websites. Data was extracted on a wide range of variables (e.g. self-monitoring, goal setting, and social media applications). To evaluate website quality a new tool, comprising three sub-scores (Behavioral Components, Interactivity and User Generated Content), was developed to assess implementation of behavior change techniques and social media applications. An overall website quality scored was obtained by summing the three sub-scores. RESULTS: Forty-six publicly available websites were included in the study. The use of self-monitoring (54.3%), goal setting (41.3%) and provision of feedback (46%) was relatively low given the amount of evidence supporting these features. Whereas the presence of features allowing users to generate content (73.9%)...

## ‣ Les Services documentaires adaptés aux personnes handicapées de l’Université de Montréal : Le savoir accessible…la connaissance…la liberté !; Les Services documentaires adaptés aux personnes handicapées de l’Université de Montréal : Accessible learning…knowledge…freedom !

Chamberland, Nicole
Fonte: Corporation des bibliothécaires professionels du Québec (CBPQ) www.cbpq.ca Publicador: Corporation des bibliothécaires professionels du Québec (CBPQ) www.cbpq.ca
Tipo: Artigo de Revista Científica Formato: 50688 bytes; application/msword
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[RÉSUMÉ FRANÇAIS] Les Services documentaires adaptés aux personnes handicapées (SDAPH) de l'Université de Montréal ont pour objectif de rendre la documentation matériellement et intellectuellement accessible dans les délais les plus courts. Dans les locaux des SDAPH, plusieurs équipements adaptés sont disponibles et utilisés tant par le personnel que par les étudiants, afin de permettre la conversion des documents sous la forme convenant à chaque étudiant. Le personnel qualifié initie les personnes handicapées à l'utilisation des différents équipements adaptés à leurs besoins. Il voit à ce que chaque étudiant ait accès le plus tôt possible aux documents qui lui sont nécessaires, dans le respect de son échéancier académique et avec le support qui convient à son handicap.; [ENGLISH ABSTRACT] Les Services documentaires adaptés aux personnes handicapées de l’Université de Montréal : Accessible learning…knowledge…freedom ! Université de Montréal’s Services documentaires adaptés aux personnes handicapées de l’Université de Montréal (SDAPH), an assistive documentation service for disabled persons at UdeM, has as a goal to make documents physically and intellectually accessible as quickly as possible. Specialize assistive technology is made available to both students and staff to facilitate the conversion of documents into formats appropriate to their needs. Training on the equipment is available from qualified personnel who also ensure that students obtain the documents they require within academic deadlines and formatted for their particular disability.

## ‣ The iLab service broker : a software infrastructure providing common services in support of Internet accessible laboratories

Yehia, Karim Y., 1980-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 91 p.; 3826084 bytes; 3825886 bytes; application/pdf; application/pdf
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Remote laboratories that are accessible via the Internet are becoming a common phenomenon in higher education institutions. This thesis describes the iLab Service Broker architecture, a software infrastructure that supports these Internet-accessible labs by providing a number of services that facilitates their administration and management. These common services are authentication, authorization, lab administration, scheduling and data storage. While Internet- accessible laboratories may be quite varied in terms of the technologies they use, they tend to have similar topologies, consisting of a lab client, lab server and database. The end-user interacts with the lab client to issue commands to, and view results from the lab server, and the database stores data from the lab server. The Service Broker's internal architecture constitutes the business logic rules that govern how the common services are administered. Its external architecture exposes these services, using web services, and makes them available to the remote laboratories in a platform-independent manner. The Service Broker attempts to cater for the different experiment models that Internet-accessible labs host. These models are the batched experiment, the interactive experiment and the sensor lab experiment.; by Karim Y. Yehia.; Thesis (S.M.)--Massachusetts Institute of Technology...

## ‣ Accessible Capacity of Secondary Users

Huang, Xiujie; Ma, Xiao; Lin, Lei; Bai, Baoming
Tipo: Artigo de Revista Científica
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A new problem formulation is presented for the Gaussian interference channels (GIFC) with two pairs of users, which are distinguished as primary users and secondary users, respectively. The primary users employ a pair of encoder and decoder that were originally designed to satisfy a given error performance requirement under the assumption that no interference exists from other users. In the scenario when the secondary users attempt to access the same medium, we are interested in the maximum transmission rate (defined as {\em accessible capacity}) at which secondary users can communicate reliably without affecting the error performance requirement by the primary users under the constraint that the primary encoder (not the decoder) is kept unchanged. By modeling the primary encoder as a generalized trellis code (GTC), we are then able to treat the secondary link and the cross link from the secondary transmitter to the primary receiver as finite state channels (FSCs). Based on this, upper and lower bounds on the accessible capacity are derived. The impact of the error performance requirement by the primary users on the accessible capacity is analyzed by using the concept of interference margin. In the case of non-trivial interference margin...

