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‣ Subcutaneous and testicular metastasis from prostatic adenocarcinoma with neuroendocrine differentiation

Dénes, F. T.; Brito, A. H.; Dos Santos, A. M.
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 52-54
Português
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The pathological finding of testicular metastasis in cases of disseminated prostatic adenocarcinoma is rare, but was more frequently reported in the past, when bilateral castration was performed more often. The existence of skin and subcutaneous metastasis adds a worse prognosis, because generally it is sign of advanced disease with an average survival time of less than one year. The synchronous occurrence of such metastasis has not been described previously, neither their association to neuroendocrine differentiation. The presence of such differentiation of prostatic adenocarcinoma represents a very unfavorable prognostic factor, as suggested in recent literature. Herein, we discuss the case of a 53 year old man, who presented with macroscopic hematuria and frequency associated to several painless subcutaneous nodules in left axilla and shoulder, as well as in the lower abdominal wall. The right testis was painful, endured and on rectal examination, the prostate was diffusely enlarged. Serum PSA was elevated, reaching 1760 ng/ml and prostatic biopsy disclosed a Gleason 10 prostatic adenocarcinoma with neuroendocrine differentiation. The same pathological pattern was detected in the right testis and in all subcutaneous nodules, documented by positive staining of chromogranin...

‣ Intraepithelial alterations in the Guinea pig lateral prostate at different ages after estradiol treatment

Scarano, W. R.; Cordeiro, R. S.; Góes, R. M.; Taboga, S. R.
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 141-148
Português
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The prostate is an accessory gland of the mammal reproductive system with great volume and high functional importance. Many works infer that, in addition to the androgenic ones, the estrogen can be associated with benign prostatic hyperplasia and prostatic cancer, but no conclusive evidence exists on the role of estrogen in normal prostatic and neoplastic tissue. The objective of this work was to evaluate the effects of chronic administration of estradiol benzoate on the lateral prostate of guinea pigs in the pre-pubescent, pubescent, post-pubescent and adult phases, with emphasis on the modifications provoked by this hormone on the glandular epithelium. The analyses of the estradiol-treated and control groups were investigated using histological procedures and transmission electron microscopy. The histopathological analysis of the lateral prostate in the treated group revealed areas where epithelial dysplasia was observed, assuming at some places a pattern of epithelial stratification characteristic of prostatic intraepithelial neoplasia. After ultrastructural analysis, the following were observed: enlargement of the internal membranes, heterogeneity in the cellular types, hypertrophy of the basal cells and apparent decrease of cytoplasmic organelles in some cells of the prostatic intraepithelial neoplasia. Still...

‣ Avaliação antropométrica, prostatica e polimorfismos de TP53 e GSTP1 em populações do estremo setentrional amazônico; Antropometric, prostatic characteristics and single nucleotide polymorphisms of TP53 and GSTP1 in populatins of northern Brazil

Mario Maciel de Lima Junior
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 03/12/2012 Português
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As doenças da glândula prostática em geral e a incidência de câncer da próstata, em particular, mostram disparidades acentuadas entre os diferentes países e etnias. De fato, etnia, idade e história familiar são os mais fortes fatores de risco conhecidos para o câncer da próstata, mas a dieta, índice de massa corporal e outros fatores também podem influenciar o seu desenvolvimento. O objetivo deste estudo é descrever aspectos clínicos, antropométricos e genéticos da próstata de índios brasileiros da região amazônica. Foram analisados um total de 228 indígenas do sexo masculino ? 40 anos submetidos a exame físico, incluindo exame retal digital da próstata (TR), e a um questionário individualizado que incluía características demográficas e estilo de vida; história médica familiar e pessoal para câncer da próstata. Amostras de sangue foram obtidas para a determinação do antígeno prostático específico (PSA) e concentrações de testosterona sérica e genotipagem para TP53 e GSTP1. Os dados da população indígena foram comparados com os de um grupo controle de 87 não-indígenas masculinos da mesma região. Entre os 14 grupos étnicos identificados, Macuxi, é a etnia de índios aculturados mais frequente (43...

