Página 1 dos resultados de 5832 itens digitais encontrados em 0.046 segundos

‣ "Câncer de boca: avaliação do conhecimento dos cirurgiões dentistas quanto aos fatores de risco e procedimentos de diagnóstico" ; "Oral cancer: assessment of the dentist´s knowledge as for risk factors and diagnosis procedures"

Morais, Teresa Márcia Nascimento de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 14/11/2003 Português
Relevância na Pesquisa
67.109854%
RESUMO O objetivo deste estudo foi avaliar o conhecimento de cirurgiões dentistas inscritos em cursos de estética quanto aos fatores predisponentes e de diagnóstico do câncer bucal, a partir de um questionário previamente testado. O desenvolvimento de materiais e técnicas odontológicas e o anseio cada vez maior do ser humano em busca da beleza têm levado um número crescente de pacientes aos consultórios odontológicos. Julgamos este momento oportuno para informar a população e diagnosticar precocemente o câncer de boca. Com relação às características gerais dos 465 participantes, houve predominância de uma população jovem, com idade inferior a 39 anos, maior participação feminina e quase 1/3 formados de 10 a 20 anos. As características clínicas da ocorrência desta neoplasia não estão claras para os entrevistados, uma vez que somente metade indicou o carcinoma espinocelular como o tipo mais comum, e aproximadamente metade tem conhecimento das características do linfonodo em metástase cervical. Cerca de 20% desconhece a região da boca e a faixa etária de maior ocorrência deste tumor, e também o seu aspecto inicial. Entretanto, 75,7% reconhecem a leucoplasia como a condição mais comumente associada ao câncer bucal. Com relação aos fatores de risco...

‣ "Comportamento dos cirurgiões-dentistas das Unidades Básicas de Saúde do município de São Paulo quanto à prevenção e ao diagnóstico precoce do câncer bucal"; Dentists behaviour from basic health units of the city of São Paulo related to oral cancer prevention and early diagnosis

Vasconcelos, Erico Marcos de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 15/09/2006 Português
Relevância na Pesquisa
67.09388%
Este estudo teve como objetivo conhecer as ações que os cirurgiões-dentistas das unidades básicas de saúde do município de São Paulo têm desenvolvido quanto à prevenção e ao diagnóstico precoce do câncer bucal, além de suas percepções para a realização de tais ações, a fim de analisar o comportamento destes profissionais a cerca das questões relativas a esta morbidade. A maioria dos diagnósticos de câncer bucal é feita em estágios avançados em São Paulo, cidade que possui as maiores taxas de incidência nacionais, semelhantes a de outras regiões do mundo. O cirurgião-dentista exerce um papel fundamental e estratégico no combate aos fatores ligados ao aparecimento desse agravo. Foram enviados, em março de 2005, 885 questionários aos cirurgiões-dentistas das 286 unidades básicas de saúde de São Paulo, via Correio. Foi feito um banco de dados utilizando o software de informática Epi Info – versão 6.04b. Participaram da pesquisa 282 profissionais, (taxa de resposta de 32%), em sua maioria do sexo feminino, com mais de 20 anos de graduação, com perfil generalista e que possui outros vínculos empregatícios. Além do baixo grau de conhecimento constatado quanto aos fatores de risco ligados à etiologia e às condições bucais em relação a possível evolução para um câncer bucal...

‣ Avaliação clínica do perfil epidemiológico de 665 pacientes com câncer oral diagnosticados entre os anos de 1970 - 2009 na FOUSP; Clinical evaluation of epidemiological profile of 665 patients diagnosed with oral cancer between 1970-2000 at FOUSP

