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‣ Correlates of changes in BMI of children from the Azores islands

Martins, D.; Maia, José A.R.; Seabra, André; Silva, R.G.; Lopes, Vítor P.; Katzmarzyk, P.; Beunen, G.
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
Português
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Objective: To model changes in body mass index (BMI), including its stability, and to investigate the association between physical activity, 1-mile run/walk and levels of gross motor coordination and BMI during 5 consecutive years. Design: A longitudinal study of children 6 years of age at baseline followed at annual intervals over 5 years. Subjects: A total of 285 children (143 boys and 142 girls) were enrolled in grade 1 (age 6 years) and followed through grade 5 (age 10 years). Measurements: BMI was recorded and physical activity was assessed by questionnaire, aerobic fitness was evaluated with the 1-mile run/walk and gross motor coordination was measured with the KTK test battery (Korperkoordination test fur Kinder). Multilevel modelling techniques were for the primary analysis. Results: Changes in BMI showed similar curvilinear trends in boys and girls, with ample inter-individual crossing trajectories that is, low tracking. Longitudinal changes in physical activity (PA) and aerobic fitness were not significantly associated with BMI-changes during the 5 years. Children who were more proficient in their motor coordination showed lower values of BMI during the 5 years. Conclusions: BMI trajectories of both boys and girls show low tracking of BMI-values. Considerable inter-individual variation exists both in baseline BMI-values and changes (velocity and acceleration) over time. PA and fitness were not associated with BMI-changes...

‣ Influence of socio-demographic issues in body mass index (bmi) of drug addicts in methadone maintenance treatment

Ferro-Lebres, Vera; Costa, Ana Filipa; Alves, Daniela; Custódio, Daniela; Natário, Liliana; Andrade, Fernando
Fonte: Wiley-Blackwell Publicador: Wiley-Blackwell
Tipo: Conferência ou Objeto de Conferência
Português
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The purpose of this study was to investigate the infl uence of social factors on the nutritional status of drug addicts. 60 drug addicts in methadone maintenance treatment of Integrated Response Center (CRI)of Bragança were evaluated. Nutritional assessment was performed by measuring the weight and height and then calculated the body mass index. The socio-demographic data were collected through a questionnaire constructed for this purpose. PASW 19.0 for Windows. The average body mass index (BMI) was 22.46 ± 3.36 kg/m2 and based on this parameter 13.3% were underweight, 65% normal weight, 20.0% overweight and 1.7% obesity grade I. BMI was signifi cantly higher in addicts who live with a spouse in relation to other housing contexts (p< 0.005). In terms of marital status, unmarried addicts had a significantly lower BMI compared to other situations. Individuals have an average of 4.10 ± 4.47 years of treatment and 78.3% performed less than 3 meals/day. The socio-demographic conditions must be taken into consideration in the process of intervention with this population. More studies must be performed in other to clarify other food behaviour variables in drug users populations.

‣ Relationship between B-Cell-specific moloney murine leukemia virus integration site 1 (BMI-1) and homologous recombination regulatory genes in invasive ductal breast carcinomas

da Silveira, Giorgia Gobbi; Oliveira-Costa, Joao Paulo; Soave, Danilo Figueiredo; Zanetti, Juliana Silva; Soares, Fernando Augusto; Ribeiro-Silva, Alfredo
Fonte: F HERNANDEZ; MURCIA Publicador: F HERNANDEZ; MURCIA
Tipo: Artigo de Revista Científica
Português
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B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is a Polycomb group protein that is able to induce telomerase activity, enabling the immortalization of epithelial cells. Immortalized cells are more susceptible to double-strand breaks (DSB), which are subsequently repaired by homologous recombination (HR). BRCA1 is among the HR regulatory genes involved in the response to DNA damage associated with the RAD51 protein, which accumulates in DNA damage foci after signaling H2AX, another important marker of DNA damage. Topoisomerase III beta (topoIII beta) removes HR intermediates before chromosomal segregation, preventing damage to cellular DNA structure. In breast carcinomas positive for BMI-1 the role of proteins involved in HR remains to be investigated. The aim of this study was to evaluate the association between BMI-1 and homologous recombination proteins. Using tissue microarrays containing 239 cases of primary breast tumors, the expression of Bmi-1, BRCA-1, H2AX, Rad51, p53, Ki-67, topoIII beta, estrogen receptors (ER), progesterone receptors (PR), and HER-2 was analyzed by immunohistochemistry. We observed high Bmi-1 expression in 66 cases (27.6%). Immunohistochemical overexpression of BMI-1 was related to ER (p=0.004)...