‣ Papel da PS20/WFDC1 no desenvolvimento prostático e regulação da distribuição das células p63 positivas; Role of PS20/WFDC1 in the prostatic development and regulation of the distribution of p53-positive cells

Augusto César Spadaccia Asciutti
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 12/07/2013 Português
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Introdução: Durante o desenvolvimento e a vida adulta de um organismo, células troncoindiferenciadas, capazes de dar origem a um ou mais tipos celulares, proliferam e se diferenciam para, tanto produzir os tecidos de um organismo em desenvolvimento, quanto repor células perdidas pelo envelhecimento, doença ou injúria. Essas células residem em um nicho especializado contendo células diferenciadas e elementos responsáveis por manter o estado predominantemente quiescente. Acredita-se que as células tronco da próstata contribuam para o desenvolvimento de câncer através da desregulação dos elementos do nicho. ps20 é um elemento secretado por células musculares lisas da próstata, o qual demonstra capacidade de inibir o crescimento da linhagem de células prostáticas cancerígenas PC3 em cultura. Evidências sugerem uma possível relação entre ps20 com a adesão celular. No entanto, seu funcionamento é pouco conhecido. Objetivos: Analisar o efeito do silenciamento do gene WFDC1/ps20 sobre o comportamento das células p63+ e arquitetura tecidual durante o desenvolvimento prostático pós-natal. Materiais e métodos: Próstatas ventrais de ratos Wistar recém nascidos foram cultivadas sobre membranas flutuantes permeáveis...

‣ Efficiency of 6- and 12-punctures biopsies to detect prostate cancer in patients with PSA< 10 ng/mL and normal digital rectal examination

Slongo,Luiz E.; Sugisawa,Mário C.; Ioshii,Sérgio O.; Tâmbara Filho,Renato; Rocha,Luiz C.A.
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2003 Português
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OBJECTIVE: Establish the efficiency of 6- and 12-punctures transrectal ultrasound-guided needle biopsies in low risk patients for prostate cancer. Six-punctures (sextant) biopsies were compared to 12-punctures biopsies, assessing which is the best strategy to detect this neoplasm. MATERIALS AND METHODS: Among 240 patients submitted to prostate biopsy, 54 with suspected small and organ-localized tumors (prostatic specific antigen < 10 ng/mL and digital exam of the prostate not suggesting cancer) in glands < 50 cm³ were selected, constituting a homogenous sample. These patients were submitted to standard 3-punctures (basal, mid, and apical) sextant biopsy in parasagittal midline of each prostatic lobe, with 3 additional lateral punctures, bilaterally. Each specimen was separately submitted to histological study. RESULTS: Twenty-two (40.7%) patients had prostatic cancer, and 28 presented prostatic hyperplasia, associated or not to inflammatory conditions. High-grade prostatic intraepithelial neoplasia (PIN) was detected in 4 patients. From 22 tumors detected by 12-punctures biopsies, 6-punctures biopsies in the parasagittal midline (sextant) diagnosed 50% of the cases, while isolated lateral punctures diagnosed 90.9% of the malignant neoplasms. Basal lateral punctures responded for 72.7% of the cancer diagnosis...

‣ The impact of prior prostatic surgery on urinary continence in patients undergoing orthotopic ileal neobladder

Arruda,Homero O. de; Suarez,Rubens; Srougi,Miguel; Paula,Adriano A. de; Cury,José
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2003 Português
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OBJECTIVE: To establish if previous surgery for benign prostatic hyperplasia (transurethral resection of the prostate or open prostatectomy), age, and preservation of prostatic apex can influence postoperative urinary continence in patients submitted to radical cystectomy and orthotopic ileal neobladder. PATIENTS AND METHODS: We analyzed 62 patients with bladder cancer who were treated with radical cystectomy and orthotopic ileal neobladder between 1987 and 1998 and had been followed for at least 24 months. The average age and median follow up were 61 years and 53 months, respectively. Postoperative urinary continence was correlated with 3 factors: patient age, preservation of prostatic apex during surgical excision and prior prostatic surgery for benign disease. Patients were defined as incontinent when they had to use more than 1 protective pad at the daytime. RESULTS: The overall incidence of urinary incontinence was 12.9% (8 out of 62 patients). The only statistically significant factor that impacted upon urinary continence was previous prostatic surgery, with respectively 33% versus 7% rate of incontinence for patients previously operated on and for those without previous operation (p = 0.023 odds ratio = 6.5, 95% confidence interval). Preservation of prostatic apex did not reach difference...

