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‣ Epidemiologia da infecção pelo vírus da hepatite b em assentados em Goiás: subsídios para ações de prevenção e controle em populações emergentes; Epidemiology of infection by hepatitis B virus in settlments in Goiás: grants for prevention and control in emerging populations

Caetano, Karlla Antonieta Amorim
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Ciências da Saúde (FM); Faculdade de Medicina - FM (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Ciências da Saúde (FM); Faculdade de Medicina - FM (RG)
Tipo: Tese de Doutorado Formato: application/pdf
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Estimates indicate a total of 240 million chronic hepatitis B carriers worldwide. In Brazil, rural settlements present adverse life conditions that favor the acquisition of health problems, such as the hepatitis B virus (HBV). The objective of the present study was to investigate the epidemiology of the infections caused by the hepatitis B and D viruses in people living in settlements in the southwest region of the state of Goiás. This is an observational, analytical, cross-sectional study, with a subsequent cohort of susceptible subjects for vaccination against HBV, assessment of adherence and vaccine response. In the period from May to July of 2011, 467 subjects were selected from seven settlements in the southwest of Goiás. All subjects were interviewed and tested for the detection of the serological markers HBsAg, anti-HBc and anti-HBs, by means of the enzyme-linked immunosorbent assay (ELISA). Reactive HBsAg samples were tested for total anti-HDV and IgM, by means of the ELISA, submitted to the detection of the HBV DNA by semi-nested PCR and genotyped by sequencing. Chemiluminescent microparticle immunoassay was used for the quantitative determination of anti-HBs. The research proposal was approved by the Research Ethics Committee of the Federal University of Goiás. Of the total sample...

‣ Vacinação contra hepatite B em mulheres profissionais do sexo: um desafio para os profissionais de saúde; Hepatitis B vaccination in women sex workers: a challenge for health professionals

Moraes, Luciene Carneiro
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Ciências da Saúde (FM); Faculdade de Medicina - FM (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Ciências da Saúde (FM); Faculdade de Medicina - FM (RG)
Tipo: Dissertação Formato: application/pdf
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Hepatitis B virus (HBV) infection is geographically distributed in the world and considered and of the most important public health risk. Female sex workers (FSW) are at high risk for HBV infection, and vaccination is the most effective strategy to prevent it. In Brazil, this vaccine is offered to all individuals under 25 years old and groups at high risk for hepatitis B, such as sex workers. This investigation aimed to evaluate the status of immunization, analyze predictor factors, compliance with and response to hepatitis B vaccine using two schemes: standard - G1 (0, 1, 6 months) and accelerated - G2 (0, 1 and 4 months). A total of 319 women was investigated and offered the hepatitis B vaccine. We identified 187 (58.6%) FSWs susceptible for hepatitis B, 170 of them received the first vaccine dose, and 84 were randomized to receive the G1 scheme, and 86 the G2 one. The second dose was administered according the proposed schemes in only 17 and 28 women in G1 and G2, respectively. Fifty-two women were rescued and received the second dose of the vaccine, regardless of the dosing interval, this group was designated GR. The third dose was administered in 6, 11 and 51 women of G1, G2 and GR, respectively. In only 60 women...

‣ Prevalência da infecção pelo vírus da hepatite B e situação vacinal em usuários de crack institucionalizados em Goiânia – Goiás; Prevalence of hepatitis B virus infection and situtation vaccine in users of crack institutionalized in Goiania-Goiás

