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‣ Arg72Pro TP53 polymorphism and cancer susceptibility: a comprehensive meta-analysis of 302 case-control studies

FRANCISCO, Guilherme; MENEZES, Paulo Rossi; ELUF-NETO, Jose; CHAMMAS, Roger
Fonte: WILEY-BLACKWELL Publicador: WILEY-BLACKWELL
Tipo: Artigo de Revista Científica
Português
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Arg72Pro is a common polymorphism in TP53, showing differences in its biological functions. Case-control studies have been performed to elucidate the role of Arg72Pro in cancer, although the results are conflicting and heterogeneous. Here, we analyzed pooled data from case-control studies to determine the role of Arg72Pro in different cancer sites. We performed a systematic review and meta-analysis of 302 case-control studies that analyzed Arg72Pro in cancer susceptibility. Odds ratios were estimated for different tumor sites using distinct genetic models, and the heterogeneity between studies was explored using I(2) values and meta-regression. We adopted quality criteria to classify the studies. Subgroup analyses were done for tumor sites according to ethnicity, histological, and anatomical sites. Results indicated that Arg72Pro is associated with higher susceptibility to cancer in some tumor sites, mainly hepatocarcinoma. For some tumor sites, quality of studies was associated with the size of genetic association, mainly in cervical, head and neck, gastric, and lung cancer. However, study quality did not explain the observed heterogeneity substantially. Meta-regression showed that ethnicity, allelic frequency and genotyping method were responsible for a substantial part of the heterogeneity observed. Our results suggest ethnicity and histological and anatomical sites may modulate the penetrance of Arg72Pro in cancer susceptibility. This meta-analysis denotes the importance for more studies with good quality and that the covariates responsible for heterogeneity should be controlled to obtain a more conclusive response about the function of Arg72Pro in cancer.; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq Brasilia...

‣ Freqüência de câncer de próstata em pacientes transplantados renais: estudo caso-controle; Frequency of prostate cancer in patients submitted to renal transplantation: a case-control study

Alvarez, Gilberto Antunes
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 03/09/2007 Português
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INTRODUÇÃO: Os pacientes submetidos a transplante renal estão sujeitos a um risco muito aumentado para câncer, porém inexistem dados concretos quanto a maior chance de tumor de próstata nesses pacientes. Neste estudo, avaliou-se a freqüência de câncer de próstata em transplantados renais comparada à de pacientes-controle, bem como a sua relação com etnia, antecedentes familiares, toque prostático, níveis de PSA e aos esquemas de imunossupressão nos pacientes transplantados renais. MÉTODOS: Neste estudo caso-controle realizado entre agosto de 2004 e junho de 2006 comparou-se a freqüência de câncer de próstata entre pacientes transplantados renais (n=119) há mais de um ano e pacientes do grupo-controle (n=184), bem como as variáveis: etnia, idade, presença de antecedentes familiares, escore internacional de sintomas prostáticos, toque retal, níveis de PSA e índice de massa corpórea (IMC). Os pacientes com PSA e/ou toque retal alterado foram submetidos à biópsias prostáticas guiadas por ultra-som transretal. As comparações das freqüências entre os dois grupos deram-se através das variáveis: idade, etnia, presença de antecedentes familiares, toque suspeito e valores de PSA>2,5ng/mL e >4,0ng/mL. Avaliou-se também a relação entre os tipos e doses de imunossupressor e presença de câncer. RESULTADOS: Não houve maior freqüência de tumor de próstata em transplantados (6...

‣ Psychiatric disorders and psychiatric consultation in a general hospital: A case- control study

Smaira, Sumaia Inaty; Kerr-Corrêa, Florence; Contel, José Onildo B.
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 18-25
Português
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Introduction: Psychiatric consultation (PC) has been considered an efficient tool to develop research, to track and to give assistance benefiting patients, health professionals and the institution. However, it has not been much used in Brazil. Although 30 to 50% of general hospital (GH) inpatients may present a psychiatric disorder, only 1 to 12% of them are referred to assessment. The aims of this study were: to assess mental disorders in a GH; to identify which of these patients are sent to psychiatric care; to verify alleged reasons for referral to psychiatric consultation, and to examine the relationship between PC and psychiatric learning (during medical school and residence). Methods: A case-control patient study was conducted (47 cases and 94 controls) to analyze in detail the following variables: socio-demographic; clinical; degree of information (about the disease and diagnostic/therapeutic procedures), and relationship between patient and health team. Psychiatric diagnoses were made according to the ICD- 10 criteria. The Self Report Questionnaire (SRQ), the CAGE and Brief Psychiatric Rating Scale (BPRS) were used as well as a specifically designed questionnaire to collect clinical and demographic data. Results: Behavioral alterations...

