Página 1 dos resultados de 1477 itens digitais encontrados em 0.037 segundos

‣ Analysis of cell cycle phases and proliferative capacity in mice bearing melanoma maintained on different dietary proteins

CASTRO, Georgia A.; MARIA, Durvanei A.; RODRIGUES, Consuelo J.; SGARBIERI, Valdemiro C.
Fonte: WILEY-BLACKWELL PUBLISHING, INC Publicador: WILEY-BLACKWELL PUBLISHING, INC
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
47.348726%
Background Diet seems to represent, directly or indirectly, 35% of all cancer reports. In this study, the influence of dietary protein on the growth of melanoma B16F10 was evaluated through analyses of cell cycle phases and proliferative capacity. Methods Flow cytometry and argyrophilic nucleolar organizer regions (AgNORs) technique were applied in mice bearing B16F10 melanoma cells fed on different dietary proteins. All data were submitted to statistical analyses. Results The G0/G1 phase increased for the animal groups fed bovine collagen hydrolysate (BCH) or BCH-P1 + whey protein isolate (WPI), compared with mice receiving only WPI, for all dietary groups treated and nontreated with paclitaxel. Mice that received BCH + WPI treated with paclitaxel showed the highest percentage of apoptosis compared with WPI group. AgNORs, total nucleolar organizer regions (NORs)/cells and dot number/cell for all dietary protein groups nontreated with paclitaxel were higher than for the WPI. The only two dietary protein groups treated with paclitaxel that presented higher total NORs and dot number/cell than the WPI group were BCH + WPI and BCH-P1 + WPI. Conclusions A significantly lower proliferative capacity and larger number of cells in the G0/G1 phase were observed for the dietary protein groups combining the two collagen hydrolysates...

‣ Analysis of cell cycle phases and proliferative capacity in mice bearing melanoma maintained on different dietary proteins

CASTRO, Georgia A.; MARIA, Durvanei A.; RODRIGUES, Consuelo J.; SGARBIERI, Valdemiro C.
Fonte: WILEY-BLACKWELL PUBLISHING, INC Publicador: WILEY-BLACKWELL PUBLISHING, INC
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
47.348726%
Background Diet seems to represent, directly or indirectly, 35% of all cancer reports. In this study, the influence of dietary protein on the growth of melanoma B16F10 was evaluated through analyses of cell cycle phases and proliferative capacity. Methods Flow cytometry and argyrophilic nucleolar organizer regions (AgNORs) technique were applied in mice bearing B16F10 melanoma cells fed on different dietary proteins. All data were submitted to statistical analyses. Results The G0/G1 phase increased for the animal groups fed bovine collagen hydrolysate (BCH) or BCH-P1 + whey protein isolate (WPI), compared with mice receiving only WPI, for all dietary groups treated and nontreated with paclitaxel. Mice that received BCH + WPI treated with paclitaxel showed the highest percentage of apoptosis compared with WPI group. AgNORs, total nucleolar organizer regions (NORs)/cells and dot number/cell for all dietary protein groups nontreated with paclitaxel were higher than for the WPI. The only two dietary protein groups treated with paclitaxel that presented higher total NORs and dot number/cell than the WPI group were BCH + WPI and BCH-P1 + WPI. Conclusions A significantly lower proliferative capacity and larger number of cells in the G0/G1 phase were observed for the dietary protein groups combining the two collagen hydrolysates...

‣ Precipitins to Dietary Proteins in Serum and Upper Intestinal Secretions of Coeliac Children

Ferguson, Anne; Carswell, F.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 08/01/1972 Português
Relevância na Pesquisa
46.97225%
We have used precipitin tests to detect antibodies to 10 dietary proteins in the serum (71 cases) and intestinal secretions (51 cases) of a group of children. Thirty-three of the patients had untreated coeliac disease. Our aims were to find out if, in coeliac patients, there was intestinal secretion of antibodies to wheat proteins only or if, as in coeliac serum, antibodies to many food proteins were present; and to confirm that secretion of antibodies to wheat or gluten was specific for coeliac disease.

