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‣ Impact of depressive symptoms on visceral sensitivity among patients with different subtypes of irritable Bowel syndrome

MEDEIROS, Maria Teresa Goncalves de; CARVALHO, Andre Ferrer; LIMA, Jose Wellington de Oliveira; SANTOS, Armenio Aguiar dos; OLIVEIRA, Ricardo Brandt de; SOUZA, Miguel Angelo Nobre e
Fonte: LIPPINCOTT WILLIAMS & WILKINS Publicador: LIPPINCOTT WILLIAMS & WILKINS
Tipo: Artigo de Revista Científica
Português
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The etiology of irritable bowel syndrome (IBS) is complex and multifaceted. Psychosocial factors play a role in such a process. Several reports suggest that IBS patients have increased psychopathology scores as compared with population controls. The influence of depressive symptoms on rectal sensitivity thresholds vary across different studies. The influence of predominant bowel habits on rectal sensitivity thresholds as determined by barostat-based investigations is not well established. The present report aimed to investigate the influence of depressive symptoms on rectal sensitivity in different subtypes of IBS patients (diarrhea/constipation-predominant vs. alternating subtypes). Depressive symptoms correlated well with first pain sensitivity threshold in alternating patients (n = 8; [rho] = -0.77; p = 0.02) but not in diarrhea/constipation predominant symptoms (n = 11; [rho] = -0.44; p = 0.27). These data suggest that depressive symptoms might impact pain thresholds differently according to the subtype of IBS.; Brazilian National Research Council (CNPq)

‣ Aspectos nutricionais na população de pacientes com síndrome do intestino irritável atendidos no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo; Nutritional concerns in the population of patients with irritable bowel syndrome treated at the Hospital of the School of Medicine, University of São Paulo (HCFMUSP)

Amarante, Daiana
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 28/05/2013 Português
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INTRODUÇÃO: A síndrome do intestino irritável (SII) é uma doença funcional do trato gastrintestinal que afeta até 20% da população adulta. Os principais sintomas envolvem o mau funcionamento do intestino, associados com dores abdominais, manifestação de diarreia ou constipação, sem alterações estruturais e bioquímicas do intestino. A maneira mais adequada de tratar o paciente é por meio de uma abordagem ampla e integral, porém individualizada, com identificação dos fatores desencadeantes e/ou agravantes da sintomatologia, inerentes a cada paciente. Em todos os níveis de atendimento, deve-se orientar o paciente com relação à dieta. OBJETIVO: o principal objetivo do estudo foi avaliar os alimentos desencadeadores de sintomas nos pacientes com diagnóstico de SII atendidos no ambulatório especializado do Serviço de Gatroenterologia Clínica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP). Além disso, foram avaliados dados clínicos, estado nutricional, ingestão alimentar e hábito intestinal desta população. METODOLOGIA: foram avaliados 140 pacientes que preencherem o critério de Roma III. As informações foram obtidas por meio de inquérito clínico e dietético aplicado pela nutricionista no momento da consulta e pela revisão do prontuário. Os dados coletados foram: idade...

‣ Factors associated with complementary and alternative medicine use in irritable bowel syndrome : A literature review

Usher, Lee; Fox, Pauline; Lafarge, Caroline; Mitchell, Kathryn
Fonte: PsychOpen Publicador: PsychOpen
Tipo: Artigo de Revista Científica
Publicado em //2013 Português
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Aim: Irritable Bowel Syndrome (IBS) is a chronic functional bowel condition, which has substantial impact on quality of life and use of healthcare services. Patients often report using complementary and alternative medicine (CAM) for symptom management despite limited evidence to support its use. Psychological factors have been shown to be important in both influencing CAM use and as avenues of intervention to assist in managing IBS symptoms. Therefore, this review assessed prevalence of and psychological factors associated with CAM use by people with IBS. Method: Five electronic databases (including AMED, EMBASE and PsychINFO) were searched for studies that examined both the extent of and the reasons for CAM use. Five studies met the inclusion criteria. Results: Prevalence of CAM use ranged from 9% to 38%. CAM use was associated with psychosocial factors, including concerns about conventional medical care (i.e., the perceived harmful effects of medication, perception that conventional medicine had failed, and lack of satisfaction with conventional care) and anxiety. Conclusion: These findings identify psychological factors associated with CAM use which could be targeted through psychologically oriented management strategies for those affected with IBS.