Rocha, Rita de Cássia Araujo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 14/12/2011 Português
Relevância na Pesquisa
67.07857%
O Carcinoma espinocelular (CEC) é o mais comum das neoplasias malignas da cavidade oral. Corresponde a cerca de 70 a 90% dos cânceres orais. Há aproximadamente 200.000 novos casos por ano no mundo. No Brasil são estimados cerca de 14.120 novos casos de câncer oral por ano. A literatura atual tem demonstrado uma alteração do perfil clínico do paciente portador de CEC em relação às quatro décadas passadas. Avaliamos os dados clínicos disponíveis de 665 pacientes diagnosticados com CEC da cavidade oral atendidos na Disciplina de Estomatologia Clínica da Faculdade de Odontologia da Universidade de São Paulo entre os anos de 1970 a 2009. As variáveis estudadas foram: idade, gênero, etnia e sitio primário do tumor. Os dados foram analisados estatisticamente entre as décadas. Os dados gerais encontrados revelaram que dos 665 casos analisados, 512 (76,99%) eram homens e 143 (21,50%) mulheres, sendo 538 (80,9%) leucodermas, 98 (14,74%) melanodermas, 15 (2,26%) feodermas e 14 (2,11%) xantodermas.Os sítios mais acometidos foram, o assoalho bucal com 150 (22,56%) casos, seguido pela língua com 142 (21,35%), mandíbula 88 (13,23%), palato 72 (10,83%), lábios 62 (9,32%), rebordo e fundo de sulco 31 (4,66%), outros (trígono retromolar...

‣ Avaliação de polimorfismos em genes de metabolismo do etanol e gene de reparo do DNA em pacientes portadores de câncer de boca; Evaluation of polymorphisms in genes of ethanol metabolism and DNA repair gene in patients with oral cancer

Takamori, Jean Tetsuo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 30/08/2012 Português
Relevância na Pesquisa
67.12818%
O carcinoma epidermóide é uma neoplasia que pode ter origem do revestimento mucoso de vários sítios das vias aerodigestivas superiores, sendo a língua o sítio primário com maior incidência. Entre os fatores de risco para a doença estão a idade, as mutações genômicas, o hábito tabagista e principalmente o consumo de etanol. O etanol é considerado um agente cocarcinogênico no processo de desenvolvimento do câncer de boca. Por outro lado, o acetaldeído, subproduto da oxidação do etanol, é tóxico e participa diretamente na carcinogênese. Assim, polimorfismos genéticos que alteram a oxidação de etanol para acetaldeído promovendo seu acúmulo podem alterar o risco de câncer oral. Os resultados sugerem que pacientes portadores do polimorfismo do gene ADH1C Ile350Val possuem maior risco de tornarem-se etilistas crônicos (OR=2,0199), mas o risco de desenvolverem câncer não é alterado quando comparado aos não portadores. Já os portadores dos polimorfismos nos genes ADH1B Arg47His (OR=0,3445), CY2E1 (ins) (OR=0,3261) e ALDH2 (GA) (OR=0,4811) apresentaram menores riscos de desenvolverem câncer oral, mas estes polimorfismos não estavam associados ao risco de tornarem-se etilistas crônicos. Observou-se também uma possível interação entre a baixa atividade da enzima ALDH2 e a expressão do gene CYP2E1 como um fator protetor no desenvolvimento do câncer de boca. Entretanto...

‣ Prevalências e características clínico-epidemiológicas do câncer bucal e de cabeça e pescoço no Hospital Estadual de Bauru/SP; Prevalence and clinical and epidemiological characteristics of oral cancer and head and neck in the state hospital Bauru/sp

Figueiredo, Andréa Mendes
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 24/05/2013 Português
Relevância na Pesquisa
67.126426%
O câncer tem sido considerado uma doença de países desenvolvidos e em desenvolvimento, sendo que a maior parte do ônus global do câncer é observada nos países em desenvolvimento, convertendo-se em um evidente problema de saúde pública mundial. Devido a sua alta incidência, prevalência e mortalidade, o câncer de cabeça e pescoço, é considerado um dos principais tumores no Brasil e no mundo, sendo o câncer bucal um dos tipos mais incidentes, correspondendo a 10% de todos os tumores malignos, com aproximadamente 390.000 novos casos a cada ano. As taxas de incidências variam conforme as regiões do Brasil, tendo a região sudeste e sul as maiores taxas de incidência do mundo, sendo a região sudeste responsável por 42% do número total de casos o Brasil. Os fatores de risco são tabagismo, alcoolismo, hábitos alimentares, radiação solar, vírus, idade, sexo, irritação mecânica/química, nível socioeconômico além de fatores genéticos. Embasados neste contexto, o objetivo deste estudo foi verificar a prevalência, perfil clínico e epidemiológico do câncer bucal e de cabeça e pescoço de pacientes registrados no Hospital Estadual de Bauru/SP, um hospital público no interior do estado de São Paulo, através de revisão de prontuários no período de junho de 2008 à janeiro de 2011...