Silva, Leandro Nascimento da
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Ciências da Saúde (FM); Faculdade de Medicina - FM (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Ciências da Saúde (FM); Faculdade de Medicina - FM (RG)
Tipo: Dissertação Formato: application/pdf
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Crack is considered a public health problem in Brazil and in the world because of its impact on social relationships, physical and mental integrity of the user, and the risk associated with infections, such as those caused by the hepatitis B virus (HBV). This study investigated the epidemiology of infection with the hepatitis B virus and immunization status among users of crack institutionalized in Goiania, Brazil. During August 2012 to April 2013, a total of 600 individuals were interviewed, and blood samples collected for the detection of serological markers of HBV (HBsAg, total anti HBc and anti-HBs) by enzyme-linked immune sorbent assay (ELISA). Subsequently a cohort of individuals susceptible to hepatitis B was formed to assess compliance, completion of the vaccination series, and vaccine response against hepatitis B, using an accelerated scheme. Prior exposure to HBV (anti-HBc) was 7.0% (95% CI: 5.22 to 9.32), and 17.7% (95% CI: 14.8 to 20.9) were anti -HBs isolated, suggesting previous vaccination against hepatitis B. The use of crack cocaine through improvised pipes, history of sexually transmitted disease, and exchanging sex for drugs or money were significantly associated with exposure to HBV (p < 0.05). Of the total of individuals who received the first dose of hepatitis B vaccine and eligible to complete the full vaccine scheme (n = 406)...

‣ Reactogenicity and immunogenicity profile of a two-dose combined hepatitis A and B vaccine in 1-11-year-old children

Roberton, D.; Marshall, H.; Nolan, T.; Sokal, E.; Diez-Domingo, J.; Flodmark, C.E.; Rombo, L.; Lewald, G.; de la Flor, J.; Casanaovas, J.; Verdaguer, J.; Mares, J.; Van Esso, D.; Dieussaert, I.; Stoffel, M.
Fonte: Elsevier Sci Ltd Publicador: Elsevier Sci Ltd
Tipo: Artigo de Revista Científica
Publicado em //2005 Português
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This study was conducted to compare the reactogenicity, immunogenicity and safety of a combined two-dose (0, 6 months) hepatitis A and B vaccine (720ELU HAV, 20 mcg HBsAg) with the established three-dose (0, 1 and 6 months) hepatitis A and B vaccine (360ELU HAV, 10 mcg HBsAg). A total of 511 children aged 1-11 years who had not previously received a hepatitis A or B vaccine were enrolled in the study. Both vaccines were well tolerated, and were shown to be safe and immunogenic. The analysis, stratified according to two age groups (1-5 year and 6-11-year-old children) demonstrated that the reactogenicity profile of the two-dose schedule was at least as good as that of the established schedule. Both vaccines and schedules provided at least 98% seroprotection against hepatitis B and 100% seroconversion against hepatitis A, 1 month after the end of the vaccination course (Month 7).

‣ Utilidad clínica del ensayo ARCHITECT HCV Ag(R) en el diágnostico de la hepatitis C

Vicente Romero, María Rosario
Fonte: Universidade de Múrcia Publicador: Universidade de Múrcia
Tipo: Tese de Doutorado Formato: application/pdf
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El virus de la Hepatitis C constituye la causa más importante de Hepatitis crónica, cirrosis hepática y hepatocarcinoma, representando la primera indicación de trasplante hepático. El espectro clínico de la enfermedad es muy amplio variando desde la hepatitis aguda con resolución espontánea hasta el desarrollo de cirrosis hepática, presentando una elevada proporción de progresión a la cronicidad. Para el manejo clínico de los pacientes con esta enfermedad se utilizan cuatro marcadores virológicos: los anticuerpos anti-VHC, el ARN viral, el genotipo del virus y el antígeno core del virus. La detección de antígeno core del VHC se realiza actualmente en pocos laboratorios, debido a que la técnica que parece dar mejores resultados es de reciente aparición y está siendo evaluada (ARCHITECT HCV Ag, Abbott Diagnostics). Nuestro objetivo ha sido ha sido evaluar este nuevo ensayo. Se seleccionaron 300 sueros con al menos una petición de carga viral de VHC (COBAS AmpliPred/ COBAS TaqMan, Roche Diagnostics) y se realizó la técnica objeto del estudio. Los datos se recogieron en una base de datos EXCEL y se analizaron con el programa SPSS (18.0). La técnica evaluada posee una sensibilidad del 89% y una especificidad del 98%. Los valores predictivos positivo y negativo fueron del 98% y 91%. Los coeficientes de probabilidad son útiles para predecir la probabilidad de estar infectado después de realizar el test. Observamos una buena correlación entre la carga viral y el antígeno core del VHC. Concluimos que el ensayo ARCHITECT HCV Ag puede incorporarse en el algoritmo diagnóstico del manejo de pacientes con hepatitis C realizado en paralelo con la detección de anticuerpos anti-VHC en donantes de tejido...