‣ The AIDS epidemic in the Amazon region: a spatial case-control study in Rondonia, Brazil

Donalisio, Maria Rita; Cordeiro, Ricardo; Lourenço, Roberto Wagner; Brown, J. Christopher
Fonte: Universidade de São Paulo (USP), Faculdade de Saúde Pública Publicador: Universidade de São Paulo (USP), Faculdade de Saúde Pública
Tipo: Artigo de Revista Científica Formato: 873-882
Português
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OBJETIVO Analisar mudanças espaciais no risco de Aids e a relação entre incidência da doença e variáveis socioeconômicas. MÉTODOS Estudo caso-controle espacial, de base populacional, realizado em Rondônia, Brasil, com 1.780 casos notificados pelo Sistema de Vigilância Epidemiológica e os controles a partir de dados demográficos de 1987 a 2006. Os casos foram agrupados em cinco períodos de cinco anos consecutivos. Um modelo aditivo generalizado foi ajustado aos dados. O status dos indivíduos (caso ou controle) foi considerado como a variável dependente e independente: um alisamento ( spline ) bidimensional das coordenadas geográficas e variáveis socioeconômicas municipais. Os valores observados para o teste Moran I foram comparados com a distribuição de referência dos valores obtidos em condições de aleatoriedade espacial. RESULTADOS O risco de Aids apresentou padrão espacial e temporal marcado. A incidência associou-se a indicadores socioeconômicos municipais, como urbanização e capital humano. As maiores taxas de incidência de Aids ocorreram em municípios ao longo da rodovia BR-364; os resultados do teste Moran I mostram correlação espacial positiva associada à contiguidade dos municípios com a rodovia...

‣ Hospital visitors as controls in case-control studies

Mendonça,Gulnar Azevedo S; Eluf-Neto,José
Fonte: Faculdade de Saúde Pública da Universidade de São Paulo Publicador: Faculdade de Saúde Pública da Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2001 Português
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OBJECTIVE: Selecting controls is one of the most difficult tasks in the design of case-control studies. Hospital controls may be inadequate and random controls drawn from the base population may be unavailable. The aim was to assess the use of hospital visitors as controls in a case-control study on the association of organochlorinated compounds and other risk factors for breast cancer conducted in the main hospital of the "Instituto Nacional de Câncer" -- INCA (National Cancer Institute) in Rio de Janeiro (Brazil). METHODS: The study included 177 incident cases and 377 controls recruited among female visitors. Three different models of control group composition were compared: Model 1, with all selected visitors; Model 2, excluding women visiting relatives with breast cancer; and Model 3, excluding all women visiting relatives with any type of cancer. Odds ratios (OR) and 95% confidence intervals were calculated to test the associations. RESULTS: Age-adjusted OR for breast cancer associated with risk factors other than family history of cancer, except smoking and breast size, were similar in the three models. Regarding family history of all cancers, except for breast cancer, there was a decreased risk in Models 1 and 2, while in Model 3 there was an increased risk...