‣ Oral cancer mortality trends in Brazilian geographical regions from 1996-2001

Loffredo, Leonor de Castro Monteiro; Pinelli, C.; Vitussi, T. R C; Sundefeld, M. L M M; Campos, J. A D B
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 133-138
Português
Relevância na Pesquisa
67.16178%
The purpose of this study was to analyse the oral cancer mortality trends in Brazil by geographic region, age and sex, from 1996 to 2001. The Brazilian Ministry of Health database DATASUS and the Brazilian Institute of Geography and Statistics were used as the source of data. Oral cancer mortality rates per 100,000 population were estimated. Statistical analyses comprised estimates of oral cancer mortality rates, grouped according to the study variables, in 1996, 1997, 1998, 1999, 2000 and 2001; also, the three-year periods 1996-1998 and 1999-2001 were analysed, allowing the oral cancer mortality trends between these two periods to be calculated. For comparison, in each geographical region, the ratio between two death rates (related to period or sex) was calculated. In the period 1996-2001, a total of 25,972 deaths due to oral cancer were reported, giving a mortality rate of 2.67. The rates for the periods 1996-1998 and 1999-2001 were 2.53 and 2.73, respectively, showing a slight increase in the rate. There was a predominance of oral cancer in males with a male/female ratio of approximately 4. All regions exhibited an increase in mortality rates, with the exception of the Southeast region. From 1996 to 2001, the average mortality rates were 3.55 and 3.58 for the Southeast and South regions...

‣ Allelic variants of XRCC1 and XRCC3 repair genes and susceptibility of oral cancer in Brazilian patients

Dos Reis, Mariana Bisarro; Losi-Guembarovski, Roberta; De Souza Fonseca Ribeiro, Enilze Maria; Cavalli, Iglenir João; Morita, Maria Celeste; Ramos, Gyl Henrique Albrecht; De Oliveira, Benedito Valdecir; Mizuno, Lauro Toyoshi; Rogatto, Silvia Regina; De S
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 180-185
Português
Relevância na Pesquisa
67.06852%
Background: The capacity for DNA repair is essential in maintaining cellular functions and homeostasis; however, this capacity can be altered based on DNA sequence variations in DNA repair genes, which may contribute to the onset of cancer. Many single-nucleotide polymorphisms (SNPs) in repair genes have been found to be associated with oral cancer. The aim of this study was to investigate the relationship between the presence of allelic variants Arg194Trp (rs:1799782) and Arg399Gln (rs: 25487) of XRCC1 gene and Thr241Met (rs: 861539) of XRCC3 gene and susceptibility to oral cancer. We also attempted to correlate the frequencies obtained for each of the SNPs to histopathological parameters. Methods: A case-control study was conducted with genomic DNA from 150 patients with oral squamous cell carcinomas and 150 controls. SNPs were genotyped by RFLP-PCR. Results: The presence of the polymorphic variants of the XRCC1 gene within codon 194 (OR 0.82, 95% CI: 0.44-1.51) and codon 399 (OR 0.94, 95% CI: 0.59-1.50) and within the XRCC3 gene (OR 0.72; 95% CI: 0.45-1.16) were not associated with an increased risk of oral cancer. A combinational analysis of SNPs in both genes indicated no association. The presence of the allelic variants of these two genes had no statistically significant effect on tumor differentiation...

