Página 3 dos resultados de 20101 itens digitais encontrados em 0.007 segundos

‣ A user test with accessible video player looking for user experience

Villena, Johana Maria Rosas; Goularte, Rudinei; Fortes, Renata Pontin de Mattos
Fonte: Springer International Publishing; Cham Publicador: Springer International Publishing; Cham
Tipo: Artigo de Revista Científica
Português
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There is a huge availability of videos that have been produced in a very fast and wide way, along with the popularity of Internet. The video authors should carefully consider the scenario since many users have different needs. It is important to keep in mind the user experience because involves a person’s behaviors, attitudes, and emotions about using a particular system, for example, the video player. In addition, usability and accessibility of video players need to be considered. The object of this study is to examine users’ needs, expectations and requirements for accessible videos. We developed an accessible video player to evaluate with users. We present the results in the form of guidelines, which highlight the characteristics of users; the characteristics that the video need to satisfy the users’ needs and the context in which users commonly watch the videos.; Program Estudantes-Convênio de Pós-Graduação – PEC-PG, of CAPES/CNPq – Brazil; 8th International Conference on Universal Access in Human-Computer Interaction (UAHCI). Crete, Greece. 22-27 June 2014.

‣ Sending classical information through relativistic quantum channels

Landulfo, André G. S.; Torres, Adriano C.
Tipo: Artigo de Revista Científica
Português
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We investigate how special relativity influences the transmission of classical information through quantum channels by evaluating the Holevo bound when the sender and the receiver are in (relativistic) relative motion. By using the spin degrees of freedom of spin-1/2 fermions to encode the classical information, we show that, for some configurations, the accessible information in the receiver can be increased when the spin detector moves fast enough. This is possible by allowing the momentum wave packet of one of the particles to be sufficiently wide while the momentum wave packets of other particles are kept relatively narrow. In this way, one can take advantage of the fact that boosts entangle the spin and momentum degrees of freedom of spin-1/2 fermions to increase the accessible information in the former. We close the paper with a discussion of how this relativistic quantum channel cannot in general be described by completely positive quantum maps. © 2013 American Physical Society.

‣ Making justice more accessible

Carneiro, Davide Rua; Novais, Paulo
Fonte: Association for Computing Machinery Publicador: Association for Computing Machinery
Tipo: Conferência ou Objeto de Conferência
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From the point of view of the Citizen, Justice is not always readily accessible. Either because it is a lengthy process, potentially expensive, sometimes unclear or simply scary, people will often avoid or withdraw from a judicial process, especially in those cases that involve relatively small amounts. This results in the giving up of a basic right, with the potential loss of rightful benefits. In this paper we briefly analyze the main aspects that impair access to Justice nowadays. We then move on to look at recent technological developments in the field of Online Dispute Resolution to argue that these can, in the near future, have a significant role in improving access to Justice. Specifically, we analyze the UMCourt Conflict Resolution Framework, developed by our research team, and address the different dimensions in which such tools contribute to make Justice more accessible, namely through better access to useful information, support in decision-making or more cost-effective processes.; Development Fund through the COMPETE Programme (operational programme for competitiveness) and by National Funds through the FCT - Fundação para a Ciência e a Tecnologia (Portuguese Foundation for Science and Technology) within projects FCOMP-01-0124-FEDER-028980 (PTDC/EEISII/1386/ 2012) and PEst-OE/EEI/UI0752/2014

‣ Ectopic gene targeting exhibits a bimodal distribution of integration in murine cells, indicating that both intra- and interchromosomal sites are accessible to the targeting vector.

