Página 2 dos resultados de 20101 itens digitais encontrados em 0.009 segundos

‣ Web Videos: concerns about accessibility based on User Centered Design

Villena, Johana Maria Rosas; Ramos, Bruno Costa; Fortes, Renata Pontin de Mattos; Goularte, Rudinei
Fonte: Elsevier; Amsterdam Publicador: Elsevier; Amsterdam
Tipo: Artigo de Revista Científica
Português
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Recently, the production and availability of multimedia Web content, as videos, have increased. In this scenario it is important to consider accessibility requirements so that any user can whelm the barriers to access content regardless of the limitations imposed by either deficiency or some temporary restriction. One of the main barriers found in the current players is the restriction to make videos accessible on the Web and little research on how to overcome those limitations has been conducted. This paper describes the three phases of User Centered Design, in which an evaluation with real users of an accessible video player is conducted. A video player, called Facilitas, is proposed in order to provide the rationale of how some of those barriers or limitations could be overcome. Its controls are new and different from the ones in other players. We have observed that by reducing accessibility barriers, the design process leads to an improved product in terms of usability. A user testing is described to explain which controls users frequently use to complete a task.; CAPES (PEC-PG); 5th International Conference on Software Development and Technologies for Enhancing Accessibility and Fighting Info-exclusion (DSAI 2013). Vigo, Spain. 13-15 november 2013.

‣ Uma abordagem de apoio a boas práticas para desenvolvimento de aplicações Web acessíveis; Approach to support good practices for developing accessible web applications

Bittar, Thiago Jabur
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 05/02/2013 Português
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A interação com aplicações Web está se tornando cada vez mais presente no dia-a-dia das pessoas, sendo útil para a disponibilização de recursos que permitem a realização de serviços, estudos ou entretenimento. Porém muitos dos recursos disponibilizados apresentam barreiras em relação à acessibilidade, impedindo que usuários finais, com algum tipo de deficiência, possam utilizá-los de forma eficiente. Como solução para esse problema, têm sido propostas diretrizes para o desenvolvimento de aplicações Web acessíveis. Entretanto, apesar da existência dessas diretrizes, o cenário atual ainda mostra que há dificuldades em relação ao desenvolvimento considerando requisitos de acessibilidade. Neste sentido, esta tese está calcada na criação de uma abordagem que permita o apoio efetivo a boas práticas para desenvolvimento Web, a partir da aproximação de tais diretrizes ao ambiente das equipes de desenvolvimento. Para tanto, são definidas atividades separadas em 3 eixos de preocupações: Treinamento em Acessibilidade, Gerência de Decisões e Desenvolvimento e Ferramental. Para validação da concepção inicial da proposta desta tese, estudos de caso são detalhados, demonstrando como o desenvolvimento Web pode ser beneficiado com melhor apoio ferramental...

‣ Identifying ribozyme-accessible sites using NUH triplet-targeting gapmers

Mir, Alain A.; Lockett, Trevor J.; Hendry, Philip
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Publicado em 01/05/2001 Português
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Accurately identifying accessible sites in RNA is a critical prerequisite for optimising the cleavage efficiency of hammerhead ribozymes and other small nucleozymes. Here we describe a simple RNase H-based procedure to rapidly identify hammerhead ribozyme-accessible sites in gene length RNAs. Twelve semi-randomised RNA–DNA–RNA chimeric oligonucleotide probes, known as ‘gapmers’, were used to direct RNase H cleavage of transcripts with the specificity expected for hammerhead ribozymes, i.e. after NUH sites (where H is A, C or U). Cleavage sites were identified simply by the mobility of RNase H cleavage products relative to RNA markers in denaturing polyacrylamide gels. Sites were identified in transcripts encoding human interleukin-2 and platelet-derived growth factor. Thirteen minimised hammerhead ribozymes, miniribozymes (Mrz), were synthesised and in vitro cleavage efficiency (37°C, pH 7.6 and 1 mM MgCl2) at each site was analysed. Of the 13 Mrz, five were highly effective, demonstrating good initial rate constants and extents of cleavage. The speed and accuracy of this method commends its use in screening for hammerhead-accessible sites.

