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‣ O papel da imunofluorescência direta na fisiopatologia e no diagnóstico diferencial da estomatite aftóide recorrente; The role of immunoflorescence in the physiopathology and differential diagnosis of recurrent aphthous stomatitis

WILHELMSEN, Niels Salles Willo; WEBER, Raimar; MIZIARA, Ivan Dieb
Fonte: ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial Publicador: ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
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A estomatite aftóide recorrente é doença caracterizada por aparecimento periódico de aftas na mucosa oral, cuja etiologia e fisiopatologia não estão bem explicadas. Estudos recentes com imunofluorescência direta mostram resultados controversos. Alguns revelam que o distúrbio básico está relacionado à imunidade humoral, enquanto outros apontam alterações da imunidade celular. Formas atípicas de estomatite aftóide podem fazer diagnóstico diferencial com doenças vésico-bolhosas como pênfigo vulgar. OBJETIVO: Verificar a presença de imunecomplexos na mucosa de pacientes com estomatite aftóide e utilidade do método no diagnóstico diferencial com dermatopatias bolhosas. CASUÍSTICA E MÉTODO: 23 pacientes portadores de estomatite aftóide, de modo prospectivo, foram incluídos no estudo. Todos foram submetidos à biópsia de mucosa sob anestesia local para retirada de dois fragmentos. Um deles foi enviado para exame histológico e, outro, para ser realizada a imunofluorescência direta. RESULTADOS: As 23 amostras no exame histológico revelaram processo inflamatório inespecífico ulcerado. As amostras enviadas para imunofluorescência resultaram negativas e apenas uma revelou presença de complemento em membrana basal. CONCLUSÃO: Baseado em nossos resultados...

‣ Psychological stress and recurrent aphthous stomatitis

GALLO, Camila de Barros; MIMURA, Maria Angela Martins; SUGAYA, Norberto Nobuo
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
69.07668%
INTRODUCTION AND OBJECTIVES: Recurrent aphthous stomatitis (RAS) is the most common type of ulcerative disease of the oral mucosa. Despite its worldwide occurrence and the extensive amount of research that has been devoted to the subject, the etiology of RAS remains unclear. Nevertheless, several hereditary, nutritional, infectious and psychological factors have been associated with RAS. The aim of this case-control study was to assess the influence of psychological stress on the manifestation of RAS. METHOD: Fifty patients were enrolled in the trial. Twenty-five RAS patients constituted the study group and another 25 non-RAS patients who were similarly matched for sex, age and socioeconomic status constituted the control group. Each patient was evaluated in terms of the four domains of stress (emotional, physical, social and cognitive) using an internationally validated questionnaire, which was comprised of 59 items and measured the frequency and intensity of stress symptoms. The RAS group was interviewed during an active RAS episode. Completed questionnaires were submitted to proper analytical software and interpreted by an expert psychologist. RESULTS: There was a higher level of psychological stress among RAS group patients when compared to the control group (P < 0.05). CONCLUSION: Psychological stress may play a role in the manifestation of RAS; it may serve as a trigger or a modifying factor rather than being a cause of the disease.; (FAPESP) São Paulo Research Foundation

‣ Expressão de receptores Toll-Like (2, 4 e 7) em células do sangue e da mucosa oral de pacientes portadores de ulceração aftosa recorrente; Toll-like receptors expression in peripheral blood and oral mucosa of recurrent aphthous stomatitis

Gallo, Camila de Barros
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 03/09/2008 Português
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A ulceração aftosa recorrente (UAR) é uma das lesões mais freqüentes da cavidade bucal, comprometendo a qualidade de vida de seus portadores muitas vezes de maneira importante. Embora sua etiopatogenia ainda não esteja esclarecida, vários fatores têm sido consistentemente relacionados ao surgimento da UAR, especialmente alterações imunológicas e genéticas, conduzindo grande parte da investigação científica para esses campos do conhecimento. Os receptores Toll-Like (TLR) reconhecem produtos moleculares derivados, principalmente, de microrganismos, desencadeando a resposta inflamatória protetora. Entretanto, anormalidades em sua função podem estar relacionadas ao desenvolvimento de doenças, pela ativação aberrante do sistema imunológico. A proposta desta investigação foi a de se avaliar a expressão dos receptores TLR-2, TLR-4 e TLR-7 através do RT-PCR em tempo real, a partir de amostras de sangue periférico e da mucosa bucal de população portadora de UAR e indivíduos controles sadios. Cinco pacientes UAR e quatro controles voluntários compuseram a casuística estudada, sendo submetidos à biópsia de lesões de UAR ou de mucosa de revestimento sadia. Na mesma sessão os pacientes tiveram sangue coletado por venopunção. Posteriormente...

