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‣ Study of genetic diversity of dog cão de gado transmontano breed by pedigree analysis

Rosa, José Luís Nunes; Malovrh, Špela; Kovac, Milena; Cadavez, Vasco
Fonte: Instituto Politécnico de Bragança Publicador: Instituto Politécnico de Bragança
Tipo: Conferência ou Objeto de Conferência
Português
Relevância na Pesquisa
368.48438%
The objective of this work was to study the genetic diversity of the Portuguese local dog breed Cao de Gado Transmontano by pedigree analysis. Pedigree data of dog breed Cao de Gado Transmontano was taken from the database of the Associação Criadores de Cao de Gado Transmontano concerning the period from 2003 to 2009. The pedigree file completeness was evaluated. The number and the proportion of animals with both parents known, sire known, and dam known were computed using the SQL procedure. Population genetic diversity parameters were computed using the PEDIG software package. The number of founders was 131 animals; however the effective number of founders was only 58 animals. A low proportion (4.6%) of animals in the population is inbred, and the inbred animals presented low (> 25%) inbreeding coefficient. However, the pedigree completeness is very small, which puts difficulties in the inbreeding calculation. These results suggest that efforts must be made to improve the pedigree quality in order to monitoring the genetic diversity of Cão de Gado Transmontano.

‣ Pedigree analysis and inbreeding depression on growth traits in Brazilian Marchigiana and Bonsmara breeds

Santana Júnior, Mário Luiz; Oliveira, Priscila Silva; Eler, Joanir Pereira; Gutierrez, J. P.; Ferraz, Jose Bento Sterman
Fonte: AMER SOC ANIMAL SCIENCE; CHAMPAIGN Publicador: AMER SOC ANIMAL SCIENCE; CHAMPAIGN
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
268.48438%
The study of population structure by pedigree analysis is useful to identify important circumstances that affect the genetic history of populations. The intensive use of a small number of superior individuals may reduce the genetic diversity of populations. This situation is very common for the beef cattle breeds. Therefore, the objectives of the present study were to analyze the pedigree and possible inbreeding depression on traits of economic interest in the Marchigiana and Bonsmara breeds and to test the inclusion of the individual inbreeding coefficient (F-i) or individual increases in inbreeding coefficient (Delta F-i) in the genetic evaluation model for the quantification of inbreeding depression. The complete pedigree file of the Marchigiana breed included 29,411 animals born between 1950 and 2003. For the Bonsmara breed, the pedigree file included 18,695 animals born between 1988 and 2006. Only animals with at least 2 equivalent generations of known pedigree were kept in the analyses of inbreeding effect on birth weight, weaning weight measured at about 205 d, and BW at 14 mo in the Marchigiana breed, and on birth weight, weaning weight, and scro-tal circumference measured at 12 mo in the Bonsmara breed. The degree of pedigree knowledge was greater for Marchigiana than for Bonsmara animals. The average generation interval was 7.02 and 3.19 for the Marchigiana and Bonsmara breed...

‣ Population structure and genetic variability in the Murrah dairy breed of water buffalo in Brazil accessed via pedigree analysis

Mendes Malhado, Carlos Henrique; Mendes Malhado, Ana Claudia; Souza Carneiro, Paulo Luiz; Ramos, Alcides de Amorim; Ambrosini, Diego Pagung; Pala, Akin
Fonte: Springer Publicador: Springer
Tipo: Artigo de Revista Científica Formato: 1891-1897
Português
Relevância na Pesquisa
369.76047%
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); The objective of this study was to use pedigree analysis to evaluate the population structure and genetic variability in the Murrah dairy breed of water buffalo (Bubalus bubalis) in Brazil. Pedigree analysis was performed on 5,061 animals born between 1972 and 2002. The effective number of founders (fe) was 60, representing 6.32 % of the potential number of founders. The effective number of ancestors (fa) was 36 and the genetic contribution of the 17 most influent ancestors explained 50 % of the genetic variability in the population. The ratio fe/fa (effective number of founders/effective number of ancestors), which expresses the effect of population bottlenecks, was 1.66. Completeness level for the whole pedigree was 76.8, 49.2, 27.7, and 12.8 % for, respectively, the first, second, third, and fourth known parental generations. The average inbreeding values for the whole analyzed pedigree and for inbreed animals were, respectively, 1.28 and 7.64 %. The average relatedness coefficient between individuals of the population was estimated to be 2.05 %-the highest individual coefficient was 10.31 %. The actual inbreeding and average relatedness coefficient are probably higher than estimated due to low levels of pedigree completeness. Moreover...