‣ RNAi-mediated silencing of the Bmi-1 gene causes growth inhibition and enhances doxorubicin-induced apoptosis in MCF-7 cells

Wu,Xiang-mei; Liu,Xing; Bu,You-quan; Sengupta,Joyeeta; Cui,Hong-juan; Yi,Fa-ping; Liu,Tao; Yuan,Chen-fu; Shi,Yan-yan; Song,Fang-zhou
Fonte: Sociedade Brasileira de Genética Publicador: Sociedade Brasileira de Genética
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2009 Português
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The oncogene Bmi-1 is a member of the Polycomb group gene family. Its expression is found to be greatly increased in a number of malignant tumors including breast cancer. This could suggest Bmi-1 as a potent therapeutic target. In this study, RNAi was introduced to down-regulate the expression of Bmi-1 in a highly malignant breast adenocarcinoma cell line, MCF-7. A thorough study of the biological behavior and chemosensitivity changes of the MCF-7 cells was carried out in context to the therapeutic potential of Bmi-1. The results obtained indicated that siRNA targeting of Bmi-1 could lead to an efficient and specific inhibition of endogenous Bmi-1 activity. The mRNA and protein expression of Bmi-1 were determined by RT-PCR and Western blot, respectively. Furthermore, silencing of Bmi-1 resulted in a drastic inhibition of the growth of MCF-7 cells as well as G1/S phase transition. The number of target cells was found to increase in phase G0/G1 and decrease in the S phase, but no increase in the basal level of apoptosis was noticed. On the other hand, a reduction in the expression of cyclin D1 and an increase in the expression of p21 were also noticed. Silencing of Bmi-1 made the MCF-7 cells more sensitive to the chemotherapeutic agent doxorubicin and induced a significantly higher percentage of apoptotic cells. Here...

‣ Identification and Characterization of Bmi-1-responding Element within the Human p16 Promoter*

Meng, Sha; Luo, Min; Sun, He; Yu, Xin; Shen, Meili; Zhang, Quancang; Zhou, Rudan; Ju, Xiaofang; Tao, Wei; Liu, Di; Deng, Hongkui; Lu, Zhigang
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
Português
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Bmi-1, the first functionally identified polycomb gene family member, plays critical roles in cell cycle regulation, cell immortalization, and cell senescence. Bmi-1 is involved in the development and progression of carcinomas and is a potent target for cancer therapy. One important pathway regulated by Bmi-1 is that involving two cyclin-dependent kinase inhibitors, p16Ink4a and p19Arf, as Bmi-1 represses the INK4a locus on which they are encoded. A close correlation between the up-regulation of Bmi-1 and down-regulation of p16 has been demonstrated in various tumors; however, how Bmi-1 regulates p16 expression is not clear. In this study, we revealed that Bmi-1 regulates the expression of p16 by binding directly to the Bmi-1-responding element (BRE) within the p16 promoter. The BRE resided at bp −821 to −732 upstream of the p16 ATG codon. BRE alone was sufficient to allow Bmi-1-mediated regulation of the CMV promoter. Bmi-1 typically functions by forming a complex with Ring2; however, regulation of p16 was independent of Ring2. Chromatin immunoprecipitation sequencing of Bmi-1-precipitated chromatin DNA revealed that 1536 genes were targeted by Bmi-1, including genes involved in tissue-specific differentiation, cell cycle, and apoptosis. By analyzing the binding sequences of these genes...