‣ Hepatitis B virus genotyping in chronic hepatitis B patients in southwestern Saudi Arabia

Asaad,Ahmed Morad; Al-Ayed,Mohamed Saeed Zayed; Aleraky,Mohamed; Qureshi,Mohamed Ansar
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2015 Português
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ABSTRACTThe distribution of hepatitis B virus genotypes in Saudi Arabia is largely unknown. To the best of our knowledge there are no data available about HBV genotypes in southwestern region of the country. This study aimed to determine the epidemiologic distribution of hepatitis B virus genotypes in chronic hepatitis B patients in southwestern region, and to verify possible correlations between these genotypes and the clinical symptoms. A total of 160 patients with chronic hepatitis B infection were enrolled in this study. Sera were tested for liver function tests, hepatitis B virus markers and DNA load by standard procedures. HBV genotyping was performed by 2-tube nested PCR for determination of six genotypes (A-F). Genotype D was the most common, found in 135 (84.4%) patients, followed by A (18; 11.3%) and E (7; 4.3%). The rate of HBeAg positivity in genotype D patients was significantly lower compared with that in genotype A and E patients (p = 0.01). There was no significant association between HBV genotypes and age, gender, liver function tests, or HBV DNA load. Genotypes D and E were predominant in chronic hepatitis B patients in southwestern Saudi Arabia. Awareness of hepatitis B virus serologic and genotypic patterns might help in the formulation of management plans...

‣ Hepatitis B and C in a Brazilian deaf community

Pacher,Bianca Messenberg; Costa,Marina Ribeiro Barreto da; Nascimento,Margarida Maria Passeri do; Moura,Maria Cecilia de; Passos,Afonso Dinis Costa
Fonte: Sociedade Brasileira de Medicina Tropical - SBMT Publicador: Sociedade Brasileira de Medicina Tropical - SBMT
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2015 Português
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ABSTRACTINTRODUCTION:Although deaf people are exposed to hepatitis B and C risk factors, epidemiological studies regarding these diseases in deaf people are lacking.METHODS:After watching an explanatory digital versatile disc (DVD) in Brazilian Sign Language, 88 deaf people were interviewed and tested for hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), hepatitis B core antibody (anti-HBc), and hepatitis C virus antibody (anti-HCV).RESULTS:The prevalence of hepatitis B markers was 8%; they were associated with incarceration and being born outside the State of São Paulo. No cases of hepatitis C were identified.CONCLUSIONS:Participants showed a substantial lack of knowledge regarding viral hepatitis, indicating a need for public policies that consider linguistic and cultural profiles.

‣ ANALYSIS OF POLYMORPHISMS IN THE INTERLEUKIN 18 GENE PROMOTOR (-137 G/C AND -607 C/A) IN PATIENTS INFECTED WITH HEPATITIS C VIRUS FROM THE BRAZILIAN AMAZON

SANTOS,Kemper Nunes dos; ALMEIDA,Marcella Kelly Costa de; FECURY,Amanda Alves; COSTA,Carlos Araújo da; MARTINS,Luísa Caricio
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2015 Português
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BackgroundThe hepatitis C virus has been recognized as the leading cause of chronic liver disease in the world. Host genetic factors have been implicated in the persistence of hepatitis C virus infection. Single nucleotide polymorphisms at positions -607 C/A (rs1946518) and -137 G/C (rs187238) in the IL-18 gene promoter have been suggested to be associated with delayed hepatitis C virus clearance and persistence of the disease.ObjectiveIdentify these polymorphisms in a population infected with hepatitis C virus from the Brazilian Amazon region.MethodsIn a cross-sectional analytical study conducted in Belém, Pará, Brazil, 304 patients infected with hepatitis C virus were divided into two groups: group A, patients with persistent infection; group B, patients with spontaneous clearance. The control group consisted of 376 volunteers not infected with hepatitis C virus. Samples were analyzed by RT-PCR for the detection of viral RNA and by RFLP-PCR to evaluate the presence of the -137 G/C and -607 C/A IL-18 gene promoter polymorphisms.ResultsComparison of polymorphism allele frequencies between the patient and control groups showed a higher frequency of allele C at position -607 among patients (P=0.02). When the association between the polymorphisms and viral infection was analyzed...