‣ Análise de pedigree e estimativas de parâmetros genéticos para características reprodutivas em bovinos da raça Brahman

Cavani, Ligia
Fonte: Universidade Estadual Paulista (UNESP) Publicador: Universidade Estadual Paulista (UNESP)
Tipo: Dissertação de Mestrado Formato: 83 f. :
Português
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272.3336%
Pós-graduação em Ciência e Tecnologia Animal - FEIS; The genetic diversity in Brahman cattle in Brazil may decrease over the years and can be even lower for stabled animals, moreover, it is expected that the phenotypic variance of reproductive characteristics can be little explained by genetic variance. The aims of this study were to evaluate the behavior of genetic diversity over a period of 18 years and stabled animals by pedigree analysis and estimates genetic parameters for ge at first interval (IPP), calving interval (IEP), reconception (REC) and stayability (HABP) reproductive traits of Brahman cattle in Brazil, aiming to develop selection strategies for genetic progress of breed. The pedigree was analyzed in three ways: considering all the pedigree information (Pt); dividing the pedigree information in two periods from 1994 to 2004 (P1) and from 2005 to 2012 (P2), according inbreeding; and dividing the pedigree data according to breeding management of animals on pasture (Ppasto) and stabled (Pest). Coefficient inbreeding (F) values were 0,31%, 0,07%, 0,50%, 0,30% and 0,22% for Pt, P1, P2, Ppasto, Pest, respectively. Generation intervals (IG) values for Pt, P1, P2, Ppasto, Pest were 4,73, 3,35, 4,50, 4,65, 4,81 years, respectively. For the results of the parameters based on the probability of gene origin: number of founders (Nf)...

‣ Genetic diversity in the Lusitano horse breed assessed by pedigree analysis

Vicente, António; Carolino, N.; Gama, L. T.
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
Publicado em /09/2012 Português
Relevância na Pesquisa
361.71117%
Genetic diversity and population structure were analyzed in the Lusitano horse breed based on pedigree information of animals registered in the Studbook, to identify factors which may have affected the genetic variability of the breed, and provide the bases for the establishment of sustainable utilization programs. Pedigree records collected from 1824 to 2009, including information on 53,411 animals, were used in the analyses. The mean generation interval was 11.33±5.23 and 9.71±4.48 years for sires and dams, respectively, while the mean number of offspring registered was 13.13±22.53 for stallions and 4.00±3.38 for mares. All great-grandparents were known for the animals in the reference population (registered foals born from 2005 to 2009, n=9712), which had a mean number of equivalent generations known of 11.20±0.71 and an average inbreeding of 11.34±7.48%. For this population, the rate of inbreeding per year was 0.173±0.070, and the effective population size computed from this rate was about 28. The mean relationship among animals from the same and from different studs was 0.31±0.16 and 0.15±0.10, respectively. In spite of the high within-stud relationship, inbreeding has been kept lower than expected due to restrictions imposed by breeders on selection and allocation of mates. The effective number of founders...

‣ The Pedigree Rate of Sequence Divergence in the Human Mitochondrial Genome: There Is a Difference Between Phylogenetic and Pedigree Rates

Howell, Neil; Smejkal, Christy Bogolin; Mackey, D. A.; Chinnery, P. F.; Turnbull, D. M.; Herrnstadt, Corinna
Fonte: The American Society of Human Genetics Publicador: The American Society of Human Genetics
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
269.76047%
We have extended our previous analysis of the pedigree rate of control-region divergence in the human mitochondrial genome. One new germline mutation in the mitochondrial DNA (mtDNA) control region was detected among 185 transmission events (generations) from five Leber hereditary optic neuropathy (LHON) pedigrees. Pooling the LHON pedigree analyses yields a control-region divergence rate of 1.0 mutation/bp/106 years (Myr). When the results from eight published studies that used a similar approach were pooled with the LHON pedigree studies, totaling >2,600 transmission events, a pedigree divergence rate of 0.95 mutations/bp/Myr for the control region was obtained with a 99.5% confidence interval of 0.53–1.57. Taken together, the cumulative results support the original conclusion that the pedigree divergence rate for the control region is ∼10-fold higher than that obtained with phylogenetic analyses. There is no evidence that any one factor explains this discrepancy, and the possible roles of mutational hotspots (rate heterogeneity), selection, and random genetic drift and the limitations of phylogenetic approaches to deal with high levels of homoplasy are discussed. In addition, we have extended our pedigree analysis of divergence in the mtDNA coding region. Finally...