‣ Changing BMI Categories and Healthcare Expenditures Among Elderly Medicare Beneficiaries

Wilkins, Tricia Lee; Rust, George S.; Sambamoorthi, Usha
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
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To examine the association between changes in BMI categories and health-care expenditures among elderly Medicare beneficiaries using longitudinal data of the Medicare Current Beneficiary Survey (MCBS) 2000–2005. Changes in BMI were (i) Stayed Normal: individuals with a normal BMI at baseline and follow-up; (ii) Stayed Overweight individuals with overweight BMI at baseline and follow-up; (iii) Stayed Obese individuals with obese BMI at baseline and follow-up; (iv) Normal-Overweight: individuals with normal BMI at baseline and overweight BMI at follow-up; (v) Overweight-Obese: individuals with overweight BMI at baseline and obese BMI at follow-up; (vi) Overweight-Normal: individuals with overweight BMI at baseline and normal BMI at follow-up; (vii) Obese-Overweight: individuals with obese BMI at baseline and overweight BMI at follow-up. Ordinary Least Squares (OLS) models on logged Year 3 expenditures were used to analyze changes in expenditures between BMI categories. Overall, 35% Stayed Normal, 34% Stayed Overweight, 18% Stayed Obese, 4% gained weight from Normal-Overweight BMI, 3% gained weight from Overweight-Obese BMI, 5% lost weight from Overweight-Normal BMI, and 3% lost weight from Obese-Overweight BMI. Adjusted models revealed those who Stayed Obese had increased total and multiple expenditure types that were significantly higher than Stayed Normal including total (11%)...

‣ Significant increases in body mass indexes (BMI) in an adult autopsy population from 1986 to 2006 - Implications for modern forensic practice

Byard, R.; Bellis, M.
Fonte: Churchill Livingstone Publicador: Churchill Livingstone
Tipo: Artigo de Revista Científica
Publicado em //2008 Português
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A study was undertaken of two coronial autopsy populations aged >or= 17 years in Adelaide, South Australia in 1986 and in 2006 to determine whether there had been any increase in body mass index over the intervening 21 years. In 1986 there were 689 cases; M:F=2.8:1. The average BMI was 25.1, with a range from 12.5 to 55.5. 47% of cases had a normal BMI (18.5-24.9), 14.8% were obese (BMI >or= 30), with a subset of 1.3% of cases classified as morbidly obese (BMI >or= 40). In 2006 there were 1176 cases; M:F=1.9:1. The average BMI was 27.1 with a range from 10.5 to 80.6. 32.1% of cases had a normal BMI, 27.2% were obese, with a subset of 4.8% of cases classified as morbidly obese. This study has confirmed that there has been a marked relative and absolute increase in numbers of obese individuals undergoing coronial post-mortem examinations in South Australia, with 218 more autopsies in 2006 involving obese bodies, including 47 more cases where morbid obesity was documented. This trend is undoubtedly occurring in other countries. Significant problems exist in trying to handle obese and particularly morbidly obese individuals in mortuaries designed for bodies with normal BMIs. Lifting, transport, transfer, storage and autopsy dissection are all difficult. Obesity enhances putrefaction that further complicates handling. Unless mortuaries are modified to deal with the increasing numbers of morbidly obese individuals...

‣ Pathogenesis of aortic sclerosis: association with low BMI, tissue nitric oxide resistance, but not systemic inflammatory activation

Sverdlov, A.; Ngo, D.; Horowitz, J.
Fonte: e-Century Publishing Corporation Publicador: e-Century Publishing Corporation
Tipo: Artigo de Revista Científica
Publicado em //2012 Português
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Aortic sclerosis (ASc) represents the earliest stage of development of aortic valve thickening, and may eventually progress to aortic valve stenosis (AS). ASc is associated with intra-valvular inflammatory activation, and potentially with attenuation of the anti-inflammatory effect of nitric oxide (NO). We have shown that ASc occurs less frequently in obese individuals, in whom systemic inflammatory activity is generally increased. We explored these relationships further by stratifying a population of 253 ageing individuals according to BMI. Increasing BMI was associated with increased hs-CRP concentrations (r=0.43; p<0.001). However, presence/absence of ASc did not significantly modify this relationship. Furthermore, increasing BMI was independent of tissue responsiveness to NO, as measured via inhibition of platelet aggregation by the NO donor sodium nitroprusside. Therefore the association of low BMI with increased risk of ASc appears to interact neither with systemic inflammatory activation in such individuals, nor with any “paradoxical” occurrence of NO resistance. (AJCD1110003).; http://www.ajcd.us/1110003A.html; Aaron L Sverdlov, Doan TM Ngo, John D Horowitz