‣ Estudo preliminar da correlação entre antígenos de histocompatibilidade (HLA) e estomatite aftóide recorrente em população brasileira; Preliminary study the correlation between human histocompatibility antigens (HLA) and recurrent aphthous stomatitis

Wilhelmsen, Niels Salles Willo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 11/02/2008 Português
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INTRODUÇÃO: A Estomatite Aftóide Recorrente (EAR) é uma doença oral com incidência em 20% da população mundial, caracterizada por úlceras mucosas de caráter recidivante. O seu diagnóstico baseia-se principalmente na história clínica do paciente. Hereditariedade pode ser um fator de risco para a doença. Entretanto, os estudos disponíveis não são conclusivos quanto aos resultados obtidos, variando segundo a população estudada. OBJETIVOS: Neste trabalho tipificamos moléculas HLA de classe I e de classe II e avaliamos a freqüência destas moléculas em 31 pacientes, da cidade de São Paulo, portadores de Estomatite Aftóide Recorrente bem como em seus subgrupos (minor, major e herpetiforme), comparando com grupo controle, composto de 961 pacientes saudáveis. CASUÍSTICA E MÉTODOS: Prospectivamente, 58 pacientes com suspeita diagnóstica de Estomatite Aftóide Recorrente no período de fevereiro de 2004 a maio de 2006, foram estudados. Estes pacientes foram submetidos a protocolo de exames e, daqueles que obedeceram os critérios de inclusão, foi extraído o Ácido Desoxi Ribonucléico (DNA), por meio de amostra de 10 ml de sangue total periférico, com o fim de proceder a tipificação HLA por Reação de Polimerização em Cadeia. RESULTADO: Nos pacientes portadores de Estomatite Aftóide Recorrente do tipo minor encontramos as freqüências HLA A33 e B35...

‣ Spongy film of cellulosic polysaccharide as a dressing for aphthous stomatitis treatment in rabbits

Teixeira,Fernanda Mossumez Fernandes; Pereira,Márcia de Figueiredo; Ferreira,Nara Lins Gomes; Miranda,Guilherme Marcelino de; Aguiar,José Lamartine de Andrade
Fonte: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia Publicador: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2014 Português
Relevância na Pesquisa
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PURPOSE: To develop an experimental model of acute inflammation, like aphthous ulcers, in oral cavity of rabbits, and also, to evaluate the results of the application of a polysaccharide spongy film of molasses from sugar cane as assist treatment in the healing process. METHODS: Twenty adult rabbits weighting between 2.5 kg and 3.9 kg were divided into two groups: experimental and control infected ulcers were induced on the jugal mucosa by surgical excision. They were treated at the experimental group by curettage and dressing with spongy film of cellulosic polysaccharide film, whereas saline solution was used in the control group. Temporal evolution of the healing area, histopathology and bacteriological analysis were used to evaluate the healing process on the 3rd (D3), 7th (D7) and 11th days (D11). RESULTS: The healing time and bacteriological study showed no statistical differences on the group means. Analyzing the histopathology of the experimental group we verified epithelial hyperplasia from D3 to D11, instead in the control group there was a greater clutter of the epithelial cells from the D3 to D11. CONCLUSION: The experimental model used caused aphthous ulcers and the polysaccharide sponge film can be used as an aid in the symptomatic treatment and healing of the ulcerative lesions of the oral mucosa.