‣ The Role of Pedigree Information in Combined Linkage Disequilibrium and Linkage Mapping of Quantitative Trait Loci in a General Complex Pedigree

Lee, S. H.; Van der Werf, J. H. J.
Fonte: Genetics Society of America Publicador: Genetics Society of America
Tipo: Artigo de Revista Científica
Publicado em /01/2005 Português
Relevância na Pesquisa
272.3336%
Combined linkage disequilibrium and linkage (LDL) mapping can exploit historical as well as recent and observed recombinations in a recorded pedigree. We investigated the role of pedigree information in LDL mapping and the performance of LDL mapping in general complex pedigrees. We compared using complete and incomplete genotypic data, spanning 5 or 10 generations of known pedigree, and we used bi- or multiallelic markers that were positioned at 1- or 5-cM intervals. Analyses carried out with or without pedigree information were compared. Results were compared with linkage mapping in some of the data sets. Linkage mapping or LDL mapping with sparse marker spacing (∼5 cM) gave a poorer mapping resolution without considering pedigree information compared to that with considering pedigree information. The difference was bigger in a pedigree of more generations. However, LDL mapping with closely linked markers (∼1 cM) gave a much higher mapping resolution regardless of using pedigree information. This study shows that when marker spacing is dense and there is considerable linkage disequilibrium generated from historical recombinations between flanking markers and QTL, the loss of power due to ignoring pedigree information is negligible and mapping resolution is very high.

‣ Inherent intractability of the ascertainment problem for pedigree data: a general likelihood framework.

Vieland, V J; Hodge, S E
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/1995 Português
Relevância na Pesquisa
270.78637%
The problem of ascertainment in segregation analysis arises when families are selected for study through ascertainment of affected individuals. In this case, ascertainment must be corrected for in data analysis. However, methods for ascertainment correction are not available for many common sampling schemes, e.g., sequential sampling of extended pedigrees (except in the case of "single" selection). Concerns about whether ascertainment correction is even required for large pedigrees, about whether and how multiple probands in the same pedigree can be taken into account properly, and about how to apply sequential sampling strategies have occupied many investigators in recent years. We address these concerns by reconsidering a central issue, namely, how to handle pedigree structure (including size). We introduce a new distinction, between sampling in such a way that observed pedigree structure does not depend on which pedigree members are probands (proband-independent [PI] sampling) and sampling in such a way that observed pedigree structure does depend on who are the probands (proband-dependent [PD] sampling). This distinction corresponds roughly (but not exactly) to the distinction between fixed-structure and sequential sampling. We show that conditioning on observed pedigree structure in ascertained data sets obtained under PD sampling is not in general correct (with the exception of "single" selection)...

‣ Generation of pedigree diagrams for web display using scalable vector graphics from a clinical trials database.

Fernando, S. K.; Brandt, C.; Nadkarni, P.
Fonte: American Medical Informatics Association Publicador: American Medical Informatics Association
Tipo: Artigo de Revista Científica
Publicado em //2001 Português
Relevância na Pesquisa
268.48438%
The standard method of studying inherited disease is to observe its pattern of distribution in families, that is, its pattern in a pedigree. For clinical studies focused on inherited disease, a pedigree diagram is a valuable visual tool for the display of inheritance patterns. We describe the creation of a web-based pedigree display module for Trial/DB, a Web accessible database developed at the Yale Center for Medical Informatics (YCMI) to support clinical research studies. The pedigree diagram is generated dynamically from the database. The icons representing each subject in the pedigree are selectable hyperlinks that will display detailed clinical data collected on the subject. Microsoft Active Server Page and Scalable Vector Graphics (SVG) are used to create the interactive pedigree diagrams.