‣ Macrophage migration inhibitory factor and oral cancer

França, Cristiane M.; Batista, Aline C.; Borra, Ricardo C.; Ventiades-Flores, Jose A.; Mendonça, Elismauro F.; Deana, Alessandro M.; Mesquita-Ferrari, Raquel A.; de Natali Caly, Decio; de Mello Rode, Sigmar; Faria, Miriam R.
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 368-373
Português
Relevância na Pesquisa
67.078486%
Background: Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with pro-inflammatory functions and involved in tumorigenesis. The aim of this study was to evaluate the expression and localization of the macrophage MIF in oral squamous carcinoma (OSC). In addition, the relationship between MIF expression and clinicopathological parameters such as survival data, tobacco use, alcohol habits, TNM stage, tumor graduation, and peritumoral inflammatory infiltrate were evaluated. Methods: Using immunohistochemistry, expression and localization of MIF was detected in 44 specimens of OSC. The absolute number and relative proportions of MIF-positive cells detected were also determined separately for tumor parenchyma vs. stroma. All counts were determined from 10 consecutive high-power fields using an integration graticule. Moreover, some parameters were analyzed separately for lip and intra-oral cancers. Results: Migration inhibitory factor-positive cells were observed in both the tumor parenchyma and in inflammatory cells of all specimens. In contrast, MIF expression was not detected in tumoral nests associated with poorly differentiated tumors. In specimens of lip cancer, a greater number of MIF-positive stromal immune cells were detected than in intra-oral cancer specimens (Mann-Whitney test...

‣ CYP1A1 genotypes and haplotypes and risk of oral cancer: a case-control study in South Indians

Balaji,Lakshmi; Singh,Krishna Balaji; Bhaskar,Lakkakula V.K.S.
Fonte: Sociedade Brasileira de Genética Publicador: Sociedade Brasileira de Genética
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2012 Português
Relevância na Pesquisa
67.041304%
The CYP1A1 gene encodes for the enzyme, aryl hydrocarbon hydroxylase, which is involved in the biotransformation of various aromatic tobacco precarcinogens. In the present study, the association between CYP1A1 gene polymorphisms (IVS1-728G > A, Thr461Asn and Ile462Val), and the risk of oral cancer, was examined among 157 patients with oral cancer and 132 age-matched controls, in a south Indian population. The strength of the association between CYP1A1 variants and oral cancer was estimated by logistic regression. It was found that Thr461Asn was not polymorphic. Both IVS1-728G > A and Ile462Val frequencies were consistent with Hardy-Weinberg equilibrium in the control group. There were no significant differences in genotype or haplotype frequencies between controls and cases with oral cancer. Hence, CYP1A1 SNPs can be considered as not being associated with oral cancer at either the genotype or haplotype levels in the population studied.

‣ Oral cavity infection: an adverse effect after the treatment of oral cancer in aged individuals

PAN,Jie; ZHAO,Jun; JIANG,Ning
Fonte: Faculdade De Odontologia De Bauru - USP Publicador: Faculdade De Odontologia De Bauru - USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2014 Português
Relevância na Pesquisa
67.09785%
Objective: The immune compromised patients after treatment of oral cancer may have a chance of infection by drug-resistant opportunistic microbes. We investigated the occurrence of opportunistic microorganisms in aged individuals receiving follow-up examinations after treatment of oral cancer in China. Material and Methods: These patients were used as test group and the respective age grouped healthy individuals as control group. In this study, the oral cavity microorganisms such as bacteria and yeast were taken for the analysis. After the screening of representative microorganisms, their aptitude of pervasiveness against drugs was studied. Here, we used antimicrobial agents which are common in clinical practice. We also performed studies to investigate the presence of toxin genes in methicillin-resistant S. aureus (MRSA). Results: The results indicate that the prevalence of drug-resistant microbes was more pronounced in oral cancer patients after initial treatment above 70 years old. The oxacillin resistance of S. aureus isolate confirms that the prevalence of MRSA is increasing in accordance to age-factor and immune compromise in elderly patients. Conclusions: This study reveals the occurrence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer in aged individuals. Special attention should be directed to MRSA during the treatment of oral cancer...