Dellaire, G; Lemieux, N; Belmaaza, A; Chartrand, P
Tipo: Artigo de Revista Científica
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Ectopic gene targeting is an alternative outcome of the gene targeting process in which the targeting vector acquires sequences from the genomic target but proceeds to integrate elsewhere in the genome. Using two-color fluorescent in situ hybridization analysis, we have determined the integration sites of the gene targeting vector with respect to the target locus in a murine fibroblast line (LTA). We found that for ectopic gene targeting the distribution of integration sites was bimodal, being either within 3 Mb of the target or on chromosomes distinct from the chromosome carrying the target locus. Inter- and intrachromosomal sites appeared to be equally accessible to the targeting vector, with site-specific variations. Interestingly, interphase analysis indicated that vector sequences which had integrated ectopically in chromosomes other than the target colocalized with the target locus at a significant frequency compared to that of colocalization to random unlinked loci. We propose that ectopic gene targeting could be used to determine which chromosomal domains within the genome are accessible to a given genetic locus. Thus, recombination access mapping may present a new paradigm for the analysis of DNA accessibility and interaction within the genome.

‣ Structural rearrangement of infecting Sindbis virions at the cell surface: mapping of newly accessible epitopes.

Meyer, W J; Johnston, R E
Tipo: Artigo de Revista Científica
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Sindbis virus glycoproteins E1 and E2 undergo a conformational alteration during early virus-cell interaction at the cell surface (D. Flynn, W. J. Meyer, J. M. MacKenzie, Jr., and R. E. Johnston, J. Virol. 64:3643-3653, 1990). Certain epitopes normally internal on native virus become accessible to monoclonal antibody (MAb) binding after attachment but before internalization of virus particles. These newly exposed epitopes, termed transitional epitopes, may be part of functionally important domains made accessible at the surface of the altered virus to facilitate entry into cells. Heating Sindbis virions at 51 degrees C for a short time induced a similar, although not identical, exposition of transitional epitopes on the E1 and E2 glycoproteins (W. J. Meyer, S. Gidwitz, V. K. Ayers, R. J. Schoepp, and R. E. Johnston, J. Virol. 66:3504-3513, 1992). In the current report, we have identified several of the transitional epitopes that become exposed as a consequence of early virus-cell interactions. Transitional epitope MAbs that bound to rearranged, heated virions and virus-cell complexes were used in antibody competition binding assays on heated Sindbis virions to map the spatial relationships between native, external, neutralizing antigenic sites and newly exposed transitional epitopes. Because the heated...

‣ The sequence A alpha-(148-160) in fibrin, but not in fibrinogen, is accessible to monoclonal antibodies.

Schielen, W J; Voskuilen, M; Tesser, G I; Nieuwenhuizen, W
Tipo: Artigo de Revista Científica
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Fibrin, but not fibrinogen, accelerates the activation of plasminogen catalyzed by tissue-type plaminogen activator. Previous work showed that essential information for this accelerating capacity of fibrin resides in the sequence corresponding to residues 148-160 of the A alpha chain of fibrinogen [A alpha-(148-160)]. Our working hypothesis, based on those findings, is that A alpha-(148-160) is buried in fibrinogen and becomes accessible to proteins such as plasminogen and/or tissue-type plasminogen activator when fibrinogen is converted to fibrin. To test this hypothesis we have raised a monoclonal antibody against synthetic A alpha-(148-160) and found that this antibody reacts with fibrin and not with fibrinogen. This finding shows that A alpha-(148-160) becomes accessible when fibrinogen is converted to fibrin and that A alpha-(148-160) is a fibrin-specific neoantigenic determinant.

‣ Detection of antibody-accessible proteins on the cell surface of Haemophilus influenzae type b.

Hansen, E J; Frisch, C F; Johnston, K H
Tipo: Artigo de Revista Científica
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A radioimmunoprecipitation method has been devised which permits the direct identification of those proteins which are both exposed on the cell surface of Haemophilus influenzae type b and accessible to antibody. Both extrinsically and intrinsically radiolabeled cells of this organism were employed as the sources of antigen in radioimmunoprecipitation experiments which involved incubation of intact bacterial cells with antisera. Several different proteins, ranging in apparent molecular weight from 33,000 to 160,000, were shown to be accessible to antibody on the cell surface of this pathogen.

‣ Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis.