‣ Pedigree and marker information requirements to monitor genetic variability

Roswitha, Baumung; Johann, Sölkner
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 15/07/2003 Português
Relevância na Pesquisa
268.48438%
There are several measures available to describe the genetic variability of populations. The average inbreeding coefficient of a population based on pedigree information is a frequently chosen option. Due to the developments in molecular genetics it is also possible to calculate inbreeding coefficients based on genetic marker information. A simulation study was carried out involving ten sires and 50 dams. The animals were mated over a period of 20 discrete generations. The population size was kept constant. Different situations with regard to the level of polymorphism and initial allele frequencies and mating scheme (random mating, avoidance of full sib mating, avoidance of full sib and half sib mating) were considered. Pedigree inbreeding coefficients of the last generation using full pedigree or 10, 5 and 2 generations of the pedigree were calculated. Marker inbreeding coefficients based on different sets of microsatellite loci were also investigated. Under random mating, pedigree-inbreeding coefficients are clearly more closely related to true autozygosity (i.e., the actual proportion of loci with alleles identical by descent) than marker-inbreeding coefficients. If mating is not random, the demands on the quality and quantity of pedigree records increase. Greater attention must be paid to the correct parentage of the animals.

‣ Evaluating Power and Type 1 Error in Large Pedigree Analyses of Binary Traits

Cummings, Anna C.; Torstenson, Eric; Davis, Mary F.; D’Aoust, Laura N.; Scott, William K.; Pericak-Vance, Margaret A.; Bush, William S.; Haines, Jonathan L.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 03/05/2013 Português
Relevância na Pesquisa
270.78637%
Studying population isolates with large, complex pedigrees has many advantages for discovering genetic susceptibility loci; however, statistical analyses can be computationally challenging. Allelic association tests need to be corrected for relatedness among study participants, and linkage analyses require subdividing and simplifying the pedigree structures. We have extended GenomeSIMLA to simulate SNP data in complex pedigree structures based on an Amish pedigree to generate the same structure and distribution of sampled individuals. We evaluated type 1 error rates when no disease SNP was simulated and power when disease SNPs with recessive, additive, and dominant modes of inheritance and odds ratios of 1.1, 1.5, 2.0, and 5.0 were simulated. We generated subpedigrees with a maximum bit-size of 24 using PedCut and performed two-point and multipoint linkage using Merlin. We also ran MQLS on the subpedigrees and unified pedigree. We saw no inflation of type 1 error when running MQLS on either the whole pedigrees or the sub-pedigrees, and we saw low type 1 error for two-point and multipoint linkage. Power was reduced when running MQLS on the subpedigrees versus the whole pedigree, and power was low for two-point and multipoint linkage analyses of the subpedigrees. These data suggest that MQLS has appropriate type 1 error rates in our Amish pedigree structure...

‣ A comparative approach to the implementation of drug pedigree discovery systems

Yu, Indy (Indy Yin)
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 70 p.
Português
Relevância na Pesquisa
270.78637%
As the use of RFID technology penetrates and reforms the supply-chain industry, standards are being produced at all levels of the RFID technology spectrum, ranging from hardware to software. The Electronic Product Code (EPC) standard uniquely identifies RFID-tagged products. An application that supports the usage of EPCs is an Electronic Drug Pedigree (E-Pedigree), which is a historical record that indicates the chain of custody of a particular drug product being passed from one supply-chain partner to another. In order to fully implement track-and-trace of pharmaceutical products, software systems need to be built so that pedigree documents can be effectively stored and searched. In this Thesis, two approaches that address the issue of pedigree document discovery are presented-one centralized, one decentralized. The centralized pedigree discovery service extracts metadata from pedigree documents submitted to a centralized server and uses them in a search engine, such as Google Base, to located desired documents that match client queries. The decentralized service allows pedigree documents to be stored locally by individual business owners. Each local server is attached to a Discovery Service Unit containing metadata of local pedigree documents...

‣ Pedigree selection for Gibberella ear rot resistance in maize

Presello, D.; Reid, L.; Butler, G.; Mather, D.
Fonte: Kluwer Academic Publ Publicador: Kluwer Academic Publ
Tipo: Artigo de Revista Científica
Publicado em //2005 Português
Relevância na Pesquisa
361.71117%
The pedigree method is often used for developing inbred lines in maize (Zea mays L.). This study was conducted to assess the effectiveness of pedigree selection for improving resistance to Gibberella ear rot in four maize populations. Selection was based on the severity of ear rot symptoms after inoculation with macroconidial suspensions of Fusarium graminearum (Schwabe) into the silk channel (for two populations) and into the developing kernels (for two other populations). Samples of the selfed families (S₁ to S₅), recovered from remnant seed from the selection programs, were evaluated for disease resistance during three years, using inoculation and evaluation protocols similar to those used during selection. Among-family selection was effective in both of the populations selected after silk inoculation and in one of the populations selected after kernel inoculation. Responses to selection were more evident in later than in earlier generations for both types of inoculation. Changes in the estimated genetic gain over generations were consistent with changes in the variances among families, which tended to increase in early generations and to decrease in later generations. Selection after kernel inoculation seemed to have been more effective than selection after silk inoculation in developing families with more stable resistance. Based on the results obtained here...