## ‣ Colimits of accessible categories

Pare, R.; Rosicky, J.
Tipo: Artigo de Revista Científica
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We show that any directed colimit of acessible categories and accessible full embeddings is accessible and, assuming the existence of arbitrarily large strongly compact cardinals, any directed colimit of acessible categories and accessible embeddings is accessible.

## ‣ Local properties of accessible injective operator ideals

Oertel, Frank
Tipo: Artigo de Revista Científica
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In addition to Pisier's counterexample of a non-accessible maximal Banach ideal, we will give a large class of maximal Banach ideals which {\it{are accessible}}. The first step is implied by the observation that a "good behaviour" of trace duality, which is canonically induced by conjugate operator ideals can be extended to adjoint Banach ideals, if and only if these adjoint ideals satisfy an accessibility condition (theorem 3.1). This observation leads in a natural way to a characterization of accessible injective Banach ideals, where we also recognize the appearance of the ideal of {\it{absolutely summing operators}} (prop. 4.1). By the famous {\it{Grothendieck inequality}}, every operator from $L_1$ to a Hilbert space is absolutely summing, and therefore our search for such ideals will be directed towards Hilbert space factorization - via an operator version of Grothendieck's inequality (lemma 4.2). As a consequence,we obtain a class of injective ideals, which are "quasi-accessible", and with the help of {\it{tensor stability}}, we improve the corresponding norm inequalities, to get accessibility (theorem 4.1 and 4.2). In the last chapter of this paper we give applications, which are implied by a non-trivial link of the above mentioned considerations to normed products of operator ideals.

## ‣ On the existence of accessible paths in various models of fitness landscapes

Hegarty, Peter; Martinsson, Anders
Tipo: Artigo de Revista Científica
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We present rigorous mathematical analyses of a number of well-known mathematical models for genetic mutations. In these models, the genome is represented by a vertex of the $n$-dimensional binary hypercube, for some $n$, a mutation involves the flipping of a single bit, and each vertex is assigned a real number, called its fitness, according to some rules. Our main concern is with the issue of existence of (selectively) accessible paths; that is, monotonic paths in the hypercube along which fitness is always increasing. Our main results resolve open questions about three such models, which in the biophysics literature are known as house of cards (HoC), constrained house of cards (CHoC) and rough Mount Fuji (RMF). We prove that the probability of there being at least one accessible path from the all-zeroes node $\mathbf {v}^0$ to the all-ones node $\mathbf {v}^1$ tends respectively to 0, 1 and 1, as $n$ tends to infinity. A crucial idea is the introduction of a generalization of the CHoC model, in which the fitness of $\mathbf {v}^0$ is set to some $\alpha=\alpha_n\in[0,1]$. We prove that there is a very sharp threshold at $\alpha_n=\frac{\ln n}{n}$ for the existence of accessible paths from $\mathbf {v}^0$ to $\mathbf {v}^1$. As a corollary we prove significant concentration...

## ‣ Effect of hydrogel particle additives on water-accessible pore structure of sandy soils: A custom pressure plate apparatus and capillary bundle model

Wei, Y.; Durian, D. J.
Tipo: Artigo de Revista Científica
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To probe the effects of hydrogel particle additives on the water-accessible pore structure of sandy soils, we introduce a custom pressure plate method in which the volume of water expelled from a wet granular packing is measured as a function of applied pressure. Using a capillary bundle model, we show that the differential change in retained water per pressure increment is directly related to the cumulative cross-sectional area distribution $f(r)$ of the water-accessible pores with radii less than $r$. This is validated by measurements of water expelled from a model sandy soil composed of 2 mm diameter glass beads. In particular, the expelled water is found to depend dramatically on sample height and that analysis using the capillary bundle model gives the same pore size distribution for all samples. The distribution is found to be approximately log-normal, and the total cross-sectional area fraction of the accessible pore space is found to be $f_0=0.34$. We then report on how the pore distribution and total water-accessible area fraction are affected by superabsorbent hydrogel particle additives, uniformly mixed into a fixed-height sample at varying concentrations. Under both fixed volume and free swelling conditions, the total area fraction of water-accessible pore space in a packing decreases exponentially as the gel concentration increases. The size distribution of the pores is significantly modified by the swollen hydrogel particles...

## ‣ Optimizing Accessible Taxi Service to Augment Traditional Public Transit Services in Delaware

Tuttle, Douglas; Eaton, Kristen