‣ Dietary proteins and food-related reward signals

Peuhkuri, Katri; Sihvola, Nora; Korpela, Riitta
Fonte: CoAction Publishing Publicador: CoAction Publishing
Tipo: Artigo de Revista Científica
Publicado em 01/06/2011 Português
Relevância na Pesquisa
47.368022%
Proteins play a crucial role in almost all biological processes. Dietary proteins are generally considered as energy yielding nutrients and as a source of amino acids for various purposes. In addition, they may have a role in food-related reward signals. The purpose of this review was to give an overview of the role of dietary proteins in food-related reward and possible mechanisms behind such effects. Dietary proteins may elicit food-related reward by several different postprandial mechanisms, including neural and humoral signals from the gastrointestinal tract to the brain. In order to exert rewarding effects, protein have to be absorbed from the intestine and reach the target cells in sufficient concentrations, or act via receptors ad cell signalling in the gut without absorption. Complex interactions between different possible mechanisms make it very difficult to gain a clear view on the role and intesity of each mechanism. It is concluded that, in principle, dietary proteins may have a role in food-related reward. However, the evidence is based mostly on experiments with animal models and one should be careful in drawing conclusions of clinical relevance.

‣ Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract

Jahan-Mihan, Alireza; Luhovyy, Bohdan L.; Khoury, Dalia El; Anderson, G. Harvey
Fonte: MDPI Publicador: MDPI
Tipo: Artigo de Revista Científica
Publicado em 11/05/2011 Português
Relevância na Pesquisa
47.301445%
Dietary proteins elicit a wide range of nutritional and biological functions. Beyond their nutritional role as the source of amino acids for protein synthesis, they are instrumental in the regulation of food intake, glucose and lipid metabolism, blood pressure, bone metabolism and immune function. The interaction of dietary proteins and their products of digestion with the regulatory functions of the gastrointestinal (GI) tract plays a dominant role in determining the physiological properties of proteins. The site of interaction is widespread, from the oral cavity to the colon. The characteristics of proteins that influence their interaction with the GI tract in a source-dependent manner include their physico-chemical properties, their amino acid composition and sequence, their bioactive peptides, their digestion kinetics and also the non-protein bioactive components conjugated with them. Within the GI tract, these products affect several regulatory functions by interacting with receptors releasing hormones, affecting stomach emptying and GI transport and absorption, transmitting neural signals to the brain, and modifying the microflora. This review discusses the interaction of dietary proteins during digestion and absorption with the physiological and metabolic functions of the GI tract...

‣ Dietary Proteins Contribute Little to Glucose Production, Even Under Optimal Gluconeogenic Conditions in Healthy Humans

Fromentin, Claire; Tomé, Daniel; Nau, Françoise; Flet, Laurent; Luengo, Catherine; Azzout-Marniche, Dalila; Sanders, Pascal; Fromentin, Gilles; Gaudichon, Claire
Fonte: American Diabetes Association Publicador: American Diabetes Association
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
47.38626%
Dietary proteins are believed to participate significantly in maintaining blood glucose levels, but their contribution to endogenous glucose production (EGP) remains unclear. We investigated this question using multiple stable isotopes. After overnight fasting, eight healthy volunteers received an intravenous infusion of [6,6-2H2]-glucose. Two hours later, they ingested four eggs containing 23 g of intrinsically, uniformly, and doubly [15N]-[13C]–labeled proteins. Gas exchanges, expired CO2, blood, and urine were collected over the 8 h following egg ingestion. The cumulative amount of dietary amino acids (AAs) deaminated over this 8-h period was 18.1 ± 3.5%, 17.5% of them being oxidized. The EGP remained stable for 6 h but fell thereafter, concomitantly with blood glucose levels. During the 8 h after egg ingestion, 50.4 ± 7.7 g of glucose was produced, but only 3.9 ± 0.7 g originated from dietary AA. Our results show that the total postprandial contribution of dietary AA to EGP was small in humans habituated to a diet medium-rich in proteins, even after an overnight fast and in the absence of carbohydrates from the meal. These findings question the respective roles of dietary proteins and endogenous sources in generating significant amounts of glucose in order to maintain blood glucose levels in healthy subjects.