‣ Psychological stress and recurrent aphthous stomatitis

Gallo,Camila de Barros; Mimura,Maria Angela Martins; Sugaya,Norberto Nobuo
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2009 Português
Relevância na Pesquisa
69.07668%
INTRODUCTION AND OBJECTIVES: Recurrent aphthous stomatitis (RAS) is the most common type of ulcerative disease of the oral mucosa. Despite its worldwide occurrence and the extensive amount of research that has been devoted to the subject, the etiology of RAS remains unclear. Nevertheless, several hereditary, nutritional, infectious and psychological factors have been associated with RAS. The aim of this case-control study was to assess the influence of psychological stress on the manifestation of RAS. METHOD: Fifty patients were enrolled in the trial. Twenty-five RAS patients constituted the study group and another 25 non-RAS patients who were similarly matched for sex, age and socioeconomic status constituted the control group. Each patient was evaluated in terms of the four domains of stress (emotional, physical, social and cognitive) using an internationally validated questionnaire, which was comprised of 59 items and measured the frequency and intensity of stress symptoms. The RAS group was interviewed during an active RAS episode. Completed questionnaires were submitted to proper analytical software and interpreted by an expert psychologist. RESULTS: There was a higher level of psychological stress among RAS group patients when compared to the control group (P < 0.05). CONCLUSION: Psychological stress may play a role in the manifestation of RAS; it may serve as a trigger or a modifying factor rather than being a cause of the disease.

‣ Laryngeal manifestations in atypical recurrent aphthous stomatitis

Miziara,Ivan Dieb; Costa,Katia Cristina; Mahmoud,Ali; Weber,Raimar; Wilhelmsen,Niels Salles Willo; Imamura,Rui
Fonte: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial Publicador: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2009 Português
Relevância na Pesquisa
59.134395%
Recurrent aphthoid stomatitis is characteristically observed in children and adolescents in the form of painful relapsing ulcers in the oral mucosa unaccompanied by evidences of systemic disease. The ulcers appear every one or two weeks for at least one entire year. Some patients suspected for recurrent aphthoid stomatitis develop lesions in atypical sites - mainly in the larynx - concurrently to the ones found in the oral mucosa. AIM: this study aims to describe a series of recurrent aphthoid stomatitis patients with atypical laryngeal injuries. Study design: this is a case series study. MATERIALS AND METHOD: patients diagnosed with recurrent aphthoid stomatitis with oral mucosa ulcers and laryngeal symptoms without altered lab test results and no evidence of systemic disease underwent fibroscopic examination, oral and laryngeal biopsies, followed by specimen evaluation by direct immunofluorescence. RESULTS: all six patients in this series had acute and chronic inflammatory processes according to pathology studies and negative direct immunofluorescence test results. CONCLUSION: laryngeal involvement in recurrent aphthoid stomatitis is rare. Therefore, during diagnostic examination thorough clinical history and meticulous physical examination accompanied by fibroscopic examination are necessary. When atypical lesions are found...

‣ Role of mucosal injury in initiating recurrent aphthous stomatitis.

Wray, D; Graykowski, E A; Notkins, A L
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 12/12/1981 Português
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The buccal mucosa of 30 patients with recurrent aphthous stomatitis and 15 healthy controls was injured by suture and penetration with a tenaculum and a hypodermic needle and each of the six puncture wounds produced monitored for up to seven days for the development of ulcers. Altogether 26 lesions were induced in 13 patients, whereas none occurred in the controls (p less than 0.001). Sutures caused most of the lesions (15), and those so induced had a mean maximum diameter of 2.3 mm and lasted for an average of four days. Ulcers induced mechanically were clinically indistinguishable from those usually seen in the patients, except that they were generally smaller and healed more quickly. These findings confirm that mechanically induced injury of the oral mucosa may cause ulceration in people susceptible to aphthous stomatitis. Such a procedure may therefore be helpful in identifying subsets of patients.

‣ Levamisole treatment of a child with severe aphthous stomatitis and neutropenia.

Verhaegen, H.; De Crée, J.; De Cock, W.; Brugmans, J.
Fonte: BMJ Group Publicador: BMJ Group
Tipo: Artigo de Revista Científica
Publicado em /08/1976 Português
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The treatment of a 12-year-old girl with a lifelone history of recurrent infections and aphthous stomatitis is reported. A profound neutropenis, first noted at the age of 2 years, occurring at least every month was observed together with multiple mouth ulcers a sore throat and swelling of the jugular glands. Levamisole, originally described as an anthelmintic, has a beneficial effect on the symptoms of recurrent aphthous stomatitis. After levamisole treatment aphthous stomatitis was milder and in the 1-year follow-up period the patient was asymptomatic several times during a phase of obvious neutrophil depression. The child no longer complained of a sore throat with swelling of the jugular glands and the recurrent staphylococcal infections of the skin disappeared. After therapy a marked increase in monocytes at the moment of neutropenia was observed.