‣ Accessible surface areas as a measure of the thermodynamic parameters of hydration of peptides.

Ooi, T; Oobatake, M; Némethy, G; Scheraga, H A
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /05/1987 Português
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A method is described for the inclusion of the effects of hydration in empirical conformational energy computations on polypeptides. The free energy of hydration is composed of additive contributions of various functional groups. The hydration of each group is assumed to be proportional to the accessible surface area of the group. The constants of proportionality, representing the free energy of hydration per unit area of accessible surface, have been evaluated for seven classes of groups (occurring in peptides) by least-squares fitting to experimental free energies of solution of small monofunctional aliphatic and aromatic molecules. The same method has also been applied to the modeling of the enthalpy and heat capacity of hydration, each of which is computed from the accessible surface area.

‣ Analytical approximation to the accessible surface area of proteins

Wodak, Shoshana J.; Janin, Joël
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /04/1980 Português
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We propose an analytical substitute to the geometrical construction that is commonly used in calculating the protein surface area that is accessible to the solvent. A statistical approach leads to an expression of accessible surface areas as a function of distances between pairs of atoms or of residues in the protein structure, assuming only that these atoms or residues are randomly distributed in space but not penetrating each other. This function gives good estimates of the accessible surface area and of the area buried in subunit contacts for a number of proteins. Its evaluation is very fast, and the function can be differentiated, which opens the way to new applications of accessibility measurements in the study of proteins. As an example, we show that the presence of domains is easily detected by an automatic procedure based on surface areas only.

‣ Oligosaccharide Side Chains of Glycoproteins that Remain in the High-Mannose Form Are Not Accessible to Glycosidases 1

Faye, Loïc; Johnson, Kenneth D.; Chrispeels, Maarten J.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /05/1986 Português
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Glycoproteins present in the soluble and organelle fractions of developing bean (Phaseolus vulgaris) cotyledons were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, affinoblotting, fractionation on immobilized concanavalin A (ConA), and digestion of the oligosaccharide side chains with specific glycosidases before and after protein denaturation. These studies led to the following observations. (a) Bean cotyledons contain a large variety of glycoproteins that bind to ConA. Binding to ConA can be eliminated by prior digestion of denatured proteins with α-mannosidase or endoglycosidase H, indicating that binding to ConA is mediated by high-mannose oligosaccharide side chains. (b) Bean cotyledons contain a large variety of fucosylated glycoproteins which bind to ConA. Because fucose-containing oligosaccharide side chains do not bind to ConA, such proteins must have both high-mannose and modified oligosaccharides. (c) For all the glycoproteins examined except one, the high-mannose oligosaccharides on the undenatured proteins are accessible to ConA and partially accessible to jack bean α-mannosidase. (d) Treatment of the native proteins with α-mannosidase removes only 1 or 2 mannose residues from the high-mannose oligosaccharides. Similar treatments of sodium dodecyl sulfate-denatured or pronase-digested glycoproteins removes all α-mannose residues. The results support the following conclusions: certain side chains remain unmodified as high-mannose oligosaccharides even though the proteins to which they are attached pass through the Golgi apparatus...

‣ Theoretical characterization of ion channel blockade. Competitive binding to periodically accessible receptors.

Starmer, C F
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /09/1987 Português
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Competitive ligand binding to periodically activated or accessible receptors is influenced by the interaction between ligand binding kinetics and the interval of time the binding site is accessible. This interaction produces a paradoxical reduction in bound receptors under certain conditions. A mathematical description of multi-ligand binding to a single binding site is presented for both the continuously and transiently accessible cases. The theoretical results predict paradoxical "agonism" and are consistent with the results of studies of lidocaine and bupivacaine binding to cardiac sodium channels.

