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‣ Beyond "Cirrhosis" A Proposal From the International Liver Pathology Study Group

Hytiroglou, Prodromos; Snover, Dale C.; Alves, Venancio; Balabaud, Charles; Bhathal, Prithi S.; Bioulac-Sage, Paulette; Crawford, James M.; Dhillon, Amar P.; Ferrell, Linda; Guido, Maria; Nakanuma, Yasuni; Paradis, Valerie; Quaglia, Alberto; Theise, Neil
Fonte: AMER SOC CLINICAL PATHOLOGY; CHICAGO Publicador: AMER SOC CLINICAL PATHOLOGY; CHICAGO
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
46.25454%
Cirrhosis is a moiphologic term that has been used for almost 200 years to denote the end stage of a variety of chronic liver diseases. The term implies a condition with adverse prognosis due to the well-known complications of portal hypertension, hepatocellular carcinoma, and liver failure. However, recent advances in the diagnosis and treatment of chronic liver diseases have changed the natural history of cirrhosis significantly. This consensus document by the International Liver Pathology Study Group challenges the usefulness of the word cirrhosis in modern medicine and suggests that this is an appropriate time to consider discontinuing the use of this term. The role of pathologists should evolve to the diagnosis of advanced stage of chronic liver disease, with emphasis on etiology, grade of activity, features suggestive of progression or regression, presence of other diseases, and risk factors for malignancy, within the perspective of an integrated clinicopathologic assessment.

‣ Caracterização do perfil fonoaudiológico de famílias atendidas pelo Programa Saúde da Família - Universidade; Characterization of Speech-Language Pathology and Audiology profile of families take care of in a Program Family Health: University

Bassi, Ana Karolina Zampronio
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 22/05/2009 Português
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O Programa Saúde da Família (PSF) possibilita a aplicação de medidas de promoção da saúde, prevenção de doenças, práticas de diagnóstico e pronto atendimento, visando evitar seqüelas incapacitantes e procurando a maior recuperação funcional possível. Nos últimos anos, a Fonoaudiologia ampliou seu campo de inserção na área da saúde. É essencial que o fonoaudiólogo, e todos os profissionais envolvidos na assistência, administração ou planejamento junto ao Sistema Único de Saúde (SUS), conheçam seus preceitos, as características administrativas e sua repercussão em um contexto mais amplo, além das práticas cotidianas pertencentes a cada especialidade. A Fonoaudiologia, com sua atuação em promoção, prevenção e reabilitação de distúrbios da comunicação humana, vem observando a necessidade da inclusão desses profissionais no PSF uma vez que assume um papel significativo na manutenção da saúde e qualidade de vida. O objetivo deste trabalho foi promover atenção e assistência fonoaudiológica às famílias das crianças assistidas por uma entidade no interior do Estado de São Paulo. O presente estudo foi realizado com 51 famílias de crianças matriculadas totalizando 209 sujeitos. Este trabalho foi realizado por uma equipe multiprofissional...

‣ A contribuição da neurolinguistica discursiva para a fonoaudiologia na construção de um novo olhar sobre a linguagem de sujeitos cerebro-lesados; The contribution of discursive neurolinguistics to speech-language pathology in the construction of a news focus on the occurred language of brain-injured individuals

Lilian Fatima Zaniboni
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 17/12/2007 Português
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A linguagem de sujeitos cérebro-lesados é um tema comum à Neurolingüística Discursiva e à Fonoaudiologia tradicional-hegemônica. Contudo, a Fonoaudiologia tradicional-hegemônica a interpreta exclusivamente como sistema de signos lingüísticos homogêneos, enquanto que a Neurolingüística a vê também como processo de significação e de subjetivação. Dessa forma, o objetivo deste estudo foi compreender como se deu a formação do domínio do saber da Fonoaudiologia sobre a linguagem, bem como apresentar contribuições da Neurolingüística para a construção de um novo olhar sobre a linguagem de sujeitos com episódio neurológico. Para tanto, foi realizada uma investigação bibliográfica sobre o surgimento da Fonoaudiologia no Brasil, observando a co-ocorrência desse acontecimento com fatores históricos, políticos, econômicos e teórico-científicos. Foi feita, ainda, uma análise de enunciados de estudos realizados nestes últimos treze anos na Fonoaudiologia que abordam a linguagem em sujeitos cérebro-lesados. Por fim, foram apresentadas cenas enunciativas entre uma fonoaudióloga e alguns sujeitos com lesão neurológica e, a partir delas, foram analisados os processos da linguagem que, tradicionalmente, são interpretados como condições patológicas. Foi possível observar que a Fonoaudiologia surgiu a partir um modelo hegemônico da Medicina higienista e normativa...