‣ Retreatment in leprosy: a case-control study

Ximenes,Ricardo Arraes Alencar; Gallo,Maria Eugênia Novinsk; Brito,Maria de Fátima de Medeiros
Fonte: Faculdade de Saúde Pública da Universidade de São Paulo Publicador: Faculdade de Saúde Pública da Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2007 Português
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OBJECTIVE: To assess risk factors for retreatment of leprosy patients. METHODS: A case-control study with patients from two reference care units in Recife, northeastern Brazil, in 2003. The case group included retreated patients (N=155) and the control group comprised those patients who were not retreated (N=155) matched by year of diagnosis and health care unit. Univariate and multivariate analyses were conducted to test the associations and odds ratios and related 95% confidence intervals were estimated. RESULTS: The following factors were found to be significantly associated (p<0.05) with retreatment: occurrence of adverse immunological reactions after treatment completion (OR=2.3; 95% CI=1.18;4.83), final bacterial index > 1 (OR=6.43; 95% CI=1.67;24.74), therapeutic regimen consisting of sulfone monotherapy (OR=10; 95% CI=0.01;0.78) and reports of household contacts (OR=2.2; 95% CI=0.24;0.85). CONCLUSIONS: The study findings reinforce that the use of dapsone monotherapy should be discontinued, and highlight the need for epidemiological monitoring of specific groups of leprosy patients after treatment completion through periodical clinical and laboratory evaluation. Further studies to explore the association between final bacterial index and retreatment are strongly recommended.

‣ Evaluating psychiatric case-control studies using the STROBE (STrengthening the Reporting of OBservational Studies in Epidemiology) statement

Goi,Pedro Domingues; Goi,Julia Domingues; Cordini,Kariny Larissa; Ceresér,Keila Mendes; Rocha,Neusa Sica da
Fonte: Associação Paulista de Medicina - APM Publicador: Associação Paulista de Medicina - APM
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2014 Português
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CONTEXT AND OBJECTIVE: Case-control studies are important in developing clinical and public health knowledge. The STROBE statement (STrengthening the Reporting of OBservational Studies in Epidemiology) was developed to establish a checklist of items that should be included in articles reporting observational studies. Our aim was to analyze whether the psychiatric case-control articles published in Brazilian journals with CAPES Qualis rating B1/B2 in 2009 conformed with the STROBE statement. DESIGN AND SETTING: Descriptive study on psychiatric papers published in Brazilian journals, within the Postgraduate Medical Program on Psychiatry, at Universidade Federal do Rio Grande do Sul. METHODS: All psychiatric case-control studies from Brazilian Qualis B1/B2 journals of psychiatry, neurology and public health in 2009 were analyzed. The four most specific items of the STROBE statement were used to evaluate whether these studies fitted within the case-control parameters: 1) selection of cases and controls; 2) controlling for bias; 3) statistical analysis; and 4) presentation of results. RESULTS: Sixteen case-control studies were identified, of which eleven (68.75%) were in psychiatry-focused journals. From analysis using the STROBE statement...

‣ Estimating Risk and Rate Levels, Ratios and Differences in Case-Control Studies

King, Gary; Zeng, Langche
Fonte: Wiley-Blackwell Publicador: Wiley-Blackwell
Tipo: Artigo de Revista Científica
Português
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Classic (or ‘cumulative’) case-control sampling designs do not admit inferences about quantities of interest other than risk ratios, and then only by making the rare events assumption. Probabilities, risk di erences and other quantities cannot be computed without knowledge of the population incidence fraction. Similarly, density (or ‘risk set’) case-control sampling designs do not allow inferences about quantities other than the rate ratio. Rates, rate di erences, cumulative rates, risks, and other quantities cannot be estimated unless auxiliary information about the underlying cohort such as the number of controls in each full risk set is available. Most scholars who have considered the issue recommend reporting more than just risk and rate ratios, but auxiliary population information needed to do this is not usually available. We address this problem by developing methods that allow valid inferences about all relevant quantities of interest from either type of case-control study when completely ignorant of or only partially knowledgeable about relevant auxiliary population information.; Government

‣ Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies

Zaitlen, Noah; Lindström, Sara; Pasaniuc, Bogdan; Cornelis, Marilyn; Genovese, Giulio; Pollack, Samuela; Barton, Anne; Bickeböller, Heike; Bowden, Donald W.; Eyre, Steve; Freedman, Barry I.; Friedman, David J.; Field, John K.; Groop, Leif; Haugen, Aage;
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Português
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Genetic case-control association studies often include data on clinical covariates, such as body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk of case or control samples. For example, in type 2 diabetes, odds ratios for established variants estimated from low–BMI cases are larger than those estimated from high–BMI cases. An unanswered question is how to use this information to maximize statistical power in case-control studies that ascertain individuals on the basis of phenotype (case-control ascertainment) or phenotype and clinical covariates (case-control-covariate ascertainment). While current approaches improve power in studies with random ascertainment, they often lose power under case-control ascertainment and fail to capture available power increases under case-control-covariate ascertainment. We show that an informed conditioning approach, based on the liability threshold model with parameters informed by external epidemiological information, fully accounts for disease prevalence and non-random ascertainment of phenotype as well as covariates and provides a substantial increase in power while maintaining a properly controlled false-positive rate. Our method outperforms standard case-control association tests with or without covariates...