‣ Treatment of postinfectious irritable bowel syndrome and noninfective irritable bowel syndrome with mesalazine

Bafutto,Mauro; Almeida,José Roberto de; Leite,Nayle Vilela; Oliveira,Enio Chaves; Gabriel-Neto,Salustiano; Rezende-Filho,Joffre
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2011 Português
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CONTEXT: Recent studies support the hypothesis that postinfectious irritable bowel syndrome and some irritable bowel syndrome patients display persistent signs of minor mucosal inflammation. Mesalazine has intestinal anti-inflammatory properties including cyclooxygenase and prostaglandin inhibition. The effects of mesalazine on postinfectious irritable bowel syndrome and noninfective irritable bowel syndrome patients are still unknown. OBJECTIVE: To observe the effects of mesalazine on postinfectious irritable bowel syndrome and noninfective irritable bowel syndrome with diarrhea patients. METHODS: Based on Rome III criteria, 61 irritable bowel syndrome with diarrhea patients (18 years old or more) were included in the evaluation. Patients were divided into two groups: postinfectious irritable bowel syndrome group, with 18 patients medicated with mesalazine 800 mg 3 times a day for 30 days; noninfective irritable bowel syndrome group, with 43 patients medicated with mesalazine 800 mg 3 times a day for 30 days. Symptom evaluations at baseline and after treatment were performed by means of a four-point Likert scale including stool frequency, stool form and consistency (Bristol Stool Scale), abdominal pain and distension (maximum score: 16; minimum score: 4). RESULTS: Postinfectious irritable bowel syndrome group presented a statistically significant reduction of the total symptom score (P<0.0001). The stool frequency was significantly reduced (P<0.0001)...

‣ THE PREVALENCE AND CLINICAL CHARACTERISTICS OF PRIMARY HEADACHE IN IRRITABLE BOWEL SYNDROME: a subgroup of the functional somatic syndromes

SOARES,Rosa LS; MOREIRA-FILHO,Pedro Ferreira; MANESCHY,Carolina Possidente; BREIJÃO,Julia Fumian; SCHMIDTE,Nathan Mielke
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2013 Português
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Context The irritable bowel syndrome and primary headache are two chronic diseases characterized by symptoms of recurring pain and affect approximately 10%-20% of the general population. Objectives To study the prevalence of primary headache in volunteers with irritable bowel syndrome in a Brazilian urban community. Methods It was evaluated the prevalence of primary headache associated with irritable bowel syndrome in adult volunteers 330 no patients.The protocol included the Rome III criteria, international classification of Headaches, later divided into four groups: I- Irritable bowel syndrome (n = 52), II- Primary headache (n = 45), III-Irritable bowel syndrome (n = 26) and headache, and IV- Controls (207). Results We not found significant difference in the average age of the four groups and the diagnosis of irritable bowel syndrome, primary headache and their association was more frequent in females. The frequent use of analgesics was greater in groups II and III. Conclusion Our results suggest that irritable bowel syndrome and primary headache are also common in third world countries. The frequency in use of analgesics in association between the two entities was relevant. The identification of irritable bowel syndrome patients with different clinical sub-types could improve the therapeutics options and the prevention strategies.

‣ Blastocystis subtypes in irritable bowel syndrome and inflammatory bowel disease in Ankara, Turkey

Dogruman-Al,Funda; Kustimur,Semra; Yoshikawa,Hisao; Tuncer,Candan; Simsek,Zahide; Tanyuksel,Mehmet; Araz,Engin; Boorom,Kenneth
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2009 Português
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Blastocystis infection has been reported to be associated with irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and chronic diarrhoea. The availability of data on the subtypes of Blastocystis found in these patient groups would be of interest in understanding the significance of Blastocystis infection in chronic illness. In this study, we identify Blastocystis subtypes found in patients presenting with IBS, IBD, chronic diarrhoea and asymptomatic patients in Ankara, Turkey. Blastocystis was detected in 11 symptomatic patients by microscopy and 19 by stool culture. Stool culture was more sensitive than microscopy in identifying Blastocystis. Using standard nomenclature adopted in 2007, Blastocystis sp. subtype 3 was the most common in all groups, followed by Blastocystis sp. subtype 2. Identical subtypes of Blastocystis are found in patients with IBS, IBD and chronic diarrhoea. These particular subtypes show low host specificity and are carried by humans and some farm animals. The subtypes of Blastocystis that are commonly found in rodents and certain wild birds were not found in these patients. We suggest a model in which the severity of enteric protozoan infection may be mediated by host factors.