‣ A novel method reveals that solvent water favors polyproline II over β-strand conformation in peptides and unfolded proteins: conditional hydrophobic accessible surface area (CHASA)

Fleming, Patrick J.; Fitzkee, Nicholas C.; Mezei, Mihaly; Srinivasan, Rajgopal; Rose, George D.
Fonte: Cold Spring Harbor Laboratory Press Publicador: Cold Spring Harbor Laboratory Press
Tipo: Artigo de Revista Científica
Publicado em /01/2005 Português
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In aqueous solution, the ensemble of conformations sampled by peptides and unfolded proteins is largely determined by their interaction with water. It has been a long-standing goal to capture these solute-water energetics accurately and efficiently in calculations. Historically, accessible surface area (ASA) has been used to estimate these energies, but this method breaks down when applied to amphipathic peptides and proteins. Here we introduce a novel method in which hydrophobic ASA is determined after first positioning water oxygens in hydrogen-bonded orientations proximate to all accessible peptide/protein backbone N and O atoms. This conditional hydrophobic accessible surface area is termed CHASA. The CHASA method was validated by predicting the polyproline-II (PII) and β-strand conformational preferences of non-proline residues in the coil library (i.e., non-α-helix, non-β-strand, non-β-turn library derived from X-ray elucidated structures). Further, the method successfully rationalizes the previously unexplained solvation energies in polyalanyl peptides and compares favorably with published experimentally determined PII residue propensities.

‣ Bias and Evolution of the Mutationally Accessible Phenotypic Space in a Developmental System

Braendle, Christian; Baer, Charles F.; Félix, Marie-Anne
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Português
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Genetic and developmental architecture may bias the mutationally available phenotypic spectrum. Although such asymmetries in the introduction of variation may influence possible evolutionary trajectories, we lack quantitative characterization of biases in mutationally inducible phenotypic variation, their genotype-dependence, and their underlying molecular and developmental causes. Here we quantify the mutationally accessible phenotypic spectrum of the vulval developmental system using mutation accumulation (MA) lines derived from four wild isolates of the nematodes Caenorhabditis elegans and C. briggsae. The results confirm that on average, spontaneous mutations degrade developmental precision, with MA lines showing a low, yet consistently increased, proportion of developmental defects and variants. This result indicates strong purifying selection acting to maintain an invariant vulval phenotype. Both developmental system and genotype significantly bias the spectrum of mutationally inducible phenotypic variants. First, irrespective of genotype, there is a developmental bias, such that certain phenotypic variants are commonly induced by MA, while others are very rarely or never induced. Second, we found that both the degree and spectrum of mutationally accessible phenotypic variation are genotype-dependent. Overall...

‣ Native mRNA antisense-accessible sites library for the selection of antisense oligonucleotides, PNAs, and siRNAs

Fang, Huafeng; Shen, Yuefei; Taylor, John-Stephen
Fonte: Cold Spring Harbor Laboratory Press Publicador: Cold Spring Harbor Laboratory Press
Tipo: Artigo de Revista Científica
Publicado em /07/2010 Português
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A procedure for rapidly generating a library of antisense-accessible sites on native mRNAs (mRNA antisense-accessible sites library [MASL]) is described that involves reverse transcription of whole cell mRNA extracts with a random oligodeoxynucleotide primer followed by mRNA-specific polymerase chain reaction (PCR). Antisense phosphorothioate oligodeoxynucleotides (ODNs), peptide nucleic acids (PNAs), and small interfering RNAs (siRNAs) can then be identified by screening against the antisense-accessible sites. The utility of this methodology is demonstrated for the identification of more effective inhibitors of inducible nitric oxide synthase (iNOS) induction than have previously been reported. This method may also be useful for constraining folding calculations of native mRNAs and for designing mRNA imaging probes.

