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‣ Secondary metabolites produced by Propionicimonas sp (ENT-18) induce histological abnormalities in the sclerotia of Sclerotinia sclerotiorum

ZUCCHI, Tiago D.; ALMEIDA, Luis G.; DOSSI, Fabio C. A.; CONSOLI, Fernando L.
Fonte: SPRINGER Publicador: SPRINGER
Tipo: Artigo de Revista Científica
Português
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Sclerotinia sclerotiorum is a highly aggressive pathogen that causes great economic losses, especially in temperate climates. Several biological control agents are available, but actinobacteria have seldom been used to control this fungus. Our objective was to evaluate the efficiency and ultrastructural effects of the secondary metabolites produced by the ant-associated actinobacterium Propionicimonas sp. ENT-18 in controlling the sclerotia of S. sclerotiorum. We demonstrated total inhibition of sclerotia treated with 62.5 mu g/10 mu l of an ethyl acetate extract of compounds produced by ENT-18, and calculated an LC(50) of 1.69 mu g/sclerotia. Histological and ultrastructural analysis indicated that the cells of the treated sclerotia were severely damaged, suggesting direct action of the biomolecule(s) produced by the actinobacterium ENT-18 on the cell structure of the medullae and rind cell wall. This is the first report demonstrating a novel property of Propionicimonas sp.-antifungal activity against S. sclerotiorum.; FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-Brazil)[07/58712-5]; FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-Brazil)[07/59019-1]

‣ Clinical etiology of myiasis in ENT: a reterograde period - interval study

Arora,Shitij; Sharma,J.K; Pippal,S.K; Sethi,Yatin; Yadav,Abhinav
Fonte: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial Publicador: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2009 Português
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Myiasis in ENT, once a deadly disease still presents as a significant outdoor problem, though advances in management including supportive therapy has led to early healing with significant reduction in bed occupancy rate. AIMS: To assess the clinico etiology, relationship of myiasis to habit and habitat of patients and to assess the changes in age, seasonal, socioeconomic incidence, nasal bacterial flora and usefulness of certain commonly done tests with reference to a gap of 25 years. MATERIALS & METHODS: The presenting study was conducted on 80 patients selected over a period of two time intervals ; first 40 cases were chosen from 1979 to 1980 and next 40 over 2003 to 2004. Cases were studied in a retrograde manner and data tabulated. RESULTS & CONCLUSIONS: Atrophic turbinates was the commonest pathological finding in nose in 30% of cases . Significant change seen was in the age group 51 and above with a rise of 30%. Mode during 2003-04 was 60 years. Incidence of palatal perforation dropped from 17.88 to 2.5% . Klebsiella emerged as a significant contributor to the nasal microbial flora. VDRL and split skin smear showed poor etiological association for the diseases.

‣ Epidemiologic Profile of an Otolaryngologic Emergency Service

Prestes,Luciano; Hamerschmidt,Rogerio; Tenorio,Sergio; Moreira,Ana Tereza; Tambara,Elizabeth
Fonte: Fundação Otorrinolaringologia Publicador: Fundação Otorrinolaringologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2014 Português
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Introduction According to current research, the number of patients seen in the emergency room is progressively increasing. There are few studies on the characteristics of ear, nose, and throat diseases treated in the emergency room. Objectives (1) To establish the epidemiologic profile of patients with these complaints treated at a referral emergency hospital in locoregional city Curitiba, and (2) to evaluate the calls that truly required emergency care. Methods This is a contemporary cross-study of urgent and emergency referrals to a hospital with otolaryngologic services during the year 2012. Data were collected and epidemiologic characteristics analyzed. Results We analyzed 1,067 patients: 312 presented in spring, 255 in summer, 253 in autumn, and 247 in winter. We found 17 diseases that were common during the year, with 244 (23.99%) upper respiratory tract infections being the most frequent disease. There was no statistically significant difference in the incidence of diseases, except that acute otitis media was most common during the summer (p = 0.02); distribution between the sexes was balanced. The predominant age group was adults. We found 9.27% cases were true emergencies. Conclusion Patients were 20 to 40 years, with upper respiratory tract infection the most incident disease; 9.27% of cases were emergencies.