‣ Relação entre o gene B-Cell-Specific Moloney Murine Leukemia Virus Integration Site 1 (BMI-1) e genes reguladores da recombinação homóloga em carcinomas ductais invasores da mama; Relationship between the gene B-Cell-Specific Moloney Murine Leukemia Virus Integration Site 1 (BMI-1) and homologous recombination regulatory genes in invasive ductal breast carcinomas

Silveira, Giórgia Gobbi da
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 02/03/2012 Português
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Bmi-1 é uma proteína do grupo Polycomb capaz de induzir atividade de telomerase, levando à imortalização de células epiteliais. As células, quando imortalizadas, se tronam mais susceptíveis a danos em dupla fita (double-strand breaks (DSB))e a recombinação homóloga é uma das duas vias de reparo dos DSBs. Dentre os genes reguladores da recombinação homóloga temos o BRCA-1, que está envolvido na resposta ao dano associado à proteína RAD51, que por sua vez se acumula rapidamente nos focos de dano ao DNA após a sinalização do H2AX, que têm se mostrado um excelente marcador de dano celular por se acumular rapidamente nos focos de lesão, desencadeando o processo de reparo. Topoisomerase III (TopoIII) remove intermediários da recombinação homóloga antes da segregação de cromossomos, prevenindo danos à estrutura do DNA celular. O papel das proteínas envolvidas na recombinação homóloga, em carcinomas ductais invasores positivos para o BMI-1, necessita ser investigado. Utilizando-se tissue microarrays contendo 239 casos de carcinomas ductais mamários primários, foi analisada a expressão imunoistoquímica de BMI-1, receptor de estrógeno, receptor de progesterona, HER-2, Ki67, p53 e BRCA-1, H2AX, RAD51 e topoisomerase III. Positividade para o Bmi-1 foi encontrada em 66 casos (27.6%). A positividade imunoistoquímica do BMI-1 relacionou-se a RE (p=0...

‣ Association of BMI with overall survival in patients with mCRC who received chemotherapy versus EGFR and VEGF-targeted therapies

Patel, G.S.; Ullah, S.; Beeke, C.; Hakendorf, P.; Padbury, R.; Price, T.J.; Karapetis, C.S.
Fonte: Wiley Publicador: Wiley
Tipo: Artigo de Revista Científica
Publicado em //2015 Português
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Although a raised body mass index (BMI) is associated with increased risk of colorectal cancer (CRC) and recurrence after adjuvant treatment, data in the metastatic setting is limited. We compared overall survival (OS) across BMI groups for metastatic CRC, and specifically examined the effect of BMI within the group of patients treated with targeted therapies (TT). Retrospective data were obtained from the South Australian Registry for mCRC from February 2006 to October 2012. The BMI at first treatment was grouped as underweight <18.5 kg/m(2) , Normal = 18.5 to <25 kg/m(2) , Overweight = 25 to <30 kg/m(2) , Obese I = 30 to <35 kg/m(2) , Obese II ≥35 kg/m(2) . Of 1174 patients, 42 were underweight, 462 overweight, 175 Obese I, and 77 Obese II. The OS was shorter for patients who were underweight and overweight compared to normal (OS 13.7 and 22.3 vs. 24.1 months, respectively, hazard ratio [HR] 2.21 and 1.23). The adjusted median OS was longer for normal versus overweight or obese I patients receiving chemotherapy + targeted therapy (35.7 vs 25.1 or 22.8 months, HR 1.59 and 1.63, respectively) with no difference in OS for chemotherapy alone. On breakdown by type of targeted therapy, overweight and obese I patients had a poorer outcome with Bevacizumab. The BMI is predictive of a poorer outcome for underweight and overweight patients in the whole population. Of those receiving chemotherapy and targeted therapy...

