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‣ Polycyclic Aromatic Hydrocarbons May Contibute for Prostate Cancer Progression
‣ Freqüência de câncer de próstata em pacientes transplantados renais: estudo caso-controle; Frequency of prostate cancer in patients submitted to renal transplantation: a case-control study
‣ Results of prostate cancer screening in non-symptomatic men
‣ Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer
‣ Histopathological characteristics of a novel knock-in mouse prostate cancer model
‣ Consumption of Fish Products across the Lifespan and Prostate Cancer Risk
‣ Genetic Polymorphisms of the Glycine N-Methyltransferase and Prostate Cancer Risk in the Health Professionals Follow-Up Study
‣ Unemployment and prostate cancer mortality in the OECD, 1990–2009
‣ Immuno-oncology of human prostate cancer : phenotypical characterization and study of the tumor-derived, androgen-regulated immunosuppressive microenvironment
‣ Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study
‣ Characterisation of the co-chaperone small glutamine-rich tetratricopeptide repeat containing protein alpha as a regulator of androgen receptor activity in prostate cancer cells.
‣ Non-pharmacological interventions for cancer-related fatigue in men treated for prostate cancer: a systematic review
‣ Androgen signalling in the prostate cancer microenvironment.
‣ Circulating fatty acids and prostate cancer risk: individual participant meta-analysis of prospective studies
‣ Curcumin action in prostate cancer cells and fibroblasts.
‣ Global levels of specific histone modifications and an epigenetic gene signature predict prostate cancer progression and development
‣ Evaluating DNA damage response (DDR) activation in human prostate cancer
‣ Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer
‣ Targeting Histone Deacetylases in Advanced Prostate Cancer
The androgen receptor (AR) signaling axis is a well-established therapeutic target in prostate cancer, due to its central role in tumor maintenance and progression. Although patients respond initially to androgen deprivation therapies and AR antagonists, they invariably progress to a castration-resistant state. Consequently, there is an unmet need for agents that target the AR signaling axis in a unique manner.
Histone deacetylase (HDAC) inhibitors repress AR signaling and prostate cancer growth in cellular and xenograft models. However, HDAC inhibitors also induce epithelial to mesenchymal (EMT) and neuroendocrine differentiation, both of which are associated with prostate cancer progression and aggressiveness. Given that 18 different HDAC isoforms have been identified in humans, and non-selective or Class I (HDAC1, 2, 3, and 8) HDAC inhibitors have been used in most of these studies, the relative contribution of individual HDAC isoforms to AR transcriptional activity and prostate cancer pathophysiology remains to be elucidated. The overarching goals of this study were to (1) determine the role of individual Class I HDACs in AR transcriptional activity and prostate cancer growth, (2) identify selective HDAC inhibitors that have reduced adverse profiles to the treatment of prostate cancer...