‣ Expression of the Small Heat-Shock Protein αB-Crystallin in Tauopathies with Glial Pathology

Dabir, Deepa V.; Trojanowski, John Q.; Richter-Landsberg, Christiane; Lee, Virginia M.-Y.; Forman, Mark S.
Fonte: American Society for Investigative Pathology Publicador: American Society for Investigative Pathology
Tipo: Artigo de Revista Científica
Publicado em /01/2004 Português
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36.418176%
Intracellular accumulations of filamentous material composed of tau proteins are defining features of sporadic and familial neurodegenerative disorders termed “tauopathies.” In Alzheimer’s disease, the most common tauopathy, tau pathology is predominantly localized within neurons; however, robust glial pathology occurs in other tauopathies. Although the pathogenesis of tauopathies remains primarily unknown, molecular chaperones such as heat-shock proteins (HSPs) are implicated in these tau disorders as well as other neurodegenerative diseases characterized by the accumulation of insoluble protein aggregates such as α-synuclein in Parkinson’s disease and polyglutamine in Huntington’s disease. We analyzed a variety of tauopathies with antibodies to a panel of HSPs to determine their role in the pathogenesis of these disorders. Although HSPs are not found in neuronal tau inclusions, we demonstrate increased expression of the small HSP αB-crystallin in glial inclusions of both sporadic and familial tauopathies. αB-crystallin was observed in a subset of astrocytic and oligodendrocytic tau inclusions as well as the neuropil thread pathology in cellular processes, but the co-expression of αB-crystallin with tau inclusions was relatively specific to tauopathies with extensive glial pathology. Thus...

‣ Region-specific Dissociation of Neuronal Loss and Neurofibrillary Pathology in a Mouse Model of Tauopathy

Spires, Tara L.; Orne, Jennifer D.; SantaCruz, Karen; Pitstick, Rose; Carlson, George A.; Ashe, Karen H.; Hyman, Bradley T.
Fonte: American Society for Investigative Pathology Publicador: American Society for Investigative Pathology
Tipo: Artigo de Revista Científica
Publicado em /05/2006 Português
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Neurofibrillary tangles form in a specific spatial and temporal pattern in Alzheimer’s disease. Although tangle formation correlates with dementia and neuronal loss, it remains unknown whether neurofibrillary pathology causes cell death. Recently, a mouse model of tauopathy was developed that reversibly expresses human tau with the dementia-associated P301L mutation. This model (rTg4510) exhibits progressive behavioral deficits that are ameliorated with transgene suppression. Using quantitative analysis of PHF1 immunostaining and neuronal counts, we estimated neuron number and accumulation of neurofibrillary pathology in five brain regions. Accumulation of PHF1-positive tau in neurons appeared between 2.5 and 7 months of age in a region-specific manner and increased with age. Neuron loss was dramatic and region-specific in these mice, reaching over 80% loss in hippocampal area CA1 and dentate gyrus by 8.5 months. We observed regional dissociation of neuronal loss and accumulation of neurofibrillary pathology, because there was loss of neurons before neurofibrillary lesions appeared in the dentate gyrus and, conversely, neurofibrillary pathology appeared without major cell loss in the striatum. Finally, suppressing the transgene prevented further neuronal loss without removing or preventing additional accumulation of neurofibrillary pathology. Together...

