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‣ O discurso da liberdade na pós-revolução. Análise de um discurso comemorativo do 25 de abril em 1977; The discourse of freedom in post-revolution. Analysis of a 1977commemorative speech on April 25th

Ramos, Rui Lima
Fonte: Universidade do Minho Publicador: Universidade do Minho
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
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36.445823%
O presente estudo recorre ao quadro conceptual e aos instrumentos metodológicos da Análise do Discurso para a identificação e descrição dos traços essenciais do discurso do Presidente da Assembleia da República na sessão solene parlamentar de comemoração do 25 de Abril de 1974, em 26 de abril de 1977, na primeira sessão da primeira legislatura da Assembleia da República em regime democrático. O estudo centra-se nas questões enunciativas, no ethos do enunciador e nas mais relevantes isotopias que perpassam o discurso. Conclui que este discurso se constrói sobre uma visão pessoal particularmente marcada, dando a ver o conjunto de valores que o seu enunciador assume como edificadores do Portugal novo saído da revolução de 25 de abril de 1974 e os compromissos que assume perante o povo português.; This study draws on the conceptual framework and methodological tools of discourse analysis for the identification and description of the essential features of the Parliament President’s speech at the solemn parliamentary session commemorating April 25th 1974, on April 26th 1977 in the first session of the first legislature of the Parliament in democracy. The study focuses on the enunciative issues, the ethos of the enunciator and the most relevant isotopies that underlie his speech. We conclude that this discourse is constructed on a particularly marked personal vision...

‣ Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL

Chiu, April; Xu, Weifeng; He, Bing; Dillon, Stacey R.; Gross, Jane A.; Sievers, Eric; Qiao, Xugang; Santini, Paul; Hyjek, Elizabeth; Lee, Joong-won; Cesarman, Ethel; Chadburn, Amy; Knowles, Daniel M.; Cerutti, Andrea
Fonte: American Society of Hematology Publicador: American Society of Hematology
Tipo: Artigo de Revista Científica
Publicado em 15/01/2007 Português
Relevância na Pesquisa
36.600732%
Hodgkin lymphoma (HL) originates from the clonal expansion of malignant Hodgkin and Reed-Sternberg (HRS) cells. These B-cell–derived elements constitute less than 10% of the tumoral mass. The remaining tissue is comprised of an inflammatory infiltrate that includes myeloid cells. Myeloid cells activate B cells by producing BAFF and APRIL, which engage TACI, BCMA, and BAFF-R receptors on the B cells. Here, we studied the role of BAFF and APRIL in HL. Inflammatory and HRS cells from HL tumors expressed BAFF and APRIL. Unlike their putative germinal center B-cell precursors, HRS cells lacked BAFF-R, but expressed TACI and BCMA, a phenotype similar to that of plasmacytoid B cells. BAFF and APRIL enhanced HRS cell survival and proliferation by delivering nonredundant signals via TACI and BCMA receptors through both autocrine and paracrine pathways. These signals caused NF-κB activation; Bcl-2, Bcl-xL, and c-Myc up-regulation; and Bax down-regulation, and were amplified by APRIL-binding proteoglycans on HRS cells. Interruption of BAFF and APRIL signaling by TACI-Ig decoy receptor, which binds to and neutralizes BAFF and APRIL, or by small-interfering RNAs targeting BAFF, APRIL, TACI, and BCMA inhibited HRS cell accumulation in vitro and might attenuate HL expansion in vivo.

‣ Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL and CD40L

Cols, Montserrat; Barra, Carolina M.; He, Bing; Puga, Irene; Xu, Weifeng; Chiu, April; Tam, Wayne; Knowles, Daniel M.; Dillon, Stacey R.; Leonard, John P.; Furman, Richard R.; Chen, Kang; Cerutti, Andrea
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
36.5819%
Chronic lymphocytic leukemia (CLL) is a clonal B cell disorder of unknown origin. Accessory signals from the microenvironment are critical for the survival, expansion and progression of malignant B cells. We found that the CLL stroma included microvascular endothelial cells (MVECs) expressing BAFF and APRIL, two TNF family members related to the T cell-associated B cell-stimulating molecule CD40 ligand (CD40L). Constitutive release of soluble BAFF and APRIL increased upon engagement of CD40 on MVECs by CD40L aberrantly expressed on CLL cells. In addition to enhancing MVEC expression of the CD40 receptor, leukemic CD40L induced cleavases that elicited intracellular processing of pro-BAFF and pro-APRIL proteins in MVECs. The resulting soluble BAFF and APRIL proteins delivered survival, proliferation, Ig gene-remodeling and differentiation signals by activating CLL cells through TACI, BAFF-R and BCMA receptors. BAFF and APRIL further amplified CLL cell survival by up-regulating the expression of leukemic CD40L. Inhibition of TACI, BCMA and BAFF-R expression on CLL cells, abrogation of CD40 expression in MVECs, or suppression of BAFF and APRIL cleavases in MVECs reduced the survival and diversification of malignant B cells. These data indicate that BAFF...