‣ Coexistence of prostate neoplasia in patients undergoing radical cystoprostatectomy due to vesical neoplasia

Romero,Frederico R.; Castro,Marília G. de; Andriolo Júnior,Adalberto; Meneses,Alex H. de; Fernandes,Roni C.; Perez,Marjo D.C.
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2004 Português
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OBJECTIVE: To assess the incidence of bladder carcinoma infiltrating the prostate and prostate adenocarcinoma in patients undergoing radical cystoprostatectomy due to bladder cancer, as well as to assess if the characteristics of the bladder neoplasia influence the prostatic involvement by this neoplasia. MATERIALS AND METHODS: We retrospectively assessed 60 male patients, who underwent radical cystoprostatectomy between July 1997 and December 2003. Mean age was 66.7 years (40 and 93 years). The product of radical cystoprostatectomies was checked for involvement of urethra and prostate parenchyma by the primary neoplasia, and for the presence of associated prostate adenocarcinoma. Bladder neoplasia characteristics, such as localization, size, multifocality, association with in situ carcinoma and histological grade, were studied in order to assess the possibility of using such characteristics as predictive factors of prostate infiltration by bladder urothelial carcinoma. RESULTS: We observed the presence of 20% of patients with bladder carcinoma infiltrating the prostatic urethra, 23.3% of patients with infiltration of the prostate parenchyma and 28.3% of patients with associate prostate adenocarcinoma, resulting in a total of 55% of patients with prostatic involvement (infiltrative bladder carcinoma and/or adenocarcinoma). We also observed a statistically significant correlation between tumor location in the trigone...

‣ Prostatic atrophy: clinicopathological significance

Billis,Athanase
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2010 Português
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Prostatic atrophy is a benign lesion that may mimic adenocarcinoma histologically and on imaging. It is more frequent in the peripheral zone and has gained importance with the increasing use of needle biopsies. Diffuse atrophy occurs secondarily to radiotherapy and/or endocrine therapy. Inflammation and/or chronic local ischemia may cause focal atrophy with an increasing frequency in age. Atrophy may be classified morphologically into diffuse and focal. The latter may be partial, complete or combined. Partial focal atrophy is the most frequent mimicker of adenocarcinoma on needle biopsies. Complete focal atrophy may be subtyped into simple, sclerotic and hyperplastic (or postatrophic hyperplasia). Combined lesions are frequent and partial atrophy may precede complete atrophy. The several morphologic types of focal atrophy may represent a morphologic continuum and the hyperplastic (or postatrophic hyperplasia) subtype seems to be at the extreme end of this continuum. Chronic inflammation associated to focal atrophy (proliferative inflammatory atrophy) has been linked to high-grade prostatic intraepithelial neoplasia and/or carcinoma. This link, however, remains controversial in the literature. The question whether inflammation directly produces tissue damage and atrophy or some other insult induces atrophy directly...

‣ Does tumor extent on needle prostatic biopsies influence the value of perineural invasion to predict pathologic stage > T2 in radical prostatectomies?

Billis,Athanase; Quintal,Maisa M. de; Meirelles,Luciana; Freitas,Leandro L. L.; Magna,Luis A.; Ferreira,Ubirajara
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2010 Português
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PURPOSE: Perineural invasion (PNI) on needle prostatic biopsies (NPB) has been controversial as a marker of extraprostatic extension and consequently for planning of nerve-sparing radical prostatectomy (RP). The aim of this study was to find whether tumor extent on NPB influences the value of PNI to predict stage > pT2 on RP. MATERIALS AND METHODS: This retrospective study was based on 264 consecutive patients submitted to radical retropubic prostatectomy. Their NPB were matched with whole-mount processed and totally embedded surgical specimens. Tumor extent on NPB was evaluated as the percentage of linear tissue in mm containing carcinoma in all cores. Considering the median value, patients were stratified into 2 groups: harboring less or more extensive tumors on NPB. Univariate and multivariate logistic regression analyses were used to relate stage > pT2 to PNI and other clinical and pathological variables. RESULTS: In patients with more extensive tumors, PNI was predictive of stage > pT2 in univariate analysis but not in multivariate analysis. In less extensive tumors, PNI showed no association between any clinical or pathological variables studied; no difference in the time to biochemical progression-free status compared to patients without PNI; and...