Sturgill-Koszycki, S; Schaible, U E; Russell, D G
Tipo: Artigo de Revista Científica
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The success of Mycobacterium as a pathogen hinges on its ability to modulate its intracellular environment. Mycobacterium avium reside in vacuoles with limited proteolytic activity, maintain cathepsin D in an immature form and remain accessible to internalized transferrin. Artificial acidification of isolated phagosomes facilitated processing of cathepsin D, demonstrating that pH alone limits proteolysis in these vacuoles. Moreover, analysis of IgG-bead phagosomes at early time points during their formation indicates that these phagosomes also acquire LAMP 1 and cathepsin D prior to the accumulation of proton-ATPases, and are transiently accessible to sorting endosomes. This suggests that the anomolous distribution of endosomal proteins in M. avium-containing vacuoles results from their arrested differentiation in an early transitional stage through which all phagosomes pass.

‣ MicroRNAs Align With Accessible Sites in Target mRNAs

Pan, Weihua; Xin, Ping; Clawson, Gary A.
Tipo: Artigo de Revista Científica
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The importance of microRNAs (miRs) in control of gene expression is now clearly recognized. While individual microRNAs are thought to target hundreds of disparate mRNAs via imperfect base pairing, little is known about the characteristics of miR target sites. Here we show that the miRs can be aligned with empirically identified accessible sites in a target RNA (Cytokeratin 19, KRT), and that some of the aligned miRs functionally down-regulate KRT expression post-transcriptionally. We employed an RNase-H-based random library selection protocol to identify accessible sites in KRT RNA. We then aligned the Sanger Institute database collection of human miRs to KRT mRNA, and also aligned them using the web-based MicroInspector program. Most miRs aligned with the accessible sites identified empirically; those not aligned with the empirically identified sites also functioned effectively in RNase-H-based assays. Similar results were obtained with a second target RNA (Mammoglobin). Transient transfection assays established that some of the miRs which aligned with KRT significantly down-regulated it at the protein level, with no effect on RNA level. The functionally effective miRs aligned within the coding region of KRT, whereas a number of miRs which aligned with the 3′-untranslated region did not produce down-regulation.

‣ Requirements elicitation for designing an accessible chat; Captura de requisitos para el diseño de un chat accesible

Calvo, Rocío; Moreno, Lourdes; Iglesias, Ana
Fonte: Asociación de Técnicos de Informática (ATI) Publicador: Asociación de Técnicos de Informática (ATI)
Tipo: info:eu-repo/semantics/publishedVersion; info:eu-repo/semantics/article Formato: application/pdf
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The use of Mobile Devices (MD) is part of our diary life. People are used to use the MDs almost every day to communicate and collaborate with friends or colleagues in different environments such as work or education among others. This paper is focused on the use of this technology for collaborative learning contexts or Computer Supported Collaborative Learning (CSCL) environments. There are different tools which support CSCL like blogs, wikis or chats. However, most of the CSCL tools used present accessibility barriers which provoke that many people cannot use these useful learning tools. In concrete, this paper is focused on eliciting requirements for the design of an accessible chat as a synchronous CSCL tool for MDs in an accessible way. To achieve it, some guidelines and standards are considered as a reference to determine the requirements that a chat should have to be accessible. Moreover, the Scenario and Personas techniques are used to elicit the requirements from the point of view of users and using a User Centered Design (UCD) approach.; El uso de dispositivos móviles (DM) forma parte de nuestra vida diaria. Las personas están acostumbradas a usar los DMs frecuentemente para comunicarse y colaborar con amigos o compañeros de trabajo utilizándolos como herramientas colaborativas. Este artículo está centrado en el uso de esta tecnología en entornos de aprendizaje colaborativo asistido por ordenador o Computer Supported Collaborative Learning (CSCL) para DMs. En la actualidad...