‣ Síndrome antifosfolípide primária e infecções por hepatites B e C; Primary antiphospholipid syndrome and hepatitis B and C infections

CARVALHO, Jozélio Freire de
Fonte: Elsevier Editora Ltda Publicador: Elsevier Editora Ltda
Tipo: Artigo de Revista Científica
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OBJETIVO: Avaliar a prevalência de sorologia positiva para hepatites B e C em pacientes com síndrome antifosfolípide (SAF) primária. PACIENTES E MÉTODOS: Estudo transversal de 47 pacientes com SAF primária (critérios de Sapporo). Foram avaliados os dados demográficos, clínicos, medicações e sorologias para hepatites B e C e PCR nos resultados positivos. RESULTADOS: A média de idade da população estudada foi de 38 ± 11 anos, sendo 80,8% do sexo feminino e 68% da cor branca. A média de duração da doença foi de 67 ± 61 meses (variando de 1 - 240 meses). Os eventos arteriais foram vistos em 61,7% dos casos, os venosos em 51% e os obstétricos em 38,3%. Cinco (10,6%) pacientes com SAF primária apresentaram sorologia positiva para hepatite B ou C. Desses, três pacientes foram positivos para anti-HBs, com anti-HBc positivo em apenas um deles, e os outros dois foram positivos para hepatite C. A análise da PCR qualitativa não detectou RNA do vírus C em nenhum desses dois pacientes positivos. CONCLUSÃO: Uma pequena percentagem de pacientes com SAF primária apresenta sorologia positiva para hepatites B e C, sendo em todos os casos pós-vacinal ou cicatriz sorológica.; OBJECTIVE: The objective of the present study was to evaluate the prevalence of hepatitis B and C serology in patients with primary antiphospholipid syndrome (APS). METHODS: This is a transversal study with 47 patients with primary APS (Sapporo's criteria). Demographic and clinical data...

‣ Hepatitis B among female sex workers in Ribeirão Preto - São Paulo, Brazil

Passos,Afonso Dinis Costa; Figueiredo,José Fernando de Castro; Martinelli,Ana de Lourdes Candolo; Villanova,Márcia Guimarães; Nascimento,Margarida Pásseri do; Gaspar,Ana Maria Coimbra; Yoshida,Clara Fumiko Tachibana
Fonte: Associação Brasileira de Saúde Coletiva Publicador: Associação Brasileira de Saúde Coletiva
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2007 Português
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OBJECTIVE: To estimate the prevalence of hepatitis B markers and to study the risk factors for this disease among female sex workers in the city of Ribeirão Preto, Brazil. METHODS: A questionnaire was given to 449 female sex workers in order to obtain information about demographic, socioeconomic and behavioral variables. Blood samples were collected and analyzed by immunoenzymatic techniques for detection of HBsAg, anti-HBs, anti-HBc and anti-HCV markers. RESULTS: The mean age of participants was 23 years, varying from 13 to 64 years. A high spatial mobility was observed, with 47.9% of participants residing in places out of the region of Ribeirão Preto or in other Brazilian states. Complete absence of previous vaccine against hepatitis B was referred by 98.2%. Overall, the presence of any hepatitis B marker was observed in 106 participants (prevalence of 23.6%; 95% CI: 19.7 27.5), with 84 positive for anti-HBs (18.7%), 100 for anti-HBc (22.3%), and only 3 for HBsAg (0.7%). The logistic regression analysis showed association between hepatitis B markers and the following co-variables: residence in Ribeirão Preto, age, low socioeconomic level, consumption of crack, intercourse with HIV-infected individuals, history of previous hepatitis...