‣ Dietary Proteins and Angiogenesis

Medina, Miguel Ángel; Quesada, Ana R.
Fonte: MDPI Publicador: MDPI
Tipo: Artigo de Revista Científica
Publicado em 17/01/2014 Português
Relevância na Pesquisa
47.13197%
Both defective and persistent angiogenesis are linked to pathological situations in the adult. Compounds able to modulate angiogenesis have a potential value for the treatment of such pathologies. Several small molecules present in the diet have been shown to have modulatory effects on angiogenesis. This review presents the current state of knowledge on the potential modulatory roles of dietary proteins on angiogenesis. There is currently limited available information on the topic. Milk contains at least three proteins for which modulatory effects on angiogenesis have been previously demonstrated. On the other hand, there is some scarce information on the potential of dietary lectins, edible plant proteins and high protein diets to modulate angiogenesis.

‣ Gastrointestinal Endogenous Proteins as a Source of Bioactive Peptides - An In Silico Study

Dave, Lakshmi A.; Montoya, Carlos A.; Rutherfurd, Shane M.; Moughan, Paul J.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 05/06/2014 Português
Relevância na Pesquisa
37.523716%
Dietary proteins are known to contain bioactive peptides that are released during digestion. Endogenous proteins secreted into the gastrointestinal tract represent a quantitatively greater supply of protein to the gut lumen than those of dietary origin. Many of these endogenous proteins are digested in the gastrointestinal tract but the possibility that these are also a source of bioactive peptides has not been considered. An in silico prediction method was used to test if bioactive peptides could be derived from the gastrointestinal digestion of gut endogenous proteins. Twenty six gut endogenous proteins and seven dietary proteins were evaluated. The peptides present after gastric and intestinal digestion were predicted based on the amino acid sequence of the proteins and the known specificities of the major gastrointestinal proteases. The predicted resultant peptides possessing amino acid sequences identical to those of known bioactive peptides were identified. After gastrointestinal digestion (based on the in silico simulation), the total number of bioactive peptides predicted to be released ranged from 1 (gliadin) to 55 (myosin) for the selected dietary proteins and from 1 (secretin) to 39 (mucin-5AC) for the selected gut endogenous proteins. Within the intact proteins and after simulated gastrointestinal digestion...

‣ Effect of Dietary Macronutrients on Food Intake, Body Weight, and Tail Width in the Marsupial S. crassicaudata

Ng, K.; Vozzo, R.; Hope, P.; Chapman, I.; Morley, J.; Horowitz, M.; Wittert, G.
Fonte: PERGAMON-ELSEVIER SCIENCE LTD Publicador: PERGAMON-ELSEVIER SCIENCE LTD
Tipo: Artigo de Revista Científica
Publicado em //1999 Português
Relevância na Pesquisa
47.03183%
The role of dietary fat, as opposed to total energy intake, in the etiology of obesity is controversial. The aim of this study was to determine the effect of macronutrient content, specifically changes in dietary fat on body weight, fat stores, and food intake in S. crassicaudata, a marsupial that stores about 25% of total body fat in its tail. Female animals were divided into three groups (n = 7-9) matched for food intake per gram of body weight. Each group of animals was fed, ad lib an isocaloric diet (1.01 kcal/g), which contained either 10, 20, or 40% of calories from fat. Body weight, food intake, and tail width (an index of body fat stores) were measured daily. Over 21 days, cumulative energy intake was less (p = 0.026) in the 40% fat group compared to the 10% fat group. Despite the differences in food intake, body weight in each group remained stable throughout the study, so that at day 21 there were no differences in the body weights between the three groups. In contrast, tail width increased in the animals who received the 40% fat diet compared to either the 10% (p = 0.016) or 20% (p = 0.001) fat intake groups, whereas there was no significant change in tail width in either of these two groups. These observations indicate that macronutrient composition has a role...

