Página 1 dos resultados de 71 itens digitais encontrados em 0.020 segundos
Resultados filtrados por Publicador: Future Science Ltd

‣ LC-MS/MS for immunosuppressant therapeutic drug monitoring

Sallustio, B.
Fonte: Future Science Ltd Publicador: Future Science Ltd
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
Relevância na Pesquisa
Due to their narrow therapeutic indices and highly variable pharmacokinetics, therapeutic drug monitoring is necessary to individualize immunosuppressant dosage following organ transplantation. Until recently, monitoring was performed primarily using immunoassays, however, there is an increasing shift to HPLC coupled with MS/MS, due to its greater sensitivity and specificity. Online sample clean-up with either a single analytical column or with 2D chromatography significantly reduces manual handling and is essential to minimize matrix effects and maximize specificity and, coupled with rapid chromatography, allows the simultaneous analysis of the major immunosuppressants, with rapid sample throughput. Thus, LC–MS/MS is an attractive and versatile technique that facilitates rapid development of analytical methods, including new immunosuppressants as they become approved for clinical use.; Benedetta C. Sallustio