‣ The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI

Zhou, A.; Dekker, G.; Lumbers, E.; Leemaqz, S.; Thompson, S.; McCowan, L.; Roberts, C.
Fonte: W B Saunders Co Ltd Publicador: W B Saunders Co Ltd
Tipo: Artigo de Revista Científica
Publicado em //2013 Português
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INTRODUCTION: This study aimed to determine the association of AGTR1 and AGTR2 polymorphisms with preeclampsia and whether these are affected by environmental factors and fetal sex. METHODS: Overall 3234 healthy nulliparous women, their partners and babies were recruited prospectively to the SCOPE study in Adelaide and Auckland. Data analyses were confined to 2121 Caucasian parent-infant trios, among whom 123 had preeclamptic pregnancies. 1185 uncomplicated pregnancies served as controls. DNA was extracted from buffy coats and genotyped by utilizing the Sequenom MassARRAY system. Doppler sonography on the uterine arteries was performed at 20 weeks' gestation. RESULTS: Four polymorphisms in AGTR1 and AGTR2 genes, including AGTR1 A1166C, AGTR2 C4599A, AGTR2 A1675G and AGTR2 T1134C, were selected and significant associations were predominately observed for AGTR2 C4599A. When the cohort was stratified by maternal BMI, in women with BMI ≥ 25 kg/m(2), the AGTR2 C4599A AA genotype in mothers and neonates was associated with an increased risk for preeclampsia compared with the CC genotype [adjusted OR 2.1 (95% CI 1.0-4.2) and adjusted OR 3.0 (95% CI 1.4-6.4), respectively]. In the same subset of women, paternal AGTR2 C4599A A allele was associated with an increased risk for preeclampsia and uterine artery bilateral notching at 20 weeks' gestation compared with the C allele [adjusted OR 1.9 (95% CI 1.1-3.3) and adjusted OR 2.1 (95% CI 1.3-3.4)...

‣ Transporte ativo para a escola e a sua relação com o IMC: um estudo em adolescentes de uma escola secundária de Guimarães: relatório de estágio; Active transportation to school and its relationship with BMI: a study of adolescents in a secondary school Guimarães: practicum report

Sousa, Hélder Cirilo Ribeiro de
Fonte: Universidade do Minho Publicador: Universidade do Minho
Tipo: Trabalho de Conclusão de Curso
Publicado em //2014 Português
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Relatório de estágio de mestrado em Ensino de Educação Física nos Ensinos Básico e Secundário; O presente relatório está enquadrado no 2º ciclo de estudos para a obtenção do grau de mestre em Ensino de Educação Física nos Ensinos Básicos e Secundário, da Universidade do Minho, referente ao ano letivo de 2013/2014. Este relatório é um documento individual que visa descrever e refletir sobre a minha participação enquanto Professor de Educação Física e apresentar as soluções encontradas para os problemas que surgiram e demonstrar a minha evolução enquanto docente. Desta forma começo por fazer um enquadramento pessoal, exibindo as minhas expetativas, e um enquadramento institucional referindo o contexto onde este estágio foi realizado. No que concerne à Realização da Prática Profissional, são caracterizadas, ao longo do relatório três grandes áreas que comtemplam todo este processo, previstas no Documento Orientador de Estágio Profissional. Comecei por abordar a organização e gestão do ensino e da aprendizagem onde foram abordadas as conceções de estágio, passando pelos planeamentos, pela parte da realização e por último a avaliação do processo de ensino. De seguida é referida a participação na escola e relação com a comunidade demonstrando que a participação em eventos para toda a comunidade educativa dinamizam a escola e são fonte de aprendizagem. Relativamente à formação e investigação educacional em Educação Física elaborei um estudo sobre o transporte ativo nas rotinas de vida dos jovens e se este está relacionado com o Índice de Massa Corporal (IMC). A amostra é composta por 151 alunos do 11º e 12º anos de escolaridade. Verificou-se que a maior parte da amostra utiliza deslocamento passivo para a escola (77...