‣ The novel prostate cancer antigen 3 (PCA3) biomarker

Bourdoumis,Andreas; Papatsoris,Athanasios G.; Chrisofos,Michael; Efstathiou,Eleni; Skolarikos,Andreas; Deliveliotis,Charalambos
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2010 Português
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PCA3 is a prostate specific, nonprotein coding RNA that is significantly over expressed in prostate cancer, without any correlation to prostatic volume and/or other prostatic diseases (e.g. prostatitis). It can now easily be measured in urine with a novel transcription-mediated amplification based test. Quantification of PCA3 mRNA levels can predict the outcome of prostatic biopsies with a higher specificity rate in comparison to PSA. Several studies have demonstrated that PCA3 can be used as a prognostic marker of prostate cancer, especially in conjunction with other predictive markers. Novel PCA3-based nomograms have already been introduced into clinical practice. PCA3 test may be of valuable help in several PSA quandary situations such as negative prostatic biopsies, concomitant prostatic diseases, and active surveillance. Results from relevant clinical studies, comparative with PSA, are warranted in order to confirm the perspective of PCA3 to substitute PSA.

‣ Inflammation and endothelial activation in benign prostatic hyperplasia and prostate cancer

Pace,Gianna; Massimo,Caterina Di; Amicis,Daniela De; Vicentini,Carlo; Ciancarelli,M. Giuliana Tozzi
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2011 Português
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PURPOSE: Emerging insights underline a link among chronic inflammation and endothelial activation with benign prostatic hyperplasia (BPH) and prostate cancer (PCa). We aim to investigate whether specific plasma markers of inflammation and endothelial activation allow to discriminate BPH and PCa. MATERIALS AND METHODS: Fifteen patients affected by BPH, 15 by PCa and 15 controls, were enrolled. Interleukin-6 (IL-6), CD40 ligand (CD40L), endothelial-selectin (E-selectin), platelet-selectin (P-selectin), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) were measured. RESULTS: In systemic blood samples, IL-6 has been found increased in patients affected by BPH (4.25 ± 0. pg/mL) and PCa (5.08 ± 0.24) respect to controls (2.62 ± 0.34; p < 0.05). CD40L was higher in BPH (4.25 ± 0.65 ng/mL; p < 0.05) than in control (2.31 ± 0.20) and PCa group (2.60 ± 0.56). E-selectin, P-selectin and VCAM-1 did not show any significant difference. Higher levels of ICAM-1 were detected in patients with PCa (573.04 ± 52.23) and BPH (564.40 ± 74.67) than in the controls (215.30 ± 11.53 ng/mL; p < 0.05). In local blood samples, IL-6 has been found significantly increased in PCa in comparison with patients with BPH; there was no difference in CD40L...

‣ Magnetic Resonance Image in the diagnosis and evaluation of extra-prostatic extension and involvement of seminal vesicles of prostate cancer: a systematic review of literature and meta-analysis

Silva,Rogerio Cardoso da; Sasse,Andre Deeke; Matheus,Wagner Eduardo; Ferreira,Ubirajara
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2013 Português
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Objective Systematic review of literature and meta-analysis to evaluate the results of magnetic resonance image 1.5T with endorectal coil in the diagnosis and evaluation of extra-prostatic extension and involvement of seminal vesicles of prostate cancer, compared to the histopathological results of the radical prostatectomy specimen. Materials and Methods It was conducted a systematic review of literature and meta-analyses of all studies data published after 2008. In those studies, the patients with prostate cancer with indication to radical prostatectomy were submitted to magnetic resonance image (MRI) at pre-operatory period and the results were compared to those of histopathological studies after the surgery. The selected terms for research included prostate cancer, magnetic resonance, radical prostatectomy, and prostate cancer diagnosis, in the databases EMBASE, LILACS, PUBMED/MEDLINE and Cochrane Library. The data were collected using a specific qualitative instrument and the meta-analysis data were presented in the forest plot graphics, homogeneity test and sROC curves and funnel plot. Results A total of seven studies were included, with a total of 603 patients. Among these studies, six evaluated the value of MRI for the detection of prostate cancer...

‣ Adenocarcinoma on needle prostatic biopsies: Does reactive stroma predicts biochemical recurrence in patients following radical prostatectomy?