‣ Relational Database Structure to Manage High-Density Tissue Microarray Data and Images for Pathology Studies Focusing on Clinical Outcome : The Prostate Specialized Program of Research Excellence Model

Manley, Sargum; Mucci, Neil R.; De Marzo, Angelo M.; Rubin, Mark A.
Fonte: American Society for Investigative Pathology Publicador: American Society for Investigative Pathology
Tipo: Artigo de Revista Científica
Publicado em /09/2001 Português
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With the completion of the Human Genome Project and high-throughput screening methods using cDNA array and tissue microarray (TMA) technology, there is a pressing need to manage the voluminous data sets generated from these types of investigations. Herein is described a database model to handle 1) clinical and pathology data, 2) TMA location information, and 3) web-based histology results. The model is useful for managing clinical, pathology, and molecular data on >1300 prostate cancer patients dating back to 1995 from the University of Michigan Specialized Program of Research Excellence for prostate cancer. The key components in this multidatabase model are 1) the TMA database, 2) the TMA-image database (TMA-I DB), and 3) the prostate pathology and clinical information databases. All databases were created in Microsoft Access (Microsoft, Redmond, WA). Desired patient, tissue, block, diagnosis, array location, and respective clinical and pathology information is obtained by linking the unique identifier fields among database tables. The TMA database is comprised of interrelated data from 336 prostate cancer patients transferred into 19 TMA blocks with 5451 TMA biopsy cores. Tissue samples include 1695 normal prostate, 3171 prostate cancer...

‣ Tau and α-Synuclein Pathology in Amygdala of Parkinsonism-Dementia Complex Patients of Guam

Forman, Mark S.; Schmidt, M. Luise; Kasturi, Sanjay; Perl, Daniel P.; Lee, Virginia M.-Y.; Trojanowski, John Q.
Fonte: American Society for Investigative Pathology Publicador: American Society for Investigative Pathology
Tipo: Artigo de Revista Científica
Publicado em /05/2002 Português
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Amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a progressive neurodegenerative disorder of Chamorro residents of Guam and the Mariana Islands, characterized by abundant neuron loss and tau neurofibrillary pathology similar to that observed in Alzheimer’s disease (AD). A variety of neurodegenerative diseases with tau pathology including ALS/PDC also have α-synuclein positive pathology, primarily in the amygdala. We further characterized the tau and α-synuclein pathology in the amygdala of a large series of 30 Chamorros using immunohistochemical and biochemical techniques. Tau pathology was readily detected in both affected and unaffected Chamorros. In contrast, α-synuclein pathology was detected in 37% of patients with PDC but not detected in Chamorros without PDC or AD. The α-synuclein aggregates often co-localized within neurons harboring neurofibrillary tangles suggesting a possible interaction between the two proteins. Tau and α-synuclein pathology within the amygdala is biochemically similar to that observed in AD and synucleinopathies, respectively. Thus, the amygdala may be selectively vulnerable to developing both tau and α-synuclein pathology or tau pathology may predispose it to synuclein aggregation. Furthermore...

‣ Goals and Objectives for Molecular Pathology Education in Residency Programs

Fonte: American Society for Investigative Pathology Publicador: American Society for Investigative Pathology
Tipo: Artigo de Revista Científica
Publicado em /11/1999 Português
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Increasing knowledge of the molecular basis of disease and advances in technology for analyzing nucleic acids and gene products are changing pathology practice. The explosion of information regarding inherited susceptibility to disease is an important aspect of this transformation. Pathology residency programs are incorporating molecular pathology education into their curricula to prepare newly trained pathologists for the future, yet little guidance has been available regarding the important components of molecular pathology training. We present general goals for pathology training programs for molecular pathology education. These include recommendations to pathology residents for the acquisition of both basic knowledge in human genetics and molecular biology and specific skills relevant to microbiology, molecular oncology, genetics, histocompatibility, and identity determination. The importance of residents gaining facility in integrating data gained via nucleic acid based-technology with other laboratory and clinical information available in the care of patients is emphasized.

‣ Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract and by Amyloid-β Deposition in APP × Tau Transgenic Mice