‣ Chronic hepatitis virus infection in patients with multiple myeloma: clinical characteristics and outcomes

Teng, Chung-Jen; Liu, Han-Tsung; Liu, Chun-Yu; Hsih, Chi-Hsiu; Pai, Jih-Tung; Gau, Jyh-Pyng; Liu, Jin-Hwang; Chiou, Tzeon-Jye; Hsu, Hui-Chi; Chen, Po-Min; Tzeng, Cheng-Hwai; Yu, Yuan-Bin
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2011 Português
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OBJECTIVES: Cytotoxic agents and steroids are used to treat lymphoid malignancies, but these compounds may exacerbate chronic viral hepatitis. For patients with multiple myeloma, the impact of preexisting hepatitis virus infection is unclear. The aim of this study is to explore the characteristics and outcomes of myeloma patients with chronic hepatitis virus infection. METHODS: From 2003 to 2008, 155 myeloma patients were examined to determine their chronic hepatitis virus infection statuses using serologic tests for the hepatitis B (HBV) and C viruses (HCV). Clinical parameters and outcome variables were retrieved via a medical chart review. RESULTS: The estimated prevalences of chronic HBV and HCV infections were 11.0% (n = 17) and 9.0% (n = 14), respectively. The characteristics of patients who were hepatitis virus carriers and those who were not were similar. However, carrier patients had a higher prevalence of conventional cytogenetic abnormalities (64.3% vs. 25.0%). The cumulative incidences of grade 3-4 elevation of the level of alanine transaminase, 30.0% vs. 12.0%, and hyperbilirubinemia, 20.0% vs. 1.6%, were higher in carriers as well. In a Kaplan-Meier analysis, carrier patients had worse overall survival (median: 16.0 vs. 42.4 months). The prognostic value of carrier status was not statistically significant in the multivariate analysis...

‣ INVESTIGACIÓN, NOTIFICACIÓN Y REALIZACIÓN DE ACCIONES DE VIGILANCIA RELACIONADAS CON TRANSMISIÓN VERTICAL DE HEPATITIS B; RASTREAMENTO, NOTIFICAÇÃO E IMPLEMENTAÇÃO DE AÇÕES DE VIGILÂNCIA RELACIONADAS À TRANSMISSÃO VERTICAL DE HEPATITE B; INVESTIGATION, NOTIFICATION AND IMPLEMENTATION OF VIGILANCE ACTIONS RELATED TO VERTICAL TRANSMISSION OF HEPATITIS B

Girondi, Juliana Balbinot Reis; Siqueira, Elizimara Ferreira; Silva, Jaques da; Silva, Jezabel Andrade; Bastiani, Janelice de Azevedo Neves
Fonte: Universidade Federal do Paraná Publicador: Universidade Federal do Paraná
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 06/10/2008 Português
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ABSTRACT: The present article reports a case of vertical transmission of hepatitis B stressing aspects related to epidemiologic vigilance: investigation, notification and implementation of diligence actions. The present clinical casepresents the prevalence of the disease during pregnancy and delivery, since three generations of the same family werecontaminated, probably, through vertical transmission. The disease control happens via investigation of HBV surfaceantigen (HBsAg) in pregnant women and via routine vaccination. It is the Epidemiologic Surveillance and the FamilyHealth Program (FHP)’s duty to adopt specific hepatitis control measures. It is necessary to make it clear to the communitythe ways the disease is transmitted, treatment and prevention of viral hepatitis. We understand our limitations whenapproaching the theme, but we expect to stimulate the interest and practice of such important actions in other professionals,because if these actions are implemented in an effective way, they tend to improve population’s quality of life.; RESÚMEN: El artículo presente hace un informe de un caso de transmisión vertical de la hepatitis B enfocando aspectos relacionados con la vigilancia epidemiologica: investigación...