Billis,Athanase; Meirelles,Luciana; Freitas,Leandro L.L.; Polidoro,Aline S.; Fernandes,Hamilton A.; Padilha,Mariana M.; Magna,Luis A.; Reis,Leonardo O.; Ferreira,Ubirajara
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2013 Português
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Objective There is evidence that reactive stroma in different cancers may regulate tumor progression. The aim of this study is to establish any possible relation of reactive stroma grading on needle prostatic biopsies to biochemical recurrence. Materials and Methods The study group comprised 266 biopsies from consecutive patients submitted to radical prostatectomy. Reactive stroma was defined as stroma surrounding neoplastic tissue and graded as 0 (absent), 1 (slight), 2 (moderate), and 3 (intense) according to tumor stroma area relative to total tumor area. Results From the total of 266 needle prostatic biopsies, 143 (53.8%), 55 (20.7%), 54 (20.3%), and 14 (5.3%) showed grades 0, 1, 2, and 3, respectively. Increasing reactive stroma grade was significantly associated with clinical stage T2, higher preoperative PSA, higher biopsy and radical prostatectomy Gleason score, more extensive tumors in radical prostatectomy, and pathologic stage > T2. Only grade 3 was significantly associated with time and risk to biochemical recurrence. On multivariate analysis only preoperative PSA and 2 methods of biopsy tumor extent evaluation were independent predictors. Conclusion Increasing reactive stroma grade on biopsies is significantly associated with several clinicopathologic adverse findings...

‣ Analysis of the risk factors for incidental carcinoma of the prostate in patients with benign prostatic hyperplasia

Antunes,Alberto Azoubel; Freire,Geraldo de Campos; Aiello Filho,Domingos; Cury,José; Srougi,Miguel
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2006 Português
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PURPOSE: To determine the occurence of incidental carcinoma of the prostate, its characteristics, and the risk factors for this diagnosis in a group of patients surgically treated for benign prostatic hyperplasia. METHODS: The study comprised a retrospective analysis of 218 patients. After surgical treatment, patients with the finding of incidental carcinoma of the prostate were compared to those without this finding. The preoperative variables analyzed were patient age, digital rectal examination, PSA, PSA density, prostate volume, and preoperative prostate biopsy. We also determined the sensitivity, specificity, positive predictive value, and negative predictive value of digital rectal examination and PSA for the finding of incidental carcinoma of the prostate at surgical specimen analysis. RESULTS: Thirteen (6.2%) out of the 218 patients presented incidental carcinoma of the prostate. Eight (61.5%) of these tumors were classified as T1a and 5 (38.5%) as T1b. Only advanced age (P = 0.003) and the presence of a suspect digital rectal examination (P = 0. 016) were statistically related to the findings of the surgical specimen analysis. The sensitivity, specificity, positive predictive value, and negative predictive value for the diagnosis of incidental carcinoma were 23.0%...

‣ Versican accumulation in human prostatic fibroblast cultures is enhanced by prostate cancer cell-derived transforming growth factor beta1

Sakko, A.; Ricciardelli, C.; Mayne, K.; Tilley, W.; LeBaron, R.; Horsfall, D.
Fonte: Amer Assoc Cancer Research Publicador: Amer Assoc Cancer Research
Tipo: Artigo de Revista Científica
Publicado em //2001 Português
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We have previously demonstrated that peritumoral stromal matrix derived from prostate cancer patients who relapse after radical surgery contains elevated levels of versican. The purpose of this study was to determine whether prostate cancer cells control stromal cell secretion of versican. Serum-free conditioned medium from three prostate adenocarcinoma cell lines, LNCaP, PC3, and DU145, was added to cultures of fibroblasts established from prostatic tissue of patients with benign prostatic hyperplasia, and the medium was harvested at 24, 48, and 72 h. Immunoblotting with an antiversican core protein antibody revealed that prostatic fibroblast medium harvested at 72 h contained increased levels of versican after treatment with either LNCaP-, PC3- or DU145-conditioned medium (2.5-, 4.5-, and 5-fold, respectively) compared with control cultures. This increase in versican in the culture medium was not observed after coincubation with transforming growth factor ß1-neutralizing antisera. The results of this study suggest that prostate tumor cells induce host stromal cells to secrete increased versican levels via a paracrine mechanism mediated by transforming growth factor ß1.; Andrew J. Sakko, Carmela Ricciardelli, Keiko Mayne, Wayne D. Tilley...