‣ Semiquantitative fecal calprotectin test in postinfectious and non-postinfectious irritable bowel syndrome: cross-sectional study

David,Liliana-Elisabeta; Surdea-Blaga,Teodora; Dumitrascu,Dan-Lucian
Fonte: Associação Paulista de Medicina - APM Publicador: Associação Paulista de Medicina - APM
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2014 Português
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CONTEXT AND OBJECTIVE: The presence of a certain degree of inflammation in the gut wall is now accepted in irritable bowel syndrome (IBS). Fecal calprotectin is considered to be a reliable test for detecting intestinal inflammation. Our aim was to assess the presence of inflammation in postinfectious IBS (PI-IBS), compared with non-postinfectious IBS (NPI-IBS). A secondary objective was to determine the usefulness of a rapid fecal calprotectin test in inflammatory bowel diseases (IBD). DESIGN AND SETTING: This was a cross-sectional study. Patients with IBS and IBD at a single tertiary gastroenterology center were prospectively included in this study. METHODS: 116 patients with Rome III IBS score (76 females; 48 ± 12 years) were investigated; 24 patients (15 females) had PI-IBS. Intestinal inflammation was assessed using the semiquantitative fecal calprotectin test. The results were expressed as T1, T2 or T3 according to the severity of inflammation (< 15 μg/g; 15-60 μg/g; > 60 μg/g). Using the same test, we evaluated 20 patients with IBD (12 males; 47 ± 13 years). RESULTS: None of the patients with IBS had a T2 or T3 positive test. Among PI-IBS patients, 33% had a T1 positive test. Among NPI-IBS patients...

‣ Role of psychiatric disorders and irritable bowel syndrome in asthma patients

Yilmaz,Ayse; Cumurcu,Birgul Elbozan; Tasliyurt,Turker; Sahan,Abdulkadir Geylani; Ustun,Yusuf; Etikan,Ilker
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2011 Português
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OBJECTIVES: The goals of the study were the following: 1) to determine the frequency of psychiatric disorders and irritable bowel syndrome in patients with asthma and 2) to compare the frequency of these disorders in patients with asthma to their frequency in healthy controls. INTRODUCTION: Patients with asthma have a higher frequency of irritable bowel syndrome and psychiatric disorders. METHODS: We evaluated 101 patients with bronchial asthma and 67 healthy subjects. All subjects completed the brief version of the Bowel Symptoms Questionnaire and a structured clinical interview for DSM-IV axis disorders (SCID-I/CV). RESULTS: There were 37 cases of irritable bowel syndrome in the group of 101 stable asthma patients (36.6%) and 12 cases in the group of 67 healthy subjects (17.9%) (p = 0.009). Irritable bowel syndrome comorbidity was not related to the severity of asthma (p = 0.15). Regardless of the presence of irritable bowel syndrome, psychiatric disorders in asthma patients (52/97; 53.6%) were more common than in the control group (22/63, 34.9%) (p = 0.02). Although psychiatric disorders were more common in asthma patients with irritable bowel syndrome (21/35, 60%) than in those without irritable bowel syndrome (31/62, 50%), the difference was not significant (p = 0.34). In asthma patients with irritable bowel syndrome and psychiatric disorders...

‣ Cluster analysis of symptoms and health seeking behaviour differentiates subgroups of patients with severe irritable bowel syndrome

Guthrie, E; Creed, F; Fernandes, L; Ratcliffe, J; Van der Jagt, J; Martin, J; Howlett, S; Read, N; Barlow, J; Thompson, D; Tomenson, B;
Fonte: Copyright 2003 by Gut Publicador: Copyright 2003 by Gut
Tipo: Artigo de Revista Científica
Publicado em /11/2003 Português
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Background: Irritable bowel syndrome (IBS) is a heterogeneous condition which is diagnosed according to specific bowel symptom clusters. The aim of the present study was to identify subgroups of IBS subjects using measures of rectal sensitivity and psychological symptoms, in addition to bowel symptoms. Such groupings, which cross conventional diagnostic approaches, may provide greater understanding of the pathogenesis of the condition and its treatment.