‣ The role of Helicobacter pylori in the development of recurrent aphthous stomatitis: SEPAHAN systematic review no. 9

Afghari, Parastoo; Khazaei, Saber; Kazemi, Shantia; Savabi, Omid; Keshteli, Ammar Hassanzadeh; Adibi, Peyman
Fonte: Medknow Publications & Media Pvt Ltd Publicador: Medknow Publications & Media Pvt Ltd
Tipo: Artigo de Revista Científica
Publicado em /12/2011 Português
Relevância na Pesquisa
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Microbial factors may play a role in the pathogenesis of recurrent aphthous stomatitis (RAS). Because of similarities in the characteristics of peptic ulcers and oral aphthous ulcers, it seems reasonable to hypothesize that Helicobacter pylori (H. pylori) could play a role in the development of RAS. The aim of the present study was to determine the relationship between H. pylori and RAS using the results obtained in other related studies. In the present systematic review, all of the relevant papers up to December 2011 were screened. The search was done using PubMed and the Cochrane library and out of 33, 9 articles were selected via the keywords of stomatitis, aphthous and H. pylori. Nine of the studies met the inclusion criteria. Among the selected articles, 6 were inconsistent with the association of H. pylori infection and RAS and 3 agreed to this assumption. The results of the literature indicate that there is no association between H. pylori infection and recurrent aphthous stomatitis.

‣ Recurrent aphthous stomatitis: genetic aspects of etiology

Ślebioda, Zuzanna; Szponar, Elżbieta; Kowalska, Anna
Fonte: Termedia Publishing House Publicador: Termedia Publishing House
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
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Recurrent aphthous stomatitis (RAS; recurrent aphthous ulcers – RAU; canker sores) is a chronic inflammatory, ulcerative condition of the oral mucosa. Its prevalence in the general population ranges between 5% and 20%, depending on the method and group studied. The etiopathogenesis of the disease is considered to be multifactorial, but remains still not fully understood. In patients with RAS, an enhanced immunologic response occurs to some trigger factors that may include: mechanical injury, stress or bacterial and viral antigens. Higher prevalence of aphthae in relatives may also indicate the genetic background of the condition. The inheritance of some specific gene polymorphisms, especially those encoding proinflammatory cytokines, which play a role in the formation of aphthous ulcer, may predispose family members to RAS. The purpose of this paper was to present the main clinical features of recurrent aphthous stomatitis, epidemiologic data and crucial etiopathogenetic factors with a special emphasis on genetic background of the condition.

‣ Remission of severe aphthous stomatitis of celiac disease with etanercept

Hasan, Adey; Patel, Hiren; Saleh, Hana; Youngberg, George; Litchfield, John; Krishnaswamy, Guha
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 24/12/2013 Português
Relevância na Pesquisa
49.07668%
Celiac disease is a common autoimmune disease triggered by gluten-containing foods (wheat, barley and rye) in genetically predisposed individuals. We present a patient with celiac disease complicated by severe aphthous stomatitis resulting in impairing swallowing, chewing and speaking. This led to weight loss, psychosocial problems as well as inability to perform her work. A variety of topical and systemic medications used resulted in either no improvement or only partial alleviation of the patient’s symptoms. After informed consent, etanercept was initiated and resulted in complete remission of aphthous stomatitis, decrease in arthralgia and fatigue and considerable improvement in her quality of life. The use of newer biological agents for selected and severe manifestations of celiac disease may lead to improved morbidity in these patients, but more studies are needed to determine long-term efficacy as well as safety of these drugs in the mucosal and/or systemic complications of this disease.