‣ Perfil dos pacientes submetidos à biópsia de próstata = : Profile of patients who undergo prostate biopsy; Profile of patients who undergo prostate biopsy

Felipe Gonçalves Schröder e Souza
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 23/06/2015 Português
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Introdução: A neoplasia de próstata é a segunda mais prevalente entre os homens, com estimativa de cerca de 68 mil casos novos no Brasil em 2014. Além disso, é a segunda causa de morte no sexo masculino por neoplasias. O câncer de próstata raramente causa sintomas em seus estágios iniciais, por isso existe a necessidade do diagnóstico precoce. Atualmente a forma de rastreamento desta neoplasia ainda é controverso, porém quando realizado, baseia-se em exame digital retal da próstata e na mensuração sérica dos níveis do PSA. Estudos de rastreamento populacional mostraram uma diminuição de 41% no casos de neoplasia avançada de próstata e risco de diagnóstico de câncer 46% maior, quando comparados a grupos não submetidos a rastreamento. O PSA não é câncer específico, então, os refinamentos do PSA (relação do PSA livre/total, densidade do PSA e velocidade do PSA) aparecem como métodos para melhorar sua especificidade, na tentativa de diminuir o número de biópsias desnecessárias. Quando existe suspeita diagnóstica, é indicada uma biópsia guiada por ultrassonografia transretal, procedimento que não é isento de complicações, principalmente as infecciosas. Objetivos: Avaliar a positividade para adenocarcinoma de próstata em biópsias guiadas por ultrassonografia transretal...

‣ Caracterização do estroma reativo no câncer de próstata : envolvimento de fatores de crescimento, metaloproteinases de matriz, receptores de hormônios sexuais e células-tronco prostáticas; Reactive stroma in prostate cancer : involvement of growth factors, matrix metalloproteinases, receptors, sex hormones and prostatic stem cells

Mauricio Moreira Silva Junior
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 28/08/2014 Português
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Caracterização do Estroma Reativo na Progressão do Câncer de Próstata: Envolvimento dos Fatores de Crescimento, Metaloproteinases da Matriz, Receptores de Hormônios Sexuais e Células-Tronco Prostáticas RESUMO A contribuição do estroma para a progressão do câncer de próstata (CaP) ainda é pouco conhecida. As células neoplásicas podem alterar seu componente estromal adjacente para formar um ambiente que possibilita e suporta a progressão tumoral. A modificação desse estroma é denominado de estroma reativo (EstR), o qual ocorre em muitos tipos de cânceres humanos relacionando-se à progressão e recidiva tumorais. Os fatores de crescimento e as metaloproteinases da matriz (MMP) são altamente expressos no CaP e podem atuar como fatores de crescimento parácrinos e/ ou autócrinos. As relações entre os hormônios sexuais esteróides e seus receptores com os fatores de crescimento e MMPs são cruciais reguladores da homeostase prostática, sendo fundamental o entendimento dessas relações com o desenvolvimento do EstR e progressão do CaP. Além disso, a ocorrência das células-tronco prostáticas cancerosas representam um passo importante na patogênese glandular. Assim, os objetivos principais do presente estudo foram caracterizar morfológica e molecularmente o microambiente do EstR em amostras com CaP...

‣ Carcinogênese prostática quimicamente induzida por N-metil N-nitrosuréia (MNU) em gerbilos da Mongólia : associação com promotores esteróides ou dieta hiperlipídica = Prostate carcinogenesis chemically induced by N-methyl-N Prostate carcinogenesis chemically induced by N-methyl-Nnitrosourea: association with steroids promoters or high-fat diet; Prostate carcinogenesis chemically induced by N-methyl-N nitrosourea (MNU) in Mongolian gerbils : association with steroids promoters or high-fat diet