‣ Immune activation in patients with irritable bowel syndrome

Liebregts, T.; Adam, B.; Bredack, C.; Roth, A.; Heinzel, S.; Lester, S.; Downie-Doyle, S.; Smith, E.; Drew, P.; Talley, N.; Holtmann, G.
Fonte: W B Saunders Co Publicador: W B Saunders Co
Tipo: Artigo de Revista Científica
Publicado em //2007 Português
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Background & Aims: We set out to test the hypothesis that irritable bowel syndrome (IBS) is characterized by an augmented cellular immune response with enhanced production of proinflammatory cytokines. We further aimed to explore whether symptoms and psychiatric comorbidity in IBS are linked to the release of proinflammatory cytokines. Methods: We characterized basal and Escherichia coli lipopolysaccharide (LPS)-induced cytokine production in peripheral blood mononuclear cells (PBMCs) from 55 IBS patients (18 mixed-, 17 constipation-, 20 diarrhea-predominant) and 36 healthy controls (HCs). PBMCs were isolated by density gradient centrifugation and cultured for 24 hours with or without (1 ng/mL) LPS. Cytokine production (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, and IL-6) was measured by enzyme-linked immunosorbent assay. Abdominal symptoms and psychiatric comorbidities were assessed by using the validated Bowel Disease Questionnaire and the Hospital Anxiety and Depression Scale. Results: IBS patients showed significantly (P < .017) higher baseline TNF-α, IL-1β, IL-6, and LPS-induced IL-6 levels compared with HCs. Analyzing IBS subgroups, all cytokine levels were significantly (P < .05) higher in diarrhea-predominant IBS (D-IBS) patients...

‣ In vitro Untersuchungen zur Wirkung von Phytopharmaka auf die Kontraktilität des Mäuse-Ileums: Mögliche Bedeutung für die Therapie des Reizdarmsyndroms; Effects of herbal extracts on contractility of ileum of mouse in vitro: Possible importance for therapy of irritable bowel syndrome

Hagelauer, Daniela
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
Português
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Das Reizdarmsyndrom ist eine der häufigsten Erkrankungen des Gastrointestinaltrakts und durch vielfältige Symptome unterschiedlicher Pathogenese gekennzeichnet. Dabei steht eine gestörte Motilität, die zum einen durch Störungen des enterischen Nervensystems, zum anderen auf reflektorischem Weg durch eine erhöhte Sensibilität, aber auch durch inflammatorische Prozesse hervorgerufen sein kann, im Vordergrund. In der Therapie des Reizdarmsyndroms werden häufig Phytotherapeutika eingesetzt, so dass in der vorliegenden Arbeit die Wirkungen von Iberogast® (STW 5) und seinen neun Einzelextrakten auf die spontane endogene Peristaltik und auf die durch verschiedene Neurotransmitter modulierte Kontraktilität untersucht wurden. Zusätzlich wurde der Frage nachgegangen, inwieweit Homöopathika, die bei gastrointestinalen Beschwerden Anwendung finden, Wirkungen auf den Darm erzielen. Dabei wurden jedoch Regeln der Homöopathie nicht beachtet. Für diese in vitro Untersuchungen wurden im Organbad phasische und induzierte tonische Kontraktionen longitudinaler Ileumpräparate der Maus gemessen und nach Amplitude, Frequenz und Tonus ausgewertet. Für STW 5 und alle Extrakte wurden in Messungen der spontanen Kontraktilität dosisabhängig inhibierende Effekte auf die Amplitude und Frequenz gefunden...

‣ A study of mechanisms underlying inflammation-induced abnormal nociceptive signaling from the colon in models of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)

IBEAKANMA, CHARLES ONYINYE
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado
Português
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Abdominal pain is a common symptom of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Although the extent differs, visceral inflammation is thought to play a significant role in nociception in these disorders. This thesis describes studies examining mechanisms of inflammation-induced changes in nociceptive signaling from the colon using human colonic biopsy and animal models of the conditions. Citrobacter rodentium infection in mice produced profound colitis at day 10 post-infection which resolved by day 30. Perforated current clamp recordings showed that inflammation induced hyperexcitability of colonic DRG neurons that persisted at day 30 post-infection. Similarly, multi-unit afferent nerve recordings revealed enhanced firing of colonic afferents following colon distension at this time. In voltage clamp studies, suppression of IA K+ currents in post-infected C. rodentium neurons was observed. Combining water-avoidance stress (WAS) and C. rodentium infection exaggerated these effects. Interactions between proteases and stress mediators underlie these actions. In vivo studies revealed WAS combined with C. rodentium post-infection induced visceral hyperalgesia and allodynia. A separate series of studies examined the possible role of cysteine proteases in post-infectious IBS. The cysteine protease cathepsin-s (Cat-S) induced neuronal excitability and...

