Página 1 dos resultados de 140 itens digitais encontrados em 0.060 segundos

‣ Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

DeFronzo, Ralph A.; Tripathy, Devjit
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
77.937686%

‣ Incretin-Based Therapies: Viewpoints on the way to consensus

Nauck, Michael. A.; Vilsbøll, Tina; Gallwitz, Baptist; Garber, Alan; Madsbad, Sten
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
67.804067%

‣ β-Cell Protection and Therapy for Latent Autoimmune Diabetes in Adults

Cernea, Simona; Buzzetti, Raffaella; Pozzilli, Paolo
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
77.96599%

‣ Changing the Treatment Paradigm for Type 2 Diabetes

Del Prato, Stefano; Penno, Giuseppe; Miccoli, Roberto
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
78.09524%

‣ Viewpoints on the Way to the Consensus Session: Where does insulin resistance start? The adipose tissue

Iozzo, Patricia
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
67.804067%

‣ Target for Glycemic Control: Concentrating on glucose

Monnier, Louis; Colette, Claude
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
67.804067%

‣ Insulin Therapy for Type 2 Diabetes

Swinnen, Sanne G.; Hoekstra, Joost B.; DeVries, J. Hans
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
77.937686%

‣ Defining and Characterizing the Progression of Type 2 Diabetes

Fonseca, Vivian A.
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
78.22584%

‣ Bile Acids and Metabolic Regulation: Mechanisms and clinical responses to bile acid sequestration

Staels, Bart; Fonseca, Vivian A.
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
77.8472%

‣ Early Insulin Treatment in Type 2 Diabetes: What are the pros?

Meneghini, Luigi F.
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
78.09524%

‣ Combined Pharmacologic/Nonpharmacologic Intervention in Individuals at High Risk of Developing Type 2 Diabetes: Pro pharmacologic therapy

Garber, Alan J.
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
77.937686%

‣ Early Insulin Use in Type 2 Diabetes: What are the cons?

Chiasson, Jean-Louis
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
77.937686%

‣ Plasma Glucose Concentration and Prediction of Future Risk of Type 2 Diabetes

Abdul-Ghani, Muhammad A.; DeFronzo, Ralph A.
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
77.96599%

‣ Antioxidant Anti-Inflammatory Treatment in Type 2 Diabetes

Ceriello, Antonio; Testa, Roberto
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
78.09524%

‣ Initiating Insulin Therapy in Type 2 Diabetic Patients Failing on Oral Hypoglycemic Agents: Basal or prandial insulin? The APOLLO trial and beyond

Bretzel, Reinhard G.; Eckhard, Michael; Landgraf, Wolfgang; Owens, David R.; Linn, Thomas
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
77.832373%

‣ Self-Monitoring of Blood Glucose as Part of the Integral Care of Type 2 Diabetes

Boutati, Eleni I.; Raptis, Sotirios A.
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
88.23898%
Results from landmark diabetes studies have established A1C as the gold standard for assessing long-term glycemic control. However, A1C does not provide “real-time” information about individual hyperglycemic or hypoglycemic excursions. Real-time information provided by self-monitoring of blood glucose (SMBG) represents an important adjunct to A1C, because it can differentiate fasting, preprandial, and postprandial hyperglycemia; detect glycemic excursions; identify hypoglycemia; and provide immediate feedback about the effect of food choices, physical activity, and medication on glycemic control. The importance of SMBG is widely appreciated and recommended as a core component of management in patients with type 1 or insulin-treated type 2 diabetes, as well as in diabetic pregnancy, for both women with pregestational type 1 and gestational diabetes. Nevertheless, SMBG in management of non–insulin-treated type 2 diabetic patients continues to be debated. Results from clinical trials are inconclusive, and reviews fail to reach an agreement, mainly because of methodological problems. Carefully designed large-scale studies on diverse patient populations with type 2 diabetes with the follow-up period to investigate long-term effects of SMBG in patients with type 2 diabetes should be carried out to clarify how to make the best use of SMBG...

‣ Nonpharmacologic Therapy and Exercise in the Prevention of Type 2 Diabetes

Tuomilehto, Jaakko
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
78.22106%

‣ Targeting AMPK for cancer prevention and treatment

Li, Weidong; Saud, Shakir M.; Young, Matthew R.; Chen, Guohong; Hua, Baojin
Fonte: Impact Journals LLC Publicador: Impact Journals LLC
Tipo: Artigo de Revista Científica
Publicado em 20/03/2015 Português
Relevância na Pesquisa
68.37677%
AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated, AMPK can promote ATP production and regulate metabolic energy. AMPK is a known target for treating metabolic syndrome and type-2 diabetes; however, recently AMPK is emerging as a possible metabolic tumor suppressor and target for cancer prevention and treatment. Recent epidemiological studies indicate that treatment with metformin, an AMPK activator reduces the incidence of cancer. In this article we review the role of AMPK in regulating inflammation, metabolism, and other regulatory processes with an emphasis on cancer, as well as, discuss the potential for targeting AMPK to treat various types of cancer. Activation of AMPK has been found to oppose tumor progression in several cancer types and offers a promising cancer therapy. This review evaluates the evidence linking AMPK with tumor suppressor function and analyzes the molecular mechanisms involved. AMPK activity opposes tumor development and progression in part by regulating inflammation and metabolism.

‣ β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

Halban, Philippe A.; Polonsky, Kenneth S.; Bowden, Donald W.; Hawkins, Meredith A.; Ling, Charlotte; Mather, Kieren J.; Powers, Alvin C.; Rhodes, Christopher J.; Sussel, Lori; Weir, Gordon C.
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
78.829688%
OBJECTIVE This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment. RESEARCH DESIGN AND METHODS A group of experts participated in a conference on 14–16 October 2013 cosponsored by the Endocrine Society and the American Diabetes Association. A writing group prepared this summary and recommendations. RESULTS The writing group based this article on conference presentations, discussion, and debate. Topics covered include genetic predisposition, foundations of β-cell failure, natural history of β-cell failure, and impact of therapeutic interventions. CONCLUSIONS β-Cell failure is central to the development and progression of T2D. It antedates and predicts diabetes onset and progression, is in part genetically determined, and often can be identified with accuracy even though current tests are cumbersome and not well standardized. Multiple pathways underlie decreased β-cell function and mass, some of which may be shared and may also be a consequence of processes that initially caused dysfunction. Goals for future research include to 1) impact the natural history of β-cell failure; 2) identify and characterize genetic loci for T2D; 3) target β-cell signaling...

‣ Goals of Treatment for Type 2 Diabetes: β-Cell preservation for glycemic control

Marchetti, Piero; Lupi, Roberto; Del Guerra, Silvia; Bugliani, Marco; D'Aleo, Valentina; Occhipinti, Margherita; Boggi, Ugo; Marselli, Lorella; Masini, Matilde
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
Relevância na Pesquisa
78.09524%