‣ Use of the i2b2 research query tool to conduct a matched case–control clinical research study: advantages, disadvantages and methodological considerations

Johnson, Emilie K; Broder-Fingert, Sarabeth; Tanpowpong, Pornthep; Bickel, Jonathan; Lightdale, Jenifer R; Nelson, Caleb P
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Português
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Background: A major aim of the i2b2 (informatics for integrating biology and the bedside) clinical data informatics framework aims to create an efficient structure within which patients can be identified for clinical and translational research projects. Our objective was to describe the respective roles of the i2b2 research query tool and the electronic medical record (EMR) in conducting a case-controlled clinical study at our institution. Methods: We analyzed the process of using i2b2 and the EMR together to generate a complete research database for a case–control study that sought to examine risk factors for kidney stones among gastrostomy tube (G-tube) fed children. Results: Our final case cohort consisted of 41/177 (23%) of potential cases initially identified by i2b2, who were matched with 80/486 (17%) of potential controls. Cases were 10 times more likely to be excluded for inaccurate coding regarding stones vs. inaccurate coding regarding G-tubes. A majority (67%) of cases were excluded due to not meeting clinical inclusion criteria, whereas a majority of control exclusions (72%) occurred due to inadequate clinical data necessary for study completion. Full dataset assembly required complementary information from i2b2 and the EMR. Conclusions: i2b2 was critical as a query analysis tool for patient identification in our case–control study. Patient identification via procedural coding appeared more accurate compared with diagnosis coding. Completion of our investigation required iterative interplay of i2b2 and the EMR to assemble the study cohort.

‣ New statistical methods to assess the effect of time-dependent exposures in case-control studies

Cao, Zhirong
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
Português
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Contexte. Les études cas-témoins sont très fréquemment utilisées par les épidémiologistes pour évaluer l’impact de certaines expositions sur une maladie particulière. Ces expositions peuvent être représentées par plusieurs variables dépendant du temps, et de nouvelles méthodes sont nécessaires pour estimer de manière précise leurs effets. En effet, la régression logistique qui est la méthode conventionnelle pour analyser les données cas-témoins ne tient pas directement compte des changements de valeurs des covariables au cours du temps. Par opposition, les méthodes d’analyse des données de survie telles que le modèle de Cox à risques instantanés proportionnels peuvent directement incorporer des covariables dépendant du temps représentant les histoires individuelles d’exposition. Cependant, cela nécessite de manipuler les ensembles de sujets à risque avec précaution à cause du sur-échantillonnage des cas, en comparaison avec les témoins, dans les études cas-témoins. Comme montré dans une étude de simulation précédente, la définition optimale des ensembles de sujets à risque pour l’analyse des données cas-témoins reste encore à être élucidée, et à être étudiée dans le cas des variables dépendant du temps. Objectif: L’objectif général est de proposer et d’étudier de nouvelles versions du modèle de Cox pour estimer l’impact d’expositions variant dans le temps dans les études cas-témoins...

‣ A follow-up case-control association study of tractable (druggable) genes in recurrent major depression