‣ Irritable bowel syndrome in women with chronic pelvic pain in a Northeast Brazilian city

Lessa,Lígia Maria Montenegro; Chein,Maria Bethânia da Costa; Silva,Diego Salvador Muniz da; Poli Neto,Omero Benedicto; Nogueira,Antônio Alberto; Coelho,Leidyane Silva Caldas; Brito,Luciane Maria Oliveira
Fonte: Federação Brasileira das Sociedades de Ginecologia e Obstetrícia Publicador: Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2013 Português
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PURPOSES: To determine the prevalence of irritable bowel syndrome (IBS) in women with chronic pelvic pain (CPP) and its associated features; to determine whether IBS and CPP constitute the same syndrome. METHODS: Cross-sectional population survey with systematic sequential sampling according to census districts in which 1470 women were interviewed with respect to the sample calculation. The participants resided in their own homes, were at least 14 years of age, experienced menarche and presented CPP according to the American College of Obstetrics and Gynaecology. The dependent variable was IBS based on Rome III criteria in women with CPP, and the following independent variables were possibly associated with IBS: age, schooling, duration of pain, sedentary lifestyle, migraine, depression, insomnia, back pain, dysmenorrhea, dyspareunia, depression, history of violence, and intestinal symptoms. The sample was subdivided into groups with and without IBS. After the descriptive analysis of the variables was performed, the respective frequencies were evaluated using GraphPad Prism 5 software. To evaluate the association between the dependent variable and the independent variables, the χ² test was used with a significance level of 5%. RESULTS: The prevalence of IBS in women with CPP was 19...

‣ Barostato rectal en el síndrome de intestino irritable; Rectal barostat in irritable bowel syndrome

Madrid Silva, Ana María; Defilippi Cafri, Carlos; Valenzuela E., Jorge; Quera P., Rodrigo; Defilippi Guerra, Claudia
Fonte: Universidade do Chile Publicador: Universidade do Chile
Tipo: Artículo de revista
Português
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Background: Many patients with irritable bowel syndrome (IBS) have lowered sensory thresholds to rectal distention when compared to control subjects, a phenomenon called visceral hypersensitivity. Aim: To investigate the usefulness of a rectal barostat as a diagnostic tool in IBS and if there are differences in visceral hypersensitivity in different groups of IBS patients. Patients and Methods: Ten healthy subjects and 19 IBS patients, defined using Rome II criteria (12 with constipation, three with diarrhea and four alternating between diarrhea and constipation), were studied. Sequential isobaric rectal distentions, from 2 mmHg up to a maximal pressure of 52 mmHg or when the patients reported pain, were carried out. Visceral hypersensitivity was defined as a pain threshold under 38 mmHg. Results: Only 26% of IBS patients had visceral hypersensitivity (16% and 43% of patients with IBS and constipation and IBS and diarrhea or alternating symptoms, respectively, p =NS). Pain threshold in controls, patients with IBS and constipation and patients with IBS and diarrhea or alternating symptoms was 43.8±6.6, 45.3±9.2 and 40.8±9.2 mmHg, respectively (p =NS). Conclusions: Our results do not support the usefulness of the electronic rectal barostat as a diagnostic method to diagnose IBS.

‣ Luminal-derived stimuli as triggers of irritable bowel syndrome-like states in the rat: role of neurotrophic factors