Bolmont, Tristan; Clavaguera, Florence; Meyer-Luehmann, Melanie; Herzig, Martin C.; Radde, Rebecca; Staufenbiel, Matthias; Lewis, Jada; Hutton, Mike; Tolnay, Markus; Jucker, Mathias
Fonte: American Society for Investigative Pathology Publicador: American Society for Investigative Pathology
Tipo: Artigo de Revista Científica
Publicado em /12/2007 Português
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Alzheimer’s disease presents morphologically with senile plaques, primarily made of extracellular amyloid-β (Aβ) deposits, and neurofibrillary lesions, which consist of intracellular aggregates of hyperphosphorylated tau protein. To study the in vivo induction of tau pathology, dilute brain extracts from aged Aβ-depositing APP23 transgenic mice were intracerebrally infused in young B6/P301L tau transgenic mice. Six months after the infusion, tau pathology was induced in the injected hippocampus but also in brain regions well beyond the injection sites such as the entorhinal cortex and amygdala, areas with neuronal projection to the injection site. No or only modest tau induction was observed when brain extracts from aged nontransgenic control mice and aged tau-depositing B6/P301L transgenic mice were infused. To further study Aβ-induced tau lesions B6/P301L tau transgenic mice were crossed with APP23 mice. Although Aβ deposition in double-transgenic mice did not differ from single APP23 transgenic mice, double-transgenic mice revealed increased tau pathology compared to single B6/P301L tau transgenic mice predominately in areas with high Aβ plaque load. The present results suggest that both extract-derived Aβ species and deposited fibrillary Aβ can induce the formation of tau neurofibrillary pathology. The observation that infused Aβ can trigger the tau pathology in the absence of Aβ deposits provides an explanation for the discrepancy between the neuroanatomical location of Aβ deposits and the development and spreading of tau lesions in Alzheimer’s disease brain.

‣ Bulls and bears: the stock market and clinical pathology research

Khong, T.
Fonte: British Med Journal Publ Group Publicador: British Med Journal Publ Group
Tipo: Artigo de Revista Científica
Publicado em //2009 Português
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Aims: To analyse the level of funded research in clinical pathology in a recent bear and bull market to act as a predictor for future funding during the current global financial crisis. Methods: The level of funding for research published in three clinical pathology journals in 2005 and 2008 to coincide with the bear market of March 2000 to October 2002 and with the subsequent bull market to October 2007 was determined using a Medline query. Other parameters examined were the type of article, affiliation of the first author and the pathology subspecialty. Results: Approximately 30% of publications were funded and did not differ between the 2 years studied. Original research papers were more likely to be funded than case reports or reviews. Research from university departments of pathology was more likely to be funded than from hospital pathology departments but there were more publications from hospital pathology departments. The proportion of research in the different subspecialties that was funded did not differ significantly between each other and between 2005 and 2008. Conclusions: Based on data from the previous bear market, which was the longest and deepest of the post 1950 era, and the subsequent bull market, which led to the all-time high in the Dow Jones Industrial Index...

‣ Assessing pathology training needs: results from a survey of general practice registrars

Bubner, T.; Laurence, C.; Tirimacco, R.
Fonte: Royal Australian College of General Practitioners Publicador: Royal Australian College of General Practitioners
Tipo: Artigo de Revista Científica
Publicado em //2012 Português
Relevância na Pesquisa
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BACKGROUND: The number of pathology tests ordered by general practitioners is rising. Some of this increase may reflect overtesting, overutilisation or training deficiency. The aim of this study was to identify the pathology training needs of general practice registrars in regards to test ordering and interpretation of common conditions found in general practice. METHODS: A pathology training needs assessment survey was distributed to 82 South Australian general practice registrars. RESULTS: The survey response rate was 55%. Pathology training diminishes as participants move through their medical training. General practice registrars had most difficulty with test ordering and interpretation in the areas of fatigue, menopausal complaints, arthritis and menstrual problems. DISCUSSION: These findings will assist those who supervise and support general practice registrars in their training. Targeted pathology training in areas identified as difficult may assist in reducing healthcare expenditure and improve the management of patients’ clinical conditions.; Tanya Bubmer, Caroline Laurence and Rosy Tirimacco

‣ Stem cell therapy for treatment of central nervous system pathology in α-mannosidosis guinea pigs.