‣ The satiating effect of dietary protein is unrelated to postprandial ghrelin secretion

Moran, L.; Luscombe-Marsh, N.; Noakes, M.; Wittert, G.; Keough, J.; Clifton, P.
Fonte: Endocrine Society Publicador: Endocrine Society
Tipo: Artigo de Revista Científica
Publicado em //2005 Português
Relevância na Pesquisa
46.94739%
CONTEXT: Increasing dietary protein relative to carbohydrate and fat enhances weight loss, at least in part by increasing satiety. The mechanism for this is unclear. OBJECTIVE: The objective of this study was to compare the effects of isocaloric test meals with differing protein to fat ratios on fasting and postprandial ghrelin, insulin, glucose, appetite, and energy expenditure before and after weight loss on the respective dietary patterns. DESIGN: The study design was a randomized parallel design of 12 wk of weight loss (6 MJ/d) and 4 wk of weight maintenance (7.3 MJ/d) with meals administered at wk 0 and 16. SETTING: The study was performed at an out-patient research clinic. PATIENTS AND OTHER PARTICIPANTS: Fifty-seven overweight (body mass index, 33.8 +/- 3.5 kg/m2) hyperinsulinemic men (n = 25) and women (n = 32) were studied. INTERVENTIONS: High-protein/low-fat (34% protein/29% fat) or standard protein/high-fat (18% protein/45% fat) diets/meals were given. MAIN OUTCOME MEASURES: The main outcome measures were weight loss and fasting and postprandial ghrelin, insulin, glucose, appetite, and energy expenditure before and after weight loss. RESULTS: Weight loss (9.2 +/- 0.7 kg) and improvements in fasting and postprandial insulin and glucose occurred independently of diet composition. At wk 0 and 16...

‣ Appetite regulatory hormone responses to various dietary proteins differ by body mass index status despite similar reductions in ad libitum energy intake

Bowen, J.; Noakes, M.; Clifton, P.
Fonte: Endocrine Society Publicador: Endocrine Society
Tipo: Artigo de Revista Científica
Publicado em //2006 Português
Relevância na Pesquisa
57.13197%
CONTEXT: Although dietary protein produces higher acute satiety relative to carbohydrate, the influence of protein source and body mass index (BMI) has not been clearly described. OBJECTIVE: The objective of the study was to assess postprandial responses to different protein sources, compared with glucose, in males with normal and high BMI. DESIGN: This was a randomized, crossover study of four preloads followed by blood sampling (+15, 30, 45, 60, 90, 120, 180 min) and buffet meal. SETTING: The study was conducted at an outpatient clinic. PARTICIPANTS: The study population included 72 men, with a BMI range 20.6-39.9 kg/m(2). INTERVENTIONS: Interventions consisted of liquid preloads (1.1 MJ, 450 ml) containing 50 g whey, soy, gluten, or glucose. MAIN OUTCOME MEASURES: Fasting and postprandial plasma glucose, insulin, ghrelin, glucagon-like peptide-1 (GLP-1) and cholecystokinin (n = 38), ad libitum energy intake, and appetite ratings were measured. RESULTS: Energy intake was 10% lower after all protein preloads, compared with the glucose treatment (P < 0.05), independent of BMI status and protein type. All protein loads prolonged the postprandial suppression of ghrelin (P < 0.01) and elevation of GLP-1 (P < 0.01) and cholecystokinin (P < 0.05). Fasting GLP-1 concentrations [overweight...

‣ Energy intake, ghrelin, and cholecystokinin after different carbohydrate and protein preloads in overweight men

Bowen, J.; Noakes, M.; Trenerry, C.; Clifton, P.
Fonte: Endocrine Society Publicador: Endocrine Society
Tipo: Artigo de Revista Científica
Publicado em //2006 Português
Relevância na Pesquisa
47.1733%
CONTEXT: Dietary proteins appear to be more satiating than carbohydrate. The mechanism and effect of protein and carbohydrate type are unclear. OBJECTIVE: The objective of the study is to compare the acute effect of different proteins and carbohydrates on indicators of appetite and appetite regulatory hormones. DESIGN: This is a randomized cross-over study of four orally consumed preloads followed by blood sampling (+15, 30, 45, 60, 90, 120, 180 min), then a buffet meal. SETTING: The study was carried out in an outpatient clinic. PATIENTS AND OTHER PARTICIPANTS: Nineteen overweight (body mass index 32.1 +/- 0.9 kg/m(2)) men participated. INTERVENTIONS: Liquid preloads (1 MJ) contained whey (55 g), casein (55 g), lactose (56 g), or glucose (56 g). MAIN OUTCOME MEASURES: Plasma ghrelin, cholecystokinin (CCK), insulin, glucose and amino acids, gastric emptying rate (plasma paracetamol), appetite rating (visual analog scale), and ad libitum energy intake were the main outcome measures. RESULTS: Energy intake was 10 +/- 3% higher after the glucose preload compared with lactose and protein preloads (P < 0.05), which were predicted by ghrelin at 120 min (P < 0.05). CCK was 71 +/- 6% higher 90 min after the protein preloads compared with glucose and lactose (P < 0.05)...