‣ Situación actual de la hepatitis B en Chile

Pereira S,Ana; Valenzuela B,María Teresa; Mora,Judith; Vera,Lilian
Fonte: Sociedad Médica de Santiago Publicador: Sociedad Médica de Santiago
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2008 Português
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Background: Hepatitis B virus infection generates carriers and 8% will evolve to a chronic phase. Aim: To perform a compilation of studies on hepatitis B in Chile and other sources of information to estímate the impact of this disease in our country. Material and methods: Published and unpublished evidence about the infection, in the general population and risk groups in our country, was compiled and reviewed critically. Informal interviews to experts, revisión of the mandatory notification book of the Ministry of Health and collection of data from ¡aboratories that study hepatitis B virus, were also carried out. Results: The seroprevalence of chronic carriers in blood donors is nearly O.3%. Among risk groups such as health care personnel, the figure is O.7%, among homosexuals 29%, among HIV positive patients 30%, among sexual workers 2% and among children with chronic hemodialysis, 9%. Prevalence rate according to notified cases in 2004 was 1.8 x 100,000 habitants. Detection of viral hepatitis B surface antigen in ¡aboratories occurs in 0.2% of donors and 1.396 of non donors. Conclusions: The seroprevalence of hepatitis B virus, the lack of notification, and the introduction of hepatitis B vaccine to our Regular Program of Immunizations...

‣ Hepatitis viruses: Not always what it seems to be

GALLEGOS-OROZCO,JUAN FERNANDO; RAKELA-BRÖDNER,JORGE
Fonte: Sociedad Médica de Santiago Publicador: Sociedad Médica de Santiago
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2010 Português
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The classic hepatotropic viruses, hepatitis A through E, are not the only viral agents able to infect the liver. Other systemic viruses may cause hepatic injury that can range from mild and transient elevation of aminotransferases to acute hepatitis and occasionally acute liver failure and fulminant hepatitis. The clinical presentation may be indistinguishable from that associated with classic hepatotropic viruses. These agents include cytomegalovirus; Epstein-Barr virus; herpes simplex virus; varicella-zoster virus; human herpesvirus 6, 7, and 8; human parvovirus B19; adenoviruses among others. Wide spectrums of clinical syndromes are associated with cytomegalovirus disease. Unique clinical syndromes may present in neonates, young adults and immunocompromised hosts infected with cytomegalovirus. Cases of fulminant hepatitis have been reported in both immunocompromised and immunocompetent hosts infected with Epstein Barr virus. Occasionally, these patients with acute hepatic failure may need liver transplantation. Herpes simplex viruses may involve the liver in neonatal infections, pregnancy, immunocompromised hosts and occasionally, immunocompetent adults. Varicella-Zoster virus has also been associated with severe acute hepatitis and fulminant hepatitis in adults. The drug of choice for these conditions is intravenous acyclovir. These may also need liver transplantation in the more severe forms of clinical presentation. Typical liver biopsy findings can be useful in determining the diagnosis of these viral infections. Human herpesviruses 6...

‣ Hepatitis crónicas virales B y C en población inmigrante en España

Calderón Sandubete,Enrique; Yang Lai,Rosa; Calero Bernal,María de la Luz; Martínez Rísquez,María Teresa; Calderón Baturone,María; Horra Padilla,Carmen de la
Fonte: Revista Española de Salud Pública Publicador: Revista Española de Salud Pública
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/12/2014 Português
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Fundamentos: En España la prevalencia de la hepatitis crónicas de origen viral puede variar a causa de los inmigrantes procedentes de áreas de elevada prevalencia de infección por virus B y C de la hepatitis. La infección por estos virus es un problema importante de salud pública global por los procesos crónicos que originan. El objetivo del estudio fue conocer el impacto de la inmigración en la prevalencia de las hepatitis crónicas virales en España. Métodos: Revisión bibliográfica cualitativa de la literatura científica sobre el tema publicada entre enero de 1998 y diciembre de 2012 utilizando las bases Medline y MEDES-MEDicina. Resultados: Se analizaron los datos procedentes de 19 artículos originales. En conjunto la prevalencia de infección por los virus B y C de la hepatitis fue mayor en la población emigrante que la descrita para la población general española. Los emigrantes de África y Europa del Este presentaron las mayores prevalencias y los inmigrantes iberoamericanos las menores. Conclusiones: La prevalencia de las infecciones por virus B y C de la hepatitis en inmigrantes sugiere que podrían tener un importante impacto en la salud pública en España.