‣ Perfil hematológico e níveis de vitamina B12, ferro e ácido fólico de pacientes com ulceração aftosa recorrente; Hematologic status and vitamin B12, iron and folic acid levels in patients with recurrent aphthous stomatitis

Giacomini, Alexandre; Soares, Lívia Prates; Yurgel, Liliane Soares; Cherubini, Karen; Figueiredo, Maria Antonia Zancanaro; Salum, Fernanda Gonçalves
Fonte: Universidade de Passo Fundo; Porto Alegre Publicador: Universidade de Passo Fundo; Porto Alegre
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
69.253955%
A ulceração aftosa recorrente (UAR) é uma das doenças mais comuns da mucosa bucal. Apesar das constantes investigações, sua etiologia permanece desconhecida e uma abordagem terapêutica curativa ainda não existe. O presente trabalho teve por objetivo investigar o perfil hematológico, os níveis séricos de vitamina B12, de ácido fólico e de ferro de pacientes com UAR e comparálos com os de indivíduos de controle. Para tanto, foram incluídos neste estudo quarenta pacientes com UAR e quarenta indivíduos de controle sem histórico conhecido da doença, emparelhados por sexo e idade. Os prontuários dos pacientes foram analisados, bem como os resultados dos exames laboratoriais: contagem de eritrócitos, hematócrito, volume corpuscular médio, níveis de hemoglobina, de vitamina B12, de ácido fólico e de ferro. Dez por cento dos pacientes com UAR apresentaram anemia e 7,5% exibiram deficiência de vitamina B12 e de ácido fólico. Em 12,5% dos casos foi observada deficiência de ferro. Não houve diferença significativa entre os grupos quanto às variáveis hematológicas e nutricionais investigadas, apesar de os pacientes com UAR terem exibido níveis inferiores de vitamina B12. Conclui-se que as alterações hematológicas e nutricionais analisadas não exibiram associação com a UAR. Entretanto...

‣ Periodic fever with aphthous stomatitis, pharyngitis and adenitis: report of 21 cases.; Síndrome PFAPA (febre periódica, estomatite aftosa, faringite, adenite): análise retrospectiva de 21 casos.

Sampaio, Isabel; Unidade de Infecciologia Pediátrica, Serviço de Pediatria, Hospital de Santa Maria, Lisboa, Portugal.; Marques, José Gonçalo
Fonte: Ordem dos Médicos Publicador: Ordem dos Médicos
Tipo: info:eu-repo/semantics/article; article; article; info:eu-repo/semantics/publishedVersion Formato: application/pdf
Publicado em 28/02/2011 Português
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PFAPA syndrome (Periodic Fever, Aphthous stomatitis, Pharyngitis, Adenitis) is a benign sporadic syndrome of unknown cause and an important diagnosis to consider in the child with recurrent fever and tonsillitis. Objectives: To describe the presentation, age of onset, time until diagnosed, episode duration, frequency of typical and atypical symptoms, clinical course after diagnosis and response to treatment in a case series of children with PFAPA.Case series of children with PFAPA referred to our consult over an eight-year period (from May 2001 to May 2009). Data were collected from medical records and telephone calls.We included 21 patients with PFAPA, with age of onset between 6 months and 5 years (median 24 months). Diagnosis was established 4 months to 3 years after onset of crises (median 24 months). Episodes recurred every 2 to 6 weeks (median 30 days), and consisted in 3 to 10 days (median 4,5 days) of fever (21/21), pharyngitis (21/21), cervical adenitis (19/21), and aphthous stomatitis (16/21). Atypical symptoms were reported sporadically and without clinical severity: abdominal pain (8 patients), nauseas/vomits (3 patients), arthralgia (3 patients), hepatosplenomegaly (1 patient), lactose intolerance (1 patient). Eighteen patients received treatment with one dose of prednisolone with rapid symptomatic relief. In two patients subsequent crises became more frequent for a short period of time and then returned to monthly periodicity. Seven treated patients experienced less frequent episodes and in four of them this occurred after diagnosis but before first dose of prednisolone. In the three untreated patients the crises bécame rare and treatment was not prescribed. Tonsillectomy was performed in two patients and in one the monthly episodes reappeared five months after the procedure.In spite including a small number of patients...