‣ Dietary effects on fertility treatment and pregnancy outcomes

Lim, S.; Noakes, M.; Norman, R.
Fonte: Lippincott Williams & Wilkins, Ltd. Publicador: Lippincott Williams & Wilkins, Ltd.
Tipo: Artigo de Revista Científica
Publicado em //2007 Português
Relevância na Pesquisa
47.06029%
PURPOSE OF REVIEW: We summarize the dietary modifications that optimize fertility treatment outcomes. RECENT FINDINGS: Body weight and nutritional status are closely related to reproductive function. However, few studies have investigated the direct effects of dietary modification on fertility treatment outcomes. Research on nutrition in pregnancy suggests that reduction in glycemic load and micronutrient supplementation may improve pregnancy outcomes. SUMMARY: Body weight and specific dietary factors may affect fertility but evidence regarding dietary effects on fertility treatment outcomes is lacking. Research suggests that diets with a low glycemic load during pregnancy may reduce the risk of gestational diabetes or large-for-gestational-age births after adjusting for body mass index and total energy intake, but the effect of protein modification remains controversial. There is also lack of information on the impact of energy restriction during pregnancy on maternal and infant outcomes. Folate supplementation is recommended for prevention of birth defects but further research is required to determine the optimal dose to reduce the risks of multiple gestations. Further information on the upper limits of caffeine and alcohol intake during pregnancy would also be useful.; Siew S. Lim...

‣ Metabolic and Mitochondrial Dysfunction in Early Mouse Embryos Following Maternal Dietary Protein Intervention

Mitchell, M.; Schulz, S.; Armstrong, D.; Lane, M.
Fonte: Soc Study Reproduction Publicador: Soc Study Reproduction
Tipo: Artigo de Revista Científica
Publicado em //2009 Português
Relevância na Pesquisa
46.880806%
Dietary supply of nutrients, both periconception and during pregnancy, influence the growth and development of the fetus and offspring and their health into adult life. Despite the importance of research efforts surrounding the developmental origins of health and disease hypothesis, the biological mechanisms involved remain elusive. Mitochondria are of major importance in the oocyte and early embryo, particularly as a source of ATP generation, and perturbations in their function have been related to reduced embryo quality. The present study examined embryo development following periconception exposure of females to a high-protein diet (HPD) or a low-protein diet (LPD) relative to a medium-protein diet (MPD; control), and we hypothesized that perturbed mitochondrial metabolism in the mouse embryo may be responsible for the impaired embryo and fetal development reported by others. Although the rate of development to the blastocyst stage did not differ between diets, both the HPD and LPD reduced the number of inner cell mass cells in the blastocyst-stage embryo. Furthermore, mitochondrial membrane potential was reduced and mitochondrial calcium levels increased in the 2-cell embryo. Embryos from HPD females had elevated levels of reactive oxygen species and ADP concentrations...