Schosser, A.; Gaysina, D.; Cohen-Woods, S.; Domenici, E.; Perry, J.; Tozzi, F.; Korszun, A.; Gunasinghe, C.; Gray, J.; Jones, L.; Binder, E.; Holsboer, F.; Craddock, N.; Owen, M.; Craig, I.; Farmer, A.; Muglia, P.; McGuffin, P.
Fonte: Wiley-Liss Publicador: Wiley-Liss
Tipo: Artigo de Revista Científica
Publicado em //2011 Português
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The High-Throughput Disease-specific target Identification Program (HiTDIP) aimed to study case-control association samples for 18 common diseases. Here we present the results of a follow-up case-control association study of HiTDIP in major depressive disorder (MDD). The HiTDIP in MDD was conducted in a sample of 974 cases of recurrent MDD of white German origin collected at the Max-Planck Institute (MP-GSK) and 968 ethnically matched controls screened for lifetime absence of depression. Six genes were identified as of interest for a follow-up, based on the strength of the association and based on the interest as potential candidate target for developing new treatment for depression: Solute Carrier Family 4 Member 10 (SLC4A10), Dipeptidyl Peptidase IV (DPP4), Dopamine Receptor D3 (DRD3), Zinc Finger Protein 80 (ZNF80), Nitric Oxide Synthase 2A (NOS2A) and Peroxisome Proliferator-Activated Receptor-Gamma, Coactivator 1, Alpha (PPARGC1A). Within the current study, we attempted to follow-up these findings in a sample from the UK, the Depression Case Control (DeCC) sample consisting of 1,196 cases and 842 screened controls, phenotyped using exactly the same methods as the MP-GSK sample. Performing Cochran-Mantel-Haenzel statistics to test for genotypic and/or allelic differences between the DeCC and MP-GSK samples...

‣ Early estimates of seasonal influenza vaccine effectiveness in Europe among target groups for vaccination: results from the I-MOVE multicentre case-control study, 2011/12

Kissling, E.; Valenciano, M.; I-MOVE, Case-Control Studies Team
Fonte: ECDC_European Centre for Disease Prevention and Control Publicador: ECDC_European Centre for Disease Prevention and Control
Tipo: Artigo de Revista Científica
Publicado em 12/04/2012 Português
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Colaboração de: Baltazar Nunes, investigador do DEP; To provide an early estimate of 2011/12 influenza vaccine effectiveness (VE), we conducted a multicentre case–control study based on seven sentinel surveillance networks. We included influenza-like illness cases up to week 7/2012 from the vaccination target groups, swabbed less than eight days after symptom onset. Laboratory-confirmed influenza A(H3) cases were compared to negative controls. Adjusted VE was 43% (95% confidence interval: -0.4 to 67.7), suggesting low to moderate VE against influenza A(H3) in the early 2011/12 season.

‣ Early estimates of seasonal influenza vaccine effectiveness in Europe: results from the I-MOVE multicentre case-control study, 2012/13

Valenciano, M.; Kissling, E.; I-MOVE Case-Control Study Team
Fonte: ECDC-European Centre for Disease Prevention and Control Publicador: ECDC-European Centre for Disease Prevention and Control
Tipo: Artigo de Revista Científica
Publicado em 14/02/2013 Português
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Baltazar Nunes: member of the I-MOVE case–control study team; We conducted a test-negative case–control study based in five European sentinel surveillance networks. The early 2012/13 adjusted influenza vaccine effectiveness was 78.2% (95% CI: 18.0 to 94.2) against influenza B, 62.1% (95% CI: −22.9 to 88.3%) against A(H1)pdm09, 41.9 (95% CI: −67.1 to 79.8) against A(H3N2) and 50.4% (95% CI: −20.7 to 79.6) against all influenza types in the target groups for vaccination. Efforts to improve influenza vaccines should continue to better protect those at risk of severe illness or complications.

‣ Nonbiologic risk factors of pulmonary tuberculosis among adults in Henan: A case-control study

Wang, Guo-jie; Sleigh, Adrian; Zhou, Gang; Jackson, Sukhan; Liu, Xi-Li
Fonte: Zhonghua Yixuehui Publicador: Zhonghua Yixuehui
Tipo: Artigo de Revista Científica
Português
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OBJECTIVE: To study the nonbiologic risk factors of tuberculosis (TB) among adults. METHODS: 1:2 matched case-control study was conducted. 158 new smear positive pulmonary TB patients with 25 - 60 years of age were notified and registered from three county anti-TB institutions in Henan from October 2002-March 2004, were selected as cases. Two healthy persons were selected to match each case, with the same sex and age group, from the nearest neighbors of the case as controls. Interview was carried out with a uniform designed questionnaire at the residence of the object. Univariate and multivariate condition logistic regression models were used. RESULTS: The results of univariate analysis showed that marital status, education, self-employed occupation, smoking, out-migration for work away from hometown, household annual income level and household property were significantly associated with TB prevalence (P < 0.05); multivariate analysis showed that marital status, self-employed occupation, smoking, household economic condition and out-migration for work, away from home were also associated with TB (P < 0.05), and OR values were 2.826, 2.350, 1.536, 0.707, 2.096, respectively. CONCLUSION: Being single, smoking, self-employed occupation and out-migration for work were nonbiologic risk factors of TB while good household economic condition was a protective factor.

