Página 2 dos resultados de 15239 itens digitais encontrados em 0.006 segundos

‣ Guidelines for the use of allergen immunotherapy. Canadian Society of Allergy and Clinical Immunology.

Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 01/05/1995 Português
Relevância na Pesquisa
26.518484%
OBJECTIVES: To recommend guidelines for the use of allergen immunotherapy to treat allergies in patients for whom allergen avoidance and drug therapy have not been sufficiently effective. OPTIONS: High-dose or low-dose allergen immunotherapy for the treatment of IgE-mediated allergy to insect stings, allergic rhinoconjunctivitis and asthma. OUTCOMES: Clinical evaluation of symptoms, objective measurement of reactions to nasal or bronchial allergen challenge, immunologic changes as a result of allergen immunotherapy and, among patients with anaphylactic reactions to stinging insects, clinical outcome of intentional sting challenge. EVIDENCE: A search of MEDLINE was conducted to identify articles that presented results of allergen immunotherapy. Proceedings of symposia held by international subcommittees and of consensus meetings, as well as references obtained from these sources, were reviewed. The articles were grouped according to their main subject: immunologic effects, specific allergies, the results of randomized placebo-controlled clinical trials, types of allergen extract and protocols for allergen immunotherapy, adverse effects and deficiencies of allergen immunotherapy. VALUES: Each member of the working group assessed the importance of such issues as basic immunologic effects...

‣ Design and function of a department of clinical immunology*

Whittingham, Senga; Mackay, I. R.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /06/1971 Português
Relevância na Pesquisa
26.518484%
The recognition and successful treatment of diseases affecting the immunological system, together with organ grafting, has led in recent years to an upsurge in demand for laboratory services, research and teaching facilities concerned with clinical and experimental aspects of immunology. These developments have stimulated us to present a plan for floor space, staffing and services for a Department of Clinical Immunology in a major medical centre or university hospital serving, say, 800–1500 beds, and an outpatient department of corresponding dimensions. Such a Department would provide basic immunodiagnostic services and should have provision for research in Clinical Immunology.

‣ Clinical immunology--guidelines for organization, training and certification: memorandum from a WHO/IUIS/IAACI meeting.

Fonte: World Health Organization Publicador: World Health Organization
Tipo: Artigo de Revista Científica
Publicado em //1994 Português
Relevância na Pesquisa
26.518484%
This Memorandum describes the status and scope of clinical immunology, allergology, and laboratory immunology, and their involvement in the diagnosis, treatment and prophylaxis of a large number of diseases. The strengthening of these specialities within the organization of health care facilities in developed and developing countries is underlined, based on appropriate training of doctors, non-medical scientists and technicians. A common core programme for basic training in clinical immunology is presented.

‣ Summary of the primer on tumor immunology and the biological therapy of cancer

Li, Yufeng; Liu, Shujuan; Margolin, Kim; Hwu, Patrick
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 28/01/2009 Português
Relevância na Pesquisa
26.518484%
The International Society for Biological Therapy of Cancer (iSBTc) is one of the "premier destinations for interaction and innovation in the cancer biologics community". It provides a primer course each year during the annual meeting to address the most important areas of tumor immunology and immunotherapy. The course has been given by prominent investigators in the area of interest, covering the core principles of cancer immunology and immunotherapy. The target audience for this program includes investigators from academic, regulatory, and biopharmaceutical venues. The program goal is to enable the attendees to learn the current status and the most recent advances in biologic therapies, and to leverage this knowledge towards the improvement of cancer therapy. The 2008 immunologic primer course was held on October 30 at the 23rd Annual meeting of iSBTc in San Diego, CA. Nine internationally renowned investigators gave excellent presentations on different topics. The topics covered in this primer included: (1) cytokines in cancer immunology; (2) anti-angiogenic therapy; (3) end stage: immune killing of tumors; (4) blocking T cell checkpoints; (5) approach to identification and therapeutic exploitation of tumor antigens; (6) T regulatory cells; (7) adoptive T cell therapy; (8) immune monitoring of cancer immunotherapy; and (9) immune adjuvants. We summarized the topics in this primer for public education. The related topic slides and schedule can be accessed online .