Robinson, Aaron James
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2004 Português
Relevância na Pesquisa
36.470486%
Lysosomal storage disorders (LSD) are a group of heritable genetic diseases resulting from a deficiency of one or more lysosomal enzpe activities, with broad pathological consequences. One of the most difficult aspects of these diseases to treat is central nervous system (CNS) pathology. Numerous strategies are being pursued in order to develop effective therapies for CNS pathology in LSD. One of these strategies involves the implantation of stem cells for the in vivo secretion of deficient enzyme in the brain, to be taken up by host cells, to therapeutic effect. α-Mannosidosis is a LSD resulting from a functional deficiency of lysosomal α-mannosidase. This deficiency results in the accumulation of various oligosaccharides in the lysosomes of affected individuals, to cause progressive neurological degeneration and other somatic pathology. We have a guinea pig model of this disease that closely models human α-mannosidosis. Although enzyme replacement therapy has shown great promise for treatment of somatic pathology in α-mannosidosis guinea pigs, it is not effective for treatment of brain pathology. Thus, this disease model was chosen as an appropriate disorder for the evaluation of intra-cranial stem cell implantation as a therapeutic approach. α-Mannosidosis guinea pigs display significant neurological abnormalities as part of the course of their disease. We postulated that the development of tests to quantitate the loss of neurological function underlying these characteristics would be useful for evaluation of therapies in this model. The first aim of this study was thus to establish such tests. The Morris water maze has been used to evaluate therapies for neurological disease in mouse models of LSD...

‣ History of induced abortion and the risk of tubal pathology

Verhoeve, H.; Steures, P.; Flierman, P.; van der Veen, F.; Mol, B.
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
Publicado em //2008 Português
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Tubal pathology is a common cause of subfertility. Identifying risk factors for tubal pathology in the medical history is important to distinguish between those couples who benefit from early tubal patency tests and those in whom presence of tubal pathology is less likely and delaying tubal tests is justified. This study evaluated whether a medical history of induced abortion is associated with an increased risk of tubal disease among subfertile couples. The reproductive history was determined for each couple. Tubal disease was diagnosed by hysterosalpingography and/or diagnostic laparoscopy. The association between reproductive history and the presence of tubal disease was assessed by calculating odds ratios (OR) and 95% confidence intervals (CI). Data from 6149 couples were available for analysis. The OR for tubal pathology after a previous induced abortion was 1.6 (95% CI 1.3 to 1.9), after a previous ectopic pregnancy, 8.4 (95% CI 6.3 to 12), after a previous spontaneous miscarriage, 1.1 (95% CI 0.87 to 1.3), and after a previous live birth, 1.0 (95% CI 0.88 to 1.2). A history of induced abortion is associated with an increased risk of tubal pathology in subfertile couples. As a consequence, in subfertile women with a history of induced abortion...

‣ The value of medical history taking as risk indicator for tuboperitoneal pathology: a systematic review

Luttjeboer, F.; Verhoeve, H.; van Dessel, H.; van der Veen, F.; Mol, B.; Coppus, S.
Fonte: Blackwell Publishing Publicador: Blackwell Publishing
Tipo: Artigo de Revista Científica
Publicado em //2009 Português
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Background: Guidelines recommend diagnostic laparoscopy in subfertile women with known co-morbidities in their medical history. Aggregated evidence underpinning these recommendations is, however, currently lacking. Objective: The objective of this study was to perform a systematic review and meta-analysis of the available evidence on the association between items reported during medical history taking and tuboperitoneal pathology. Search strategy: MEDLINE (from 1966 to May 2007), EMBASE (from 1960 to January 2007) and bibliographies of retrieved primary articles. Selection criteria: All relevant studies that compared medical history with the presence or absence of tubal pathology. Data collection and analysis Studies: comparing medical history with the presence or absence of tubal pathology were included. A diagnosis of tubal pathology had to be made by hysterosalpingography, laparoscopy or a combination of both. In the absence of invasive tubal testing, tuboperitoneal pathology was considered to be absent in case of intrauterine pregnancy. Homogeneity between studies was assessed, and the association between medical history and tubal pathology was expressed as a common odds ratio with a 95% CI. No language restriction was applied. Main results: We included 32 studies. In cohort studies...

‣ Are patient characteristics associated with the accuracy of hysterosalpingography in diagnosing tubal pathology? An individual patient data meta-analysis