‣ The Rice Dwarf Virus P2 Protein Interacts with ent-Kaurene Oxidases in Vivo, Leading to Reduced Biosynthesis of Gibberellins and Rice Dwarf Symptoms1

Zhu, Shifeng; Gao, Feng; Cao, Xuesong; Chen, Mao; Ye, Gongyin; Wei, Chunhong; Li, Yi
Fonte: American Society of Plant Biologists Publicador: American Society of Plant Biologists
Tipo: Artigo de Revista Científica
Publicado em /12/2005 Português
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The mechanisms of viral diseases are a major focus of biology. Despite intensive investigations, how a plant virus interacts with host factors to cause diseases remains poorly understood. The Rice dwarf virus (RDV), a member of the genus Phytoreovirus, causes dwarfed growth phenotypes in infected rice (Oryza sativa) plants. The outer capsid protein P2 is essential during RDV infection of insects and thus influences transmission of RDV by the insect vector. However, its role during RDV infection within the rice host is unknown. By yeast two-hybrid and coimmunoprecipitation assays, we report that P2 of RDV interacts with ent-kaurene oxidases, which play a key role in the biosynthesis of plant growth hormones gibberellins, in infected plants. Furthermore, the expression of ent-kaurene oxidases was reduced in the infected plants. The level of endogenous GA1 (a major active gibberellin in rice vegetative tissues) in the RDV-infected plants was lower than that in healthy plants. Exogenous application of GA3 to RDV-infected rice plants restored the normal growth phenotypes. These results provide evidence that the P2 protein of RDV interferes with the function of a cellular factor, through direct physical interactions, that is important for the biosynthesis of a growth hormone leading to symptom expression. In addition...

‣ Traditional management of ear, nose and throat (ENT) diseases in Central Kenya

Njoroge, Grace N; Bussmann, Rainer W
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 27/12/2006 Português
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Diseases of ear, nose and throat (ENT) often have serious consequences including hearing impairment, and emotional strain that lower the quality of life of patients. In Kenya, upper respiratory infections are among the most common infections encountered in outpatient facilities. Some of these infections are becoming difficult to control because some of the causing microorganisms have acquired antibiotic resistance and hence the need to develop new drugs with higher efficacy. Ethnobotanical studies have now been found to be instrumental in improving chances of discovering plants with antimicrobial activity in new drug development. In Kenya the majority of local people are turning to herbal remedies for primary health care needs. In most cases the sources of these remedies are undocumented and the knowledge about them passed orally form generation to generation, hence under threat of disappearing with current rates of modernisation.

‣ ENT assessment in the integrated management of candidate for (maxillary) sinus lift

Pignataro, L; Mantovani, M; Torretta, S; Felisati, G; Sambataro, G
Fonte: Pacini Editore SpA Publicador: Pacini Editore SpA
Tipo: Artigo de Revista Científica
Publicado em /06/2008 Português
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As stated at the 1996 Consensus Conference at Babson College, a (maxillary) sinus lift is a “safe and predictable” procedure for increasing alveolar bone height in the postero-superior alveolar regions in order to allow oral rehabilitation and restore masticatory function by means of the insertion of a dental implant even in the case of an atrophic maxilla. However, the procedure has a well-known impact on the delicate homeostasis of the maxillary sinus: the concomitant presence of systemic, naso-sinusal or maxillary sinus disease may favour the development of post-operative complications (particularly maxillary rhino-sinusitis), which can compromise a good surgical outcome. On the basis of these considerations, the management of sinus lift candidates should include the careful identification of any situations contraindicating the procedure and, if naso-sinusal disease is suspected, a clinical assessment by an ear, nose and throat specialist, which should include nasal endoscopy and, if necessary, a computed tomography scan of the maxillo-facial district, particularly the ostio-meatal complex. This first preventive-diagnostic step should be dedicated to detect presumably irreversible and potentially reversible contraindications to a sinus lift...