Jardí Pujol, Ferran
Fonte: [Barcelona] : Universitat Autònoma de Barcelona, Publicador: [Barcelona] : Universitat Autònoma de Barcelona,
Tipo: Tesis i dissertacions electròniques; info:eu-repo/semantics/doctoralThesis; info:eu-repo/semantics/publishedVersion Formato: application/pdf
Publicado em //2014 Português
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En el tracto gastrointestinal, los estímulos de origen luminal se han implicado en la patofisiología del síndrome del intestino irritable (IBS). Aunque los mecanismos por los cuales contribuyen al inicio/mantenimiento de la sintomatología permanecen poco definidos, se ha propuesto la implicación de un circuito neuroinmune dependiente de mastocitos (MCs) y factores neurotróficos (NTFs). Este trabajo profundiza en la capacidad de los estímulos luminales, incluyendo factores relacionados con la microbiota comensal, las infecciones intestinales y los antígenos alimentarios, para producir alteraciones de tipo IBS en el colon de la rata, con especial énfasis en la implicación de los NTFs. Con este propósito, se han utilizado dos modelos de disfunción intestinal dependientes de mastocitos de mucosa (MMCs): la exposición oral a ovoalbúmina (OVA) y la infección por Trichinella spiralis. Tanto la exposición oral a OVA durante 6 semanas como la infección por T. spiralis activaron los MMCs del colon, si bien el reclutamiento celular sólo tuvo lugar durante la infección. La exposición a OVA durante 6 semanas alteró la contractilidad colónica, tanto in vivo como in vitro, un efecto que no se observó en tratamientos cortos (1 semana).Sin embargo...

‣ Role of psychiatric disorders and irritable bowel syndrome in asthma patients

Yilmaz, Ayse; Cumurcu, Birgul Elbozan; Tasliyurt, Turker; Sahan, Abdulkadir Geylani; Ustun, Yusuf; Etikan, Ilker
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2011 Português
Relevância na Pesquisa
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OBJECTIVES: The goals of the study were the following: 1) to determine the frequency of psychiatric disorders and irritable bowel syndrome in patients with asthma and 2) to compare the frequency of these disorders in patients with asthma to their frequency in healthy controls. INTRODUCTION: Patients with asthma have a higher frequency of irritable bowel syndrome and psychiatric disorders. METHODS: We evaluated 101 patients with bronchial asthma and 67 healthy subjects. All subjects completed the brief version of the Bowel Symptoms Questionnaire and a structured clinical interview for DSM-IV axis disorders (SCID-I/CV). RESULTS: There were 37 cases of irritable bowel syndrome in the group of 101 stable asthma patients (36.6%) and 12 cases in the group of 67 healthy subjects (17.9%) (p = 0.009). Irritable bowel syndrome comorbidity was not related to the severity of asthma (p = 0.15). Regardless of the presence of irritable bowel syndrome, psychiatric disorders in asthma patients (52/97; 53.6%) were more common than in the control group (22/63, 34.9%) (p = 0.02). Although psychiatric disorders were more common in asthma patients with irritable bowel syndrome (21/35, 60%) than in those without irritable bowel syndrome (31/62, 50%), the difference was not significant (p = 0.34). In asthma patients with irritable bowel syndrome and psychiatric disorders...

‣ Influência da resposta individual ao estresse e das comorbidades psiquiátricas na síndrome do intestino irritável; Influence of individual response to stress and psychiatric comorbidity in irritable bowel syndrome

Ribeiro, Luana Medeiros; Alves, Natália Galdino; Silva-Fonseca, Vilma Aparecida da; Nemer, Aline Silva de Aguiar
Fonte: Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria Publicador: Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2011 Português
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CONTEXTO: A síndrome do intestino irritável (SII) é um distúrbio clínico comum, porém ainda pouco compreendida, uma vez que o desenvolvimento dos seus sintomas está fortemente relacionado ao estresse, ansiedade e depressão. OBJETIVOS: Revisar a literatura a fim de verificar se, de fato, existe influência do estresse e das comorbidades psiquiátricas no desenvolvimento, diagnóstico e tratamento para os portadores da SII. MÉTODOS: A revisão foi realizada por meio de pesquisa na base de dados MedLine e Lilacs entre 1990 e 2009, usando-se as palavras-chave "estresse", "comportamento", "psiquiatria" e "síndrome do intestino irritável". RESULTADOS: Foram selecionados 38 artigos que relacionaram a síndrome do intestino irritável à reação individual ao estresse e comorbidade psiquiátrica, incluindo ansiedade e depressão. CONCLUSÃO: A reatividade do indivíduo ao estresse e os fatores psicossociais desempenham um papel etiológico importante, embora não determinante, podendo interferir no funcionamento intestinal mediante a alteração na motilidade ou espasmo, na diminuição ou aumento de secreção e,finalmente, na irritação. É necessário desenvolver uma metodologia para definir e medir a somatização para o auxílio no diagnóstico clínico e a inclusão dos fatores psicossociais relacionados ao desenvolvimento e persistência dos sintomas nos critérios diagnósticos para a SII.; BACKGROUND: The irritable bowel syndrome (IBS) is a common clinical disorder...