‣ An Approach to User Interface Design of an Accessible User Agent

González, María; Moreno, Lourdes; Martínez, Paloma
Tipo: info:eu-repo/semantics/acceptedVersion; info:eu-repo/semantics/conferenceObject; info:eu-repo/semantics/bookPart
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The increase in rich and interactive content on the web has allowed the growth of the number and type of users that access them. This implies that such content should be accessible to anyone, including people with disabilities. Therefore, it should be accompanied with media alternatives (captions, audio description), which should be handled by an accessible user agent that provides support for them. This paper presents: 1) an approach with accessibility requirements following standards to include accessibility in a user agent for delivering accessible multimedia content, and based on it, 2) a conceptualization that provides an abstract user interface model with the ability to be integrated into the development process.; This research work is supported by the Research Network MAVIR (S2009/TIC-1542 (www.mavir.net/)). We thank the European project ITEA UsiXML to provide the documentation of the UsiXML specification.; Proceeding of: Conference on Software Development for Enhancing Accessibility and Fighting Info-exclusion (DSAI 2012), took place 19-22 July, 2012, in Douro Region, Portugal. The event web site is http://dsai2012.utad.pt/

‣ Públicos especiais: promoção do turismo acessível nas salinas/ Workshop; Públicos especiales: promoción del turismo accesible en las salinas/ Taller; Special public: the promotion of accessible tourism in saltpans/ Workshop; Publics spéciaux: promotion du tourisme accessible dans les marais salants/ Atelier

Martins, Filomena; Silva, Margarida Ferreira da; Albuquerque, Helena
Fonte: UA Editora Publicador: UA Editora
Português
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‣ Which way is up : towards accessible wayfinding in transit stations; Towards accessible wayfinding in transit stations

Leven, Dalia (Dalia Beth)
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 203 p.; 57524752 bytes; 57524083 bytes; application/pdf; application/pdf
Português
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Passengers' most frequent interaction with a rail transit system is at its stations, which represent the beginning, the end and sometimes the middle of transit trips. The design of these stations can greatly affect a user's travel experience by creating friendly, efficient, attractive environments that are inherently usable as transit stations. Many types of devices are necessary in these stations to help people navigate from one point to another within a transit system. Wayfinding devices are the elements, whether architectural or graphic, that provide information not only on how to navigate a station, but also how to use the services provided there. Because they provide such important information, these elements must be accessible to all potential passengers. This thesis used the structure of Systems Engineering to give a clear focus to the problem of design accessible wayfinding systems in transit stations. In order to create a comprehensive listing of design requirements for these systems, a detailed inventory of all potential user groups was developed. Following directly from this, a framework was developed that allows for easy cataloging of the design requirements for each of these groups.; (cont.) Three technical areas that are developed in this thesis cover all of the issues inherent in wayfinding design include content...

‣ Mapping of RNA accessible sites by extension of random oligonucleotide libraries with reverse transcriptase.

Allawi, H T; Dong, F; Ip, H S; Neri, B P; Lyamichev, V I
Tipo: Artigo de Revista Científica
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A rapid and simple method for determining accessible sites in RNA that is independent of the length of target RNA and does not require RNA labeling is described. In this method, target RNA is allowed to hybridize with sequence-randomized libraries of DNA oligonucleotides linked to a common tag sequence at their 5'-end. Annealed oligonucleotides are extended with reverse transcriptase and the extended products are then amplified by using PCR with a primer corresponding to the tag sequence and a second primer specific to the target RNA sequence. We used the combination of both the lengths of the RT-PCR products and the location of the binding site of the RNA-specific primer to determine which regions of the RNA molecules were RNA extendible sites, that is, sites available for oligonucleotide binding and extension. We then employed this reverse transcription with the random oligonucleotide libraries (RT-ROL) method to determine the accessible sites on four mRNA targets, human activated ras (ha-ras), human intercellular adhesion molecule-1 (ICAM-1), rabbit beta-globin, and human interferon-gamma (IFN-gamma). Our results were concordant with those of other researchers who had used RNase H cleavage or hybridization with arrays of oligonucleotides to identify accessible sites on some of these targets. Further...