Broeze, K.; Opmeer, B.; Van Geloven, N.; Coppus, S.; Collins, J.; Den Hartog, J.; van der Linden, P.; Marianowski, P.; Ng, E.; van der Steeg, J.; Steures, P.; Strandell, A.; van der Veen, F.; Mol, B.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Publicado em //2011 Português
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BACKGROUND: Conventional meta-analysis has estimated the sensitivity and specificity of hysterosalpingography (HSG) to be 65% and 83%. The impact of patient characteristics on the accuracy of HSG is unknown. The aim of this study was to assess by individual patient data meta-analysis whether the accuracy of HSG is associated with different patient characteristics. METHODS: We approached authors of primary studies reporting on the accuracy of HSG using findings at laparoscopy as the reference. We assessed whether patient characteristics such as female age, duration of subfertility and a clinical history without risk factors for tubal pathology were associated with the accuracy of HSG, using a random intercept logistic regression model. RESULTS: We acquired data of seven primary studies containing data of 4521 women. Pooled sensitivity and specificity of HSG were 53% and 87% for any tubal pathology and 46% and 95% for bilateral tubal pathology. In women without risk factors, the sensitivity of HSG was 38% for any tubal pathology, compared with 61% in women with risk factors (P = 0.005). For bilateral tubal pathology, these rates were 13% versus 47% (P = 0.01). For bilateral tubal pathology, the sensitivity of HSG decreased with age [factor 0.93 per year (P = 0.05)]. The specificity of HSG was very stable across all subgroups. CONCLUSIONS: The accuracy of HSG in detecting tubal pathology was similar in all subgroups...

‣ Evidence that meningeal mast cells can worsen stroke pathology in mice

Arac, A.; Grimbaldeston, M.A.; Nepomuceno, A.R.B.; Olayiwola, O.; Pereira, M.P.; Nishiyama, Y.; Tsykin, A.; Goodall, G.J.; Schlecht, U.; Vogel, H.; Tsai, M.; Galli, S.J.; Bliss, T.M.; Steinberg, G.K.
Fonte: American Society for Investigative Pathology Publicador: American Society for Investigative Pathology
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
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Stroke is the leading cause of adult disability and the fourth most common cause of death in the United States. Inflammation is thought to play an important role in stroke pathology, but the factors that promote inflammation in this setting remain to be fully defined. An understudied but important factor is the role of meningeal-located immune cells in modulating brain pathology. Although different immune cells traffic through meningeal vessels en route to the brain, mature mast cells do not circulate but are resident in the meninges. With the use of genetic and cell transfer approaches in mice, we identified evidence that meningeal mast cells can importantly contribute to the key features of stroke pathology, including infiltration of granulocytes and activated macrophages, brain swelling, and infarct size. We also obtained evidence that two mast cell-derived products, interleukin-6 and, to a lesser extent, chemokine (C-C motif) ligand 7, can contribute to stroke pathology. These findings indicate a novel role for mast cells in the meninges, the membranes that envelop the brain, as potential gatekeepers for modulating brain inflammation and pathology after stroke.; Ahmet Arac, Michele A. Grimbaldeston, Andrew R.B. Nepomuceno, Oluwatobi Olayiwola...

‣ Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations

Gama Sosa, Miguel A.; Gasperi, Rita De; Rocher, Anne B.; Wang, Athena Ching-Jung; Janssen, William G.M.; Flores, Tony; Perez, Gissel M.; Schmeidler, James; Dickstein, Dara L.; Hof, Patrick R.; Elder, Gregory A.
Fonte: American Society for Investigative Pathology Publicador: American Society for Investigative Pathology
Tipo: Artigo de Revista Científica
Publicado em /01/2010 Português
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Mutations in the presenilin 1 (PS1) gene are the most commonly recognized cause of familial Alzheimer's disease (FAD). Besides senile plaques, neurofibrillary tangles, and neuronal loss, Alzheimer's disease (AD) is also accompanied by vascular pathology. Here we describe an age-related vascular pathology in two lines of PS1 FAD-mutant transgenic mice that mimics many features of the vascular pathology seen in AD. The pathology was especially prominent in the microvasculature whose vessels became thinned and irregular with the appearance of many abnormally looped vessels as well as string vessels. Stereologic assessments revealed a reduction of the microvasculature in the hippocampus that was accompanied by hippocampal atrophy. The vascular changes were not congophilic. Yet, despite the lack of congophilia, penetrating vessels at the cortical surface were often abnormal morphologically and microhemorrhages sometimes occurred. Altered immunostaining of blood vessels with basement membrane-associated antigens was an early feature of the microangiopathy and was associated with thickening of the vascular basal laminae and endothelial cell alterations that were visible ultrastructurally. Interestingly, although the FAD-mutant transgene was expressed in neurons in both lines of mice...

‣ Continuum model of tendon pathology: Where are we now?