‣ Adaptation to elastic loads and BMI robot controls during rat locomotion examined with point-process GLMs

Song, Weiguo; Cajigas, Iahn; Brown, Emery N.; Giszter, Simon F.
Fonte: Frontiers Media S.A. Publicador: Frontiers Media S.A.
Tipo: Artigo de Revista Científica
Português
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Currently little is known about how a mechanically coupled BMI system's actions are integrated into ongoing body dynamics. We tested a locomotor task augmented with a BMI system driving a robot mechanically interacting with a rat under three conditions: control locomotion (BL), “simple elastic load” (E) and “BMI with elastic load” (BMI/E). The effect of the BMI was to allow compensation of the elastic load as a function of the neural drive. Neurons recorded here were close to one another in cortex, all within a 200 micron diameter horizontal distance of one another. The interactions of these close assemblies of neurons may differ from those among neurons at longer distances in BMI tasks and thus are important to explore. A point process generalized linear model (GLM), was used to examine connectivity at two different binning timescales (1 ms vs. 10 ms). We used GLM models to fit non-Poisson neural dynamics solely using other neurons' prior neural activity as covariates. Models at different timescales were compared based on Kolmogorov-Smirnov (KS) goodness-of-fit and parsimony. About 15% of cells with non-Poisson firing were well fitted with the neuron-to-neuron models alone. More such cells were fitted at the 1 ms binning than 10 ms. Positive connection parameters (“excitation” ~70%) exceeded negative parameters (“inhibition” ~30%). Significant connectivity changes in the GLM determined networks of well-fitted neurons occurred between the conditions. However...

‣ The Interaction of Childhood Height and Childhood BMI in the Prediction of Young Adult BMI

Stovitz, Steven D.; Pereira, Mark A.; Vazquez, Gabriela; Lytle, Leslie A.; Himes, John H.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
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The purpose of this study was to examine the interaction of childhood height and childhood BMI in the prediction of young adult BMI. The 2,802 subjects in this study were from the Child and Adolescent Trial for Cardiovascular Health (CATCH). The subjects' heights and weights were measured in 3rd grade (mean age 8.7 years) and again in 12th grade (mean age 18.3 years). The associations and interactions between height (cm) and BMI (kg/m2) were assessed using mixed linear regression models with adult BMI as the dependent variable. We found a significant interaction between childhood height and childhood BMI in the prediction of adult BMI (P < 0.0001). Stratification by Centers for Disease Control and Prevention (CDC) reference quintiles revealed that a positive association between childhood height and adult BMI existed only for those subjects in the top quintile of childhood BMI, within whom predicted adult BMI ranged from 27.5 (95% confidence interval = 26.4-28.6) for those in the shortest height quintile to 30.2 (95% confidence interval = 29.7-30.6) for those in the highest height quintile. Among children with high BMI levels, those who were taller, as compared to those who were shorter, had significantly higher young adult BMI levels. This pattern seems primarily due to the positive association of childhood height and childhood BMI. Clinicians should recognize the risk of excess body weight in young adulthood for all children who have a high BMI...

‣ BMI and self-perceived body shape in Portuguese children

Coelho, Eduarda Maria; Padez, Cristina; Moreira, Pedro; Rosado, Victor; Mourão-Carvalhal, Isabel
Fonte: Universidade Autônoma de Barcelona Publicador: Universidade Autônoma de Barcelona
Tipo: Artigo de Revista Científica Formato: application/pdf
Publicado em //2013 Português
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This study examined the relationship between Portuguese children’s self-perceived body shape and body mass index (BMI) by gender, and BMI values were determined for each silhouette. Method: A sample of 4,211 children aged 7-10 was used. Their body image was assessed using Collins’s body image silhouettes, while cole et al.’s cutoffs were used to define obesity. Results: The higher the number of the selected silhouette, the higher the mean BMI, except in the case of silhouettes 2 and 7 for boys and 7 for girls. Most of the individuals who selected silhouette number 5 or higher were obese. For both sexes, the ANOVA showed significant differences in the BMI depending on the selected figures (p < .001). The correlation coefficient between the body image silhouettes and the BMI was .54 (p < .001) for the total sample, .50 (p < .001) for males and .57 (p < .001) for females. in the regression models, the percentage of variance in the BMI explained by the selected images was 25.6% in boys and 30.8% in girls. Conclusion: The study suggested that in childhood (7-10 years), no stable awareness of body shape has been developed, with girls being more accurate than boys. The body shape obtained with the scale was moderately correlated with the BMI...