‣ Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

Krishna Rao, S.; Mejia, G.; Roberts-Thomson, K.; Logan, R.
Fonte: Asian Pacific Organization for Cancer Prevention Publicador: Asian Pacific Organization for Cancer Prevention
Tipo: Artigo de Revista Científica
Publicado em //2013 Português
Relevância na Pesquisa
67.041304%
The prevalence of oral cancers (OC) is high in Asian countries, especially in South and Southeast Asia. Asian distinct cultural practices such as betel-quid chewing, and varying patterns of tobacco and alcohol use are important risk factors that predispose to cancer of the oral cavity. The aim of this review is to provide an update on epidemiology of OC between 2000 and 2012. A literature search for this review was conducted on Medline for articles on OC from Asian countries. Some of the articles were also hand searched using Google. High incidence rates were reported from developing nations like India, Pakistan, Bangladesh, Taiwan and Sri Lanka. While an increasing trend has been observed in Pakistan, Taiwan and Thailand, a decreasing trend is seen in Philippines and Sri Lanka. The mean age of occurrence of cancer in different parts of oral cavity is usually between 51-55 years in most countries. The tongue is the leading site among oral cancers in India. The next most common sites in Asian countries include the buccal mucosa and gingiva. The 5 year survival rate has been low for OC, despite improvements in diagnosis and treatment. Tobacco chewing, smoking and alcohol are the main reasons for the increasing incidence rates. Low socioeconomic status and diet low in nutritional value lacking vegetables and fruits contribute towards the risk. In addition...

‣ Public awareness of oral cancer, of oral potentially malignant disorders and of their risk factors in some rural populations in Sri Lanka

Amarasinghe, H.K.; Usgodaarachchi, U.S.; Johnson, N.W.; Lalloo, R.; Warnakulasuriya, S.
Fonte: Wiley Publicador: Wiley
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
Relevância na Pesquisa
67.06342%
OBJECTIVE: The aim of this study was to investigate the level of public awareness of oral cancer, of oral potentially malignant disorders (OPMD) and of risk factors for developing these diseases in a province of Sri Lanka, a country with one of the highest incidences of these diseases in the world. METHODS: A cross-sectional community-based survey was carried out in Sabaragamuwa province by interviewing 1029 subjects above 30 years of age, over a 1-year period from November 2006. RESULTS: The level of public awareness of oral cancer was 84%, but only 23% for OPMD. Awareness was especially poor in low socioeconomic groups. The majority of subjects were not aware of the symptoms of oral cancer and of OPMD. Thirty-two percent were unaware that chewing betel quid was a risk factor for these diseases, as were 65% for tobacco smoking and 81% for heavy consumption of alcohol. Overall, 76% were not aware of any of the dangers inherent in the frequent use of areca nut. The majority of smokers, betel quid chewers and alcohol consumers were not aware that their lifestyles were placing their long-term health at serious risk. CONCLUSIONS: Knowledge of oral cancer, OPMD and their associated risk factors was poor among this population, indicating an urgent need to implement public health education and promotion strategies.; Hemantha K. Amarasinghe...

‣ Epidemiology of oral cancer in India: a life course study.

Krishna Rao, Sree Vidya
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2014 Português
Relevância na Pesquisa
67.288745%
Background: Oral cancer is a malignant disease contributing to one third of the total cancer burden in India. There is a worldwide social disparity in oral cancer incidence and survival. Life course epidemiology has shown that early-life socioeconomic conditions (SEC) could influence adult health through various pathways. Thus, the socioeconomic disparities in the occurrence of oral cancer underscore the importance of understanding the ‘life course processes’ operating between SEC at different stages in life and oral cancer. In addition to understanding socioeconomic disparities, practical solutions are required to reduce the burden of the disease. Early diagnosis and prompt treatment could reduce morbidity and mortality. Though visual screening helps in early diagnosis, it requires training and calibration of the screeners. Developing a simple screening model that can be utilized by untrained health care workers will be helpful in triaging asymptomatic adults with oral cancer. Therefore a study was designed with the following hypotheses. Research hypotheses 1. Accumulation of socioeconomic disadvantage over the life course is associated with oral cancer in the Indian population. 2. Early-life socioeconomic disadvantage has a lasting effect on the oral cancer outcome in adulthood in the Indian population. 3. An oral cancer screening model developed for the Indian population...