‣ Molecular immunology lessons from therapeutic T-cell receptor gene transfer

Thomas, Sharyn; Stauss, Hans J; Morris, Emma C
Fonte: Blackwell Science Inc Publicador: Blackwell Science Inc
Tipo: Artigo de Revista Científica
Publicado em /02/2010 Português
Relevância na Pesquisa
26.518484%
The T-cell receptor (TCR) is critical for T-cell lineage selection, antigen specificity, effector function and survival. Recently, TCR gene transfer has been developed as a reliable method to generate ex vivo large numbers of T cells of a given antigen-specificity and functional avidity. Such approaches have major applications for the adoptive cellular therapy of viral infectious diseases, virus-associated malignancies and cancer. TCR gene transfer utilizes retroviral or lentiviral constructs containing the gene sequences of the TCR-α and TCR-β chains, which have been cloned from a clonal T-cell population of the desired antigen specificity. The TCR-encoding vector is then used to infect (transduce) primary T cells in vitro. To generate a transduced T cell with the desired functional specificity, the introduced TCR-α and TCR-β chains must form a heterodimer and associate with the CD3 complex in order to be stably expressed at the T-cell surface. In order to optimize the function of TCR-transduced T cells, researchers in the field of TCR gene transfer have exploited many aspects of basic research in T-cell immunology relating to TCR structure, TCR–CD3 assembly, cell-surface TCR expression, TCR-peptide/major histocompatibility complex (MHC) affinity and TCR signalling. However...

‣ The Unfinished Legacy of Liver Transplantation: Emphasis on Immunology

Starzl, Thomas E.; Lakkis, Fadi G.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /02/2006 Português
Relevância na Pesquisa
26.591958%
Liver transplantation radically changed the philosophy of hepatology practice, enriched multiple areas of basic science, and had pervasive ripple effects in law, public policy, ethics, and theology. Why organ engraftment was feasible remained enigmatic, however, until the discovery in 1992 of donor leukocyte microchimerism in long-surviving liver, and other kinds of organ recipients. Following this discovery, the leukocyte chimerism-associated mechanisms were elucidated that directly linked organ and bone marrow transplantation and eventually clarified the relationship of transplantation immunology to the immunology of infections, neoplasms, and autoimmune disorders. We describe here how the initially controversial paradigm shift mandated revisions of cherished dogmas. With the fresh insight, the reasons for numerous inexplicable phenomena of transplantation either became obvious or have become susceptible to discriminate experimental testing. The therapeutic implications of the “new immunology” in hepatology and in other medical disciplines, have only begun to be explored. Apart from immunology, physiologic investigations of liver transplantation have resulted in the discovery of growth factors (beginning with insulin) that are involved in the regulation of liver size...

‣ Dana-Farber Repository for Machine Learning in Immunology

Zhang, Guang Lan; Lin, Hong Huang; Keskin, Derin B.; Reinherz, Ellis L.; Brusic, Vladimir
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
26.518484%
The immune system is characterized by high combinatorial complexity that necessitates the use of specialized computational tools for analysis of immunological data. Machine learning (ML) algorithms are used in combination with classical experimentation for the selection of vaccine targets and in computational simulations that reduce the number of necessary experiments. The development of ML algorithms requires standardized data sets, consistent measurement methods, and uniform scales. To bridge the gap between the immunology community and the ML community, we designed a repository for machine learning in immunology named Dana-Farber Repository for Machine Learning in Immunology (DFRMLI). This repository provides standardized data sets of HLA-binding peptides with all binding affinities mapped onto a common scale. It also provides a list of experimentally validated naturally processed T cell epitopes derived from tumor or virus antigens. The DFRMLI data were preprocessed and ensure consistency, comparability, detailed descriptions, and statistically meaningful sample sizes for peptides that bind to various HLA molecules. The repository is accessible at http://bio.dfci.harvard.edu/DFRMLI/.

‣ Standardizing immunophenotyping for the Human Immunology Project

Maecker, Holden T.; McCoy, J. Philip; Nussenblatt, Robert
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 17/02/2012 Português
Relevância na Pesquisa
26.518484%
The heterogeneity in the healthy human immune system, and the immunological changes that portend various diseases, have been only partially described. Their comprehensive elucidation has been termed the ‘Human Immunology Project’. The accurate measurement of variations in the human immune system requires precise and standardized assays to distinguish true biological changes from technical artefacts. Thus, to be successful, the Human Immunology Project will require standardized assays for immunophenotyping humans in health and disease. A major tool in this effort is flow cytometry, which remains highly variable with regard to sample handling, reagents, instrument setup and data analysis. In this Review, we outline the current state of standardization of flow cytometry assays and summarize the steps that are required to enable the Human Immunology Project.