‣ Estudio clínico de la hepatitis autoinmune del adulto en Valencia

García-Torres,M. L.; Primo,J.; Ortuño,J. A.; Martínez,M.; Antón,M. D.; Zaragoza,A.; González,O.; Devesa,F.; Merino,C.; Olmo,J. A. del
Fonte: Revista Española de Enfermedades Digestivas Publicador: Revista Española de Enfermedades Digestivas
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/07/2008 Português
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Introducción: existen factores geográficos que influyen en las características de la hepatitis autoinmune (HAI). Objetivo: conocer las características epidemiológicas, clínicas y respuesta al tratamiento de la hepatitis autoinmune en la provincia de Valencia. Material y métodos: se trata de un estudio realizado en ocho hospitales de Valencia, recogiendo de forma prospectiva los casos de hepatitis autoinmune diagnosticados en el año 2003 y de forma retrospectiva los diagnosticados entre 1994 y 2002. Resultados: se incluyeron 81 pacientes con HAI, siendo el 94% mujeres. La forma de presentación fue: 43% asintomático, 27% hepatitis aguda y 30% enfermedad hepática crónica. La mayoría (90%) fueron del tipo 1, mientras que las de tipo 2 fueron más jóvenes (p = 0,007) y con predominio de hepatitis aguda (p = 0,04). Existía otra enfermedad autoinmune en uno de cada 4 casos. Al momento del diagnóstico una tercera parte de los pacientes presentaba cirrosis. La cirrosis se presentó sobre todo en pacientes de más de 60 años (p < 0,01) y sin diferencias según la formas clínica (p = 0,1). El tratamiento se indicó en 57 casos y con respuesta -completa o parcial- en el 87,7%. No se encontraron diferencias significativas en la respuesta terapéutica según la forma de presentación ni los tipos de hepatitis autoinmune. Conclusiones: en nuestra zona la hepatitis autoinmune del adulto se presenta sobre todo en mujeres y de manera asintomática. La mayoría es tipo 1 y en el 25% de los casos coexiste otra enfermedad autoinmune. Al diagnóstico la tercera parte presenta cirrosis hepática...

‣ Epidemiología de las hepatitis virales en México

Panduro,Arturo; Melendez,Griselda Escobedo; Fierro,Nora A; Madrigal,Bertha Ruiz; Zepeda-Carrillo,Eloy Alfonso; Román,Sonia
Fonte: Instituto Nacional de Salud Pública Publicador: Instituto Nacional de Salud Pública
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2011 Português
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Las hepatitis virales son una de las causas principales de daño hepático en México. En este estudio se analiza el estado actual de las hepatitis virales en México. La Secretaría de Salud informa un total de 192 588 casos de hepatitis virales entre 2000 y 2007. De éstos, 79% corresponden aVHA, 3.3% aVHB, 6% a VHC y 11.7% a casos sin agente etiológico descrito. No obstante, el VHB se podría estar subdiagnosticando, ya que hay zonas de alta endemia en poblaciones indígenas, existen limitaciones en la sensibilidad y especificidad de las pruebas inmunológicas y podría ser común la hepatitis B oculta. ElVHE podría ser uno de los agentes etiológicos de aquellos casos que carecen de un agente etiológico conocido. Se proponen estrategias específicas para el control de las hepatitis virales tendientes a disminuir el número de casos.