Bianca Facchim Gonçalves
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 30/08/2013 Português
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Um dos principais desafios no campo de pesquisa do câncer prostático é a busca por sistemas modelo que permitam a investigação dos aspectos patológicos, bioquímicos e genéticos desta doença. O gerbilo Meriones unguiculatus tem possibilitado a avaliação de lesões prostáticas e sua evolução de estágio benigno para maligno (invasivo) após período relativamente curto de tratamento com o carcinógeno N-Metil-N-Nitrosuréia (MNU), um potente causador de metilação do DNA por ação direta. Assim, o presente trabalho teve por objetivos: 1) Determinar a incidência, multiplicidade e latência tumoral de lesões espontâneas e quimicamente induzidas nos lobos prostáticos ventral e dorsolateral do gerbilo; 2) Investigar se o estradiol exerce papel protetor e/ou promotor sobre neoplasias induzidas por MNU; 3) Avaliar o potencial promotor da dieta hiperlipídica sobre a carcinogênese induzida na próstata ventral; 4) Analisar a participação de produtos alterados de genes ras e do status global de metilação do DNA do epitélio prostático no processo tumoral mediado por MNU. Para tanto foram utilizados animais adultos submetidos à dose única intraperitoneal de MNU (50mg/Kg), exceto o grupo controle. Os grupos experimentais foram submetidos à exposição crônica de andrógeno...

‣ Análise dos fatores de risco para o diagnóstico do carcinoma incidental da próstata em pacientes com hiperplasia prostática benigna; Analysis of the risk factors for incidental carcinoma of the prostate in patients with benign prostatic hyperplasia

Antunes, Alberto Azoubel; Freire, Geraldo de Campos; Aiello Filho, Domingos; Cury, José; Srougi, Miguel
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 01/01/2006 Português
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OBJETIVO: Determinar a ocorrência do carcinoma incidental da próstata, suas características e fatores de risco para o diagnóstico em um grupo de pacientes tratados cirurgicamente para hiperplasia prostática benigna. MÉTODOS: O estudo compreendeu a análise retrospectiva de 218 pacientes. Após o tratamento cirúrgico, os pacientes com achado de carcinoma incidental da próstata foram comparados com os pacientes sem este achado. As variáveis pré-operatórias analisadas foram idade, toque retal, PSA, densidade do PSA, volume prostático e biópsia prostática pré-operatória. Também foram determinados a sensibilidade, especificidade, valor preditivo positivo e valor preditivo negativo do toque retal e do PSA para o diagnóstico do carcinoma incidental da próstata. RESULTADOS: Treze (6.2%) dos 218 pacientes apresentaram carcinoma incidental da próstata. Oito (61.5%) deles foram classificados com T1a e 5 (38.5%) como T1b. Apenas a idade avançada (p=0.003) e a presença de um toque retal suspeito (p=0.016) se relacionaram estatisticamente com este achado na peça cirúrgica. A sensibilidade, especificidade, valore preditivo positivo e negativo para o diagnóstico de carcinoma incidental da próstata foram de 23.0%, 96.6%, 30.0%...

‣ Correlação entre exposição ao óxido de etileno e câncer de próstata: doença ocupacional?; Correlation between prostatic cancer and ethylene oxide exposure: occupational disease?

Peixinho, Ricardo Ribeiro; Miziara, Carmen Silvia M. G.
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; RC Formato: application/pdf
Publicado em 14/12/2013 Português
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There are several articles in the medical literature that seek to verify if occupational exposure to chemical agents would occasion an increase in the incidence of prostate cancer, although prostate cancer is a multifactorial disease that likely involves both environmental and genetic factors. There is evidence that the prostate cancer risk varies most prominently with age, ethnicity, family history, and diet. The objective of this paper was to check if ethylene oxide could have a causal nexus to the development of prostatic cancer. The review articles published within the last twenty years have shown that there is still no consistent evidence that any chemical agent has an influence on the incidence of prostatic cancer. Consequently, to date there is no way of establishing if ethylene oxide has a causal nexus - to the development of this pathology.; Estudos publicados na literatura médica tentam demonstrar a relação entre a exposição ocupacional a agentes químicos e o aumento de incidência de câncer de próstata. A doença é de etiologia multifatorial, envolvendo fatores genéticos, ambientais, a idade, a etnia, a história familiar e a dieta. O objetivo desse estudo foi verificar a possibilidade da associação entre a exposição laboral ao óxido de etileno e o desenvolvimento de câncer de próstata para o estabelecimento do nexo causal ou da concausa por meio de revisão de literatura nas principais bases de dados disponíveis dos últimos 20 anos. A conclusão desse estudo foi que ainda não existem evidências consistentes de que qualquer agente químico tenha influência no aparecimento do câncer de próstata. Consequentemente...