‣ An outbreak of Legionnaires disease at the Melbourne Aquarium, April 2000: investigation and case-control studies

Greig, Jane E; Carnie, John A; Tallis, G M; Ryan, Norbert J; Tan, Agnes; Gordon, Ian R; Zwolak, Bernard; Leydon, Jennie A; Guest, Charles; Hart, William G
Fonte: Australasian Medical Association Publicador: Australasian Medical Association
Tipo: Artigo de Revista Científica
Português
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Objective: To investigate the source and risk factors associated with Australia's largest outbreak of Legionnaires' disease. Design and setting: Epidemiological and environmental investigation of cases of Legionnaires' disease associated with visits to the Melbourne Aquarium; two case-control studies to confirm the outbreak source and to investigate risk factors for infection, respectively Participants: Patients with confirmed Legionnaires' disease who visited the Melbourne Aquarium between 11 and 27 April 2000 were compared (i) with control participants from the community, and (ii) with control participants selected from other visitors to the Aquarium during this period. Main outcome measures: Risk factors for acquiring Legionnaires' disease. Results: There were 125 confirmed cases of Legionnaires' disease caused by Legionella pneumophila serogroup 1 associated with the Aquarium; 76% of patients were hospitalised, and four (3.2%) died. The Aquarium cooling towers were contaminated with this organism. Visiting the Aquarium was significantly associated with disease (odds ratio [OR], 207; 95% Cl, 73-630). The case-control study indicated that current smoking was a dose-dependent risk (multivariable OR for currently smoking > 70 cigarettes/week...

‣ Estudo de caso controle para avaliar o impacto do abuso sexual infantil nos transtornos alimentares; A case-control study to assess the impact of childhood sexual abuse on eating disorders

Paraventi, Felipe; Claudino, Angélica de Medeiros; Morgan, Christina Marcondes; Mari, Jair de Jesus
Fonte: Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria Publicador: Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2011 Português
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CONTEXTO: O objetivo deste estudo foi investigar se antecedente de abuso sexual na infância (ASI) está associado com transtornos alimentares na vida adulta. MÉTODOS: Realizou-se um estudo de caso controle (N = 120) comparando mulheres com transtornos alimentares tratadas em ambulatório universitário especializado com um grupo controle de pacientes de clínica não psiquiátrica (ambulatório de oftalmologia). RESULTADOS: Este estudo encontrou maior prevalência de ASI na anorexia nervosa (AN) comparada ao grupo controle (50% versus 14,8%; OR = 5,8 IC 95% = 1,3-25,6; p < 0,05), entretanto não identificou diferença estatística entre os grupos comparando com casos de bulimia nervosa (BN) (26,7% versus 27% no grupo controle; OR = 0,99; IC 95% = 0,24-4,1) e com transtorno de compulsão alimentar periódica (TCAP), apesar da maior prevalência de ASI observada neste último em relação ao grupo controle (43,7% versus 27,3%; OR = 2,1 IC 95% = 0,5- 8,1). Considerando-se a presença de dois ou mais episódios de ASI, observou-se também maior prevalência em AN (35,7% versus 3,7% nos controles; OR = 14,4 IC 95% = 1,5-140,8; p < 0,05). CONCLUSÃO: Este estudo mostrou forte associação da anorexia nervosa com antecedentes de abuso sexual na infância.; BACKGROUND: The aim of this study is to evaluate if exposure to childhood sexual abuse (CSA) is related with eating disorders in adult life. METHODS: A case-control study was performed comparing women with diagnoses of eating disorders - from PROATA (acronym in Portuguese meaning Eating Disorders Program) of Federal University of São Paulo - and non-psychiatric clinic patients as control group at Ophthalmology Centre. RESULTS: The prevalence of CSA for binge-eating disorder was 43.7%...