‣ Hepatitis B y C en pacientes oncológicos

López,Carmen Esther
Fonte: Sociedad Venezolana de Gastroentereología Publicador: Sociedad Venezolana de Gastroentereología
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2010 Português
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La mayoría de los niños que padecen enfermedades hemato-oncológicas reciben múltiples transfusiones y esto aumenta el riesgo para adquirir estas infecciones. Por otro lado, en estos niños inmunosuprimidos la infección suele ser subclínica. Suele diagnosticarse al observar elevación de aminotransferasas. Objetivo: evaluar la respuesta al tratamiento de hepatitis en niños con antecedentes oncológicos. Materiales: 80 pacientes con antecedentes de tratamiento hematoncológico, del año 2000 a 2008 con serologías positivas para hepatitis viral. Resultados: 39 (48,75%) presentan Hepatitis B, 19 (23,75%) Hepatitis C, 22 (27,75%) coinfección Hepatitis B y C. En el grupo HBV, 7 negativizaron espontáneamente DNAHBV. 20 recibieron tratamiento con diferentes esquemas: 3 IFN, 4 lamivudina, 3 lamivudina + IFN, 10 Lamivudina + PEG; 7/20 negativizaron ADN VHB. 6/10 con tratamiento combinado negativizaron DNAHBV (60%). En el grupo con Hepatitis C, todos genotipo 1; 3 negativizaron RNAHCV espontáneamente; 10 recibieron tratamiento, 3/10 tratados con IFN + RIBAVIRINA y 7 con PEG + RIBAVIRINA. 1/3 y 4/7 (57,14%), negativizaron RNAHCV, respectivamente. En el grupo con coinfección, 14 tratados: 2 IFN; 4 IFN + RIBAVIRINA; 8 PEG + RIBAVIRINA. 11/12 con esquema combinado culminaron tratamiento; negativizaron 1/11 (9%) DNAHBV y 5/11 (45...

‣ Hepatitis B among female sex workers in Ribeirão Preto - São Paulo, Brazil

Passos,Afonso Dinis Costa; Figueiredo,José Fernando de Castro; Martinelli,Ana de Lourdes Candolo; Villanova,Márcia Guimarães; Nascimento,Margarida Pásseri do; Gaspar,Ana Maria Coimbra; Yoshida,Clara Fumiko Tachibana
Fonte: Associação Brasileira de Pós -Graduação em Saúde Coletiva Publicador: Associação Brasileira de Pós -Graduação em Saúde Coletiva
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2007 Português
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OBJECTIVE: To estimate the prevalence of hepatitis B markers and to study the risk factors for this disease among female sex workers in the city of Ribeirão Preto, Brazil. METHODS: A questionnaire was given to 449 female sex workers in order to obtain information about demographic, socioeconomic and behavioral variables. Blood samples were collected and analyzed by immunoenzymatic techniques for detection of HBsAg, anti-HBs, anti-HBc and anti-HCV markers. RESULTS: The mean age of participants was 23 years, varying from 13 to 64 years. A high spatial mobility was observed, with 47.9% of participants residing in places out of the region of Ribeirão Preto or in other Brazilian states. Complete absence of previous vaccine against hepatitis B was referred by 98.2%. Overall, the presence of any hepatitis B marker was observed in 106 participants (prevalence of 23.6%; 95% CI: 19.7 27.5), with 84 positive for anti-HBs (18.7%), 100 for anti-HBc (22.3%), and only 3 for HBsAg (0.7%). The logistic regression analysis showed association between hepatitis B markers and the following co-variables: residence in Ribeirão Preto, age, low socioeconomic level, consumption of crack, intercourse with HIV-infected individuals, history of previous hepatitis...

‣ Epidemiología de las hepatitis virales en México

Panduro,Arturo; Melendez,Griselda Escobedo; Fierro,Nora A; Madrigal,Bertha Ruiz; Zepeda-Carrillo,Eloy Alfonso; Román,Sonia
Fonte: Instituto Nacional de Salud Pública Publicador: Instituto Nacional de Salud Pública
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2011 Português
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Las hepatitis virales son una de las causas principales de daño hepático en México. En este estudio se analiza el estado actual de las hepatitis virales en México. La Secretaría de Salud informa un total de 192 588 casos de hepatitis virales entre 2000 y 2007. De éstos, 79% corresponden aVHA, 3.3% aVHB, 6% a VHC y 11.7% a casos sin agente etiológico descrito. No obstante, el VHB se podría estar subdiagnosticando, ya que hay zonas de alta endemia en poblaciones indígenas, existen limitaciones en la sensibilidad y especificidad de las pruebas inmunológicas y podría ser común la hepatitis B oculta. ElVHE podría ser uno de los agentes etiológicos de aquellos casos que carecen de un agente etiológico conocido. Se proponen estrategias específicas para el control de las hepatitis virales tendientes a disminuir el número de casos.