‣ Understanding Immunology via Engineering Design: The Role of Mathematical Prototyping

Klinke, David J.; Wang, Qing
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
26.518484%
A major challenge in immunology is how to translate data into knowledge given the inherent complexity and dynamics of human physiology. Both the physiology and engineering communities have rich histories in applying computational approaches to translate data obtained from complex systems into knowledge of system behavior. However, there are some differences in how disciplines approach problems. By referring to mathematical models as mathematical prototypes, we aim to highlight aspects related to the process (i.e., prototyping) rather than the product (i.e., the model). The objective of this paper is to review how two related engineering concepts, specifically prototyping and “fitness for use,” can be applied to overcome the pressing challenge in translating data into improved knowledge of basic immunology that can be used to improve therapies for disease. These concepts are illustrated using two immunology-related examples. The prototypes presented focus on the beta cell mass at the onset of type 1 diabetes and the dynamics of dendritic cells in the lung. This paper is intended to illustrate some of the nuances associated with applying mathematical modeling to improve understanding of the dynamics of disease progression in humans.

‣ Broadening the translational immunology landscape

Peakman, M
Fonte: Blackwell Science Inc Publicador: Blackwell Science Inc
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
26.518484%
It is just over 5 years since Clinical and Experimental Immunology came under the direction of a new team of Editors and made a concerted effort to refresh its approach to promoting clinical and applied immunology through its pages. There were two major objectives: to foster papers in a field which, at the time, we loosely termed ‘translational immunology’; and to create a forum for the presentation and discussion of immunology that is relevant to clinicians operating in this space. So, how are we doing with these endeavours? This brief paper aims to summarize some of the key learning points and successes and highlight areas in which translational gaps remain.

‣ JTM’s Tumor immunology goes broad: announcing the Immunobiology and Immunotherapy section

Bot, Adrian; Marincola, Francesco; Romero, Pedro
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 04/01/2013 Português
Relevância na Pesquisa
26.518484%
For the last four years the Journal of Translational Medicine (JTM) has hosted the Section of Tumor Immunology and Biological Cancer Therapy. Under the editorial leadership of Dr. Pedro Romero and with the direct support of the Society for Immunotherapy of Cancer (SITC), this section enriched the communication between basic immunological sciences and the clinical investigation arena in oncology. We are re-launching this Section of JTM, now entitled Immunobiology and Immunotherapy, succeeding Tumor Immunology and Biological Cancer Therapy. While aiming to build on the editorial success and focus of its predecessor, this novel Section will have a broader scope, hosting translational immunology topics pertaining to immunotherapy beyond oncology, including disciplines such as inflammation, autoimmunity, transplantation, metabolic disorders and others. As the vision of this re-launched Section of JTM broadens up to serve a communication need for translational immunologists involved with immunotherapy irrespectively of the therapeutic area, a novel and focused journal entitled Journal for Immunotherapy of Cancer (JITC) has just been initiated, sponsored by the SITC.

‣ Highlights of 10 years of immunology in Nature Reviews Immunology

Medzhitov, Ruslan; Shevach, Ethan M.; Trinchieri, Giorgio; Mellor, Andrew L.; Munn, David H.; Gordon, Siamon; Libby, Peter; Hansson, Göran K.; Shortman, Ken; Dong, Chen; Gabrilovich, Dmitry; Gabryšová, Leona; Howes, Ashleigh; O’Garra, Anne
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 23/09/2011 Português
Relevância na Pesquisa
26.518484%
As Nature Reviews Immunology reaches its 10th anniversary, we’ve asked the authors of one of the top-cited articles of each year to look back on the state of research at the time their Review was published, to consider why the article has had the impact it has and to discuss the future directions of their field. This Viewpoint article provides an interesting snapshot of some of the fundamental advances in the field of immunology over the past 10 years — including Toll-like receptor signalling, immune regulation mediated by regulatory T cells, indoleamine 2,3-dioxygenase, myeloid-derived suppressor cells and interleukin-10, the development and heterogeneity of macrophages, dendritic cells and T helper cells, and the immune processes involved in diseases such as atherosclerosis — and looks forward to what the next 10 years may bring.

‣ Recent advances in the field of nutritional immunology: Nutritional Immunology: Role in Health and Disease Carefree, AZ, USA, 10–15 July 2011

Monk, Jennifer M; Hou, Tim Y; Chapkin, Robert S
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /11/2011 Português
Relevância na Pesquisa
26.518484%
Every 4 years, researchers in the cross-disciplinary field of nutritional immunology convene for a FASEB-sponsored meeting entitled, “Nutritional Immunology: Role in Health and Disease”, which was held this summer in Carefree, AZ, USA. The scope of the conference encompassed a diverse list of research topics, including, but not restricted to, obesity and immune dysfunction, nutrient–gene interactions, mucosal immunity and a discussion of future directions for the field. Here, we summarize some of the findings shared at the conference, specifically focusing on obesity, immunological function of dietary components (n-3 polyunsaturated fatty acids and flavanoids), gut immunity and the microbiota, and relevant emerging technologies and databases.