McCreesh, Karen; Lewis, Jeremy
Fonte: Wiley Publicador: Wiley
Tipo: info:eu-repo/semantics/article; all_ul_research; ul_published_reviewed
Português
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peer-reviewed; Chronic tendon pathology is a common, and often disabling condition, the causes of which remain poorly understood. The continuum model of tendon pathology was proposed in order to provide a model for the staging of tendon pathology, and to assist clinicians in managing this often complex condition (Cook and Purdam 2009). The model presents clinical, histological and imaging evidence for the progression of tendon pathology as a three-stage continuum: reactive tendinopathy, tendon disrepair, and degenerative tendinopathy. It also provides clinical information to assist in identifying the stage of pathology, in addition to proposed treatment approaches for each stage. The usefulness of such a model is determined by its ability to incorporate and inform new and emerging research. This review examines the degree to which recent research supports or refutes the continuum model, and proposes future directions for clinical and research application of the model.; ACCEPTED; peer-reviewed

‣ Alzheimer's Disease Amyloid-\(\beta\) Links Lens and Brain Pathology in Down Syndrome

Moncaster, Juliet A.; Lu, Suqian; Burton, Mark A.; Ghosh, Joy G.; Soscia, Stephanie J.; Mocofanescu, Anca; Kuszak, Jer R.; Pineda, Roberto; Moir, Robert D.; Ericsson, Maria; Folkerth, Rebecca Dunn; Robb, Richard Moore; Clark, John I.; Tanzi, Rudolph Emile
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Português
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36.456162%
Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication of chromosome 21 invariably includes the APP gene (21q21) encoding the Alzheimer's disease (AD) amyloid precursor protein (APP). Triplication of the APP gene accelerates APP expression leading to cerebral accumulation of APP-derived amyloid-\(\beta\) peptides (A\(\beta\)), early-onset AD neuropathology, and age-dependent cognitive sequelae. The DS phenotype complex also includes distinctive early-onset cerulean cataracts of unknown etiology. Previously, we reported increased A\(\beta\) accumulation, co-localizing amyloid pathology, and disease-linked supranuclear cataracts in the ocular lenses of subjects with AD. Here, we investigate the hypothesis that related AD-linked A\(\beta\) pathology underlies the distinctive lens phenotype associated with DS. Ophthalmological examinations of DS subjects were correlated with phenotypic, histochemical, and biochemical analyses of lenses obtained from DS, AD, and normal control subjects. Evaluation of DS lenses revealed a characteristic pattern of supranuclear opacification accompanied by accelerated supranuclear A\(\beta\) accumulation...

‣ Avaluation of decs indexing language in speech-language pathology and audiology area, in the user´s view: an observation study of the information retrieval with a verbal protocol; Avaliação da linguagem documentária decs na área de fonoaudiologia na perspectiva do usuário: estudo de observação da recuperação da informação com protocolo verbal 10.5007/1518-2924.2006v11n21p16

Boccato, Vera Regina Casari; UFSCAR - São Carlos - SP; Fujita, Mariângela Spotti Lopes; Universidade Estadual Paulista - UNESP - Marília
Fonte: Departamento de Ciência da Informação – UFSC Publicador: Departamento de Ciência da Informação – UFSC
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 08/11/2007 Português
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The proposition of this study is to assess, by observing the user, the DeCS – Health Sciences. Descriptors indexing language, in the Speech-Language Pathology and Audiology area, utilized for the retrieval of information in the LILACS System - Latin American and Caribbean Health Sciences -, produced by BIREME – Latin-American and Caribbean Health Sciences Information Center, utilizing the verbal protocol technique, for the fact of the researchers of the area of Speech-Language Pathology and Audiology to need an information system that uses a indexing language that represents the values and the culture of this system where it is inserted. With this proposal, it is had for objective to contribute for the improvement of the indexing language DeCS, being aimed at better terminological representation in the area of the Brazilian Speech-Language Patholoy and Audiology as a determinative factor for the development of scientific research of quality. The used methodological approach was the qualitative-cognitive one, has been the technique verbal protocol applied in the researchers (subjects) of the Speech-Language Pathology and Audiology Department at the Dental School – University of São Paulo – FOB-USP, at Bauru, SP, representing the four forming specialties in the area...