‣ Rhino-Bronchial Syndrome. The SIO-AIMAR (Italian Society of Otorhinolaryngology, Head Neck Surgery-Interdisciplinary Scientific Association for the Study of the Respiratory Diseases) survey

PASSALI, D.; BENEDETTO, F.; BENEDETTO, M.; CHIARAVALLOTI, F.; DAMIANI, V.; PASSALI, F.M.; BELLUSSI, L.M.; THE WORKING GROUP,
Fonte: Pacini Editore SpA Publicador: Pacini Editore SpA
Tipo: Artigo de Revista Científica
Publicado em /02/2011 Português
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In spite of the amount of literature demonstrating the relationship between upper and lower airways, both from the anatomical, and pathophysiological point of view, little is known about the epidemiology, diagnosis and treatment of the Rhino-Bronchial Syndrome (RBS). After the publication, in 2003, of a Consensus Report defining the Rhino-Bronchial Syndrome, an interdisciplinary group of experts made up from the Italian ENT Society (SIO) and the Interdisciplinary Scientific Association for the Study of Respiratory Diseases (AIMAR) met again in 2005 in order to study a protocol which would have, as the main tasks, the analysis of RBS signs and symptoms and standardization of the diagnostic approach. A secondary endpoint was to characterize the most effective therapeutic options and to correct the great dyshomogeneity in the therapeutic approaches. With this aim, 9 ENT and Pneumology Centres were selected, based on the ability to multidisciplinary cooperation, availability of useful instrumentation and homogeneous distribution over the entire National territory. Overall, 159 patients were enrolled according to clinical history (major and minor symptoms of upper and lower airways) and inclusion/exclusion criteria. All underwent a two level diagnostic approach. In 116 patients...

‣ Psychological implications in ENT diseases

Sood, V. P.; Jain, Ajay
Fonte: Springer-Verlag Publicador: Springer-Verlag
Tipo: Artigo de Revista Científica
Português
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We are sometimes faced with psychic derangement or overlay in some of the ENT diseases and the link between patient’s psyche and any ENT disease at times becomes signifi cant and troublesome. The conditions in the fi eld between otorhinolaryngology and psychiatry can be classifi ed as psychiatric symptoms resulting from ENT diseases or interventions and those expressing themselves as ENT symptoms due to mental ailment. The former include hearing impairment, dizziness, tinnitus, choked airway, bad oral breath, stuffy nose, traumatic interventions and external nasal deformities. The later include exaggerated and diminished pharyngeal refl ex, globus hystericus, speech disorders, vasomotor rhinitis, nose picking, choked feeling, dizziness and headache. At times diseases originate in the human mind (consciousness), causing negative thoughts like jealousy, anger, and depression due to frustration. p ]A healthy mind in a healthy body generates sound and noble thoughts. Once a healthy body-mind relationship is established, we can be reasonably sure that greater happiness and success is within our reach. Patient seeking help from ENT surgeons to change their physical appearances and or function may not understand that the ultimate goal of surgery is to bring about psychological change by modifying the physical change...

‣ Infection, inflammation and exercise in cystic fibrosis

van de Weert-van Leeuwen, Pauline Barbera; Arets, Hubertus Gerardus Maria; van der Ent, Cornelis Korstiaan; Beekman, Jeffrey Matthijn
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Português
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Regular exercise is positively associated with health. It has also been suggested to exert anti-inflammatory effects. In healthy subjects, a single exercise session results in immune cell activation, which is characterized by production of immune modulatory peptides (e.g. IL-6, IL-8), a leukocytosis and enhanced immune cell functions. Upon cessation of exercise, immune activation is followed by a tolerizing phase, characterized by a reduced responsiveness of immune cells. Regular exercise of moderate intensity and duration has been shown to exert anti-inflammatory effects and is associated with a reduced disease incidence and viral infection susceptibility. Specific exercise programs may therefore be used to modify the course of chronic inflammatory and infectious diseases such as cystic fibrosis (CF).

‣ Ophthalmological Manifestations of ENT Diseases: An Overview

Ghosh, Debangshu; Khanna, Swagata; Baruah, D. K.
Fonte: Springer India Publicador: Springer India
Tipo: Artigo de Revista Científica
Português
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A total number of 62 cases of ophthalmological manifestations caused by various ENT diseases, mostly paranasal tumour extensions, nasopharyngeal tumour and furunculosis of nose were analysed in a retrospective study in relation to their age, sex, clinical, radiological and HP profile. CT scan was considered as the most dependable investigating tool. Different modalities of medical and surgical treatment have been adopted according to location and nature of the disease. A close cooperation is needed between otolaryngologist and ophthalmologist to overcome this challenge.