‣ Incorporating pedigree information into the analysis of agricultural genetic trials.

Oakey, Helena
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2008 Português
Relevância na Pesquisa
357.30324%
This thesis presents a statistical approach which incorporates pedigree information in the form of relationship matrices into the analysis of standard agricultural genetic trials, where elite lines are tested. Allowing for the varying levels of inbreeding of the lines which occur in these types of trials, the approach involves the partitioning of the genetic effect of lines into additive genetic effects and non-additive genetic effects. The current methodology for creating relationship matrices is developed and in particular an approach to create the dominance matrix under full inbreeding in a more efficient manner is presented. A new method for creating the dominance matrix assuming no inbreeding is also presented. The application of the approach to the single site analyses of wheat breeding trials is shown. The wheat lines evaluated in these trials are inbred lines so that the total genetic effect of each of the lines is partitioned into an additive genetic effect and an epistatic genetic effect. Multi-environment trial analysis is also explored through the application of the approach to a sugarcane breeding trial. The sugarcane lines are hybrids and therefore the total genetic effect of each hybrid is partitioned into an additive genetic effect...

‣ Pedigree with frontotemporal lobar degeneration - motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9

Luty, A.; Kwok, J.; Thompson, E.; Blumbergs, P.; Brooks, W.; Loy, C.; Dobson-Stone, C.; Panegyres, P.; Hecker, J.; Nicholson, G.; Halliday, G.; Schofield, P.
Fonte: BioMed Central Ltd. Publicador: BioMed Central Ltd.
Tipo: Artigo de Revista Científica
Publicado em //2008 Português
Relevância na Pesquisa
361.71117%
Background: Frontotemporal lobar degeneration (FTLD) represents a clinically, pathologically and genetically heterogenous neurodegenerative disorder, often complicated by neurological signs such as motor neuron-related limb weakness, spasticity and paralysis, parkinsonism and gait disturbances. Linkage to chromosome 9p had been reported for pedigrees with the neurodegenerative disorder, frontotemporal lobar degeneration (FTLD) and motor neuron disease (MND). The objective in this study is to identify the genetic locus in a multi-generational Australian family with FTLD-MND. Methods: Clinical review and standard neuropathological analysis of brain sections from affected pedigree members. Genome-wide scan using microsatellite markers and single nucleotide polymorphism fine mapping. Examination of candidate genes by direct DNA sequencing. Results: Neuropathological examination revealed cytoplasmic deposition of the TDP-43 protein in three affected individuals. Moreover, we identify a family member with clinical Alzheimer's disease, and FTLD-Ubiquitin neuropathology. Genetic linkage and haplotype analyses, defined a critical region between markers D9S169 and D9S1845 on chromosome 9p21. Screening of all candidate genes within this region did not reveal any novel genetic alterations that co-segregate with disease haplotype...

‣ Recommendations for standardized human pedigree nomenclature. Pedigree Standardization Task Force of the National Society of Genetic Counselors.

Bennett, R L; Steinhaus, K A; Uhrich, S B; O'Sullivan, C K; Resta, R G; Lochner-Doyle, D; Markel, D S; Vincent, V; Hamanishi, J
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /03/1995 Português
Relevância na Pesquisa
271.62906%
The construction of an accurate family pedigree is a fundamental component of a clinical genetic evaluation and of human genetic research. Previous surveys of genetic counselors and human genetic publications have demonstrated significant inconsistencies in the usage of common pedigree symbols representing situations such as pregnancy, termination of pregnancy, miscarriage, and adoption, as well as less common scenarios such as pregnancies conceived through assisted reproductive technologies. The Pedigree Standardization Task Force (PSTF) was organized through the Professional Issues Committee of the National Society of Genetic Counselors, to establish recommendations for universal standards in human pedigree nomenclature. Nomenclature was chosen based on current usage, consistency among symbols, computer compatibility, and the adaptability of symbols to reflect the rapid technical advances in human genetics. Preliminary recommendations were presented for review at three national meetings of human genetic professionals and sent to > 100 human genetic professionals for review. On the basis of this review process, the recommendations of the PSTF for standardized human pedigree nomenclature are presented here. By incorporating these recommendations into medical genetics professional training programs...