‣ Correlation between histocompatibility antigens and recurrent aphthous stomatitis in the brazilian population; Estudo da associação entre antígenos de histocompatibilidade e estomatite aftoide recorrente em população brasileira

WILHELMSEN, Niels Salles Willo; WEBER, Raimar; MONTEIRO, Francisco; KALIL, Jorge; MIZIARA, Ivan Dieb
Fonte: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial Publicador: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
69.87213%
Recurrent aphthous stomatitis is a common oral mucosa disorder that affects 20% of the world's population, characterized by recurring painful ulcers in the mouth. The diagnosis is primarily based on the patient's clinical history. Inheritance may pose as a risk factor for the disease; however, the studies available are inconclusive as to the results attained, and they vary according to the population studied. AIM: to typify class I and class II HLA molecules and to assess how frequent these molecules are present in the Brazilian population with Recurrent Aphthous Stomatitis, compared to healthy controls. MATERIALS AND METHODS: In this prospective, cross-sectional and investigative study, thirty one patients with diagnostic hypothesis of recurrent aphthous stomatitis were seen from February of 2004 to May of 2006. We obtained the DNA from those patients who matched the inclusion criteria and typified their HLA by PCR. RESULTS: In those patients with Recurrent Minor Aphthous Stomatitis we found statistically significant occurrences of HLA-A33 and HLA-B35. CONCLUSION: HLA-A33 and HLA-B35 may be associated with recurrent minor aphthous stomatitis in the Brazilian's population.; A Estomatite Aftoide Recorrente é uma doença oral com incidência em 20% da população mundial...

‣ Assessment of Serum Enzymatic Antioxidant Levels in Patients with Recurrent Aphthous Stomatitis: A Case Control Study

Gupta, Ishita; Shetti, Arvind; Keluskar, Vaishali; Bagewadi, Anjana
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
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Background and Aim. Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder characterized by recurrent, painful oral aphthae. Despite extensive research, the exact etiology of RAS remains elusive. Recently oxidant-antioxidant imbalance of the body has been implicated in the pathogenesis of recurrent aphthous stomatitis. Thus, the aim of the study was to evaluate the enzymatic antioxidant levels in patients with recurrent aphthous stomatitis. Materials and Methods. The serum levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were measured in 30 patients with recurrent aphthous stomatitis and compared to the control group, which included 30 healthy subjects. Student's t-test was performed for statistical evaluation. Results. The mean levels of superoxide dismutase (130.2 ± 15.94 U/mL) and glutathione peroxidase (3527.93 ± 488.32 U/L) were found to be significantly lower in study group as compared to control group (211.9 ± 20.93 U/mL, 8860.93 ± 1105.31 U/L, resp.) (P = 0.000) while level of catalase in study group was significantly higher when compared to control group (10981.00 ± 1018.07 U/mL versus 9764.00 ± 1621.19 U/mL) (P = 0.000). Conclusion. Enzymatic antioxidant system is impaired in recurrent aphthous stomatitis patients and seems to play a crucial role in its pathogenesis.

‣ Impaired lymphocyte stimulation by some streptococcal antigens in patients with recurrent aphthous stomatitis and rheumatic heart disease*

Francis, T. C.; Oppenheim, J. J.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /04/1970 Português
Relevância na Pesquisa
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The effects of pathogenic and non-pathogenic streptococci, streptococcal cell wall products, and phytohaemagglutinin on human peripheral leucocyte cultures from four groups were studied. These groups were: (1) normals, (2) patients with aphthous stomatitis, (3) patients with Behçet's and (4) patients with rheumatic heart disease. The degree of lymphocyte stimulation by these materials was measured by uptake of [3H]thymidine into DNA in vitro. In normals, patients with aphthous stomatitis, and Behçet's disease, the human pathogenic group A streptococci produced significantly greater stimulation of DNA synthesis than did the less pathogenic non-haemolytic streptococci. Lymphocytes from patients with aphthous stomatitis showed significantly less stimulation of DNA synthesis than comparable normal controls when exposed to heat-killed Streptococcal 2A, organisms which have been implicated in the disease. Human pathogenic strains of group A streptococci which have been implicated in rheumatic heart disease stimulated significantly less in vitro proliferation of lymphocytes from patients with rheumatic heart disease than of those from a comparable group of normal controls. This hypo-responsiveness persisted when the patients' lymphocytes were cultured in normal human serum. The chronically ill Behçet's patients' lymphocytes did not differ significantly from normal. These observations indicate a deficiency of the cellular response of certain patients to antigens from organisms thought to be aetiologically related to their disease.