‣ Making our offices universally accessible: guidelines for physicians

Jones, K E; Tamari, I E
Tipo: Artigo de Revista Científica
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OBJECTIVE: To develop recommendations for office-based physicians who wish to make their offices accessible to all patients. OPTIONS: Include taking steps to make offices more accessible, or not; offices may be accessible to varying degrees. OUTCOMES: Outcomes of accessibility involve patient-care, economic, ethical and legal issues. Stakeholders in these outcomes include patients, physicians, government and society. EVIDENCE: Data were obtained from a series of searches of MEDLINE, CINAHL and Healthstar (previously Health) databases for articles on disability and family medicine, primary (health) care and family practice, and on access and offices, and health services accessibility, and from a telephone survey of 50 stakeholders. VALUES: A high value was placed on services to persons with disabilities and on stakeholder input. Universal accessibility was valued as an overall goal; improved accessibility was also highly valued. BENEFITS, HARMS AND COSTS: Benefits to patients include improved access to care as guaranteed by the Canada Health Act and in keeping with provincial Human Rights Codes. Benefits to physicians include contact with a broader patient population and freedom from fear of litigation. Costs of improved accessibility vary depending on individual circumstances and on whether an office is being built or renovated; some improvement costs are minimal. RECOMMENDATIONS: All physicians should take measures to improve practice accessibility. Improved access should be considered in each of the following areas: transportation and entrance to the facility...

‣ Locking of accessible information and implications for the security of quantum cryptography

Koenig, Robert; Renner, Renato; Bariska, Andor; Maurer, Ueli
Tipo: Artigo de Revista Científica
Português
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The unconditional security of a quantum key distribution protocol is often defined in terms of the accessible information, that is, the maximum mutual information between the distributed key S and the outcome of an optimal measurement on the adversary's (quantum) system. We show that, even if this quantity is small, certain parts of the key S might still be completely insecure when S is used in applications, such as for one-time pad encryption. This flaw is due to a locking property of the accessible information: one additional (physical) bit of information might increase the accessible information by more than one bit.; Comment: 5 pages; minor changes

‣ Accessible images revisited

Brooke-Taylor, Andrew; Rosický, Jiří
Tipo: Artigo de Revista Científica
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We extend and improve the result of Makkai and Par\'e that the powerful image of any accessible functor F is accessible, assuming there exists a sufficiently large strongly compact cardinal. We reduce the required large cardinal assumption to the existence of {\mu}-strongly compact cardinals for sufficiently large {\mu}, and also show that under this assumption the {\lambda}-pure powerful image of F is accessible. From the first of these statements, we obtain that the tameness of every Abstract Elementary Class follows from a weaker large cardinal assumption than was previously known. We provide two ways of employing the large cardinal assumption to prove each result - one by a direct ultraproduct construction and one using the machinery of elementary embeddings of the set-theoretic universe.; Comment: 11 pages

‣ Variational approach vs accessible soliton approximation in nonlocal nonlinear media

Aleksić, Branislav N.; Aleksić, Najdan B.; Petrović, Milan S.; Strinić, Aleksandra I.; Belić, Milivoj R.
Tipo: Artigo de Revista Científica
Português
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We discuss differences between the variational approach to solitons and the accessible soliton approximaion in a highly nonlocal nonlinear medium. We compare results of both approximations by considering the same system of equations in the same spatial region, under the same boundary conditions. We also compare these approximations with the numerical solution of the equations. We find that the variational highly nonlocal approximation provides more accurate results and as such is more appropriate solution than the accessible soliton approximation. The accessible soliton model offers a radical simplification in the treatment of highly nonlocal nonlinear media, with easy comprehension and convenient parallels to quantum harmonic oscillator, however with a hefty price tag: a systematic numerical discrepancy of up to 100% with the numerical results.

‣ The Accessible Lasso Models

Harris, Naftali; Sepehri, Amir
Tipo: Artigo de Revista Científica
A new line of research on the lasso exploits the beautiful geometric fact that the lasso fit is the residual from projecting the response vector $y$ onto a certain convex polytope. This geometric picture also allows an exact geometric description of the set of accessible lasso models for a given design matrix, that is, which configurations of the signs of the coefficients it is possible to realize with some choice of $y$. In particular, the accessible lasso models are those that correspond to a face of the convex hull of all the feature vectors together with their negations. This convex hull representation then permits the enumeration and bounding of the number of accessible lasso models, which in turn provides a direct proof of model selection inconsistency when the size of the true model is greater than half the number of observations.