‣ Meupedigree.com.br: Sistema de Gestao de Cadastro de Cachorros e Pedigree - SGCCP

Sousa, Jania B??rbara de; Alc??ntara, Rafael Teodoro de
Fonte: Centro Universitário de Brasília Publicador: Centro Universitário de Brasília
Tipo: Trabalho de Conclusão de Curso
Português
Relevância na Pesquisa
357.30324%
Este trabalho apresenta an??lise para o desenvolvimento do sistema de informa????o Web que realizar?? o relacionamento entre as entidades: CBKC, Kennel Clube, Canil e Cliente. Objetivo maior de informatizar o processo do Pedigree. Para o desenvolvimento do trabalho foram empregados os conhecimentos adquiridos no decorrer do curso, como t??cnicas de elicita????o de requisitos, reuni??es e entrevistas, modelagem de dados e documenta????o. O preciso levantamento dos requisitos ofereceu conhecimento rico para a elabora????o de toda a documenta????o necess??ria ?? continuidade deste projeto, a experi??ncia de membros do grupo com a atua????o no com??rcio de cachorros facilitou o processo. O trabalho foi iniciado com intuito de contribuir para a formaliza????o do com??rcio de animais e colaborar para o relacionamento das entidades acima citadas.

‣ Comparing Pedigree Graphs

Kirkpatrick, Bonnie; Reshef, Yakir; Finucane, Hilary; Jiang, Haitao; Zhu, Binhai; Karp, Richard M.
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
271.62906%
Pedigree graphs, or family trees, are typically constructed by an expensive process of examining genealogical records to determine which pairs of individuals are parent and child. New methods to automate this process take as input genetic data from a set of extant individuals and reconstruct ancestral individuals. There is a great need to evaluate the quality of these methods by comparing the estimated pedigree to the true pedigree. In this paper, we consider two main pedigree comparison problems. The first is the pedigree isomorphism problem, for which we present a linear-time algorithm for leaf-labeled pedigrees. The second is the pedigree edit distance problem, for which we present 1) several algorithms that are fast and exact in various special cases, and 2) a general, randomized heuristic algorithm. In the negative direction, we first prove that the pedigree isomorphism problem is as hard as the general graph isomorphism problem, and that the sub-pedigree isomorphism problem is NP-hard. We then show that the pedigree edit distance problem is APX-hard in general and NP-hard on leaf-labeled pedigrees. We use simulated pedigrees to compare our edit-distance algorithms to each other as well as to a branch-and-bound algorithm that always finds an optimal solution.

‣ Introduction. Evolutionary dynamics of wild populations: The use of long-term pedigree data

Kruuk, Loeske; Hill, W.G.
Fonte: Royal Society of London Publicador: Royal Society of London
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
357.30324%
Studies of populations in the wild can provide unique insights into the forces driving evolutionary dynamics. This themed issue of Proc. R. Soc. B focuses on new developments in long-term analyses of animal populations where pedigree information has been

‣ Preliminary report: Pedigree analysis of the Brangus cattle in South Africa

Steyn,J.W.; Neser,F.W.C.; Hunlun,C.; Lubout,P.C.
Fonte: South African Journal of Animal Science Publicador: South African Journal of Animal Science
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2012 Português
Relevância na Pesquisa
364.69723%
The aim of the study was to investigate some population parameters, including generation interval, inbreeding and effective population size of Brangus cattle in South Africa (SA) to assist in constructing an effective selection programme for the SA Brangus breed. Pedigree analysis can describe the genetic variability and change over time, making it an important tool to be used to assess parameters like generation interval, inbreeding, effective population size and number of animals selected against number born. These traits can be used to make more informed selection decisions in order to maintain a genetically healthy population through a better understanding of the dynamics within the population. A Population Structure- and Pedigree Analysis Report was generated with the PopReport programme from the Institute of Farm Animal Genetics (FLI) with a Brangus datafile containing 65 536 animals. Results were reported for the time period of 1986 to 2008 and the following results were obtained: 3-generation pedigree completeness is at 73.8% for 2008, with an inbreeding coefficient of 1.39% and an annual increase in inbreeding of 0.058%. Weighted generation interval was 5.17 years and the effective population size based on the average inbreeding was 166.7 animals.