‣ Butyrylated starch protects colonocyte DNA against dietary protein-induced damage in rats

Bajka, B.; Clarke, J.; Cobiac, L.; Topping, D.
Fonte: Oxford Univ Press Publicador: Oxford Univ Press
Tipo: Artigo de Revista Científica
Publicado em //2008 Português
Relevância na Pesquisa
47.03183%
Dietary resistant starch (RS), as a high amylose maize starch (HAMS), prevents dietary protein-induced colonocyte genetic damage in rats, possibly through the short-chain fatty acid (SCFA) butyrate produced by large bowel bacterial RS fermentation. Increasing butyrate availability may improve colonic health and dietary high amylose maize butyrylated starch (HAMSB) is an effective method of achieving this goal. In this study, rats (n = 8 per group) were fed diets containing high levels (25%) of dietary protein as casein with 10 or 20% dietary HAMSB and HAMS. Colonocyte genetic damage was measured by the comet assay and was 2-fold higher in rats fed 25% protein than those fed 15% protein (P < 0.001). Concurrent feeding of 25% protein and either HAMS or HAMSB lowered genetic damage significantly relative to a low-RS high-protein control diet. The 20% HAMSB diet was twice as effective as 20% HAMS in opposing genetic damage. Large bowel digesta butyrate was significantly increased in rats fed 20% compared with 10% HAMS and in rats fed 20% compared with 10% HAMSB. The levels were significantly higher in the HAMSB groups relative to the HAMS groups. Hepatic portal venous SCFA were higher in rats fed HAMS and highest in those fed HAMSB. Caecal digesta ammonia was increased by HAMSB and correlated negatively with digesta pH. Ammonia is cytotoxic and lower digesta pH could lower its absorption...

‣ The interaction between dietary proteins and resistant starch on large bowel health.

Toden, Shusuke
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2007 Português
Relevância na Pesquisa
57.638135%
A review of the literature revealed that diet plays an important role in serious human noninfectious large bowel diseases including cancer and inflammatory bowel diseases. Dietary protein (especially as red and processed meats) has been implicated as a positive risk factor for colorectal cancer while starch which is not digested in the small intestine (resistant starch, RS) appears to be protective. The series of experiments described in this thesis were aimed to determine the effects of dietary proteins and RS on indices of colon health in an animal model, the laboratory rat. Genetic damage is a prerequisite for carcinogenesis and this was assessed by a specific assay (the comet assay) which gives a measure of DNA strand breaks. Loss of mucus barrier function is thought to contribute to inflammatory bowel disease by permitting bacterial translocation and this was measured optically using a microscope micrometer. Other biomarkers were measured as described below. There were four major experiments. 1. Effects of dietary red meat and casein on colonic DNA damage and interaction with resistant starch Previous studies had shown that higher dietary protein (as casein) induced genetic damage in rat colonocytes and that RS (fed as a high amylose maize starch) was protective. This study was aimed at establishing whether a high protein diet fed as cooked red meat had similar effects and whether RS was protective. Rats were fed diets containing either 15 % or 25% casein or 25% barbecued lean red beef...

‣ Dietary effects on incretin hormone secretion

Wu, T.; Rayner, C.; Jones, K.; Horowitz, M.
Fonte: Academic Press Publicador: Academic Press
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
Relevância na Pesquisa
47.136675%
The delivery of nutrients from the stomach into the duodenum and their subsequent interaction with the small intestine to stimulate incretin hormone release are central determinants of the glycemic response. The incretin effect has hitherto been attributed to the secretion of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) from enteroendocrine cells in the intestinal epithelium. A number of recent studies have yielded fundamental insights into the influence of individual nutrients on incretin release and the mechanisms involved in the detection of carbohydrates, fats, and proteins by enteroendocrine cells, including the K(ATP) channel, sodium-glucose cotransporter 1 (SGLT1), sweet taste receptors, G-protein-coupled receptors (GPRs), and oligopeptide transporter 1 (PepT1). Dietary modification, including modifying macronutrient composition or the consumption of "preloads" in advance of a meal, represents a novel approach to manipulate the incretin response and thereby regulate glucose homeostasis in patients with type 2 diabetes. This review focuses on the effects of individual nutrients on incretin hormone secretion, our current understanding of the signaling mechanisms that trigger secretion by enteroendocrine cells...