‣ Associations between BMI and home, school and route environmental exposures estimated using GPS and GIS: do we see evidence of selective daily mobility bias in children?

Burgoine, Thomas; Jones, Andy P.; Brouwer, Rebecca J. Namenek; Neelon, Sara E. Benjamin
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Article; published version
Português
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This is the final published version. It first appeared at http://www.ij-healthgeographics.com/content/14/1/8.; Background This study examined whether objective measures of food, physical activity and built environment exposures, in home and non-home settings, contribute to children?s body weight. Further, comparing GPS and GIS measures of environmental exposures along routes to and from school, we tested for evidence of selective daily mobility bias when using GPS data. Methods This study is a cross-sectional analysis, using objective assessments of body weight in relation to multiple environmental exposures. Data presented are from a sample of 94 school-aged children, aged 5?11 years. Children?s heights and weights were measured by trained researchers, and used to calculate BMI z-scores. Participants wore a GPS device for one full week. Environmental exposures were estimated within home and school neighbourhoods, and along GIS (modelled) and GPS (actual) routes from home to school. We directly compared associations between BMI and GIS-modelled versus GPS-derived environmental exposures. The study was conducted in Mebane and Mount Airy, North Carolina, USA, in 2011. Results In adjusted regression models, greater school walkability was associated with significantly lower mean BMI. Greater home walkability was associated with increased BMI...

‣ Metabolic disorders of liver and iron in diabetic and non-diabetic patients BMI < 35 or > 35 before gastric bypass

Garciacaballero,Manuel; Reyes-Ortiz,Alexander; Martínez-Moreno,José Manuel; Toval-Mata,José Antonio
Fonte: Nutrición Hospitalaria Publicador: Nutrición Hospitalaria
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/05/2014 Português
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Introduction: The presence of abnormalities in the metabolic pathways of iron and liver functioning can produce insulin resistance or metabolic syndrome. Therefore, it is important to examine those alterations that may lead to the development of diseases. Nutritional status is another important factor that is intimately linked to diabetes and obesity. Patients and Methods: We studied 131 patients (78 nondiabetic patients and 53 diabetic), 37 patients BMI ≤ 35 (3 BMI < 25, 18 BMI 25-29.9, 16 BMI 30-34.9) and 94 patients BMI ≥ 35 (81 BMI 35-49.9 and 13 BMI ≥ 50). Subjects underwent to laboratory studies related to liver functioning and iron metabolism. Nutritional status was also determined in our patients. Results: Iron was altered 14% of patients BMI >35 and diabetics reached 3% to 25%. Vitamin B12 was low 4% of non-diabetics BMI > 35, and high in 6% of diabetics BMI < 35. The 6% of diabetics BMI < 35 had hyperbilirubinemia. Transaminases are elevated in patients BMI >35 but exacerbated on diabetics. GGT is raised 41% to 47% in BMI >35. ALP is elevated in 25% of diabetics. Total protein and serum albumin were altered in diabetics causing mild malnutrition. 90% of patients had normal nutrition and 10% mild malnutrition. Conclusions: The metabolisms Hepatic and iron are closely related to the onset of obesity and diabetes. If there is weight gain...

‣ Glycemic and lipid metabolic disorders in diabetic and non-diabetic patients bmi < 35 or > 35 before gastric bypass