‣ Síndrome do intestino irritável: um exercício em análise funcional do comportamento; Irritable bowel syndrome: an exercise in functional analysis of behavior

Bohm, Carlos Henrique; Universidade de Brasilia; Gimenes, Lincoln da Silva; Universidade de Brasília
Fonte: UFPR Publicador: UFPR
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; avaliado por pares; Formato: application/pdf
Publicado em 15/03/2011 Português
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Irritable Bowel Syndrome (IBS) is characterized by an alteration of the frequency of the intestinal evacuations, which are associated with abdominal discomfort. The etiology of this health problem is not very well known yet. The psychological literature offers support to IBS comprehension by stress model, adjunctive bowel motility model and operant model. This study was an exercise in functional analysis of behavior with a woman, IBS patient, through interviews and self-monitoring (SM) of daily activities and the symptoms to verify the existence of functional relations between these two events. The participant showed a diarrhea symptom which had a consistent remission during a period of vacation, as a function of changes in the academic demands. Her symptoms seemed postponing aversive activities, indicating the operant control. This study demonstrated the possibility of using functional analysis as an instrument capable of helping in SII comprehension. Keywords: functional analysis of behavior; irritable bowel syndrome; self-monitoring; daily activities.; Na Síndrome do Intestino Irritável (SII), há a alteração na frequência das evacuações intestinais associadas ao quadro de desconforto abdominal. A etiologia desse problema de saúde ainda é pouco conhecida. A literatura psicológica fornece suporte para a compreensão da SII por meio do modelo de estresse...

‣ Irritable bowel syndrome immune hypothesis: the role of lymphocytes and mast cells

Ortiz Lucas,M.; Saz Peiró,P.; Sebastián Domingo,J. J.
Fonte: Revista Española de Enfermedades Digestivas Publicador: Revista Española de Enfermedades Digestivas
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/11/2010 Português
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Objective: To review the available evidence on the role of T-lymphocytes and mast cells in the etiopathogenesis of Irritable Bowel Syndrome. Methods: Bibliographic retrieval on PubMed including the terms "Irritable Bowel Syndrome, "Immune System", "T-Lymphocytes" and "Mast Cells". Results: Twenty-five case-control studies and one randomized controlled trial were retrieved. Noteworthy in the blood is the increase in activated T cells destined to migrate to the bowel in these patients. A high frequency of T-lymphocytes is described in the intestinal mucosa, although the study findings are, at times, contradictory. An evident increase in mast cells (and in their activity) between the terminal ileum and descending colon is also observed. Conclusions: The heterogeneity of diagnostic criteria and experimentation methods could account for some of the differences in the results found in the selected research. There are indications that give reason to believe these patients have "low-grade intestinal inflammation", and the increase in T-lymphocytes and mast cells has been associated with disorders found in IBS such as the communication between the intestine and the nervous system, the increase in intestinal permeability and changes in the microbiota.

‣ Linaclotide in the treatment of patients with irritable bowel syndrome and constipation: analysis of an opportunity

Carballo,Fernando
Fonte: Revista Española de Enfermedades Digestivas Publicador: Revista Española de Enfermedades Digestivas
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/06/2013 Português
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Linaclotide is a secretagogue that provides a combined effect on visceral pain. The European Medicines Agency has authorized its indication for the symptomatic treatment of moderate to severe irritable bowel syndrome with constipation in adults. The purpose of this review is to discuss the clinical framework for linaclotide use in our setting, the drug's characteristics and pre-clinical development, and the clinical studies supporting its use in order to establish relevant views regarding its validity and clinical applicability. The results suggest that the only -non-severe- adverse effect associated with this drug is diarrhea. As regards effectiveness, linaclotide consistently shows favorable, significant differences in absolute risk versus placebo for all objective outcome variables described by regulatory agencies, with a combined pain and constipation response between 12.6% and 22.8% according to the variable and trial under consideration. This response is sustained and drug-related, as it goes away upon discontinuation. To conclude, linaclotide has a safety and efficacy profile that, from a clinical perspective, warrants its use for patients meeting irritable bowel syndrome and constipation criteria, with significant symptoms that cannot be relieved with other less specific measures. In the absence of predictive rules for response...