‣ McCarthy, ed., Love, Sex and Marriage (April Harper)

April Harper
Fonte: The Medieval Review Publicador: The Medieval Review
Tipo: Revisão
Português
Relevância na Pesquisa
36.280586%
April Harper, SUNY Oneonta, harpera@oneonta.edu

‣ Academic Senate Minutes of April 4, 2013

Gifford, Vivian
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Final Paper
Português
Relevância na Pesquisa
36.280586%
Academic Senate Minutes of April 4, 2013

‣ Academic Senate Agenda of April 4, 2013

AS Executive Committee
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Outros
Português
Relevância na Pesquisa
36.280586%
Academic Senate Agenda of April 4, 2013

‣ Academic Senate Agenda of April 18, 2013

AS Executive Committee
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Outros
Português
Relevância na Pesquisa
36.280586%
Academic Senate Agenda of April 18, 2013

‣ Academic Senate Agenda of April 25, 2013

AS Executive Committee
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Outros
Português
Relevância na Pesquisa
36.280586%
Academic Senate Agenda of April 25, 2013

‣ Academic Senate Minutes of April 18, 2013

Gifford, Vivian
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Final Paper
Português
Relevância na Pesquisa
36.280586%
Academic Senate Minutes of April 18, 2013

‣ Academic Senate Minutes of April 25, 2013

Gifford, Vivian
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Final Paper
Português
Relevância na Pesquisa
36.280586%
Academic Senate Minutes of April 25, 2013

‣ Proposed Revision to Policy E4 - Faculty Employment Policies - AS Discussion and Vote on April 14 2011

Faculty Affairs Committee
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Trabalho em Andamento
Português
Relevância na Pesquisa
36.280586%
Proposed Revision to Policy E4.0 (Faculty Employment Policies)for AS Discussion and Vote on April 14 2011

‣ Academic Senate Agenda for April 14, 2011

AS Executive Committee
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Outros
Português
Relevância na Pesquisa
36.280586%
Academic Senate Agenda for April 14 2011

‣ Academic Senate Minutes of April 24 2014

Richmond, Michael; Gifford, V.
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Final Paper
Português
Relevância na Pesquisa
36.280586%
Academic Senate Minutes of April 24 2014

‣ April 16, 2014 Institute Council Meeting Minutes

Rex, Katrina
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Minutes
Português
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36.280586%
April 16, 2014 Institute Council Meeting Minutes

‣ Academic Senate Agenda of April 17, 2014

AS Executive Committee
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Outros
Português
Relevância na Pesquisa
36.280586%
Academic Senate Agenda of April 17, 2014

‣ Academic Senate Agenda of April 24, 2014

AS Executive Committee
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Outros
Português
Relevância na Pesquisa
36.280586%
Academic Senate Agenda of April 24, 2014

‣ ICC Program Review Summary (April 28, 2011)

Border, Charlie
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Conferência ou Objeto de Conferência
Português
Relevância na Pesquisa
36.280586%
ICC Program Review Summary (April 28, 2011)

‣ Academic Senate Agenda for April 28, 2011

AS Executive Committee
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Outros
Português
Relevância na Pesquisa
36.280586%
Academic Senate Agenda for April 28, 2011

‣ Academic Senate Minutes of April 14, 2011

Goodwin, Latty; Gifford, V.
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Final Paper
Português
Relevância na Pesquisa
36.280586%
Academic Senate Minutes of April 14, 2011

‣ Revised Policy E7.0 (Draft of April 8, 2014) - For 4/17/2014 AS Meeting

Faculty Affairs Committee (FAC); Waterstram-Rich, Kristen FAC Chair
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Trabalho em Andamento
Português
Relevância na Pesquisa
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Revised Policy E7.0 (Draft of April 8, 2014) for April 17, 2014 AS Meeting