‣ Jaridonin, a Novel Ent-Kaurene Diterpenoid from Isodon rubescens, Inducing Apoptosis via Production of Reactive Oxygen Species in Esophageal Cancer Cells

Ma, Yong-Cheng; Ke, Yu; Zi, Xiaolin; Zhao, Wen; Shi, Xiao-Jing; Liu, Hong-Min
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /07/2013 Português
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Isodon rubescens, a Chinese herb, has been used as a folk, botanical medicine in China for inflammatory diseases and cancer treatment for many years. Recently, we isolated a new ent-kaurene diterpenoid, named Jaridonin, from Isodon rubescens. The chemical structure of Jaridonin was verified by Infrared (IR), Nuclear magnetic resonance (NMR), and Mass spectrum (MS) data as well as X-ray spectra. Jaridonin potently reduced viabilities of several esophageal cancer cell lines, including EC109, EC9706 and EC1. Jaridonin treatment resulted in typical apoptotic morphological characteristics, increased the number of annexin V-positive staining cells, as well as caused a G2/M arrest in cell cycle progression. Furthermore, Jaridonin resulted in a significant loss of mitochondrial membrane potential, release of cytochrome c into the cytosol, and then activation of Caspase-9 and -3, leading to activation of the mitochondria mediated apoptosis. Furthermore, these effects of Jaridonin were accompanied by marked reactive oxygen species (ROS) production and increased expression of p53, p21waf1/Cip1 and Bax, whereas two ROS scavengers, N-acetyl-L-cysteine (L-NAC) and Vitamin C, significantly attenuated the effects of Jaridonin on the mitochondrial membrane potential...

‣ Effect of Long-Term Voluntary Exercise Wheel Running on Susceptibility to Bacterial Pulmonary Infections in a Mouse Model

van de Weert – van Leeuwen, Pauline B.; de Vrankrijker, Angélica M. M.; Fentz, Joachim; Ciofu, Oana; Wojtaszewski, Jørgen F. P.; Arets, Hubertus G. M.; Hulzebos, Hendrikus J.; van der Ent, Cornelis K.; Beekman, Jeffrey M.; Johansen, Helle K.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 23/12/2013 Português
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Regular moderate exercise has been suggested to exert anti-inflammatory effects and improve immune effector functions, resulting in reduced disease incidence and viral infection susceptibility. Whether regular exercise also affects bacterial infection susceptibility is unknown. The aim of this study was to investigate whether regular voluntary exercise wheel running prior to a pulmonary infection with bacteria (P. aeruginosa) affects lung bacteriology, sickness severity and phagocyte immune function in mice. Balb/c mice were randomly placed in a cage with or without a running wheel. After 28 days, mice were intranasally infected with P. aeruginosa. Our study showed that regular exercise resulted in a higher sickness severity score and bacterial (P. aeruginosa) loads in the lungs. The phagocytic capacity of monocytes and neutrophils from spleen and lungs was not affected. Although regular moderate exercise has many health benefits, healthy mice showed increased bacterial (P. aeruginosa) load and symptoms, after regular voluntary exercise, with perseverance of the phagocytic capacity of monocytes and neutrophils. Whether patients, suffering from bacterial infectious diseases, should be encouraged to engage in exercise and physical activities with caution requires further research.

‣ Early Experience with the Endowedge Technique and Snorkel Technique for Endovascular Aneurysm Repair with Challenging Neck Anatomy

Igari, Kimihiro; Kudo, Toshifumi; Uchiyama, Hidetoshi; Toyofuku, Takahiro; Inoue, Yoshinori
Fonte: The Editorial Committee of Annals of Vascular Diseases Publicador: The Editorial Committee of Annals of Vascular Diseases
Tipo: Artigo de Revista Científica
Português
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Objectives: This study was evaluating the outcomes of endovascular aneurysm repair (EVAR) using the endowedge technique (EnT) and/or snorkel technique (SnT) for abdominal aortic aneurysms (AAAs).