‣ Oral and general health-related quality of life in patients treated for oral cancer compared to control group

Barrios, Roc??o; Bravo P??rez, Manuel; Gil Montoya, Jos?? Antonio; Mart??nez Lara, Ildefonso; Garc??a Medina, Blas; Tsakos, Georgios
Fonte: Biomed Central Publicador: Biomed Central
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
67.09124%
Background: Health-related quality of life (HRQoL) is gaining importance as a valuable outcome measure in oral cancer area. The aim of this study was to assess the general and oral HRQoL of oral and oropharyngeal cancer patients 6 or more months after treatment and compare them with a population free from this disease.; Methods: A cross-sectional study was carried out with patients treated for oral cancer at least 6 months post-treatment and a gender and age group matched control group. HRQoL was measured with the 12-Item Short Form Health Survey (SF-12); oral HRQoL (OHRQoL) was evaluated using the Oral Health Impact Profile (OHIP-14) and the Oral Impacts on Daily Performances (OIDP). Multivariable regression models assessed the association between the outcomes (SF-12, OHIP-14 and OIDP) and the exposure (patients versus controls), adjusting for sex, age, social class, functional tooth units and presence of illness.; Results: For patients (n???=???142) and controls (n???=???142), 64.1% were males. The mean age was 65.2 (standard deviation (sd): 12.9) years in patients and 67.5 (sd: 13.7) years in controls. Patients had worse SF-12 Physical Component Summary scores than controls even in fully the adjusted model [??-coefficient???=??????0.11 (95% CI: ???5.12-(???0.16)]. The differences in SF-12 Mental Component Summary were not statistically significant. Regarding OHRQoL patients had 11.63 (95% CI: 6.77-20.01) higher odds for the OHIP-14 and 21.26 (95% CI: 11.54-39.13) higher odds for OIDP of being in a worse category of OHRQoL compared to controls in the fully adjusted model.; Conclusion: At least 6 months after treatment...

‣ Oral cancer knowledge and awareness among dental students

Soares,Tânderson Rittieri Camêlo; Carvalho,Maria Eugênia de Almeida; Pinto,Lucielma Salmito Soares; Falcão,Carlos Alberto; Matos,Francisca Tereza Coelho; Santos,Tanit Clementino
Fonte: Faculdade de Odontologia de Piracicaba - UNICAMP Publicador: Faculdade de Odontologia de Piracicaba - UNICAMP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2014 Português
Relevância na Pesquisa
67.13774%
AIM: To assess the knowledge and attitude of undergraduate dental students about oral cancer. METHODS: A cross-sectional, quantitative study was conducted based on a questionnaire containing 15 questions about prevention, clinical aspects, and attitudes towards oral cancer. One hundred-thirty-three undergraduate dental students between the second and fifth years were enrolled. The statistical significance was measured by Pearson's chi-square test. RESULTS: There was a predominance of females (58.65%) and most students were between 20 and 30 years of age (75.19%). The risk factors for oral cancer mainly described by the students were smoking (92.48%) and drinking (84.21%). Squamous cell carcinoma was described as the most common type of oral cancer by 48.12% of the students. As much as 53.38% of the participants considered the tongue as the most affected anatomic region, 57.89% reported ulcers as the most frequent clinical aspect, and 44.36% attributed a firm and painless aspect to the regional metastatic lymph nodes. Most students reported regularly conducting a thorough examination of the oral cavity (81.95%). Two of the 15 variables showed differences between the students, according to the school time: previous head and neck carcinoma (Pearson's chi-square...