‣ Tumor immunology and cancer immunotherapy: summary of the 2014 SITC primer

Page, David B.; Bourla, Ariel Bulua; Daniyan, Anthony; Naidoo, Jarushka; Smith, Eric; Smith, Melody; Friedman, Claire; Khalil, Danny N.; Funt, Samuel; Shoushtari, Alexander N.; Overwijk, Willem W.; Sharma, Padmanee; Callahan, Margaret K.
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 16/06/2015 Português
Relevância na Pesquisa
26.518484%
The pioneers of tumor immunology and cancer immunotherapy, including the late William B. Coley and Lloyd J. Old, have championed the potential for immunotherapy for over a century. Finally, advances in our understanding of the fundamentals of tumor immunology are translating into clinical success, with recent US Food and Drug Administration approval of several immunotherapies that improve clinical outcomes across prostate cancer, metastatic melanoma, non-small cell lung cancer and lymphocytic leukemia. In tandem with these clinical successes, new technologies such as high-throughput DNA/RNA sequencing, genetic engineering, and streamlined ex vivo cell culturing have paved the way for the next generation of immunotherapies and provided new tools for investigating potential biomarkers of response to existing therapies. During the November 2014 Annual Meeting of the Society of the Immunotherapy of Cancer, leaders in tumor immunology and cancer immunotherapy convened at the second annual SITC Primer to review both current knowledge and future directions in the field. Here, we will review the key discussions across a variety of topics, including innate immunity, adaptive immunity, dendritic cells, adoptive T cell therapy, anti-tumor antibodies...

‣ HST.176 Cellular and Molecular Immunology, Fall 2002; Cellular and Molecular Immunology

Pillai, Shiv; Anderson, Paul; Auchincloss, Hugh; Balk, Steven; Cherayil, Bobby; Davis, Benjamin; Hafler, David A.; Lichtman, Andrew H.; Ploegh, Hidde L.; Rajewsky, K., 1936-; Schmidt, Emmett Vance, 1952-; Sharpe, Arlene; Sykes, Megan; Andrian, Ulrich von;
Fonte: MIT - Massachusetts Institute of Technology Publicador: MIT - Massachusetts Institute of Technology
Formato: 16773 bytes; 15053 bytes; 53213 bytes; 14472 bytes; 59437 bytes; 16614 bytes; 16761 bytes; 11 bytes; 4586 bytes; 21366 bytes; 11602 bytes; 38351 bytes; 4755 bytes; 27322 bytes; 25313 bytes; 4039 bytes; 301 bytes; 354 bytes; 339 bytes; 180 bytes; 285 bytes
Português
Relevância na Pesquisa
26.518484%
Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, lymphocyte activation, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. Consists of lectures and tutorials in which clinical cases are discussed with faculty tutors. Details of the case covering a number of immunological issues in the context of disease are posted on a student Web site. Sections are integrated with HST.031 Human Pathology. (Only HST students may register under HST.175, graded P/D/F).

‣ Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone mice

Zhou, Zhenhai; Niu, Haitao; Zheng, Ying-Yi; Morel, Laurence
Fonte: BioMed Central (BMC Immunology); BioMed Central (BMC Immunology) Publicador: BioMed Central (BMC Immunology); BioMed Central (BMC Immunology)
Tipo: mixed material
Publicado em //2011 Português
Relevância na Pesquisa
26.518484%
Publication of this article was funded in part by the University of Florida Open-Access publishing Fund. In addition, requestors receiving through the UFOAP project are expected to submit a post-review, final draft of the article to UF's institutional repository, IR@UF, (www.uflib.ufl.edu/UFir) at the time of funding. The institutional Repository at the University of Florida community, with research, news, outreach, and educational materials.; Zhou et al. BMC Immunology 2011, 12:7 http://www.biomedcentral.com/1471-2172/12/7; Pages 1-13; doi:10.1186/1471-2172-12-7 Cite this article as: Zhou et al.: Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone mice. BMC Immunology 2011 12:7.