‣ Rising Methicillin-Resistant Staphylococcus aureus Infections in Ear, Nose, and Throat Diseases

Thirumazhisi Sachithanandam, Sangeetha
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
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The increasing incidence of methicillin-resistant Staphylococcus aureus infections (MRSA) in ENT diseases is becoming a big clinical concern. Here two patients are described who developed MRSA infections presented with unusual post-FESS epistaxis and postmastoidectomy perichondrial abscess and failed treatment with broad spectrum intravenous antibiotics. Following treatment with oral linezolid combined with local mupirocin dressing both patients fully recovered.

‣ Diseases of the middle ear in childhood

Minovi, Amir; Dazert, Stefan
Fonte: German Medical Science GMS Publishing House Publicador: German Medical Science GMS Publishing House
Tipo: Artigo de Revista Científica
Publicado em 01/12/2014 Português
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Middle ear diseases in childhood play an important role in daily ENT practice due to their high incidence. Some of these like acute otitis media or otitis media with effusion have been studied extensively within the last decades. In this article, we present a selection of important childhood middle ear diseases and discuss the actual literature concerning their treatment, management of complications and outcome. Another main topic of this paper deals with the possibilities of surgical hearing rehabilitation in childhood. The bone-anchored hearing aid BAHA® and the active partially implantable device Vibrant Soundbridge® could successfully be applied for children. In this manuscript, we discuss the actual literature concerning clinical outcomes of these implantable hearing aids.

‣ Perfil epidemiológico em otorrinolaringologia de Curitiba e Região Metropolitana

Prestes, Luciano Campelo
Fonte: Universidade Federal do Paraná Publicador: Universidade Federal do Paraná
Tipo: Dissertação Formato: 51f. : il. algumas color., grafs., tabs.; application/pdf
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Orientador: Prof. Dr. Rogério Hamerschmidt; Co-orientador: Prof. Dr. Jorge Eduardo Fouto Matias; Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Clínica Cirúrgica. Defesa: Curitiba, 17/10/2014; Inclui referências; Resumo: Introdução: Segundo pesquisas atuais, observa-se aumento progressivo do número de pacientes atendidos em serviços de urgência/emergência. São escassos os estudos sobre as características das doenças otorrinolaringológicas atendidas em pronto- socorro. Objetivos: 1- Criar, aplicar e validar o protocolo de Perfil Epidemiológico em Otorrinolaringologia. 2 Estabelecer o perfil epidemiológico dos pacientes com queixas otorrinolaringológicas atendidos em um hospital de referência na cidade de Curitiba e região. 3- Realizar o planejamento e adequação da instituição de acordo com a demanda e o perfil dos pacientes atendidos. Métodos: Primeiramente foi elaborado um protocolo específico Perfil Epidemiológico em Otorrinolaringologia, a partir de Protocolo Mestre. Foi realizado um estudo retrospectivo, contemporâneo e transversal, dos atendimentos de urgência e emergência do hospital de referência em Otorrinolaringologia durante o ano de 2012. Através do programa SINPE© realizou-se a coleta de dados e posterior análise epidemiológica. Foram analisados 1067 pacientes...

‣ Langzeitresultate der Behandlung von Tumorerkrankungen im Bereich von Mundhöhle und Oropharynx; Long-term results in the treatment of tumor diseases in the area of oral cavity and oropharynx