‣ Oral cancer susceptibility associated with the CYP1A1 and GSTM1 genotypes in Chilean individuals

Roco Arriagada, Angela Margarita; Miranda Melo, Carla Estefanía; Quiñones Sepúlveda, Luis Abel; Santander, Paula; Saavedra Saavedra, Iván Nicolás; Cáceres Lillo, Dante Daniel; Squicciarini Rueda, Valentina; Espinoza, Iris; Lee, Kuen; Cordero, Karina
Fonte: Universidade do Chile Publicador: Universidade do Chile
Tipo: Artículo de revista
Português
Relevância na Pesquisa
67.041304%
Polycyclic aromatic hydrocarbons (PAHs) contained in tobacco smoke acquire carcinogenicity following their activation by xenobiotic-metabolizing enzymes to highly reactive metabolites The cytochrome P4501A1 (CYP1A1) enzyme is central to the metabolic activation of these PAHs, and GSTM1 is the main enzyme responsible for its detoxification CYP1A1 and GSTM1 polymorphisms were evaluated in 124 Chilean healthy controls and 48 oral cancer patients through PCR-based restriction fragment length polymorphism In the healthy controls, frequencies of the CYP1A1 variant alleles for ml (CYP1A1*2A) and the GSTM1null genotype were found to be 0 25 and 0 19, respectively In the oral cancer patients, these frequencies were 0 33 and 0 50, respectively Thus, the GSTM1 and ml rare alleles were significantly more frequent in the oral cancer patients compared to the controls The estimated relative risk for oral cancer associated with the single genotype CYP1A1 or GSTM1 was 2 08 for wt/ml, 1 04 for ml/ml and 4 16 for the GSTM1null genotype For smokers, the estimated relative risk (adjusted by age and gender) was higher in the individuals carrying the ml allele of CYP1A1 [wt/ml odds ratio (OR)=5 68, P=0 0080, ml/ml OR=7 77, P=0 0420] or GSTM1null genotype (OR=20 81 P<0 0001) Combined genotypes CYP1A1 and GSTM1 increased the risk significantly (wt/ml/GSTM1null OR=19 14...

‣ Time elapsed between the first symptoms, diagnosis and treatment of oral cancer patients in Belo Horizonte, Brazil

Abdo,Evandro Neves; Garrocho,Arnaldo de Almeida; Barbosa,Alvimar Afonso; Oliveira,Enaldo Lopes de; França-Filho,Lyzio; Negri,Sérgio Luiz Coelho; Pordeus,Isabela Almeida
Fonte: Medicina Oral, Patología Oral y Cirugía Bucal (Internet) Publicador: Medicina Oral, Patología Oral y Cirugía Bucal (Internet)
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/11/2007 Português
Relevância na Pesquisa
76.931895%
Objective: One of the most important objectives of a public health service is early diagnosis of disease, which provides a better prognosis and reduction in treatment cost. We investigated the delay for diagnosis and treatment of oral cancer in a public hospital. Material and methods: One hundred eighty records of patients who attended for their first consultation in the department of head and neck surgery in a public hospital from Belo Horizonte-Brazil, between the period from 1 January 1999 to 31 December 2001 were analysed. The following variables were analyzed: gender, age, evolution time (ET), time elapsed from referral to hospital and first appointment (RT), time elapsed from first appointment and treatment (TT), total time elapsed from first noticing the lesion and starting treatment (TTE), sites and staging. Results: Results for males and females were, respectively: mean age = 57.9 and 60.8 years; ET= 169.4 and 215.4 days; RT = 27.9 and 40.6 days; TT = 40.9 and 44.9days; TTE = 207.9 and 263.8 days. No correlation was observed between age and TTE for either gender. Women presented the highest mean values for ET and TTE (p<0.01). Conclusion: It was concluded that public health policy should be developed to address the excessively long time lapsed between diagnosis and treatment as well as improve public health education programs to promote early oral cancer identification.

‣ A histological and clinical study on oral cancer: Descriptive analyses of 365 cases

