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‣ A novel human CD4(+) T-cell inducer subset with potent immunostimulatory properties

NDHLOVU, Lishomwa C.; LEAL, Fabio E.; ECCLES-JAMES, Ijeoma G.; JHA, Aashish R.; LANTERI, Marion; NORRIS, Philip J.; BARBOUR, Jason D.; WACHTER, Douglas J.; ANDERSSON, Jan; TASKEN, Kjetil; TORHEIM, Eirik A.; AANDAHL, Einar M.; KALLAS, Esper G.; NIXON, Doug
Fonte: WILEY-V C H VERLAG GMBH Publicador: WILEY-V C H VERLAG GMBH
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
26.645024%
The complexity of immunoregulation has focused attention on the CD4(+) T ""suppressor"" regulatory cell (T(reg)), which helps maintain balance between immunity and tolerance. An immunoregulatory T-cell population that upon activation amplifies cellular immune responses was described in murine models more than 30 years ago; however, no study has yet identified a naturally occurring T ""inducer"" cell type. Here, we report that the ectoenzyme CD39/NTPDase1 (ecto-nucleoside triphosphate diphosphohydrolase 1) helps to delineate a novel population of human ""inducer"" CD4(+) T cells (T(ind)) that significantly increases the proliferation and cytokine production of responder T cells in a dose-dependent manner. Furthermore, this unique T(ind) subset produces a distinct repertoire of cytokines in comparison to the other CD4(+) T-cell subsets. We propose that this novel CD4(+) T-cell population counterbalances the suppressive activity of suppressor T(reg) in peripheral blood and serves as a calibrator of immunoregulation.; National Institutes of Health (NIH), University of California, San Francisco-Gladstone Institute of Virology & Immunology Center[P30 AI027763]; National Institutes of Health (NIH), University of California, San Francisco-Gladstone Institute of Virology & Immunology Center[AI060379]; National Institutes of Health (NIH)...