Spengler, Krischan Robert
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
Português
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Zur Untersuchung der Langzeitergebnisse wurden alle Patienten mit einer malignen Tumorerkrankung im Bereich der Mundhöhle und des Oropharynx erfasst, die zwischen 1982 und 1991 an der HNO-Klinik in Tübingen therapiert worden sind. Insgesamt sind 609 Patienten in die Auswertung eingeflossen. Getrennt nach vier Tumorregionen wurden die 5-Jahres-Überlebensraten ermittelt und zur Erstdiagnose und zu den verschiedenen Therapieschemata in Beziehung gebracht. Bei den untersuchten Tumorerkrankungen kann insgesamt von einer Inzidenzzunahme ausgegangen werden. Es zeigt sich tendenziell eine Vorverlagerung des Diagnosezeitpunktes; bezüglich der Ausdehnung der Primärtumoren lassen sich zwischen älteren und jüngeren Patienten keine bedeutsamen Unterschiede feststellen. Das männliche Geschlecht stellt einen positiven Vorhersagewert für das Auftreten von Plattenepithelkarzinomen sowie für eine Verschlechterung der Überlebenswahrscheinlichkeit dar. Dabei spielen schädigende Noxen wie Alkohol und Rauchen eine bedeutende Rolle. Die Überlebensraten sind weitgehend geschlechts- und altersunabhängig. Bezüglich einer niederen histologischen Differenzierung kann kein negativer Vorhersagewert abgeleitet werden, allerdings zeigt sich eine prognostische Bedeutung des Lymphknotenbefalls bei Erstdiagnose. Außerdem ist die Überlebensrate mit zunehmender Tumorausbreitung reduziert; es ließ sich aber kein signifikanter Unterschied zwischen den einzelnen T-Stadien nachweisen. Eine verminderte Überlebensrate kann somit nicht alleine dem verwendeten Therapiemodus zugeschrieben werden. Die deutlich schlechtere Prognose von ausgedehnteren Tumoren hängt direkt mit dem Risiko für die Entwicklung von Fernmetastasen zusammen. Bei vor allem lymphogenem Metastasierungsweg ist deshalb die Durchführung einer Neck Dissection nicht nur ein therapeutischer sondern auch ein wichtiger prognostischer Faktor. Auf die häufig radikalen chirurgischen Maßnahmen kann in den vergangenen Jahren zunehmend – zu Gunsten eines funktionserhaltenden Eingriffs –verzichtet werden. Im Gegensatz zu den Patienten mit Karzinom im Bereich des Oropharynx und der Mundhöhle zeigte sich bei Behandlung der Mundboden-Karzinom-Patienten ein signifikanter Unterschied bezüglich der registrierten Überlebenszeiten...

‣ Langzeitresultate der Behandlung von Tumorerkrankungen im Bereich von Hypopharynx und Larynx; Long-term results in the treatment of tumor diseases in the area of hypopharynx and larynx

Spengler, Lennart Walter
Fonte: Universität Tübingen Publicador: Universität Tübingen
Tipo: Dissertation; info:eu-repo/semantics/doctoralThesis
Português
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Ziel der Arbeit war die Erfassung von Langzeitbehandlungsergebnissen bei Patienten mit Karzinomen im Bereich des Hypopharynx und Larynx, die zwischen 1982 und 1991 an der HNO-Klinik in Tübingen therapiert worden sind. Insgesamt sind so 730 Patienten in die Auswertung eingeflossen. Aufgeteilt in vier Tumorregionen wurden die 5-Jahres-Überlebensraten zu den verschiedenen Therapieschemata ermittelt. Der Vergleich ist allerdings prinzipiell dadurch erschwert, dass die verschiedenen Therapieformen bei den einzelnen Tumorstadien unterschiedlich häufig eingesetzt wurden. Eine Inzidenzzunahme in jüngerer Zeit erklärt sich durch eine höhere Anzahl an festgestellten Erkrankungen und eine Vorverlagerung des Diagnosezeitpunktes. Das Patientenalter spielt bezüglich der Ausdehnung der Primärtumoren bei Erstdiagnose keine Rolle. Ein positiver Vorhersagewert für das Auftreten der Erkrankungen ist das männliche Geschlecht. Damit verbunden ist eine Verschlechterung der Überlebenswahrscheinlichkeit. Als prädisponierende Faktoren spielen vor allem der Alkohol- und Nikotinkonsum eine große Rolle. Ein Häufigkeitsgipfel der Erstdiagnosen zeigt sich zwischen dem 50-60. Lebensjahr. Prognostische Bedeutung hat der Lymphknotenbefall bei Erstdiagnose und das damit verbundene Risiko für eine Fernmetastasierung. Die Neck Dissection stellt deswegen ebenfalls einen wichtigen prognostischen Faktor dar. Ein negativer Vorhersagewert bezüglich einer geringeren histologischen Differenzierung lässt sich hier nicht ableiten. Die vergleichende Betrachtung der unterschiedlichen Therapieschemata ergibt bei Patienten mit Karzinomen im Bereich des glottischen Larynx und des supraglottischen Larynx keinen signifikanten Unterschied bezüglich der registrierten Überlebenszeiten. Bei der Patientengruppe mit Karzinomen im Bereich des Hypopharynx zeigt sich ein signifikanter Unterschied bezüglich der medianen Überlebenszeit zu Gunsten einer operativen Therapie. Eine solitäre Operation als auch eine Operation mit Anwendung einer adjuvanten Therapieform sind hier einer alleinigen Radiatio oder einer alleinigen Chemotherapie deutlich überlegen...