Dias,Gonçalo Seguro; Almeida,Arlindo Pereira de
Fonte: Medicina Oral, Patología Oral y Cirugía Bucal (Internet) Publicador: Medicina Oral, Patología Oral y Cirugía Bucal (Internet)
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/11/2007 Português
Relevância na Pesquisa
77.06425%
Cancer is the second cause of death in Portugal right after cardio vascular diseases. In Portugal the incidence of oral and pharynx cancer (OPC) is higher than uterus and larynx cancers, and in US its frequency is higher than melanoma or uterus cancer, diseases that concern more population than oral cancer. Aims. The aim of this paper is to identify preferable anatomic location for oral cancer, mean age of patients, the use of tobacco and alcohol, histological characteristics, staging, type of therapeutics, presence of metastases and 1 and 5 year follow up. Matherials and Methods. Data was collected from clinical charts of 365 cases from the Centro de Lisboa do Instituto Português de Oncologia with histological confirmation of malign tumor of the mouth. These cases are the total of oral malign tumors in the years of 1997, 1998 and 1999 in that institution. Results. We observe that despite modern diagnostic and treatment techniques 37,9% of all patients died after first year with evidence of tumor. From all patients just 23,7% were free of disease after 5 years of treatment. Tongue was the principal region affected and the average age was 62, 25 years. It was concluded that 57, 8% of patient were smokers and 43,8% were alcohol drinkers. A high number of patients were submitted to radiotherapy either alone or with other treatment options.

‣ Factors related to survival from oral cancer in an Andalusian population sample (Spain)

Vallecillo Capilla,Manuel; Romero Olid,Maria Nuria; Olmedo Gaya,Maria Victoria; Reyes Botella,Candela; Bustos Ruiz,Vicente
Fonte: Medicina Oral, Patología Oral y Cirugía Bucal (Internet) Publicador: Medicina Oral, Patología Oral y Cirugía Bucal (Internet)
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/11/2007 Português
Relevância na Pesquisa
76.98416%
Introduction: Approximately 3% of malignant tumors originate in the oral cavity. The majority are squamous cell carcinomas, and a small percentage, malignant tumors of the salivary glands, lymphoreticular diseases, bone tumors, melanomas, sarcomas, malignant odontogenic tumors and metastases of tumors from other locations. The prognosis of these pathologies depends on the size, infiltration, and site of the lesion, the presence or absence of metastatic spread, and to a certain degree the differentiation of the tumor. The prognosis of an oral cancer remains generally negative, with 5-year survival figures below 50%, producing high rates of mortality and morbidity. Objectives: To evaluate the influence of different variables on survival in an oral cancer population. Patients and methods: Two-hundred and sixteen patients with oral squamous cell carcinoma were studied over a period of five years, evaluating 42 variables grouped into five data sections: personal, lesion, site, stage, and risk factors. Results and conclusions: Average survival was 2088 days, with a standard deviation of 98 days. The factors most associated with mortality were: location in the gingiva (p=0.0590), in the trigone (p=0.0104), size (T3-T4) (p=0.0004) and lymph node involvement (N2a-N2b) (p=0.0035). Tobacco and alcohol...

‣ Oral cancer knowledge and awareness among dental students

Soares, Tânderson Rittieri Camêlo; Carvalho, Maria Eugênia de Almeida; Pinto, Lucielma Salmito Soares; Falcão, Carlos Alberto; Matos, Francisca Tereza Coelho; Santos, Tanit Clementino
Fonte: UNICAMP/FOP Publicador: UNICAMP/FOP
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ;
Publicado em 13/10/2015 Português
Relevância na Pesquisa
67.13774%
Aim: To assess the knowledge and attitude of undergraduate dental students about oral cancer. Methods: A cross-sectional, quantitative study was conducted based on a questionnaire containing 15 questions about prevention, clinical aspects, and attitudes towards oral cancer. One hundredthirty-three undergraduate dental students between the second and fifth years were enrolled. The statistical significance was measured by Pearson’s chi-square test. Results: There was a predominance of females (58.65%) and most students were between 20 and 30 years of age (75.19%). The risk factors for oral cancer mainly described by the students were smoking (92.48%) and drinking (84.21%). Squamous cell carcinoma was described as the most common type of oral cancer by 48.12% of the students. As much as 53.38% of the participants considered the tongue as the most affected anatomic region, 57.89% reported ulcers as the most frequent clinical aspect, and 44.36% attributed a firm and painless aspect to the regional metastatic lymph nodes. Most students reported regularly conducting a thorough examination of the oral cavity (81.95%). Two of the 15 variables showed differences between the students, according to the school time: previous head and neck carcinoma (Pearson’s chi-square...