‣ Accessible Surfaces of Beta Proteins Increase with Increasing Protein Molecular Mass More Rapidly than Those of Other Proteins

Glyakina, Anna V.; Bogatyreva, Natalya S.; Galzitskaya, Oxana V.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 01/12/2011 Português
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Here we present a systematic analysis of accessible surface areas and hydrogen bonds of 2554 globular proteins from four structural classes (all-α, all-β, α/β and α+β proteins) that is aimed to learn in which structural class the accessible surface area increases with increasing protein molecular mass more rapidly than in other classes, and what structural peculiarities are responsible for this effect. The beta structural class of proteins was found to be the leader, with the following possible explanations of this fact. First, in beta structural proteins, the fraction of residues not included in the regular secondary structure is the largest, and second, the accessible surface area of packaged elements of the beta-structure increases more rapidly with increasing molecular mass in comparison with the alpha-structure. Moreover, in the beta structure, the probability of formation of backbone hydrogen bonds is higher than that in the alpha helix for all residues of α+β proteins (the average probability is 0.73±0.01 for the beta-structure and 0.60±0.01 for the alpha-structure without proline) and α/β proteins, except for asparagine, aspartic acid, glycine, threonine, and serine (0.70±0.01 for the beta-structure and 0.60±0.01 for the alpha-structure without the proline residue). There is a linear relationship between the number of hydrogen bonds and the number of amino acid residues in the protein ().

‣ Conserved Walker A Cysteines 431 and 1074 in Human P-glycoprotein Are Accessible to Thiol-Specific Agents in the Apo and ADP-Vanadate Trapped Conformations

Sim, Hong-May; Bhatnagar, Jaya; Chufan, Eduardo E.; Kapoor, Khyati; Ambudkar, Suresh V.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
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P-glycoprotein (P-gp) is an ATP-binding cassette efflux transporter involved in the development of multidrug resistance in cancer cells. Although the mechanism of P-gp efflux has been extensively studied, aspects of its catalytic and transport cycle are still unclear. In this study, we used the conserved C431 and C1074 in the Walker A motif of nucleotide-binding domains (NBDs) as reporter sites to interrogate the interaction between the two NBDs during the catalytic cycle. Disulfide crosslinking of the C431 and C1074 residues in a cysless background can be observed in the presence of M14M and M17M crosslinkers, which have spacer arm lengths of 20 Å and 25 Å, respectively. However, crosslinking with both crosslinkers was prevented in the ADP-vanadate trapped (closed) conformation. Both C431 and C1074 alone or together (double mutant) in the apo and closed conformations were found to be accessible to fluorescein-5-maleimide (FM) and methanethiosulfonate derivatives of rhodamine and verapamil. In addition, C1074 showed 1.4-fold and 2-fold higher degrees of FM labeling compared to C431 in the apo and closed conformations, respectively, demonstrating that C1074 is more accessible than C431 in both conformations. In the presence of P-gp substrates...

‣ An Objective Approach to Determining the Weight Ranges of Prey Preferred by and Accessible to the Five Large African Carnivores

Clements, Hayley S.; Tambling, Craig J.; Hayward, Matt W.; Kerley, Graham I. H.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 02/07/2014 Português
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Broad-scale models describing predator prey preferences serve as useful departure points for understanding predator-prey interactions at finer scales. Previous analyses used a subjective approach to identify prey weight preferences of the five large African carnivores, hence their accuracy is questionable. This study uses a segmented model of prey weight versus prey preference to objectively quantify the prey weight preferences of the five large African carnivores. Based on simulations of known predator prey preference, for prey species sample sizes above 32 the segmented model approach detects up to four known changes in prey weight preference (represented by model break-points) with high rates of detection (75% to 100% of simulations, depending on number of break-points) and accuracy (within 1.3±4.0 to 2.7±4.4 of known break-point). When applied to the five large African carnivores, using carnivore diet information from across Africa, the model detected weight ranges of prey that are preferred, killed relative to their abundance, and avoided by each carnivore. Prey in the weight ranges preferred and killed relative to their abundance are together termed “accessible prey”. Accessible prey weight ranges were found to be 14–135 kg for cheetah Acinonyx jubatus...