Garciacaballero,Manuel; Reyes-Ortiz,Alexander; Martínez-Moreno,José Manuel; Toval-Mata,José Antonio
Fonte: Nutrición Hospitalaria Publicador: Nutrición Hospitalaria
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/05/2014 Português
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Introduction: Obesity and diabetes are diseases with high prevalence worldwide. There is currently no effective medical treatment for combat the weight gain. It is precursor of diseases such as diabetes or metabolic syndrome. It is necessary to know if weight gain has cumulative effects on the glycemic and lipid metabolism as precursors of complications or comorbidities. Patients and methods: We studied 131 patients (78 nondiabetic and 53 diabetic), 37 BMI < 35 (3 BMI < 25, 18 BMI 25-29.9, 16 BMI 30-34.9) and 94 BMI > 35 (81 BMI 35-49.9 and 13 BMI > 50). We analyzed BMI, gender, diabetes and the time of evolution. Lipid profile, glucose, HbA1c and C-peptide evaluated after 12-hour fasting. Results: Diabetic and diabese patients showed high triglycerides. Non-diabetics have impaired glucose (58% BMI < 35 and 36% BMI > 35). The 20% of non-diabetics BMI < 35 had high C-peptide, and 19% of BMI > 35 had high levels. The 5% of diabetics BMI < 35 had low C-peptide and 36% of BMI > 35 had high levels. HbA1c was higher in 40% of non-diabetic patients BMI < 35 compared to 13% BMI > 35. Conclusions: Glucose and triglycerides increase with age and years of development of T2DM. Age of 51 and more, and men are more affected. The weight increase has cumulative effect by altering the metabolism favoring the onset of diabetes and comorbidities. Despite having intensive control treatment of diabetes...

‣ International BMI-for-age references underestimate thinness and overestimate overweigth and obesity in Bolivian adolescents

Baya Botti,A.; Pérez-Cueto,F. J. A.; Vasquez Monllor,P. A.; Kolsteren,P. W.
Fonte: Nutrición Hospitalaria Publicador: Nutrición Hospitalaria
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/06/2010 Português
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Background: Since no growth standards for adolescents exist and a single reference applicable everywhere is still in debate, it is recognized that the best reference should be derived from the growth pattern of the healthy population that will use it. In 2007 a study developed references for body mass index for 12th to 18th y Bolivian school adolescent (BAP. Objectives: To compare nutritional status outcomes applying BMI references from the BAP, the Center for Disease Control and Prevention CDC 2000, the International Task Force (IOTF), and the 2007 WHO, to determine appropriateness of use in Bolivian adolescents. Subjects/methods: References were applied in 3306 adolescents, 45.0% male, 55% female, 12th to 18th y selected from a nationally representative sample. Results: Main findings reveal that the CDC and the 2007 WHO underestimate underweight (p < 0.001) and the three international references overestimate overweight (p < 0.001) with variation between ages and gender. Conclusions: Bolivian health providers are advised to replace CDC, OITF and 2007WHO references for the use of BAP in Bolivia which reflects its healthy adolescent population growth pattern. International references may lead to incorrect conclusions when applied on Bolivian adolescents. They could deflect efforts from population which need prompt intervention and mislead treatments and budget to unnecessary ones. We recommend validation of international references where appropriate until a standard is released.

‣ Diabetes surgery in type 2 BMI 24-29 vs IMC 30-34 diabetic patients: is there differences among restrictive, malabsorptive and gastric bypass procedures?

Garciacaballero,M.; Navarrete,S.; Favretti,F .; Celik,A.; Castillo,D. Del
Fonte: Nutrición Hospitalaria Publicador: Nutrición Hospitalaria
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/01/2013 Português
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Diabetes mellitus (DM) is a public health problem with a prevalence of 345 million people worldwide that it may double by the year 2030 and have a high costs and mortality. Gastrointestinal surgery is accepted as a form of treatment that was already suggested for obese in 1987 by Pories, confirmed for obese patients by the meta-analysis of Buchwald and the direct comparison of gastric bypass with medical treatment in the study of Schauer that demonstrate a 4 fold greater resolution rate of DM with surgery. Improvement occurs immediately after surgery, before the patients lose weight in with BMI > 35; but there is doubt if the existent evidence is enough to extrapolate these results to patients with BMI < 35 and especially with BMI < 30, in spite that four reviews in patients with this BMI and DM2 demonstrated the same results when stomach, duodenum and part of jejunum is bypassed as happen gastric bypass (better results with this of one anastomosis than of two anastomosis, Rouxen-Y) BPD. For patients with a BMI between 30 and 35 restrictive techniques: LAGB and SGL are good but not better than the mixed: RYGB, BAGUA, or SG-DJB with remission from 60 to 100%, minor in the derivative: BPD and above on the IID with a 81% of remission. There are no differences in the metabolic control in comparison to the obese...