‣ Correlation between histocompatibility antigens and recurrent aphthous stomatitis in the brazilian population

Wilhelmsen,Niels Salles Willo; Weber,Raimar; Monteiro,Francisco; Kalil,Jorge; Miziara,Ivan Dieb
Fonte: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial Publicador: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2009 Português
Relevância na Pesquisa
69.87213%
Recurrent aphthous stomatitis is a common oral mucosa disorder that affects 20% of the world's population, characterized by recurring painful ulcers in the mouth. The diagnosis is primarily based on the patient's clinical history. Inheritance may pose as a risk factor for the disease; however, the studies available are inconclusive as to the results attained, and they vary according to the population studied. AIM: to typify class I and class II HLA molecules and to assess how frequent these molecules are present in the Brazilian population with Recurrent Aphthous Stomatitis, compared to healthy controls. MATERIALS AND METHODS: In this prospective, cross-sectional and investigative study, thirty one patients with diagnostic hypothesis of recurrent aphthous stomatitis were seen from February of 2004 to May of 2006. We obtained the DNA from those patients who matched the inclusion criteria and typified their HLA by PCR. RESULTS: In those patients with Recurrent Minor Aphthous Stomatitis we found statistically significant occurrences of HLA-A33 and HLA-B35. CONCLUSION: HLA-A33 and HLA-B35 may be associated with recurrent minor aphthous stomatitis in the Brazilian's population.

‣ Etiologia e tratamento da estomatite aftosa recorrente - revisão de literatura; ; Etiology and treatment of recurrent aphthous stomatitis - literature review

Costa, Gilliene B. F.; Castro, Jurema F. L.
Fonte: Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto Publicador: Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 30/03/2013 Português
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Objetivos: Descrever as características e os principais achados relatados na literatura quanto à provável etiologia e tratamentos das lesões causadas pela Estomatite Aftosa Recorrente (EAR). Métodos:Realizou-se a revisão da literatura nas bases de dados PubMed, SciELO e LILACS, no período de tempo do ano de 2005 a 2012. Utilizaram-se, isoladamente e em combinação, os descritores a seguir: Stomatitis, Aphthous; Oral Ulcer; Risk Factors e Therapeutics. Resultados: A patogênese da estomatite aftosa recorrente ainda continua indefinida, havendo confirmação científica quanto à sua relação com fatores imunológicos e mutações genéticas. Os procedimentos realizados e recursos utilizados para o tratamento das lesões são paliativos, no intuito de aliviar a dor, não existindo uma terapêutica de cura. Conclusão: Por ser a etiologia da EAR ainda incerta, o tratamento atual das lesões é bastante variado,e baseia-se no alívio dos sintomas da doença, variando, desde o uso de produtos naturais, como a própolis, passando por anti-inflamatórios, até à aplicação do laser de baixa potência.; ; Objectives: To describe the characteristics and key findings reported in the literature about the possible etiology and treatment of lesions caused by Recurrent Aphthous Stomatitis (RAS). Methods: It was conducted a literature review in the databases PubMed...

‣ Psychological stress and recurrent aphthous stomatitis

Gallo, Camila de Barros; Mimura, Maria Angela Martins; Sugaya, Norberto Nobuo
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2009 Português
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INTRODUCTION AND OBJECTIVES: Recurrent aphthous stomatitis (RAS) is the most common type of ulcerative disease of the oral mucosa. Despite its worldwide occurrence and the extensive amount of research that has been devoted to the subject, the etiology of RAS remains unclear. Nevertheless, several hereditary, nutritional, infectious and psychological factors have been associated with RAS. The aim of this case-control study was to assess the influence of psychological stress on the manifestation of RAS. METHOD: Fifty patients were enrolled in the trial. Twenty-five RAS patients constituted the study group and another 25 non-RAS patients who were similarly matched for sex, age and socioeconomic status constituted the control group. Each patient was evaluated in terms of the four domains of stress (emotional, physical, social and cognitive) using an internationally validated questionnaire, which was comprised of 59 items and measured the frequency and intensity of stress symptoms. The RAS group was interviewed during an active RAS episode. Completed questionnaires were submitted to proper analytical software and interpreted by an expert psychologist. RESULTS: There was a higher level of psychological stress among RAS group patients when compared to the control group (P < 0.05). CONCLUSION: Psychological stress may play a role in the manifestation of RAS; it may serve as a trigger or a modifying factor rather than being a cause of the disease.