‣ Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape

Camp, J. Gray; Frank, Christopher L.; Lickwar, Colin R.; Guturu, Harendra; Rube, Tomas; Wenger, Aaron M.; Chen, Jenny; Bejerano, Gill; Crawford, Gregory E.; Rawls, John F.
Fonte: Cold Spring Harbor Laboratory Press Publicador: Cold Spring Harbor Laboratory Press
Tipo: Artigo de Revista Científica
Publicado em /09/2014 Português
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Microbiota regulate intestinal physiology by modifying host gene expression along the length of the intestine, but the underlying regulatory mechanisms remain unresolved. Transcriptional specificity occurs through interactions between transcription factors (TFs) and cis-regulatory regions (CRRs) characterized by nucleosome-depleted accessible chromatin. We profiled transcriptome and accessible chromatin landscapes in intestinal epithelial cells (IECs) from mice reared in the presence or absence of microbiota. We show that regional differences in gene transcription along the intestinal tract were accompanied by major alterations in chromatin accessibility. Surprisingly, we discovered that microbiota modify host gene transcription in IECs without significantly impacting the accessible chromatin landscape. Instead, microbiota regulation of host gene transcription might be achieved by differential expression of specific TFs and enrichment of their binding sites in nucleosome-depleted CRRs near target genes. Our results suggest that the chromatin landscape in IECs is preprogrammed by the host in a region-specific manner to permit responses to microbiota through binding of open CRRs by specific TFs.

‣ Geographical Analysis of Aneurysmal Subarachnoid Hemorrhage in Japan Utilizing Publically-Accessible DPC Database

Fukuhara, Toru
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 26/03/2015 Português
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Since the launch of the novel medical reimbursement system Diagnosis Procedure Combination (DPC) in 2003 in Japan, inpatient data has been accumulated over time as part of a Japanese governmental nationwide database. This is partially accessible by the public, and this study examined the adequacy of this database as epidemiological research material by extracting the data relating to aneurysmal subarachnoid hemorrhage (aSAH) with special attention given to the limitations that this involves. Datasets after 2010 are considered suitable for analysis because of the numbers of participating hospitals and the analysis term. Extracting the data by prefecture, those with a continuously high aSAH incidence were Aomori, Iwate, Akita, Yamagata, Kochi and Kumamoto Prefectures, and those with low aSAH incidence were Kanagawa, Shiga, Kyoto, Shimane and Ehime Prefectures. Although these obtained results are informative, a publically-accessible DPC database has several limitations. Some limitations have been resolved: the analyzed term each year is now 12-months and the number of participating hospitals seems to have stabilized around 1700. However, other limitations such as masking the numbers in each hospital reporting less than 10 patients still exist...

‣ Accessible versus Holevo Information for a Binary Random Variable

Jain, Rahul; Nayak, Ashwin
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Português
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The accessible information acc(E) of an ensemble E is the maximum mutual information between a random variable encoded into quantum states, and the probabilistic outcome of a quantum measurement of the encoding. Accessible information is extremely difficult to characterize analytically; even bounds on it are hard to place. The celebrated Holevo bound states that accessible information cannot exceed chi(E), the quantum mutual information between the random variable and its encoding. However, for general ensembles, the gap between the acc(E) and chi(E) may be arbitrarily large. We consider the special case of a binary random variable, which often serves as a stepping stone towards other results in information theory and communication complexity. We give explicit lower bounds on the the accessible information acc(E) of an ensemble E = {(p, rho_0), (1-p, rho_1)}, with 0 <= p <= 1, as functions of p and chi(E). The bounds are incomparable in the sense that they surpass each other in different parameter regimes. Our bounds arise by measuring the ensemble according to a complete orthogonal measurement that preserves the fidelity of the states rho_0,rho_1. As an intermediate step, therefore, we give new relations between the two quantities acc(E)...