‣ Weight-loss diets in people with type 2 diabetes and renal disease: a randomized controlled trial of the effect of different dietary protein amounts

Jesudason, D.; Pedersen, E.; Clifton, P.
Fonte: Amer Soc Clinical Nutrition Publicador: Amer Soc Clinical Nutrition
Tipo: Artigo de Revista Científica
Publicado em //2013 Português
Relevância na Pesquisa
46.880806%
BACKGROUND: Higher-protein weight-loss diets (defined as >25% of energy as protein) are not recommended for individuals with type 2 diabetes because of their potential adverse effect on renal function. OBJECTIVE: We aimed to examine the effect of such diets on renal function over 12 mo in people with type 2 diabetes and early renal disease. DESIGN: Overweight and obese people with type 2 diabetes were screened to identify those with an albumin:creatinine ratio from 3 to 30 mg/mmol. Seventy-six subjects were randomly assigned to either a moderate-protein weight-loss diet or a standard-protein weight-loss diet for 12 mo. The primary endpoint was the change in renal function as assessed by the isotope glomerular filtration rate (GFR), estimated GFR, and cystatin C. Forty-five subjects (moderate protein: n = 21; standard protein: n = 24) completed the study. RESULTS: The mean (±SE) weight loss was not different between diets at 9.7 ± 13.4 kg for the moderate-protein diet and 6.6 ± 7.1 kg for the standard-protein diet. There were no changes in renal function or albuminuria or blood pressure, although glycated hemoglobin was lowered with both diets. Changes in renal function were related to the baseline estimated GFR. Patients with stage 1–3 renal disease (<120 mL • min−1 • 1.73 m−2; n = 33) had an improvement in renal function...

‣ Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines

Moran, L.J.; Ko, H.; Misso, M.; Marsh, K.; Noakes, M.; Talbot, M.; Frearson, M.; Thondan, M.; Stepto, N.; Teede, H.J.
Fonte: Oxford University Press (OUP) Publicador: Oxford University Press (OUP)
Tipo: Artigo de Revista Científica
Publicado em //2013 Português
Relevância na Pesquisa
46.880806%
Polycystic ovary syndrome (PCOS) is a common condition associated with a complex reproductive, metabolic and psychological presentation, which is worsened by obesity. Despite lifestyle interventions being recommended as primary initial therapy, it remains unclear which dietary composition is optimal for weight management and improving the clinical features of PCOS. This is a summary of a systematic review published in the Journal of the Academy of Nutrition and Dietetics (Moran et al., 2013) comparing the effect of different dietary compositions on anthropometric, reproductive, metabolic and psychological outcomes in PCOS.; Lisa J. Moran, Henry Ko, Marie Misso, Kate Marsh, Manny Noakes, Mac Talbot, Meredith Frearson, Mala Thondan, Nigel Stepto and Helena J. Teede; Erratum in Human Reproduction Update. 2014 Jan-Feb; 20(1):152.

‣ Dietary proteins on reproductive performance in three consecutive generations of rats

Nepomuceno de Pontes Pessoa,Débora Catarine; Salzano Lago,Eunice; Regueira Teodósio,Naíde; Martins Bion,Francisca
Fonte: Sociedad Latinoamericana de Nutrición Publicador: Sociedad Latinoamericana de Nutrición
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2000 Português
Relevância na Pesquisa
67.23026%
The cumulative effects of the long-term consumption of the Regional Basic Diet (RBD) of Northeast Brazil on gestational and lactational performances were assessed in three consecutive generations of Sprague Dawley rats (n= 1,334). The animals were distributed into three groups: RBD (8% predominantly vegetable- based proteins), Control (8% casein) and Standard (22% casein). Primiparous fertilized rats aged 120 days old and their offsprings made up generation l. Consecutive generations were obtained by mating products from previous generations. Statistical differences between groups and generations were analysed by the method of Kruskal-Wallis. In comparison with their respective controls, data for RBD-fed groups were as follows: decreased conception rates, gradual declines in gestational body weight gains and reduction in the mean number of youngs per litter; the weight loss of lactating rats aggravated in consecutive generations; suckling rats had lower values for birthweight and weight gain, higher values for death rates (including soon after weaning) and severe immaturity at weaning (21 days), This dietary experimental model proved to be valid in terms of providing information for further studies about the relationship between quality and quantity of dietary proteins in order to allow decisisons on supplementary feeding programmes for people now most in need.