‣ Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice

Xia, Chang-Qing; Chernatynskaya, Anna V.; Wasserfall, Clive H.; Wan, Suigui; Looney, Benjamin M.; Eisenbeis, Scott; Williams, John; Clare-Salzler, Michael J.; Atkinson, Mark A.
Fonte: Bio-Med Central (BMC Immunology); Bio-Med Central (BMC Immunology) Publicador: Bio-Med Central (BMC Immunology); Bio-Med Central (BMC Immunology)
Tipo: mixed material
Publicado em //2012 Português
Relevância na Pesquisa
26.518484%
Publication of this article was funded in part by the University of Florida Open-Access publishing Fund. In addition, reqestors receiving funding through the UFOAP project are expected to submit a post-review, final draft of the article to UF's institutional repository, IR@UF, (www.uflib.ufl.edu/UFir) at the time of funding. The institutional Repository at the University of Florida community, with research, news, outreach, and educational materials.; Xia et al. BMC Immunology 2012, 13:70 http://www.biomedcentral.com/1471-2172/13/70; Pages 1-13; doi:10.1186/1471-2172-13-70 Cite this article as: Xia et al.: Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice. BMC Immunology 2012 13:70.

‣ The Classics of Immunology

Smith, Kendall A
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 10/03/2005 Português
Relevância na Pesquisa
26.518484%
Medical Immunology will be publishing invited Reviews and Commentaries from investigators who are at the forefront of their fields, to up-date our readers as to the current state of their art. These Reviews and Commentaries will be accompanied by Editorials that place the current work into the perspective of the first contribution in an area, which resulted in a "Classic" paper. Where possible, links will be provided to the original publication, so that the modern student of immunology can read the original and draw their own conclusions as to the value of the "Classic" contribution, and its relationship to our contemporary views as to how the immune system functions. To begin this process at the very dawn of immunology, we highlight Sir Edward Jenner's first descriptions of the use of cowpox to immunize individuals against the dread disease smallpox.

‣ The iSBTc/SITC primer on tumor immunology and biological therapy of cancer: a summary of the 2010 program

Balwit, James M; Hwu, Patrick; Urba, Walter J; Marincola, Francesco M
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 31/01/2011 Português
Relevância na Pesquisa
26.591958%
The Society for Immunotherapy of Cancer, SITC (formerly the International Society for Biological Therapy of Cancer, iSBTc), aims to improve cancer patient outcomes by advancing the science, development and application of biological therapy and immunotherapy. The society and its educational programs have become premier destinations for interaction and innovation in the cancer biologics community. For over a decade, the society has offered the Primer on Tumor Immunology and Biological Therapy of Cancer™ in conjunction with its Annual Scientific Meeting. This report summarizes the 2010 Primer that took place October 1, 2010 in Washington, D.C. as part of the educational offerings associated with the society's 25th anniversary. The target audience was basic and clinical investigators from academia, industry and regulatory agencies, and included clinicians, post-doctoral fellows, students, and allied health professionals. Attendees were provided a review of basic immunology and educated on the current status and most recent advances in tumor immunology and clinical/translational caner immunology. Ten prominent investigators presented on the following topics: innate immunity and inflammation; an overview of adaptive immunity; dendritic cells; tumor microenvironment; regulatory immune cells; immune monitoring; cytokines in cancer immunotherapy; immune modulating antibodies; cancer vaccines; and adoptive T cell therapy. Presentation slides...

‣ Making allergic and hypersensitivity conditions visible in the International Classification of Diseases-11

Tanno, Luciana Kase; Calderon, Moises A.; Demoly, Pascal
Fonte: Asia Pacific Association of Allergy, Asthma and Clinical Immunology Publicador: Asia Pacific Association of Allergy, Asthma and Clinical Immunology
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
26.645024%
Understanding that the International Classification of Diseases (ICD)-11 revision would be an opportunity to standardize the code definitions for all allergic and hypersensitivity conditions, an international collaboration of Allergy Academies, including first the World Allergy Organization, the American Academy of Allergy Asthma and Immunology and the European Academy of Allergy and Clinical Immunology, has been coordinating tremendous efforts since 2013 to provide a better classification of these disorders in the new ICD-11. During this process, a strategic action plan has been constructed to keep bilateral dialog with representatives of the ICD revision by providing them scientific and technical evidences for the need of changes in the ICD framework. As a major achievement of this process, was the construction of the "allergic and hypersensitivity conditions" parented subchapter guided by the World Health Organization ICD representatives and further supported by three more regional allergy societies: the Latin American Society of Allergy, Asthma and Immunology, the American College of Allergy Asthma and Immunology, and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology. Believing that the outcomes of all past and future actions will impact positively to the Allergy specialty...