‣ Association between Intimate Partner Violence and Posttraumatic Stress Disorder: A Case-Control Study

Contreras-Pezzotti,Leddy Marina; Arteaga-Medina,Juan Ernesto; Fidel Latorre,José; Folino,Jorge Óscar; Campo-Arias,Adalberto
Fonte: Revista Colombiana de Psiquiatría Publicador: Revista Colombiana de Psiquiatría
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2010 Português
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Background: Intimate partner violence (IPV) against women is a common form of interpersonal violence in both developed and developing countries, and represents a forensic and public health problem. IPV is related to Post-traumatic Stress Disorder (PTSD). This relationship however, has not been investigated in Colombian population. Objective: To determine the strength of the association between IPV and PTSD in women referred for forensic psychiatric evaluation in Bucaramanga, Colombia. Method: A case-control study was designed. A total of 132 cases involving women referred for forensic psychiatric evaluation met criteria for PSTD according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). A group of 262 women without PTSD were taken as controls. First, odds ratio (OR) was computed. Logistic regression was used to control confounding variables. Results: A total of 76 (56.6%) in the case group reported IPV during the past year compared to 85 (32.6%) in the control group. IPV and PTSD were associated (OR=3.09, 95%CI: 1.58-6.03) after controlling for age, employment, medico-legal loss or injury, and current aggressor (partner). Conclusions: IPV increased the risk for PTSD three-fold among women attending forensic assessment in Bucaramanga...

‣ Retreatment in leprosy: a case-control study

Ximenes,Ricardo Arraes Alencar; Gallo,Maria Eugênia Novinsk; Brito,Maria de Fátima de Medeiros
Fonte: Faculdade de Saúde Pública da Universidade de São Paulo Publicador: Faculdade de Saúde Pública da Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2007 Português
Relevância na Pesquisa
66.4712%
OBJECTIVE: To assess risk factors for retreatment of leprosy patients. METHODS: A case-control study with patients from two reference care units in Recife, northeastern Brazil, in 2003. The case group included retreated patients (N=155) and the control group comprised those patients who were not retreated (N=155) matched by year of diagnosis and health care unit. Univariate and multivariate analyses were conducted to test the associations and odds ratios and related 95% confidence intervals were estimated. RESULTS: The following factors were found to be significantly associated (p<0.05) with retreatment: occurrence of adverse immunological reactions after treatment completion (OR=2.3; 95% CI=1.18;4.83), final bacterial index > 1 (OR=6.43; 95% CI=1.67;24.74), therapeutic regimen consisting of sulfone monotherapy (OR=10; 95% CI=0.01;0.78) and reports of household contacts (OR=2.2; 95% CI=0.24;0.85). CONCLUSIONS: The study findings reinforce that the use of dapsone monotherapy should be discontinued, and highlight the need for epidemiological monitoring of specific groups of leprosy patients after treatment completion through periodical clinical and laboratory evaluation. Further studies to explore the association between final bacterial index and retreatment are strongly recommended.

‣ Nested case-control study in a serological survey to evaluate the effectiveness of a Chagas disease control programme in Brazil

Carneiro,M.; Moreno,E.C.; Antunes,C.M.F.
Fonte: World Health Organization Publicador: World Health Organization
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2001 Português
Relevância na Pesquisa
66.60192%
OBJECTIVE: To identify risk factors associated with Trypanosoma cruzi infections in areas under surveillance in the State of Minas Gerais, Brazil. METHODS:A model using a nested case-control design incorporated within a serological survey of schoolchildren which was employed to evaluate the effectiveness of the Chagas disease control programme. FINDINGS:In a sample of 40 374 schoolchildren (aged 7-14 years) surveyed, 16 children tested positive for T. cruzi antibody (by indirect immunofluorescence and indirect haemagglutination). In the case-control study, each case was randomly matched to three seronegative controls (classroom and age + 1 year). Compared to controls, T. cruzi-seropositive children were more likely to have a seropositive mother (odds ratio (OR) = 6.8; 95% confidence interval (CI) = 0.71-63.9) or a seropositive family member (OR = 8.6; 95% CI = 1.0-75.5). CONCLUSION:Use of the nested case-control model in a sero-epidemiological survey to evaluate risk factors for T. cruzi transmission was adequate for assessing the effectiveness of a Chagas disease control programme.