‣ Complementarity of quantum discord and classically accessible information

Zwolak, Michael; Zurek, Wojciech H.
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Português
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The sum of the Holevo quantity (that bounds the capacity of quantum channels to transmit classical information about an observable) and the quantum discord (a measure of the quantumness of correlations of that observable) yields an observable-independent total given by the quantum mutual information. This split naturally delineates information about quantum systems accessible to observers -- information that is redundantly transmitted by the environment -- while showing that it is maximized for the quasi-classical pointer observable. Other observables are accessible only via correlations with the pointer observable. Further, we prove an anti-symmetry property relating accessible information and discord. It shows that information becomes objective -- accessible to many observers -- only as quantum information is relegated to correlations with the global environment, and, therefore, locally inaccessible. The resulting complementarity explains why, in a quantum Universe, we perceive objective classical reality while flagrantly quantum superpositions are out of reach.; Comment: 12 pages, 4 figures

‣ Optimal reference states for maximum accessible entanglement under the local particle number superselection rule

White, G. A.; Vaccaro, J. A.; Wiseman, H. M.
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Português
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Global conservation laws imply superselection rules (SSR) which restrict the operations that are possible on any given state. Imposing the additional constraint of local operations and classical communication (LOCC) forbids the transfer of quantum systems between spatially separated sites. In the case of particle conservation this imposes a SSR for local particle number. That is, the coherences between subspaces of fixed particle number at each site are not accessible and any state is therefore equivalent to its projection onto these subspaces. The accessible entanglement under the SSR is less than (or equal to) that available in the absence of the SSR. An ancilla can be used as a reference system to increase the amount of accessible entanglement. We examine the relationship between local particle number uncertainty and the accessible entanglement and consider the optimal reference states for recovering entanglement from certain systems. In particular we derive the optimal ancilla state for extracting entanglement for a single shared particle and make steps towards the optimum for general systems.; Comment: 14 pages, 6 figures, clarified a key result but otherwise mostly minor changes

‣ The source and accessible entanglement of few-body systems

Sauerwein, D.; Schwaiger, K.; Cuquet, M.; de Vicente, J. I.; Kraus, B.
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Publicado em 11/08/2015 Português
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Entanglement is the resource to overcome the natural limitations of spatially separated parties restricted to Local Operations assisted by Classical Communications (LOCC). Recently two new classes of operational entanglement measures, the source and the accessible entanglement, for arbitrary multipartite states have been introduced. Whereas the source entanglement measures from how many states the state of interest can be obtained via LOCC, the accessible entanglement measures how many states can be reached via LOCC from the state at hand. We consider here pure bipartite as well as multipartite states and derive explicit formulae for the source entanglement. Moreover, we obtain explicit formulae for a whole class of source entanglement measures that characterize the simplicity of generating a given bipartite pure state via LOCC. Furthermore, we show how the accessible entanglement can be computed numerically. For generic four-qubit states we first derive the necessary and sufficient conditions for the existence of LOCC transformations among these states and then derive explicit formulae for their accessible and source entanglement.; Comment: 22 pages (including appendix), 9 figures, 1 table

‣ "We are also travellers": An action story about disabled women mobilising for an accessible public transport system in Khayelitsha and Nyanga, Cape Metropole, South Africa

Lorenzo,Theresa
Fonte: South African Journal of Occupational Therapy Publicador: South African Journal of Occupational Therapy
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2008 Português
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The paper reports on the experiences of disabled women in Khayelitsha and Nyanga in Cape Town in mobilising for an accessible public transport system so that they had equal opportunities to participation in social and economic development. The paper highlights various policies linked to addressing/achieving equal rights and access for disabled people across sectors, with a specific focus on the centrality of accessible public transport to development. The specific aim of this action story was to explore the experiences of disabled women in mobilising for change regarding an accessible public transport system as a strategy for social inclusion. A qualitative research approach using participatory action research (PAR) was chosen as the research design to allow for emergent process of collaboration and dialogue. Purposive sampling and snowballing were used to select the sample of disabled women living in Khayelitsha and Nyanga in Cape Town. Data was generated through pioneering narrative action reflection (NAR) workshops, as an innovative method to generate data of disability experiences collectively rather than on a one-to-one basis. The method enables storytelling and action learning by marginalised groups in impoverished contexts to mobilise collectively for equal opportunities and social inclusion. The theme "We are also travellers" emerged with two sub-themes that described the barriers and strategies for inclusion...