‣ Ear, nose and throat (ENT) involvement in zoonotic diseases : a systematic review

Galletti, Bruno; Mannella, Valentina K.; Santoro, Roberto; Rodríguez Morales, Alfonso Javier; Freni, Francesco; Galleti, Claudio; Galleti, Francesco; Cascio, Antonio
Fonte: Universidade Tecnológica de Pereira Publicador: Universidade Tecnológica de Pereira
Tipo: Artigo de Revista Científica Formato: PDF
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Introducción: Las zoonosis son infecciones de transmisión del animal al hombre, ya sea directamente (a través del contacto directo o contacto con productos de origen animal) o indirectamente (a través de un vector intermedio, tal como un artrópodo). Los agentes causales incluyen bacterias, parásitos, virus y hongos. El propósito de esta revisión es hacer un examen preciso de todas las enfermedades zoonóticas que pueden ser responsables de oído, nariz y garganta (ENT) participación. Metodología: Se realizó una búsqueda en PubMed combinando los términos (otorrinolaringología o Rinología o laringología o otología or mastoiditis u otitis o sinusitis o laringitis o rinitis o faringitis o de la epiglotitis o disfonía o la oreja o la laringe o la nariz or faringe) con cada uno de los agentes etiológicos de las zoonosis para el período entre enero de 1997 y agosto de 2012 sin restricciones de lenguaje. Resultados: Se seleccionaron un total de 164 artículos y se examina. Laringe es el órgano más frecuentemente afectado ENT, seguido de la cavidad oral, faringe, y el cuello. Las bacterias fueron los microorganismos más representativos implicados. La nariz y las glándulas salivales mayores fueron los más afectados frecuentemente por protozoos; senos paranasales...

‣ Enteropatia sensible al gluten en pacients amb malalties autoimmunes sistèmiques: Aspectes fisiopatològics i rellevància clínica

Vives Fernández, Maria José; Fonollosa Pla, Vicent
Fonte: [Barcelona] : Universitat Autònoma de Barcelona, Publicador: [Barcelona] : Universitat Autònoma de Barcelona,
Tipo: Tesis i dissertacions electròniques; info:eu-repo/semantics/doctoralThesis; info:eu-repo/semantics/publishedVersion Formato: application/pdf
Publicado em //2015 Português
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La malaltia celíaca(MC) és una patologia inflamatòria de la mucosa del budell prim mediada pel gluten, que es resol amb la retirada d'aquest element de la dieta. La seva repercussió clínica i potencials complicacions fan important establir-ne el diagnòstic. El diagnòstic de la MC és complexe per les múltiples formes de presentació de la malaltia i per què prop del 50% dels pacients es mantenen asimptomàtics. Es fonamenta en la histologia, però actualment es disposa de marcadors serològics i genètics que permeten detectar individus amb risc. El cribatge de la malaltia s'aplica a individus amb sospita de MC i en poblacions establertes de risc, utilitzant tests serològics (anticossos antitransglutaminassa tisular –anti-tTG- i anticossos antiendomisi –EMA-). La sensibilitat i especificitat d'aquests tests, però, varia segons el grau de lesió de la mucosa; en aquest sentit, estudis recents demostren que, en una població de risc, complementar l'estratègia de cribatge habitual amb l'estudi genètic (HLA-DQ2 i HLA-DQ8), seguit de l'estudi histològic del budell prim, permet diagnosticar tres vegades més pacients amb MC que la serologia sola. La relació entre la MC i malalties autoimmunes organoespecífiques està ben establerta. Sembla també...